The Kissmetrics webinar titled 'E-commerce Promotion 101' focuses on using non-intrusive popups to boost online sales, featuring insights from experts Emil Kristensen and Thue Madsen. The session covers various strategies such as personalizing popups, using them as guides, promoting products, and collecting visitor feedback. Key takeaways include the importance of A/B testing to optimize popups for higher conversion rates while adhering to best practices.