Dr Qs NitroMax is a supplement that contains L-arginine, L-citrulline, quercetin, folic acid, and vitamins C and E. These ingredients work to support nitric oxide production and blood flow throughout the body. Nitric oxide is important for circulatory, immune, and nervous system functions. The key active ingredients, L-arginine and L-citrulline, are precursors the body uses to make nitric oxide. They may help optimize blood flow and oxygen delivery while supporting cardiovascular health, brain function, and male sexual function.
IT IS The Most Important Health Discovery Ever. Earthing ranks right up there with the discovery of penicillin. The Earth is an electrical planet and our bodies are bioelectrical beings. When we are physically in touch with the Earth, we absorb electrons (negatively charged) from the Earth’s surface. This help to neutralize the (positively charged) free radicals in our body that damage our cells. The destructive activity of free radicals in the body has been linked with many diseases and accelerated aging.
Isoprostanes (IsoPs) are important molecules since they provide an accurate measure of oxidative stress.
It has been verified that the levels of IsoPs are increased in several human diseases. Therefore, they have been widely used in research to explore the role of oxidative stress in the pathogenesis of disease and their measurement can impact positively on clinical medicine.
INSTITUT KURZ is specialized in the measurement of isoprostanes.
Visit our website: https://www.institut-kurz.com/
It is well established that muscle contraction during exercise lead to elevated levels of reactive oxygen species in skeletal muscle ,hence the growing interest of oxidative stress in exercise
IT IS The Most Important Health Discovery Ever. Earthing ranks right up there with the discovery of penicillin. The Earth is an electrical planet and our bodies are bioelectrical beings. When we are physically in touch with the Earth, we absorb electrons (negatively charged) from the Earth’s surface. This help to neutralize the (positively charged) free radicals in our body that damage our cells. The destructive activity of free radicals in the body has been linked with many diseases and accelerated aging.
Isoprostanes (IsoPs) are important molecules since they provide an accurate measure of oxidative stress.
It has been verified that the levels of IsoPs are increased in several human diseases. Therefore, they have been widely used in research to explore the role of oxidative stress in the pathogenesis of disease and their measurement can impact positively on clinical medicine.
INSTITUT KURZ is specialized in the measurement of isoprostanes.
Visit our website: https://www.institut-kurz.com/
It is well established that muscle contraction during exercise lead to elevated levels of reactive oxygen species in skeletal muscle ,hence the growing interest of oxidative stress in exercise
we are teleologically cardioprotected. we are already cardioprotected. nature has given us everything we need to be unbreakable.we just have to push the right buttons.
please, pay heed to the turtles! they know best!
The Logical & Scientific facts about Cholesterolfathi neana
We are in the era of Information, Real time communication and the evolution of evidence based science and medicine. It is the era of a great scientific revolution supported by evidences which is reflected upon the way of thinking leading to a lot of change in the old inherited concepts. Many people have been asking the Question: “How to reduce blood cholesterol naturally without using harmful drugs” ? But nobody ask the real question “Does high cholesterol really cause heart disease”? . The answer to this question may be surprising to many!
Ed Nemeth tells his personal compelling story abut hyperbarics and how he discovered the benefits of HBOT. His exploration into HBOT led him to open his own clinics in Sacramento where he met and treated retired football player George Visger.
A vitamin is an organic molecule (or related set of molecules) that is anessential micronutrient which an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrients cannot besynthesized in the organism, either at all or not in sufficient quantities, and therefore must be obtained through the diet.
Vitamins are classified as either water-soluble or fat-soluble. In humans there are 13 vitamins: 4 fat-soluble (A, D, E, and K) and 9 water-soluble (8 B vitamins and vitamin C). Water-soluble vitamins dissolve easily in water and, in general, are readily excreted from the body, to the degree that urinary output is a strong predictor of vitamin consumption. Because they are not as readily stored, more consistent intake is important. Fat-soluble vitamins are absorbed through the intestinal tractwith the help of lipids (fats). Vitamins A and D can accumulate in the body, which can result in dangerous hypervitaminosis. Fat-soluble vitamin deficiency due to malabsorption is of particular significance in cystic fibrosis.
