Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas. Smoking and health history can affect the risk of pancreatic cancer. Signs and symptoms of pancreatic cancer include jaundice, pain, and weight loss. • Imaging tests that Create Pictures of Your Internal Organs. • Using a Scope to Create Ultrasound Pictures of Your Pancreas. • Removing a Tissue Sample for Testing (Biopsy) • Blood Test