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What is Diabetes?

Diabetes 101
                                         Diabetes mellitus is a group of diseases
                                          characterized by high levels of blood
       Ginny Burns RN MEd CDE             glucose resulting from defects in insulin
                                          production, insulin action or both.




Why do we care?                  What Does This Mean?


                                 Diabetes is now recognized as
20.8 million people               one of the largest epidemics
                                  humanity has ever faced and
   Diagnosed 14.6 million        a leading cause of death!!!!
   Undiagnosed 6.2 million
   7% of the total population




                                 Estimated Costs of Diabetes?
                                     Total cost: $132 billion

   70% of people with               Direct Medical costs: $92 billion
    diabetes will die of
    cardiovascular disease.          Indirect costs: $40 billion




                                                                                      1
What about people?                                Ethnic Groups over 20 years
    Every 24 hours:                                  8.7% White
    New cases: 4,100                                 9.5% Hispanic
    Deaths: 810                                      13.3% Black
    Amputations: 230                                 27% SW Native Americans
    Kidney Failure: 120
    Blindness: 55                                    21% of all Americans over age 60




                                                  What about Utah?
   61% of all
    Hispanic/Latino                             154,000 people in Utah have been
                                                 diagnosed
    Americans born in                           1 out of every 25 people in Utah have
                                                 diabetes
    2000 AD will have                           Sixth leading cause of death in Utah and
                                                 US
        Diabetes




Types of Abnormal Glucose?                        Types of Abnormal Glucose?
   1. Type 1 diabetes---previously called           3. Gestational diabetes---a form of
    insulin-dependent diabetes (IDDM) or              glucose intolerance that is diagnosed in
    juvenile-onset diabetes.                          some women during pregnancy.

   2. Type 2 diabetes---previously called           4. Prediabetes---term used to
    non-insulin-dependent diabetes                    distinguish people who are at in
    (NIDDM) or adult-onset diabetes.                  increased risk for developing diabetes.




                                                                                                 2
How Food is Digested
                                                                       Diagnosing diabetes
       1. Food enters
          stomach
                                                                           Fasting plasma
                                 4. Pancreas
                               releases insulin   5. Insulin unlocks        glucose test (see
                                                       receptors            figure to the right)
                                                        6. Glucose
                                                        enters cell        If fasting glucose test is
                                                                            positive, confirm results
                                 3. Glucose enters
                                    bloodstream                             by repeating on a
  2. Food is converted                                                      different day.
      into glucose




  Symptoms                                                             Type 1
      Extreme thirst                                                      5-10% of all diagnosed cases
      Frequent urination                                                  May be autoimmune, genetic or
      Extreme hunger                                                       environmental
      Blurry vision                                                       Beta-cell destruction usually leading to
      Unexplained weight loss                                              absolute insulin deficiency
      Tingling or numbness in the hands or feet
                                                                           Onset usually abrupt in young but can
       Constant fatigue
   
                                                                            be slow in older patients
      Dry / irritated skin (above and beyond Utah standards)
                                                                           Usually normal weight or slender
      Wounds that are slow to heal




                                                                       What happens in Type 1 diabetes?
  Type 1
                                                                            1. Food enters
                                                                               stomach

                                                                                                          4. Pancreas
                                                                                                         cells produce
                                                                                                           no insulin
   Insulin is the medication that is used!!!!!                                                                       5. Glucose rises in blood

   Symlin, insulin pumps, glucose sensors
                                                                                                          3. Glucose enters
                                                                                                             bloodstream
                                                                       2. Food is converted
                                                                           into glucose




                                                                                                                                                 3
Type 2                                                 Type 2
   90-95% of all diabetes cases
   Onset is usually very slow
   Older age? Children?                                And Obesity
   Family history, history of gestational DM
   Depression?
   Complications are often present at
    diagnosis: retinopathy, neuropathy
    nephropathy




                                                     What Happens in Type 2 diabetes?
Type 2
   Hypertension is most often present                      1. Food enters
                                                               stomach

   Cholesterol levels often abnormal                                            4. Pancreas
                                                                              releases too little 5. Insulin is less
   Medications:                                                                    insulin            effective

      oral diabetes medications, lipid                                                                  6. Less glucose
                                                                                                           enters cell
      lowering agents, hypertensive
      medications, pain medications for
                                                                                3. Glucose enters
                                                                                   bloodstream
                                                       2. Food is converted
      neuropathy, insulin, Byetta, Symlin                  into glucose

