1) Dr. Sagar Sharma is conducting a study on the efficacy of Pratimarsha Nasya in preventing premature greying of hair (Akala Palitya). 2) The study will involve administering Anu taila nasal drops to patients with Akala Palitya and assessing changes in hair greying and other parameters over 60 days. 3) The objectives are to study Akala Palitya, evaluate the effects of Pratimarsha Nasya treatment, and establish it as a daily nasal cleansing practice.

1. .
Rajiv Gandhi University of Health Sciences, Karnataka
COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT
FOR DISSERTATION
“A CLINICAL STUDY TO ASSESS THE EFFICACY OF PRATIMARSHA
NASYA IN PREVENTION OF AKALA PALITYAW.S.R TO PREMATURE
GREYING OF HAIR”
BY
DR SAGAR SHARMA
1ST Year P.G Scholar, Dept. of Post Graduate Studies In Swasthavritta,
S.J.G Ayurvedic Medical College & Hospital P.G.Studies & Research
Centre, Gavimath campus,
Koppal, Karnataka
GUIDE
DR. M.KARUNAKAR REDDY M.D (Ayu.)
Professor & HOD, Department of Swasthavritta
S.J.G.A.M.C., Koppal
CO-GUIDE
DR. PRABHU C NAGALAPUR M.D(Ayu.)
Lecturer, Department of Swasthavritta
S.J.G.A.M.C, Koppal
Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College
& Hospital
P.G.Studies & Research Centre, Gavimath campus,
Koppal, Karnataka
2013-14

2. .
From:
DR SAGAR SHARMA
Ist Year M.D., Department of Post Graduate Studies in Swasthavritta
S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus
Koppal-583231, Karnataka
To:
The Registrar,
Rajiv Gandhi University of Health Sciences
Bangalore, Karnataka
Through:
The Principal and the Head of the Department of Swasthavritta
S.J.G. Ayurvedic Medical College & Hospital, Gavimath Campus
Koppal-583231, Karnataka
Respected Sir,
Sub: Regarding the submission of completed Proforma for Registration of subject for
Dissertation
I request you to kindly register the below mentioned subject against my name for the
submission of dissertation to the Rajiv Gandhi University of Health Sciences, Bangalore,
Karnataka for the partial fulfillment of M.D. (Ayurveda)
Title of the Dissertation
“A CLINICAL STUDY TO ASSESS THE EFFICACY OF PRATIMARSHA
NASYA IN PREVENTION OF AKALA PALITYA W.S.R TO PREMATURE
GREYING OF HAIR”
Herewith I am enclosing complete Proforma for registration of the subject for dissertation.
Thanking you,
Yours faithfully
Place: Koppal
Date:
Dr. SAGAR SHARMA

3. .
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES BENGALURU,
KARNATAKA
ANNEXURE II
PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION
1. Name of the candidate & Address : DR. SAGAR SHARMA
# 143, WARD 10, OPPOSITE ASHIRWAD
LODGE, GUNJ PARA MAHASAMUND
DISTRICT-MAHASAMUND - 493445
CHHATISHGARH
2. Name of the Institution : DEPT OF P.G STUDIES IN SWASTHAVRITTA
S.J.G.AYURVEDIC MEDICAL COLLEGE,
HOS HOSPITAL AND P.G RESEARCH CENTRE,
GAVIMATH CAMPUS, KOPPAL-583231
KARNATAKA
3. Course of Study & Subject : AYURVEDA VACHASPATHI M.D.(Ayu)
IN SWASTHAVRITTA
4. Date of Admission to the Course : 18/9/2013
5. Title of the Topic : “A CLINICAL STUDY TO ASSESS THE
EFFICACY OF PRATIMARSHA NASYA IN
PREVENTION OF AKALA PALITYA W.S.R
TO PREMATURE GREYING OF HAIR”

4. .
6. BRIEF RESUME OF THE INTENDED WORK: -
6.1 NEED FOR THE STUDY:
The stress and strain of modern life induces premature ageing. Akala Palitya is
an accompaniment of premature ageing and poses a clinical challenge to the medical
practitioners. The incidence of premature ageing along with Akala Palitya is on
increase, particularly in tropical and developing countries. According to W.H.O in
India, its incidence is high in the age group of 20-30 years.
There are a large number of home remedies as well as over the counter
product available in market such as dyes, lotions etc. are used in Akala Palitya.
However these products often carry adverse reactions such as increased hair fall,
increased graying of otherwise normal hair and sometimes allergic reactions. The
present clinical study is intended to fill this gap where an effective, safe and non
sensitizing way of treating Akala Palitya is to be made available.
Acharya Vagbhata while mentioning the treatment of Palitya told Nasya as the
first line of treatment. Pratimarsha Nasya by Anu Taila rejuvenates the tissues of
head. By removing ama it cleanses and opens the channels of head which improves
oxygenation. As Akala Palitya is a Shirogata Roga and is caused due to accumulation
of Ama, Pratimarsha Nasya by Anu Taila may be very effective in its treatment and
prevention of the same.
Hence a clinical trial “To evaluate efficacy of Pratimarsha Nasya in
Prevention of Akala Palitya” is undertaken.
6.2 REVIEW OF LITERATURE:
The literature from Ayurvedic, modern texts, journals and internet sources
required for sufficient data for the study will be reviewed.
1.The body heat aggravated by grief, exertion and anger moving on to the head and
getting mixed with the doshas cooks (ripens) the hair and produces the disease
Palitya1.
2. Sharangadhara explained Palitya in Sira Kapal gata roga2.
3. Pratimarsha Nasya is indicated in Vali, Palitya and Urdhwa Jatru vikaras3.