Protective role of co q10 or l carnitine on the integrity of the myocardium i...Prof. Hesham N. Mustafa
Doxorubicin (DOX) is a chemotherapeutic agent used for treatment of different cancers and its clinical usage is hindered by the oxidative injury-related cardiotoxicity. This work aims to declare if the harmful effects of DOX on heart can be alleviated with the use of Coenzyme Q10 (CoQ10) or L-carnitine. The study was performed on seventy two female Wistar albino rats divided into six groups, 12 animals each: Control group; DOX group (10mg/kg); CoQ10 group (200mg/kg); L-carnitine group (100mg/kg); DOX+CoQ10 group; DOX+L-carnitine group. CoQ10 and L-carnitine treatment orally started 5days before a single dose of 10mg/kg DOX that injected intraperitoneally (IP) then the treatment continued for 10days. At the end of the study, serum biochemical parameters of cardiac damage, oxidative stress indices, and histopathological changes were investigated. CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 β), tumor necrosis factor alpha (TNF-α), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. Both corrected the cardiac alterations histologically and ultrastructurally. With a visible improvements in α-SMA, vimentin and eNOS immunohistochemical markers. CoQ10 or L-carnitine supplementation improves the functional and structural integrity of the myocardium.
Keywords: Cardiotoxicity; CoQ10 and L-carnitine; Dox; Vimentin; eNOS.
Nutritional immunology is a fascinating but highly complex and conflicted subject area. With almost every nutrient we consume having the ability to affect our immune response in one way or another and the activation of the immune system dramatically increasing nutrient requirements, understanding the genetic, cellular and metabolic mechanisms that interact, control and conflict with the immune system and how to manipulate them to our advantage, is fundamental to optimal health.
We are thrilled to announce that we have linked up with Professor Phillip Calder, a world renowned and highly cited expert in nutritional immunology, with over 500 publications to his name. Professor Calder will be joining us as our guest speaker for our January Webinar to help us kick off what promises to be our most exciting year of clinical nutrition education yet.
In this detailed Q&A session Professor Calder will shed light on a whole host of fascinating topics from the latest research into nutrition immunology, his projects involving nutrigenomics, probiotics and omega-3s, the real science behind effective clinical omega-3 interventions, his thoughts on the best forms of lipid supplementation, and doing some serious nutrition science myth busting.
During this webinar, Sophie covers the double-edged sword of inflammation and oxidative stress as driving factors in chronic modern illness and why addressing these factors with nutritional intervention does not always produce the desired effects; it may even, in some cases, be harmful. Taking a personalised and functional medicine approach, Sophie reviews the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Metabolic response to trauma - In Perspective of Maxillofacial SurgeryMaxfac Center
Metabolic responses that occur following trauma and its clinical implications to minimize morbidity and mortality.
Mentor: Dr Saikat Saha MDS, OMFS, SIliguri, West Bengal, India
Address: MAXFAC Center for Oral and Maxillofacial and Head & Neck Surgery, Siliguri
Email : maxfacmail@gmail.com
"Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury" appeared in a 2012 issue of 'Physiology' and summarized the research Stephen M. Black and his team conducted into acute lung injury.
Learn more about his research on his blog: http://stephenmblack.com/blog/
we are teleologically cardioprotected. we are already cardioprotected. nature has given us everything we need to be unbreakable.we just have to push the right buttons.
please, pay heed to the turtles! they know best!
The Logical & Scientific facts about Cholesterolfathi neana
We are in the era of Information, Real time communication and the evolution of evidence based science and medicine. It is the era of a great scientific revolution supported by evidences which is reflected upon the way of thinking leading to a lot of change in the old inherited concepts. Many people have been asking the Question: “How to reduce blood cholesterol naturally without using harmful drugs” ? But nobody ask the real question “Does high cholesterol really cause heart disease”? . The answer to this question may be surprising to many!
Ed Nemeth tells his personal compelling story abut hyperbarics and how he discovered the benefits of HBOT. His exploration into HBOT led him to open his own clinics in Sacramento where he met and treated retired football player George Visger.
A vitamin is an organic molecule (or related set of molecules) that is anessential micronutrient which an organism needs in small quantities for the proper functioning of its metabolism. Essential nutrients cannot besynthesized in the organism, either at all or not in sufficient quantities, and therefore must be obtained through the diet.
