This study investigated the effects of different dialysate calcium concentrations on parathyroid hormone levels, cardiovascular stability, and valvular calcifications in end-stage renal disease patients on regular hemodialysis. 80 patients were divided into two groups - Group A received 1.25 mmol/L dialysate calcium while Group B received 1.75 mmol/L. Results showed higher levels of parathyroid hormone and valvular calcifications in Group B compared to Group A. The study recommends individualizing dialysate calcium concentrations and performing echocardiography on all new hemodialysis patients to monitor for valvular calcifications.