                                                                                        7. Glucose rises in blood




Diabetes Complications                                 Diabetes Complications
   Cardiovascular Disease (CVD):                          Eyes
       2 to 4 times the risk of heart disease and          Glaucoma, cataracts, retinopathy
        stroke compared with people without
        diabetes
                                                           Kidneys
       Diabetes appears to particularly increase           Nephropathy, renal failure
        the risk of CVD in women                           Nerves
       Major cause of death in all patients with           Neuropathy, amputations
        DM
                                                           Gums and teeth




                                                                                                                          4
Preventing Complications                               Preventing Complications
                                                 Glycemic Control
   Developing self-management skills is at          Control the amount of sugars and carbohydrates
    the foundation of diabetes                        consumed
    management:                                  Aggressive Lipid Lowering
                                                     Lower the amount of “bad fats” in your diet
       Self-monitoring of blood glucose         Management of Hypertension
       Meal planning                                Decrease blood pressure and find ways to manage
       Exercise                                      stress
       Medication compliance




Gestational Diabetes?                                  Gestational?
   Diabetes diagnosed in pregnancy                       No known cause of gestational
   2-5% of all pregnancies                                diabetes, but there are some ideas
   More common in obese women                                Hormones from the placenta may block the
                                                               action of the mother's insulin in her body
   More common if family hx of DM                             causing insulin resistance
   More frequent in African Americans,                       The stress of the pregnancy may also
    Hispanic/Latino Americans and                              cause insulin resistance
    American Indians                                      Usually disappears after pregnancy
                                                          Risk for Type 2 diabetes later in life




Gestational?                                           Gestational?
Screening 24-26 wks.                                    Women have 20-50% chance of
50gram glucose drink with blood draw 1                   developing diabetes in the next 5-10
  hour after drink.                                      yrs.
Positive if results are equal or greater               It appears that the largest risk comes
                                                         from weight!!
  than 140mg/dL

                                                       Encourage normal body weight!!!




                                                                                                            5
Pre-diabetes—do we care?                     Pre-diabetes and Obesity?
   Estimated 61 million people
   Estimated 70% progress to DM             Are they connected?
   Lifestyle changes may prevent or delay
    the onset to DM


                                                     YES!!!
   Complications begin when glucose
    levels are elevated!!!!




Obesity 1990                                 Obesity in 2001




Diabetes in 1990                             Diabetes in 2001




                                                                         6
What can we do?                           What about exercise?
                                             We need to move, move,
                                              move, move, move, move,
    Make Lifestyle                            move and move some
                                              more!!
    changes!!!                               About 1 hr every day should be the
                                              minimum. 10,000 steps is great!!!




What about food?                          Diets? Or Just Healthy Eating?
Mike Huckabee, Governor from Arkansas,       Eat Less
 said he lost several hundred pounds by      Decrease highly processed foods
 following the advice of his MD:
                                             Increase fruits and vegetables
                                              Do not drink your carbohydrates
“If is wasn’t a food 100
                                          



 years ago, don’t eat
 it”!!!!!




Questions?
   Twitter:@AskGinny
   Blog:http://askginnyaboutdiabetes.
       blogspot.com
                   or

