Older adults were interviewed to understand their perspectives on involvement in health care innovation and regional health innovation ecosystems (RHIEs). Results showed that older adults are interested in involvement and see multiple potential roles, from developing ideas to testing technologies. Diversity among older adults was emphasized as a factor in planning involvement. Barriers like ageism were also identified. Engaging older adults in developing RHIEs could provide insights to enhance the value, acceptability, and use of new health technologies for aging populations. Next steps will use concept mapping to further understand stakeholder perspectives on older adult involvement in RHIEs.