The document discusses electrolyte and fluid balance in the body. It explains that total body water is divided between intracellular fluid and extracellular fluid. It then covers various causes and presentations of fluid loss or excess, including isotonic volume depletion from diarrhea, dehydration from water loss, and fluid overload from conditions like congestive heart failure. Management involves evaluating sodium and assessing the type of fluid imbalance, and correcting it with intravenous saline or water as appropriate.
water and electrolyte (2).pptx Body is composed of about 60-70% water Distr...Shivangi sharma
URINE
Major route of water loss
Normal urine 1-2L/day.
Water loss through kidneys well regulated to meet body demands.
Urine production cannot be completely shut down, despite there being no water intake
due to the fact that some amount of water (about 500ml/day) is essential as the medium to eliminate the waste products from the body.
water and electrolyte (2).pptx Body is composed of about 60-70% water Distr...Shivangi sharma
URINE
Major route of water loss
Normal urine 1-2L/day.
Water loss through kidneys well regulated to meet body demands.
Urine production cannot be completely shut down, despite there being no water intake
due to the fact that some amount of water (about 500ml/day) is essential as the medium to eliminate the waste products from the body.
-water balance --> body composed of about 60-70% water
-total body water-->42L, ICF --> 28L, ECF --> 14L
- water output by urine,skin,lungs,feces.
-electrolyte bALANCE , expressed as mEq/L.
-water balance --> body composed of about 60-70% water
-total body water-->42L, ICF --> 28L, ECF --> 14L
- water output by urine,skin,lungs,feces.
-electrolyte bALANCE , expressed as mEq/L.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Normal Physiology
• Total body water is 60% of body weight in males, 50% of body
weight in females, i.e. 30 litres
• Intracellular water - 20 litres (2/3).
• Extracellular water - 10 litres (1/3).
- Plasma (1/4) (2.5 litres).
- Interstitial fluid (7.5 litres).
3. Normal Physiology
• ECF volume and osmolality regulation is controlled by three hormones.
• Aldosterone, ADH, atrial natriuretic hormone.
Ion ICF ECF and plasma
Sodium 10 mmol/L 140 mmol/L
Potassium 150 mmol/L 4.5 mmol/L
Chloride Trace only 105 mmol/L
4. WATER LOSS (VOLUME LOSS )
• It is decrease in the whole body fluid volume which includes both ECF
and ICF.
• It is usually ECF loss which is more important and assessed.
• It can be isotonic volume depletion with both salt and water loss leading
into hypovolaemia, or only water loss with only minimal loss of
electrolytes leading into dehydration.
5. Causes and Features
• Isotonic volume depletion occurs due to diarrhoea, vomiting, and
excess diuresis
• Here normal or decreased sodium is observed
• This causes hypotension and decreased tissue perfusion.
6. Causes and Features
• Dry tongue, rapid pulse, cold clammy extremities, sunken eyes,
hypotension, oliguria, raised blood urea, decreased urinary sodium.
• Hypovolaemia can be mild (< 2l fluid loss); moderate (2–3 L fluid
loss); severe (>3 L fluid loss).
7. Causes and Features
• Only pure water loss occurs due to poor fluid intake and diabetes
insipidus.
• It causes dehydration with proportionate decrease in total body water
(2/3rd ICF, 1/3rd ECF)
• As ECF including intravascular fluid loss is less, hypotension is less
8. Causes and Features
• Severe thirst, confusion and convulsions due to hypernatraemia;
blood pressure is relatively normal.
• Dehydration can be mild (weight loss 5%); moderate (10%); severe
(15%).
9. Management
• Evaluation is done by doing serum sodium, urinary sodium, and
blood urea.
• Isotonic volume depletion is corrected by 0.9% normal saline.
• Pure water depletion is corrected by more water intake/ intravenous
5% dextrose.
• Monitoring fluid therapy by skin and tongue examination, weight
gain, pulse, blood pressure, CVP, PCWP.
10. WATER EXCESS (ECF VOLUME EXCESS)
• It can be divided into water and salt excess or
predominantly water excess called as water intoxication.
• Water and salt excess occurs in CCF, cirrhosis,
nephrotic syndrome, hypoproteinaemia, renal failure,
excessive saline infusion.
11. WATER EXCESS (ECF VOLUME EXCESS)
• Water intoxication occurs in TURP, excess infusion of 5% dextrose
only, SIADH secretion, psychogenic polydypsia.
• It is managed by stopping fluid infusion or procedure (TURP); fluid
restriction, and treating the cause.
12. Causes
• Excessive amount of intravenous dextrose (5%).
• During colorectal bowel wash for preparation of large bowel for
surgery, if water is used instead of saline, especially in children.
13. Causes
• In TURP (Transurethral resection of prostate) when excess irrigating
fluid water or glycine is used (commonly used).
• In syndrome of inappropriate antidiuretic hormone (SIADH) which is
commonly associated with lobar pneumonia, empyema, oat cell
carcinoma and head injury.
14. Clinical features
• Drowsiness, weakness
• Convulsions and coma
• Nausea, vomiting
• Passage of dilute urine
• Distended neck veins
16. Treatment
• Water and salt restriction and observation.
• Monitoring in ICU.
• Management of fluid and electrolyte balance.
• Infusion of hypotonic sodium chloride.
17. Treatment
• Administration of diuretics and hypertonic saline should be avoided,
as it may cause rapid changes in serum sodium and water level
which will lead to neuronal demyelination and fatal outcome.
18. ECF LOSS
• Here only ECF loss is present with normal ICF.
• It is seen in vomiting, diarrhoea, intestinal obstruction.
• Treatment is infusion of normal saline.
19. ECF EXCESS
• Only ECF excess without an ICF excess.
• Excessive infusion of saline with impaired excretion.
• Raised JVP (earliest and best clinical sign), cardiac failure and
peripheral oedema.
• Treatment is fluid restriction and diuretics like frusemide
20. ECF EXCESS
• Only ECF excess without an ICF excess.
• Excessive infusion of saline with impaired excretion.
• Raised JVP (earliest and best clinical sign), cardiac failure and
peripheral oedema.
• Treatment is fluid restriction and diuretics like frusemide