Glomerular Filtration and determinants of glomerular filtration .pptx
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Dysautonomia boles
1. Too Hot, Too Cold, Too High, Too Low -
Blame it on Dysautonomia!
MitoAction Webcast
6-May, 2011
Richard G. Boles, M.D.
Medical Genetics
Childrens Hospital Los Angeles
Associate Professor of Pediatrics
Keck School of Medicine at USC
2. Maternal Inheritance of
Functional Disorders
Cancer Dyslexia Bipolar, Migraine
Colitis Colitis Seizures, GERD, Migraine, Bipolar
CVS, Migraine, Depression, Seizures, Migraine
Bipolar, Anxiety Hearing loss
CVS CRPS CRPS SIDS Migraine Migraine Abdominal Ptosis
Migraine GERD Migraine CP Preemie Muscle CVS migraine Reyes syndrome
Seizures Seizures Blind weakness Failure to thrive
Muscle Migraine Hypoglycemia
Weakness Depression
Depression
ASD/VSD
Many of these conditions involve abnormal autonomic nervous
system activity, and can be thought of as dysautonomias.
3. Gardner 2006
Boles
The functional
depression
symptoms
tinnitus migraine elephant
fibromyalgia
cyclic vomiting
functional
abdominal
pain irritable bowel syndrome
complex regional
pain syndrome interstitial cystitis
restless legs
syndrome
The elephant is lying down due to chronic fatigue
5. The Autonomic Nervous System
Turns On and Off the βFight or
Flightβ Response
ο·β Sympathetic Nervous System
β’β On switch β tiger stalking
ο·β Parasympathetic Nervous System
β’β Off switch β tiger gone
8. Case Report
ο·β 15-year-old girl with cyclic vomiting syndrome,
constipation and chronic fatigue
β’β During vomiting episodes and viral infections she is
unable to read.
β’β Eye examinations are normal by two ophthalmologists.
β’β The school is alleging psychiatric disease or malingering.
β’β She is more comfortable wearing a hat, even indoors,
and wears a hat to the clinic visit.
9. Autonomic Nervous System
- The Eye
ο·β Sympathetic Nervous System
β’β On switch β tiger stalking
β’β Pupils dilate for better peripheral vision
β’β Lens focuses on distance
ο·β Parasympathetic Nervous System
β’β Off switch β tiger gone
β’β Pupils constrict to focus vision on central object
β’β Lens focuses on near
10. Autonomic Nervous System
- The Eye
ο·β Sympathetic Nervous System
β’β On switch β tiger stalking
β’β Pupils dilate for better peripheral vision causing photophobia;
she is uncomfortable outdoors in the sunlight or under
florescent lights. Wearing a hat is adaptive, so are sunglasses.
β’β Lens focuses on distance making it difficult to read. The
solution is reading glasses during illnesses.
ο·β Parasympathetic Nervous System
β’β Off switch β tiger gone
β’β Pupils constrict to focus vision on central object
β’β Lens focuses on near
11. Autonomic Nervous System
- Blood Vessels
ο·β Postural orthostatic
tachycardia syndrome
ο·β Color changes/rash: flushed,
pallor, mottled, circles under eyes
ο·β Heat and cold intolerance
ο·β Pain syndromes
β’β migraine/abdominal migraine
β’β complex regional pain syndrome
12. Case Report
ο·β 14-year-old boy with mild dysautonomic
symptoms, including chronic pain syndromes.
Sister and multiple matrilineal relatives have
functional/dysautonomic-related symptoms/
conditions
β’β Presented with sudden episodes of loss of
consciousness with pallor. Episodes are preceded by
nausea and dizziness.
13. Autonomic Nervous System
- Blood Vessels
ο·β Postural orthostatic
tachycardia syndrome
β’β Dizziness, blackouts
β’β Often precipitated by standing up
β’β More common in adolescents
β’β First-line treatment is increased fluids and salt
β’β Can be dramatic and appear as seizure
β’β May require medication
16. Autonomic Nervous System
- The Heart
ο·β Fast (tachycardia) and slow
(bradycardia) heart rates are
very common in mito disease.
ο·β In adults, heart attacks are not uncommon,
but rare in children. Usually, there was a
trigger (Imitrex, surgery) or no mito-care.
ο·β Chest pain in mito kids is almost always
GERD, and occasionally costochondritis.
ο·β Syncope is usually due to dysautonomia.
ο·β Cardiac birth defects are likely increased.
17. Autonomic Nervous System
- Secretory Glands
ο·β Sweat glands
ο·β Salivary glands www.buzzle.com
ο·β Lacrimal (tear) glands
ο·β Mammary (milk) glands
ο·β Reproductive system glands
ο·β Digestive system glands
18. Autonomic Nervous System
- The Gut
ο·β Sympathetic Nervous System
β’β On switch β tiger stalking
β’β Blood flow increases to brain and muscle, for quick thinking
and the power to act.
β’β Blood flow decreases to the gut, this is no time for digestion.
ο·β Parasympathetic Nervous System
β’β Off switch β tiger gone
β’β Blood flow increases to the gut allowing for digestion.
