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Drug Abuse PPT by nirav

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niravkd

addiction and abuse

Education
1 of 77
Drug abuse and addiction 14-times Olympic gold medal winner Michael Phelps caught with cannabis pipe
Confusion in definition !!! ,[object Object],[object Object],[object Object],[object Object],[object Object]
American Psychiatric Association 's Diagnostic and Statistical Manual of Mental Disorders (DSM) ,[object Object],[object Object]
Substance Dependence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmacology behind addiction - reinforcement ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THE MESOLIMBIC DOPAMINERGIC REWARD PATHWAY
 
Animal models
Animal models ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Dopamine Hypothesis of Addiction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TOLERANCE ,[object Object],[object Object],[object Object],[object Object]
Acquired tolerance ,[object Object],[object Object],[object Object],[object Object]
Acquired tolerance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acquired tolerance ,[object Object],[object Object],[object Object],[object Object]
Acquired tolerance ,[object Object],[object Object],[object Object],[object Object]
Physical dependence ,[object Object],[object Object],[object Object],[object Object]
Withdrawal Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object]
Psychological dependence ,[object Object],[object Object],[object Object]
Classification of drugs of abuse ,[object Object],[object Object],[object Object]
Drugs that activate GPCR Partial agonist 5-HT 2A R LSD, mescaline disinhibition Weak agonist GABA b R Gamma- hydroxybutyric acid(GHB) disinhibition agonist CB1R Cannabinoids disinhibition agonist μ - OR Opiods Effect on DA neurons Action Molecular target drugs
Drugs that bind to ionotrophic receptor and ion channels Effect on DA neurons Action Molecular target drugs - antagonists NMDA Phencyclidine, ketamine disinhibition Positive modulator GABA A Benzodiazepines Excitement, disinhibition? GABA A ,5-HT3, nACh, NMDA Alcohol Excitement, disinhibition? Agonist nAChR Nicotine
Drugs that bind to transporter of biogenic amines Effect on DA neurons Action Molecular target drugs Blocks DA uptake Reverses transport SERT>DAT, NET Ecstasy Blocks DA uptake Reverses transport DAT,SERT, NET,VMAT Amphetamine Blocks DA uptake Inhibitor DAT,SERT, NET Cocaine
[object Object],[object Object],[object Object],[object Object]
Opioids – God's own medicine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Heroin- most commonly abused opiate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tolerance – opioids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physical dependence and withdrawal syndrome - opioids Yawning ,fever Dysphoric mood, craving for drug Tachycardia Anxiety Gooseflesh Insomnia Sweating Irritability Mydriasis Restlessness signs symptoms
Rx of withdrawal syndrome ,[object Object],[object Object],[object Object],[object Object]
Rx of opioid addiction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
CANNABINOIDS ,[object Object],[object Object],[object Object]
CANNABINOIDS – ganja- marijuana-hashish- charas ,[object Object],[object Object],[object Object],[object Object]
Common Routes- CANNABINOIDS ,[object Object],[object Object],[object Object],[object Object]
actions - cannabis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tolerance ,depenadence, withdrawal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of cannabis addiction ,[object Object],[object Object]
GAMMA-HYDROXYBUTYRIC ACID (GHB) ,[object Object],[object Object],[object Object],[object Object],[object Object]
GHB – liquid ecstasy - club drug ,[object Object],[object Object],[object Object],[object Object]
LSD, MESCALINE & PSILOCYBIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LSD, MESCALINE & PSILOCYBIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
nicotine ,[object Object],[object Object],[object Object],[object Object],[object Object]
nicotine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tolerance ,dependence, withdrawal -nicotine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of nicotine addiction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of nicotine addiction ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
ethanol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
William Shakespeare and action of ethanol in MACBETH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic alcohol abuse = alcoholism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
alcoholism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tolerance , dependence, withdrawal - alcohol abuse ,[object Object],[object Object],[object Object],[object Object]
Alcohol withdrawal syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of withdrawal syndrome - alcoholism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of alcoholism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BENZODIAZEPINES (BZDs) ,[object Object],[object Object],[object Object],[object Object]
BZDs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Benzodiazepine withdrawal ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of BZDs addiction ,[object Object],[object Object],[object Object],[object Object],[object Object]
KETAMINE & PHENCYCLIDINE (PCP) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KETAMINE & PHENCYCLIDINE (PCP) ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
cocaine ,[object Object],[object Object],[object Object],[object Object]
 
cocaine ,[object Object],[object Object],[object Object]
Effects of cocaine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Speedball ,[object Object],[object Object],[object Object],[object Object]
Tolerance ,dependence, withdrawal - cocaine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Rx of cocaine addiction ,[object Object],[object Object],[object Object],[object Object],[object Object]
AMPHETAMINE ,[object Object],[object Object],[object Object],[object Object]
AMPHETAMINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MDMA = ecstasy ,[object Object],[object Object],[object Object]
MDMA = ecstasy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
references ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]

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Drug Abuse PPT by nirav

  • 1. Drug abuse and addiction 14-times Olympic gold medal winner Michael Phelps caught with cannabis pipe
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  • 20. Drugs that activate GPCR Partial agonist 5-HT 2A R LSD, mescaline disinhibition Weak agonist GABA b R Gamma- hydroxybutyric acid(GHB) disinhibition agonist CB1R Cannabinoids disinhibition agonist μ - OR Opiods Effect on DA neurons Action Molecular target drugs
  • 21. Drugs that bind to ionotrophic receptor and ion channels Effect on DA neurons Action Molecular target drugs - antagonists NMDA Phencyclidine, ketamine disinhibition Positive modulator GABA A Benzodiazepines Excitement, disinhibition? GABA A ,5-HT3, nACh, NMDA Alcohol Excitement, disinhibition? Agonist nAChR Nicotine
  • 22. Drugs that bind to transporter of biogenic amines Effect on DA neurons Action Molecular target drugs Blocks DA uptake Reverses transport SERT>DAT, NET Ecstasy Blocks DA uptake Reverses transport DAT,SERT, NET,VMAT Amphetamine Blocks DA uptake Inhibitor DAT,SERT, NET Cocaine
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  • 28. Physical dependence and withdrawal syndrome - opioids Yawning ,fever Dysphoric mood, craving for drug Tachycardia Anxiety Gooseflesh Insomnia Sweating Irritability Mydriasis Restlessness signs symptoms
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