5. .
PREVIOUS WORK DONE:
1. Sunita Rani -Clinical evaluation of Nasya in Palitya GAMC-Mysore, 1993
2. Nalini.C- A clinical study on Akala Palitya and its management GAMC-Bangalore1999-
2000
3. Kaleshwar Rao- Role of Nimadi Taila Nasya with or without Neelibringadi taila
lepana in management of Palitya Hyderabad-1999
4. Loknath .J. Avdhani-Evalution of Bhringraj Taila Nasya with & without
Bhringarajadi Rasayana in the Management of Akala Palitya -2012
6.3 OBJECTIVES OF THE STUDY:
1. To study in detail about Akala Palitya W.S.R to Premature graying of hair.
2. Evaluation of efficacy of Pratimarsha Nasya in management of Akala Palitya.
3. To study Pratimarsha Nasya as Dinacharya procedure.
7. MATERIALS AND METHODS:
7.1 SOURCE OF DATA:
Patients will be selected from OPD, IPD and special camps conducted by S.J.G
Ayurveda College and Research centre, Koppal
7.2 METHOD OF COLLECTION OF DATA:
Patients who are fulfilling the criteria for diagnosis and inclusion will be selected for
the study irrespective of sex, religion, educational background, professional
background and economical status.
7.3 a) STUDY DESIGN: Randomized Single blind clinical trial
7.3 b) INCLUSION CRITERIA:
Patients fulfilling the following criteria will be selected for study
1. Patients having features of Akala Palitya.
2. Patients in age group of 18-30 years.
3. Patients who are fit for Nasya.

6. .
7
7.3 c) EXCLUSION CRITERIA:
Following patients are excluded from the study.
1. Infectious diseases of scalp like Alopecia areata.
2. Akala Palitya associated with the diseases of pigmentation like Vitiligo, Leprosy
and Albinism
3. Any other pre diagnosed systemic disorders
7.3 d) CRITERIA OF DIAGNOSIS:
Diagnosis is made on the basis of clinical signs and symptoms of Palitya, such as
graying of hair, roughness of the hair
7.3 e) ASSESSMENT CRITERIA:
Assessment will be made based on subjective and objective parameters as follows-
Subjective parameters- Akala kesha vaivarmyata
Objective parameters- Random Hair Count
7.3 f) STUDY DURATION:
Total Duration - 120days
Treatment Duration - 60 days
Follow up - 60th day after treatment duration
7.3 g) METHOD OF ADMINISTRATION OF DRUG 4:
DOSE- 2 bindu of Anu taila in each nostril two times in a day i.e. in morning
and evening.
7.3h) PREPARATION OF DRUG-Anu
taila will be prepared in Bhaisajya Kalpana Department according to the
Classical texts, in Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College &
Hospital P.G.Studies & Research Centre, Gavimath campus, Koppal, Karnataka.

7. .
8
7.3 i) ASSESSMENT OF RESULTS:
The data will be collected before & after treatment and analyzed by using various
Statistical tools with the help of bio-statistician.
7.3 j) DOES THE STUDY REQUIRE ANY INVESTIGATIONS TO BE
CONDUCTED ON PATIENTS OR OTHER HUMANS OR ANIMALS?
IF SO PLEASE DESCRIBE BRIEFLY.
Hematological Investigations will be done, if necessary.
7.4 HAS ETHICAL CLEARANCE BEEN OBTAINED FROM YOUR
INSTITUTION IN CASE 7.3? - YES
8. LIST OF REFERENCES: -
1. Vagabhatt. Ashtanga Hridaya, translated by Prof. K.R.Shrikanth Murthy, :
Reprinted Edition 2008 Choukhamba krishnadas academy, Varanasi. Vol 3.
Ut.ch 23, sl 29-31,P860.
2. Sharangadhara. Sharangadhara Samhita with commentaries Deepika of
Adhamallaand Goodhartha deepika of Kashiram Vaidya, 2005-16th edtion.
Choukhamba orienTaila,Varanasi: . Pr.kh ch 7, SL 151-152, p 116.
3. Govind Das. Bhaishajya Ratnavali edited with siddhiprada Hindi commentary
By Prof. Siddhinandana mishra, Varanasi: Choukhamba Surabharati
Prakashana; 2005. Ut. Kh. Ch 8, sl 38-45, p 344.
4. Sharangadhara. Sharangadhara Samhita, English Translated by Dr.G.Prabhakar
Rao, 1st Edition 2013, Choukhamba Publications New Delhi, Uttar Khand ch 8, sl
40, p 296.

8. .
9
9. Signature of the Candidate :
10. Remarks of the Guide : Recommended for Registration
11. Name and designation of guide :
11.1. Guide : DR. M.KARUNAKAR REDDY M.D(Ayu)
11.2 Signature :
11.3 Co –guide :DR. PRABHU. C. NAGALAPUR M.D(Ayu)
11.4 Signatures :
11.5 Head of the department : DR. M.KARUNAKAR REDDY M.D(Ayu)
11.6 Signature :
12.1 Remarks of Principal :
The above synopsis is scrutinized by the Post Graduate studies and Research
centre committee of S.J.G Ayurveda Medical College, Koppal and submitted for
registration as subject for dissertation at R.G.U.H.S, Bangalore.
Principal /C.M.O