Vitamins are classified as either water-soluble or fat-soluble. In humans there are 13 vitamins: 4 fat-soluble (A, D, E, and K) and 9 water-soluble (8 B vitamins and vitamin C). Water-soluble vitamins dissolve easily in water and, in general, are readily excreted from the body, to the degree that urinary output is a strong predictor of vitamin consumption. Because they are not as readily stored, more consistent intake is important. Fat-soluble vitamins are absorbed through the intestinal tractwith the help of lipids (fats). Vitamins A and D can accumulate in the body, which can result in dangerous hypervitaminosis. Fat-soluble vitamin deficiency due to malabsorption is of particular significance in cystic fibrosis.
Protective role of co q10 or l carnitine on the integrity of the myocardium i...Prof. Hesham N. Mustafa
Doxorubicin (DOX) is a chemotherapeutic agent used for treatment of different cancers and its clinical usage is hindered by the oxidative injury-related cardiotoxicity. This work aims to declare if the harmful effects of DOX on heart can be alleviated with the use of Coenzyme Q10 (CoQ10) or L-carnitine. The study was performed on seventy two female Wistar albino rats divided into six groups, 12 animals each: Control group; DOX group (10mg/kg); CoQ10 group (200mg/kg); L-carnitine group (100mg/kg); DOX+CoQ10 group; DOX+L-carnitine group. CoQ10 and L-carnitine treatment orally started 5days before a single dose of 10mg/kg DOX that injected intraperitoneally (IP) then the treatment continued for 10days. At the end of the study, serum biochemical parameters of cardiac damage, oxidative stress indices, and histopathological changes were investigated. CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 β), tumor necrosis factor alpha (TNF-α), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. Both corrected the cardiac alterations histologically and ultrastructurally. With a visible improvements in α-SMA, vimentin and eNOS immunohistochemical markers. CoQ10 or L-carnitine supplementation improves the functional and structural integrity of the myocardium.
Keywords: Cardiotoxicity; CoQ10 and L-carnitine; Dox; Vimentin; eNOS.
Nutritional immunology is a fascinating but highly complex and conflicted subject area. With almost every nutrient we consume having the ability to affect our immune response in one way or another and the activation of the immune system dramatically increasing nutrient requirements, understanding the genetic, cellular and metabolic mechanisms that interact, control and conflict with the immune system and how to manipulate them to our advantage, is fundamental to optimal health.
We are thrilled to announce that we have linked up with Professor Phillip Calder, a world renowned and highly cited expert in nutritional immunology, with over 500 publications to his name. Professor Calder will be joining us as our guest speaker for our January Webinar to help us kick off what promises to be our most exciting year of clinical nutrition education yet.
In this detailed Q&A session Professor Calder will shed light on a whole host of fascinating topics from the latest research into nutrition immunology, his projects involving nutrigenomics, probiotics and omega-3s, the real science behind effective clinical omega-3 interventions, his thoughts on the best forms of lipid supplementation, and doing some serious nutrition science myth busting.
During this webinar, Sophie covers the double-edged sword of inflammation and oxidative stress as driving factors in chronic modern illness and why addressing these factors with nutritional intervention does not always produce the desired effects; it may even, in some cases, be harmful. Taking a personalised and functional medicine approach, Sophie reviews the underlying mechanisms that can be targeted with nutritional interventions and explains how to ensure your therapeutic approach is right for your clients.
Metabolic response to trauma - In Perspective of Maxillofacial SurgeryMaxfac Center
Metabolic responses that occur following trauma and its clinical implications to minimize morbidity and mortality.
Mentor: Dr Saikat Saha MDS, OMFS, SIliguri, West Bengal, India
Address: MAXFAC Center for Oral and Maxillofacial and Head & Neck Surgery, Siliguri
Email : maxfacmail@gmail.com
"Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury" appeared in a 2012 issue of 'Physiology' and summarized the research Stephen M. Black and his team conducted into acute lung injury.
Learn more about his research on his blog: http://stephenmblack.com/blog/
Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume, or more importantly, an extract found in red wine, resveratrol.
Effects of Different Proportions of Salvianolic Acid and Hydroxysafflor Yello...Premier Publishers
In this experiment, SD rats were injected intravenously with different proportions of test samples to observe the protective effect of intravenous injection of pituitrin (PIT) that induced myocardial ischemia in rats, and to determine the lipid peroxidation product of Malondialdehyde (MDA) in rat brain and the content and activity of Superoxide Dismutase (SOD), Creatine Kinase (CK) and Lactate Dehydrogenase(LDH). The role of the anti–myocardial ischemia model in the test and its optimal ratio were studied. Each group of test samples was injected through the tail vein and the Ⅱ lead ECG was traced. After injection for 30 min, the rats were sublingually injected with 2U/kg pituitrin, and Ⅱ lead ECG was recorded for 5 min. After 3 hours’ observation, the rats were sacrificed from the cervical spine, and the hearts were removed and placed in a refrigerator at –20 °C to measure various biochemical indicators. Intravenous injection of each group of tested products has the effect of reducing the content of MDA, LDH, and CK in myocardial tissue, which can enhance the activity of SOD in myocardial tissue, and has statistical significance compared with the model group (P≤0.05 or P≤0.01). Through comprehensive comparison, the A:B=1:10 dose group was found to have the best results.
