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Weight control
by
Neutraceuticals
There is a very high prevalence of obesity globally; hence
nutrition and exercise play key roles in its prevention and
treatment.
Nutraceuticals like conjugated linoleic acid (CLA), capsaicin,
Momordica Charantia (MC), and Psyllium fibre possess potential
anti-obesity properties.
A blend of glucomannan, chitosan, fenugreek, G Sylvester, and
vitamin C in the dietary supplement significantly reduced body
weight and promoted fat loss in obese individuals.
Cancer Treatment
by
Neutraceuticals
Prostate cancer
Mode of Action
Antiproliferation, cell cycle inhibition, angiogenesis inhibition
and promotion of apoptosis
Nutraceutical: Vitamin D
Mode of Action
Antioxidation, antiproliferation, and promotion of apoptosis
Nutraceutical: Catechins in green tea
Colon cancer
Mode of Action
Tumor marker suppression, promotion of apoptosis, metastasis
inhibition, and antiproliferation
Nutraceutical: Polyphenols
Mode of Action
Antioxidant, antiproliferation, promotion of apoptosis,
inflammatory protein inhibition
Nutraceutical: Terpenoids
Breast cancer
Mode of Action
Antiproliferation and promotion of apoptosis
Nutraceutical: Curcumin
Mode of Action
Cell cycle inhibition, promotion of apoptosis, and inhibition of
metastasis
Nutraceutical: Vitamin D
Oral cancer
Mode of Action
Prevent tumor initiation
Nutraceutical: Strawberry
Mode of Action
Antiproliferation, promotion of apoptosis, and angiogenesis
inhibition
Nutraceutical: Geraniol
Heart disease
Flavonoids
Nutraceuticals
Worldwide, the burdens of chronic diseases like cardiovascular diseases,
cancers, diabetes and obesity is rapidly increasing.
 Chronic diseases contributed approximately 59% of the 56.5 million total
reported deaths in the world and 46% of the global burden of disease.
Cardiovascular disease (CVD) is the name for the group of disorders of the
heart and blood vessels and includes hypertension (high blood pressure),
coronary heart disease (heart attack), cerebrovascular disease (stroke), heart
failure, peripheral vascular disease, etc
This apart, nutraceuticals in the form of antioxidants, dietary fibres, omega-
3 polyunsaturated fatty acids (n-3 PUFAs), vitamins, and minerals are
recommended together with physical exercise for the prevention and
treatment of CVD.
It has been demonstrated that the molecules like polyphenols
present in grapes and in wine alter cellular metabolism and signalling,
which is consistent with reducing arterial disease
Flavonoids
Flavonoids are widely distributed in onion, endives, cruciferous
vegetables, black grapes, red wine, grapefruits, apples, cherries and
berries.
Flavanoids in plants are available as flavones (containing the
flavonoid apigenin found in chamomile);
flavanones (hesperidins -citrus fruits; silybin- milk)
 thistle flavonols (tea: quercetin, kaempferol and rutin grapefruit;
rutinbuckwheat; ginkgo flavon glycosides – ginkgo)
play a major role in curing the cardiovascular diseases.
Flavonoids block the angiotensin-converting enzyme (ACE)
that raises blood pressure; by blocking the “suicide” enzyme
cyclooxygenase that breaks down prostaglandins, prevents
platelet stickiness and hence platelet aggregation.
Flavonoids also protect the vascular system and strengthen the
tiny capillaries that carry oxygen and essential nutrients to all
cells.
 Flavonoids block the enzymes that produce estrogens, thus
reducing the risk of estrogen-induced cancers.
Osteoarthritis Treatment
By
Nutraceuticals
 Osteoarthritis (OA), a debilitating joint disorder, is the most
common form of arthritis.
 Joint discomfort from OA and other joint disorders may
reduce physical activity in individuals experiencing this
condition, resulting in energy imbalance and weight gain.
 Increased weight can exacerbate existing problems, through
additional stress on joints
Glucosamine (GLN) and chondroitin sulfate (CS)
Glucosamine (GLN) and chondroitin sulfate (CS) is widely used
to alleviate symptoms of OA.
These nutraceuticals have both nutrient and pharmaceutical
properties and seem to regulate gene expression and synthesis
of NO and PGE2, providing a plausible explanation for their anti-
inflammatory activities
Stress Management
by
Neutraceuticals
Nutraceutical options for addressing some of the most
common issues associated with stress
B-ComplexVitamins
The B-complex vitamins are intimately involved in the
function of the nervous system, and so can play a role in
helping to counter some of the negative effects of stress.
In fact, the ability of humans to respond to stress can be
influenced by nutritional status—including the status of key
B vitamins.
Phosphatidylserine
Research has demonstrated that phosphatidylserine (PS) was
able to blunt the release of cortisol—the “stress hormone”—in
response to exercise stress.
In some cases, PS supplementation also resulted in improved
mood
L-Theanine
The amino acid L-theanine has been shown to increase both serotonin and
dopamine production, and possibly gamma amino butyric acid (GABA) as well.
