Hypersensitivities

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Sebastiaan van Jole

Hypersensitivities

Health & Medicine

Today
•HSR type 4
•HSR type 3
•HSR type 2
•HSR type 1
•Anaphylactic shock (and how to differentiate it from angioedema)
•Shock
•Summary

CONTACT GLUTENDELAYED
Antigen:
Insect venom
Mycobacteriae
Response:
Swelling, induration, erythema
Wheal and flare
Antigen:
Haptens, e.g.:
Poison ivy, rubber, nickel
Response:
Erythema, vesicles
Infiltrate and abcesses
HSR type 4: mediated byT-cells
Antigen:
Gliadin
Peptides in prolamins
Response:
Villous atrophy
Malabsorption

HSR type 3: Immune complexes
•HSR TYPE 4
•HSR TYPE 3
•HSR TYPE 2
•HSR TYPE 1
•ANAPHYLACTIC SHOCK
•SHOCK
Example:Arthus reaction hemorrhage, necrosis

HSR type 2
CYTOTOXIC NON-CYTOXIC
example: erythroblastosis fetalis example: myasthenia gravis

HSR type 1: Hypersensitivit-e
•HSR TYPE 4
•HSR TYPE 3
•HSR TYPE 2
•HSR TYPE 1
•ANAPHYLACTIC SHOCK
•SHOCK

HSR type 1: Anaphylaxis
Immediate
phase
Late
phase

Shock
•HSR TYPE 4
•HSR TYPE 3
•HSR TYPE 2
•HSR TYPE 1
•ANAPHYLACTIC SHOCK
•SHOCK
Hypovolemic
Cardiogenic
Neurogenic
Septic
Anaphylactic
Principle: Hypoperfusion, Cells go anaerobic, metabolic acidosis

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