EUTOX CME ERA-EDTA 2016 Vienna
A short overview on unhealthy endothelium during CKD and the role of selected uremic toxins mainly indoles, but with chocolate and zebrafish inside.
Nitric oxide and its role in reproductiondavid sonwani
Nitirc oxide an noble gas signaling molecule present in all types of living organism as an excretory product. has multiple role in body including defense cure and mainly reproduction.
— Oxidative stress is well known to be involved in the
pathogenesis of lifestyle-related diseases, including, hypertension,
diabetes mellitus, coronary artery diseases, and malignancies.
However, oxidative stress also has a useful role in physiologic
adaptation and in the regulation of intracellular signal
transduction. Therefore, a significant description of oxidative
stress may be “a condition where oxidative forces go beyond the
antioxidant systems due to loss of the equilibrium between them”.
Significant Nitric Oxide (NO) confirmed as a envoy of
vasodilatation, derivative from the endothelium. Coronary artery
disease also defined as atherosclerotic heart diseases are the
outcome of the growth of antheromatous plaques (made up of
fats, cholesterol etc) within the walls of the coronary arteries that
provide the myocardium with oxygen and nutrients. The evidence
of the plaque in the lumen (free space in the artery for the flow of
nutrients, oxygen etc.) of an artery causes tapering of lumen of
the artery by declining its diameter. NO levels show a significant
relation with higher BMI and hypertension in coronary artery
disease. Many research have shown that adipose tissue contains
NO synthetase enzyme, and is thus an impending NO source.
Biological activity of Nitric Oxide provides clinicians with
additional therapeutic options in the treatment of cardiovascular
disease which will subordinate oxidative stress, a process which is
becoming gradually more standard as critical in the
pathophysiology of vascular disease.
The imbalance between free radical production and endogenous antioxidant defence may result in cellular oxidative stress, causing oxidative damage to various cellular components, such as DNA, proteins and membrane lipids. The human system employs the use of endogenous enzymatic and non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress.
Unsurprisingly, oxidative damage has been implicated in and is believed to be a key factor causing various pathological conditions, such as cardiovascular disease, neurodegenerative disease, diabetes and cancer. Free radicals can be quenched through a number of mechanisms. Antioxidants directly scavenge free radicals (e.g., via hydrogen atom transfer or electron transfer), prevent free radical formation by chelating metal ions and by interrupting the radical chain reactions of lipid peroxidation, thus retarding its progression. Enzymatic antioxidants include superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Non-enzymatic antioxidants include vitamins A, C, and E, glutathione, alpha-lipoic acid, carotenoids, and coenzyme Q10. Other antioxidants include polyphenols, minerals (copper, zinc, manganese, and selenium), and cofactors (B-vitamins). Together, antioxidants work synergistically with each other using different mechanisms against different free radicals and stages of oxidative stress.