Evidence from human electroencephalograph (EEG) studies show that it
also significantly increases brain activity in the alpha frequency band, which
indicates that it relaxes the mind without inducing drowsiness.
 Other research indicates that L-theanine has a significant effect on
improving mental alertness while promoting relaxation.
Additional studies have shown that supplementation with L-theanine
resulted in a reduction in some physiological indicators of stress within 15
minutes, suppressed the initial stress response of students, and significantly
reduced anxiety and reduced the blood-pressure increase in high-stress-
response adults.
Rhodiola Rosea Root Extract
Rhodiola rosea root, another adaptogen, has been used for
centuries in the traditional systems of healthcare throughout
Russia, Scandinavia, and other countries where it was used to
increase physical endurance, work productivity, and longevity,
as well as to treat fatigue, mood, and promote a healthy
nervous system.
Panax Ginseng
Panax ginseng root, or ginseng for short, is a traditional
Chinese herb which has been used for thousands of years in
various aspects of healthcare.
It is also one of the most widely researched herbs in modern
science with over 5,000 published studies.
Ginseng helps stabilize physiological processes and promote
homeostasis, especially in the case of stress and fatigue. This
property was seen in two human clinical studies examining the
effects of ginseng on mental performance
Diabetes
by
Neutraceuticals
Diabetes mellitus is characterized by abnormally high levels of
blood glucose, either due to insufficient insulin production or due
to its ineffectiveness.
The most common forms of diabetes are type 1 diabetes (5%),
an autoimmune disorder, and type 2 diabetes (95%), which is
associated with obesity.
Docosahexaenoic acid (DHA): omega-3-fatty acid
Docosahexaenoic acid modulates insulin resistance and is also
vital for neuro visual development.
This is especially important in women with gestational
diabetes mellitus which foster the recommendation for essential
fatty acids during pregnancy
Lipoic acid
Lipoic acid is a universal antioxidant, now used in Germany for
the treatment of diabetic neuropathy.
It is possible that lipoic acid may be more effective as a long-
term dietary supplement aimed at the prophylactic protection of
diabetics from complications
Dietary fibres
Dietary fibres from psyllium have been used extensively both
as pharmacological supplements, food ingredients, in processed
food to aid weight reduction, for glucose control in diabetic
patients and to reduce lipid levels in hyperlipidemia
Magnesium
Good magnesium status reduces diabetes risk and improves
insulin sensitivity;
chromium picolinate, calcium and vitamin D appear to promote
insulin sensitivity and improve glycemic control in some
diabetics;
extracts of bitter melon and of cinnamon have the potential to
treat and possibly prevent diabetes.
However, it has been suggested that Nutraceuticals with
meaningful doses of combinations may substantially prevent
diabetes.

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DS&N Unit I_2.pptx

  • 2. There is a very high prevalence of obesity globally; hence nutrition and exercise play key roles in its prevention and treatment. Nutraceuticals like conjugated linoleic acid (CLA), capsaicin, Momordica Charantia (MC), and Psyllium fibre possess potential anti-obesity properties. A blend of glucomannan, chitosan, fenugreek, G Sylvester, and vitamin C in the dietary supplement significantly reduced body weight and promoted fat loss in obese individuals.
  • 4. Prostate cancer Mode of Action Antiproliferation, cell cycle inhibition, angiogenesis inhibition and promotion of apoptosis Nutraceutical: Vitamin D Mode of Action Antioxidation, antiproliferation, and promotion of apoptosis Nutraceutical: Catechins in green tea
  • 5. Colon cancer Mode of Action Tumor marker suppression, promotion of apoptosis, metastasis inhibition, and antiproliferation Nutraceutical: Polyphenols Mode of Action Antioxidant, antiproliferation, promotion of apoptosis, inflammatory protein inhibition Nutraceutical: Terpenoids
  • 6. Breast cancer Mode of Action Antiproliferation and promotion of apoptosis Nutraceutical: Curcumin Mode of Action Cell cycle inhibition, promotion of apoptosis, and inhibition of metastasis Nutraceutical: Vitamin D
  • 7. Oral cancer Mode of Action Prevent tumor initiation Nutraceutical: Strawberry Mode of Action Antiproliferation, promotion of apoptosis, and angiogenesis inhibition Nutraceutical: Geraniol
  • 9. Worldwide, the burdens of chronic diseases like cardiovascular diseases, cancers, diabetes and obesity is rapidly increasing.  Chronic diseases contributed approximately 59% of the 56.5 million total reported deaths in the world and 46% of the global burden of disease. Cardiovascular disease (CVD) is the name for the group of disorders of the heart and blood vessels and includes hypertension (high blood pressure), coronary heart disease (heart attack), cerebrovascular disease (stroke), heart failure, peripheral vascular disease, etc This apart, nutraceuticals in the form of antioxidants, dietary fibres, omega- 3 polyunsaturated fatty acids (n-3 PUFAs), vitamins, and minerals are recommended together with physical exercise for the prevention and treatment of CVD.
