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•   MECHANISM OF ADH•   DEFINITION•   TYPES F DI•   CRANIAL DI•   NEPHROGENIC DI•   CLINICAL FEATURES•   INVESTIGATION•   ...
“Diabetes insipidius is an  uncommon disorder  which is characterised  by the persistent  excretion of excessive  quantiti...
NEPHROGE CRANIAL                  DIPSOGENIC    GESTATIONAL                 -NIC DIABETES                  DIABETES      D...
FAMILIAL:(vasopressin receptorgeneaqua porin-2 genedefect).IdIopAthIc.RenAL tubuLARAcIdosIs.hypokALeMIAhypeRcALceMIA...
Polyuria        Nocturia               DehydrationCompensatorypolydipisia
Samples of blood and urine Dynamic testAssesment of Anterior pituitary function and supresellar anatomyMRIPlasma elec...
 Treatment of reversible underlying cause (eg. A hypothalamic tumour)CRANIAL DI• Des-amino-des-aspartate-arginine vasopr...
NEPHROGENIC DI•   THIAZIDE DIURETICS hydrochlorothiazides•   CARBAMAZEPINE 200 – 400 mg daily•   CHLORPROPAMIDE 200-400 m...
Diabetes Insipidus
Diabetes Insipidus
Diabetes Insipidus
Diabetes Insipidus
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Diabetes Insipidus

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Diabetes Insipidus

  1. 1. • MECHANISM OF ADH• DEFINITION• TYPES F DI• CRANIAL DI• NEPHROGENIC DI• CLINICAL FEATURES• INVESTIGATION• MANAGEMENT
  2. 2. “Diabetes insipidius is an uncommon disorder which is characterised by the persistent excretion of excessive quantities of dilute urine and by thirst”Either due to deficiency of ADH or insensitivity to its action
  3. 3. NEPHROGE CRANIAL DIPSOGENIC GESTATIONAL -NIC DIABETES DIABETES DIABETES DIABETESINSIPIDIUS INSIPIDIUS INSIPIDIUS INSIPIDIUS
  4. 4. FAMILIAL:(vasopressin receptorgeneaqua porin-2 genedefect).IdIopAthIc.RenAL tubuLARAcIdosIs.hypokALeMIAhypeRcALceMIAdRugs (lithium ,demeclocycline)
  5. 5. Polyuria Nocturia DehydrationCompensatorypolydipisia
  6. 6. Samples of blood and urine Dynamic testAssesment of Anterior pituitary function and supresellar anatomyMRIPlasma electrolytesCalciumInvestigation of renal tract
  7. 7.  Treatment of reversible underlying cause (eg. A hypothalamic tumour)CRANIAL DI• Des-amino-des-aspartate-arginine vasopressin DDAVPIntranasally (10 – 20 µg once or twice dailyOrally 200µg thrice dailyand IM 2-4µg once daily
  8. 8. NEPHROGENIC DI• THIAZIDE DIURETICS hydrochlorothiazides• CARBAMAZEPINE 200 – 400 mg daily• CHLORPROPAMIDE 200-400 mg daily• NSAIDS (indomethacin 15 mg 8 hourlyLithium-induced nephrogenic DI may be effectively managed with the administration of amiloride, a potassium-sparing diuretic often used in conjunction with thiazide or loop diuretics.

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