The benefits associated with antioxidants are numerous and diverse but it can be a minefield when choosing the appropriate antioxidant support for clients. In this hour-long webinar, Dr Nina Bailey discusses the direct and indirect benefits and actions of key antioxidants including (but not limited to) astaxanthin, alpha lipoic acid, polyphenols and co-enzyme Q10, with a focus on:
-Antioxidant sources and benefits
-Mechanisms and actions
-When to combine antioxidants for synergistic effects
-Overcoming bioavailability issues
-Targeted intervention, which antioxidant(s) and why
L'idrossitirosolo è in grado di proteggere e aumentare l'attività dei mitocon...CreAgri Europe
L'idrossitirosolo, un polifenolo estratto dalle olive, attraverso una protezione dei mitocondri, le centrali energetiche della cellula, è in grado di aumentare la resistenza muscolare negli animali da esperimento
1. Dr Qs NitroMax
Clinical Applications
•• Optimize Flow of Blood and Oxygen to Peripheral Tissues*
•• Helps Maintain Healthy Male Sexual Function*
•• Supports Lean Body Mass/Athletic Performance*
•• Supports Healthy Dilation of Blood Vessels*
•• Supports the Healthy Flow of Blood and Oxygen to the Brain for
Healthy Mood, Mind, and Memory*
Dr Qs NitroMax is Dr. Q Vitamins’s exciting formula based on the latest Nobel Prize-winning research on
nitric oxide, a naturally occurring compound in the body. Nitric oxide is an important messenger that signals
a variety of responses at the cellular level which are beneficial to circulatory, immune, and nervous system
functions. Dr Qs NitroMax is a refreshing, effervescent powder that offers therapeutic levels of L-arginine
and L-citrulline, two amino acids the body uses to make nitric oxide.*
All Dr. Q Vitamins Formulas Meet or Exceed cGMP Quality Standards
Discussion
Nitric oxide (NO) is produced by various body cells from the amino acid L-arginine through the enzymatic action of nitric
oxide synthase (NOS). NO has critical roles in regulating the function of organs and systems throughout the body. It is
well known that NO production by vascular endothelium plays a critical role in blood flow regulation and that the abnormal
production of NO can adversely affect blood flow, delivery of nutrients and oxygen, and other vascular functions.
L-Citrulline is a precursor to L-arginine that readily permeates the intestinal wall and enters the bloodstream. L-citrulline
is processed by the kidney, where it is converted to L-arginine; and oral L-citrulline supplementation in humans has been
shown to increase plasma L-arginine availability for NO synthesis.[4] In an animal study, oral supplementation with “L-arginine,
L-citrulline, and/or antioxidants (vitamins C and E) showed marked support of endothelium-dependent vasorelaxation and
blood flow, maintenance of a healthy endothelium, and decrease in superoxide production and oxidation-sensitive gene
expression …”[5]
Quercetin A major flavonoid naturally occurring in plants, quercetin has been shown in a study on mice using microarray
DNA analyses and pathway analyses to inhibit LPS-induced expression of IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12,
iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40.[6] Experimental models suggest that quercetin prevents the
redox imbalance associated with decreased intracellular NO levels and superoxide overproduction, and it prevents the
overexpression of inducible NOS (iNOS).[7,8]
Folic Acid Research suggests that homocysteine may decrease the bioavailability of NO.[9] Therefore, folate’s deleterious
effect on homocysteine may provide the added benefit of increasing NO levels through enhancing NO bioavailability.
Another role of folic acid in NO production relates to tetrahydrobiopterin (THBP, also known as BH4)—an essential cofactor
for NOS. Inadequate folate may impair the synthesis of THBP,[10] and 5-MTHF (bioactive folate) may normalize the activity
of NOS in THBP-depleted endothelial cells.[11] In a placebo-controlled study of patients receiving 400 mcg/d of folic acid for
seven weeks before coronary artery bypass grafting, improved vascular function was observed and attributed to improved
availability of THBP for NOS and reduced vascular oxidative stress.[12]
Vitamins C and E Free-radical injury reduces NO availability, and antioxidants appear to preserve NO. In addition, healthy
endothelial function is associated with low oxidative stress, particularly decreased superoxide production and reduced
oxidized LDL (OxLDL), which, if elevated, can reduce endothelium-derived NO activity. Vitamins C and E administration
can reduce both superoxide and OxLDL, thereby improving NO activity.[13] According to Heller et al, “The effect of alphatocopherol seems to be dependent on tissue saturation with ascorbic acid, and both vitamins may act synergistically to
provide optimal conditions for endothelial NO formation.”[14]
“More than any other single factor, nitric oxide may be the key to living a longer, healthier life.” – Dr. Louis Ignarro, 1998
Nobel Prize Laureate
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Dr Qs NitroMax
L-Arginine is the principal substrate for the family of NOS enzymes that catalyze the biosynthesis of NO. Some of
L-arginine’s benefits include support of immune response, ammonia detoxification, growth hormone secretion (during
rest), improved exercise performance (at 6 g/d), wound healing, reduced platelet aggregation, and vasodilation.[1,2]
ADMA (asymmetric dimethylarginine) is a newly identified factor confronting cardiovascular health. As an endogenous
NOS inhibitor, accumulation of ADMA impairs NO formation by competing with L-arginine for NOS binding. Under these
conditions, supplementation with L-arginine may support maintenance of near-normal levels.[1] New research also suggests
that ADMA accumulation in oxidized low-density lipoproteins (OxLDL) may signal vascular smooth muscle cell (VSMC)
migration—which plays a critical role in the etiology of intimal thickening—and L-arginine markedly blocked ADMA-induced
VSMC migration.[3]
2. Supplement Facts
Serving Size: 1 Scoop (8 g)
Servings Per Container: 30
Amount Per Serving
Calories
Total Carbohydrate
Vitamin C (as ascorbic acid)
Folate (as folic acid)
Sodium (as sodium bicarbonate)
L-Arginine
L-Citrulline
Quercetin (as quercetin dihydrate)
(from Dimorphandra mollis)(bud)
Mixed Tocopherols
d-Gamma Tocopherol
20
3g
300 mg
2,000 mcg
220 mg
%Daily Value†
1%
500%
500%
9%
2g
500 mg
500 mg
**
**
**
230 mg
160 mg
Directions
Pour one level scoop of powder into a tall, empty glass.