19. Autonomic Nervous System
- The Gut
ο·β Sympathetic Nervous System
β’β On switch β tiger stalking
β’β Blood flow increases to brain and muscle, for quick thinking
and the power to act.
β’β Blood flow decreases to the gut, this is no time for digestion.
ο·β Parasympathetic Nervous System
β’β Off switch β tiger gone
β’β Blood flow increases to the gut allowing for digestion.
Thus, βindigestionβ caused by decreased gut dysmotility is
common in sympathetic-driven conditions precipitated in
part by mitochondrial dysfunction.
21. Mito-dysmotility
Often occurs at different
levels in the same child
Intermittent
Very common in mito disease
Occurs in many different
Gastroesophageal mito disorders
reflux
Delayed X
gastric Another example of mito
emptying disease preferentially
X affecting the high-energy
demand tissues of muscle
X Irritable bowel and nerve:
X
Malabsorption
The GI tract is composed of
muscle, and synchronized by
nerves.
www.drugdevelopment-technology.com
22. Level of Dysmotility: Esophagus
Gastroesophageal Reflux Disease
βGERDβ
ο·β High prevalence:
β’β Very common in the general population.
β’β Nearly universal in mito
ο·β Clinical presentations: quite varied:
β’β Heartburn, abdominal pain
β’β Chronic nausea
β’β Chronic sinusitis, βallergyβ
β’β Cough, βasthmaβ
β’β Failure-to-thrive
β’β Malaise, fatigue
31. Level of Dysmotility: Large Intestine
Irritable Bowel
ο·β High prevalence:
β’β Very common in the general population.
β’β Nearly universal in mito
ο·β Clinical presentations:
β’β Constipation
β’β Diarrhea
β’β Alternating constipation and diarrhea
β’β Abdominal pain (usually relieved by BM)
β’β Distension/bloating
β’β Vomiting
β’β Failure-to-thrive
β’β Metabolic decompensation (fasting-invoked)
32. Level of Dysmotility: Large Intestine
Irritable Bowel
ο·β Diagnosis:
β’β Imaging (x-ray for stool)
β’β Tubes (colonoscopy)
β’β Motility studies
ο·β Treatment:
β’β Diet
β’β low-fat βheart-healthy dietβ
β’β prune juice, etc.
β’β Medications
β’β Polyethylene glycol (MiraLax, GoLytely)
β’β Milk of magnesia
β’β Amitiza
β’β Mechanical (enemas)
ο·β Prognosis: Usually intermittent, serious cases can progress
to pseudoobstruction
33. Level of Dysmotility: Large Intestine
Irritable Bowel
ο·β Diagnosis:
β’β Imaging (x-ray for stool)
β’β Tubes (colonoscopy)
β’β Motility studies
ο·β Treatment:
β’β Diet
β’β low-fat βheart-healthy dietβ
β’β prune juice, etc.
β’β Medications
β’β Polyethylene glycol (MiraLax, GoLytely)
β’β Milk of magnesia
β’β Amitiza
β’β Mechanical (enemas)
ο·β Prognosis: Usually intermittent, serious cases can progress
to pseudoobstruction
34. Diagnosis
ο·β Clinical β intermittent, multiple functional
symptoms
ο·β Increased symptoms with illness, fasting
ο·β Maternal inheritance
ο·β Urine organic acids, ketosis
ο·β Other biochemical testing
ο·β mtDNA sequencing
ο·β Ruling out other possible diagnoses
ο·β Response to mitochondrial-targeted therapies
35. Six Questions Predict Mitochondrial Function
Gardner and Boles, Bio Psycho Soc Med 2008
β’β My heart sometimes beats hard
β
or irregularly for no real
reason.β (Somatic Anxiety, item
34, p = 0.003).
β’β I often have aches in my
β
shoulders and in the back of my
neck.β (Muscular Tension, item 4, p
= 0.031).
β’β My body often feels stiff and
β
tense.β (Muscular Tension, item
33, p = 0.031).
β’β I think I must economize my
β
energy.β (Psychasthenia, item 40,
p = 0.015).
β’β In order to get something done I
β
have to spend more energy than 13/14 subjects with ATP production rates
most others.β (Psychasthenia, item
53, p = 0.031). below the normal range answered at least two
β’β I feel easily pressured when I am
β
of those six items as βApplies Completelyβ,
urged to speed compared to only 1/7 subjects with ATP
up.β (Psychasthenia, item 93, p =
0.014).
production rates within our control range (chi-
square P = 0.0003).
36. Therapy: General Principles
ο·β Combine mitochondrial-directed treatment
together with symptom-directed treatment.
ο·β Mitochondrial-directed treatment is to:
β’β Decrease energy demand
β’β Increase energy supply
37. Therapy: Agents
ο·β Lifestyle Changes:
β’β Fasting avoidance
β’β β3+3 dietβ
β’β Special caution during viral illnesses, may need IV fluid
β’β Hydration
β’β Exercise in moderation
ο·β Cofactors:
β’β Co-enzyme Q10
β’β L-carnitine
β’β Riboflavin
β’β Creatine
β’β Antioxidants (vitamins C and E)
ο·β Medications:
β’β βPsychtropicsβ (amitriptyline)
β’β PPIs (Prilosec)
β’β PEG (Miralax)
