Diuretics
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This document discusses questions about a person's creatinine clearance rate and how it and sodium reabsorption may change with diuretic use. It provides calculations of the person's creatinine clearance on two days based on urine and plasma creatinine levels. It notes creatinine clearance is used to estimate glomerular filtration rate and renal function, but can overestimate GFR. It asks if the person's creatinine clearance or GFR may change due to factors like decreased blood volume from a diuretic and discusses how a diuretic inhibits sodium reabsorption.
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3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
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2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
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Diuretics
- 1. Assignment 2 Nick: questions e and f: Plasma sodium, aldosterone and creatinin will not change (However, this answer might change) Sebastiaan: questions g and h
- 2. What is this person’s creatinin clearance rate? Urine flow per day * Concentration of creatinine in urine Concentration of creatinin in plasma Day 1: 2,44 L/Day * 7 mmol/L 0.102 mmol/L = 167,45 L/Day Day 7: 2,40 L/Day * 7 mmol/L 0.099 mmol/L = 169,7 L/Day
- 3. Why even calculate creatinin clearance? • Estimate of GFR • Thus estimate of Renal function • However.. using creatinin overestimates GFR http://www.clinicalculator.com/english/nephrology/cockroft/cca.htm Correction factors are often used: This answer would be: 122,73 L/Day
- 4. Will his CCR change? Why would it change? • Decreased blood volume • Decreased blood flow • ADH, Ras, Renal artery stenosis or: Will his GFR change? Thiazide?
- 5. Question h: What is the sodium reabsorption per day, and how is it influenced by the diuretic?