  • 10. It has been demonstrated that the molecules like polyphenols present in grapes and in wine alter cellular metabolism and signalling, which is consistent with reducing arterial disease Flavonoids Flavonoids are widely distributed in onion, endives, cruciferous vegetables, black grapes, red wine, grapefruits, apples, cherries and berries. Flavanoids in plants are available as flavones (containing the flavonoid apigenin found in chamomile); flavanones (hesperidins -citrus fruits; silybin- milk)  thistle flavonols (tea: quercetin, kaempferol and rutin grapefruit; rutinbuckwheat; ginkgo flavon glycosides – ginkgo) play a major role in curing the cardiovascular diseases.
  • 11. Flavonoids block the angiotensin-converting enzyme (ACE) that raises blood pressure; by blocking the “suicide” enzyme cyclooxygenase that breaks down prostaglandins, prevents platelet stickiness and hence platelet aggregation. Flavonoids also protect the vascular system and strengthen the tiny capillaries that carry oxygen and essential nutrients to all cells.  Flavonoids block the enzymes that produce estrogens, thus reducing the risk of estrogen-induced cancers.
  • 13.  Osteoarthritis (OA), a debilitating joint disorder, is the most common form of arthritis.  Joint discomfort from OA and other joint disorders may reduce physical activity in individuals experiencing this condition, resulting in energy imbalance and weight gain.  Increased weight can exacerbate existing problems, through additional stress on joints
  • 14. Glucosamine (GLN) and chondroitin sulfate (CS) Glucosamine (GLN) and chondroitin sulfate (CS) is widely used to alleviate symptoms of OA. These nutraceuticals have both nutrient and pharmaceutical properties and seem to regulate gene expression and synthesis of NO and PGE2, providing a plausible explanation for their anti- inflammatory activities
  • 16. Nutraceutical options for addressing some of the most common issues associated with stress B-ComplexVitamins The B-complex vitamins are intimately involved in the function of the nervous system, and so can play a role in helping to counter some of the negative effects of stress. In fact, the ability of humans to respond to stress can be influenced by nutritional status—including the status of key B vitamins.
  • 17. Phosphatidylserine Research has demonstrated that phosphatidylserine (PS) was able to blunt the release of cortisol—the “stress hormone”—in response to exercise stress. In some cases, PS supplementation also resulted in improved mood
  • 18. L-Theanine The amino acid L-theanine has been shown to increase both serotonin and dopamine production, and possibly gamma amino butyric acid (GABA) as well. Evidence from human electroencephalograph (EEG) studies show that it also significantly increases brain activity in the alpha frequency band, which indicates that it relaxes the mind without inducing drowsiness.  Other research indicates that L-theanine has a significant effect on improving mental alertness while promoting relaxation. Additional studies have shown that supplementation with L-theanine resulted in a reduction in some physiological indicators of stress within 15 minutes, suppressed the initial stress response of students, and significantly reduced anxiety and reduced the blood-pressure increase in high-stress- response adults.
  • 19. Rhodiola Rosea Root Extract Rhodiola rosea root, another adaptogen, has been used for centuries in the traditional systems of healthcare throughout Russia, Scandinavia, and other countries where it was used to increase physical endurance, work productivity, and longevity, as well as to treat fatigue, mood, and promote a healthy nervous system.
  • 20. Panax Ginseng Panax ginseng root, or ginseng for short, is a traditional Chinese herb which has been used for thousands of years in various aspects of healthcare. It is also one of the most widely researched herbs in modern science with over 5,000 published studies. Ginseng helps stabilize physiological processes and promote homeostasis, especially in the case of stress and fatigue. This property was seen in two human clinical studies examining the effects of ginseng on mental performance
  • 22. Diabetes mellitus is characterized by abnormally high levels of blood glucose, either due to insufficient insulin production or due to its ineffectiveness. The most common forms of diabetes are type 1 diabetes (5%), an autoimmune disorder, and type 2 diabetes (95%), which is associated with obesity. Docosahexaenoic acid (DHA): omega-3-fatty acid Docosahexaenoic acid modulates insulin resistance and is also vital for neuro visual development. This is especially important in women with gestational diabetes mellitus which foster the recommendation for essential fatty acids during pregnancy
  • 23. Lipoic acid Lipoic acid is a universal antioxidant, now used in Germany for the treatment of diabetic neuropathy. It is possible that lipoic acid may be more effective as a long- term dietary supplement aimed at the prophylactic protection of diabetics from complications Dietary fibres Dietary fibres from psyllium have been used extensively both as pharmacological supplements, food ingredients, in processed food to aid weight reduction, for glucose control in diabetic patients and to reduce lipid levels in hyperlipidemia
  • 24. Magnesium Good magnesium status reduces diabetes risk and improves insulin sensitivity; chromium picolinate, calcium and vitamin D appear to promote insulin sensitivity and improve glycemic control in some diabetics; extracts of bitter melon and of cinnamon have the potential to treat and possibly prevent diabetes. However, it has been suggested that Nutraceuticals with meaningful doses of combinations may substantially prevent diabetes.