Add 3 oz of chilled water and lightly stir. Let stand one
minute. Add 3 more oz of chilled water and lightly stir. Let
stand one minute and drink. Take one to two times daily,
or as directed by your healthcare practitioner.
Children, pregnant or lactating women, and individuals
taking any medication should consult their healthcare
practitioner prior to use.
Cautions
**
**
Do NOT use if you have low blood pressure.
†Percent Daily Values are based on a 2,000 calorie diet.
** Daily Value not established.
Other Ingredients: Citric acid, organic dried cane syrup, natural
orange flavor (no MSG), silica, and stevia leaf extract.
References
1. Böger RH. The pharmacodynamics of L-arginine. J Nutr. 2007 Jun;137(6 Suppl 2):1650S-55S. [PMID: 17513442]
2. Bailey SJ, Winyard PG, Vanhatalo A, et al. Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and
enhances high-intensity exercise tolerance. J Appl Physiol. 2010 Nov;109(5):1394-403. [PMID: 20724562]
3. Sun L, Zhang T, Yu X, et al. Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and
leads to VSMC migration through p38 and ERK1/2 signaling cascade. FEBS Lett. 2011 Sep 2;585(17):2727-34. [PMID: 21821030]
4. Sureda A, Cordova A, Ferrer MD, et al. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and
nitric oxide production after exercise. Free Radic Res. 2009 Sep;43(9):828-35. [PMID: 19585317]
5. Hayashi T, Juliet PA, Matsui-Hirai H, et al. l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-dietinduced atherosclerosis in rabbits. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13681-86. [PMID: 16157883]
6. Qureshi AA, Tan X, Reis JC, et al. Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by delta-tocotrienol
and quercetin. Lipids Health Dis. 2011 Dec 20;10(1):239. [Epub ahead of print] [PMID: 22185406]
7. Kostyuk VA, Potapovich AI, Suhan TO, et al. Antioxidant and signal modulation properties of plant polyphenols in controlling vascular
inflammation. Eur J Pharmacol. 2011 May 11;658(2-3):248-56. [PMID: 21371465]
8. Zhang ZJ, Cheang LC, Wang MW, et al. Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and proinflammation gene expression in PC12 cells and in zebrafish. Int J Mol Med. 2011 Feb;27(2):195-203. [PMID: 21132259]
9. Tawakol A, Forgione MA, Stuehlinger M, et al. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol.
2002 Sep 18;40(6):1051-58. [PMID: 12354427]
10. Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide. 2011
Aug 1;25(2):81-88. [PMID: 21550412]
11. McCarty MF. Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate. Med Hypotheses.
2004;63(4):709-18. [PMID: 15325022]
12. Shirodaria C, Antoniades C, Lee J, et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for
folate therapy in patients with coronary artery disease. Circulation. 2007 May 1;115(17):2262-70. [PMID: 17420345]
13. Carr A, Frei B. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic Biol Med.
2000 Jun 15;28(12):1806-14. [PMID: 10946222]
14. Heller R, Werner-Felmayer G, Werner ER. Alpha-Tocopherol and endothelial nitric oxide synthesis. Ann N Y Acad Sci. 2004 Dec;1031:7485. [PMID: 15753135]
Does Not Contain
Wheat, gluten, yeast, soy protein, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial
sweeteners, or preservatives.
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
DRS-122
REV. 04/10/13