       askginny@utah.gov




                                                                                   7

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What is Diabetes

  • 1. What is Diabetes? Diabetes 101  Diabetes mellitus is a group of diseases characterized by high levels of blood Ginny Burns RN MEd CDE glucose resulting from defects in insulin production, insulin action or both. Why do we care? What Does This Mean? Diabetes is now recognized as 20.8 million people one of the largest epidemics humanity has ever faced and  Diagnosed 14.6 million a leading cause of death!!!!  Undiagnosed 6.2 million  7% of the total population Estimated Costs of Diabetes?  Total cost: $132 billion  70% of people with  Direct Medical costs: $92 billion diabetes will die of cardiovascular disease.  Indirect costs: $40 billion 1
  • 2. What about people? Ethnic Groups over 20 years Every 24 hours:  8.7% White New cases: 4,100  9.5% Hispanic Deaths: 810  13.3% Black Amputations: 230  27% SW Native Americans Kidney Failure: 120 Blindness: 55  21% of all Americans over age 60 What about Utah?  61% of all Hispanic/Latino  154,000 people in Utah have been diagnosed Americans born in  1 out of every 25 people in Utah have diabetes 2000 AD will have  Sixth leading cause of death in Utah and US Diabetes Types of Abnormal Glucose? Types of Abnormal Glucose?  1. Type 1 diabetes---previously called  3. Gestational diabetes---a form of insulin-dependent diabetes (IDDM) or glucose intolerance that is diagnosed in juvenile-onset diabetes. some women during pregnancy.  2. Type 2 diabetes---previously called  4. Prediabetes---term used to non-insulin-dependent diabetes distinguish people who are at in (NIDDM) or adult-onset diabetes. increased risk for developing diabetes. 2
  • 3. How Food is Digested Diagnosing diabetes 1. Food enters stomach  Fasting plasma 4. Pancreas releases insulin 5. Insulin unlocks glucose test (see receptors figure to the right) 6. Glucose enters cell  If fasting glucose test is positive, confirm results 3. Glucose enters bloodstream by repeating on a 2. Food is converted different day. into glucose Symptoms Type 1  Extreme thirst  5-10% of all diagnosed cases  Frequent urination  May be autoimmune, genetic or  Extreme hunger environmental  Blurry vision  Beta-cell destruction usually leading to  Unexplained weight loss absolute insulin deficiency  Tingling or numbness in the hands or feet  Onset usually abrupt in young but can Constant fatigue  be slow in older patients  Dry / irritated skin (above and beyond Utah standards)  Usually normal weight or slender  Wounds that are slow to heal What happens in Type 1 diabetes? Type 1 1. Food enters stomach 4. Pancreas cells produce no insulin Insulin is the medication that is used!!!!! 5. Glucose rises in blood Symlin, insulin pumps, glucose sensors 3. Glucose enters bloodstream 2. Food is converted into glucose 3
  • 4. Type 2 Type 2  90-95% of all diabetes cases  Onset is usually very slow  Older age? Children? And Obesity  Family history, history of gestational DM  Depression?  Complications are often present at diagnosis: retinopathy, neuropathy nephropathy What Happens in Type 2 diabetes? Type 2  Hypertension is most often present 1. Food enters stomach  Cholesterol levels often abnormal 4. Pancreas releases too little 5. Insulin is less  Medications: insulin effective oral diabetes medications, lipid 6. Less glucose enters cell lowering agents, hypertensive medications, pain medications for 3. Glucose enters bloodstream 2. Food is converted neuropathy, insulin, Byetta, Symlin into glucose 7. Glucose rises in blood Diabetes Complications Diabetes Complications  Cardiovascular Disease (CVD):  Eyes  2 to 4 times the risk of heart disease and Glaucoma, cataracts, retinopathy stroke compared with people without diabetes  Kidneys  Diabetes appears to particularly increase Nephropathy, renal failure the risk of CVD in women  Nerves  Major cause of death in all patients with Neuropathy, amputations DM  Gums and teeth 4
  • 5. Preventing Complications Preventing Complications  Glycemic Control  Developing self-management skills is at  Control the amount of sugars and carbohydrates the foundation of diabetes consumed management:  Aggressive Lipid Lowering  Lower the amount of “bad fats” in your diet  Self-monitoring of blood glucose  Management of Hypertension  Meal planning  Decrease blood pressure and find ways to manage  Exercise stress  Medication compliance Gestational Diabetes? Gestational?  Diabetes diagnosed in pregnancy  No known cause of gestational  2-5% of all pregnancies diabetes, but there are some ideas  More common in obese women  Hormones from the placenta may block the action of the mother's insulin in her body  More common if family hx of DM causing insulin resistance  More frequent in African Americans,  The stress of the pregnancy may also Hispanic/Latino Americans and cause insulin resistance American Indians  Usually disappears after pregnancy  Risk for Type 2 diabetes later in life Gestational? Gestational? Screening 24-26 wks.  Women have 20-50% chance of 50gram glucose drink with blood draw 1 developing diabetes in the next 5-10 hour after drink. yrs. Positive if results are equal or greater It appears that the largest risk comes from weight!! than 140mg/dL Encourage normal body weight!!! 5
  • 6. Pre-diabetes—do we care? Pre-diabetes and Obesity?  Estimated 61 million people  Estimated 70% progress to DM Are they connected?  Lifestyle changes may prevent or delay the onset to DM YES!!!  Complications begin when glucose levels are elevated!!!! Obesity 1990 Obesity in 2001 Diabetes in 1990 Diabetes in 2001 6
  • 7. What can we do? What about exercise?  We need to move, move, move, move, move, move, Make Lifestyle move and move some more!! changes!!!  About 1 hr every day should be the minimum. 10,000 steps is great!!! What about food? Diets? Or Just Healthy Eating? Mike Huckabee, Governor from Arkansas,  Eat Less said he lost several hundred pounds by  Decrease highly processed foods following the advice of his MD:  Increase fruits and vegetables Do not drink your carbohydrates “If is wasn’t a food 100  years ago, don’t eat it”!!!!! Questions?  Twitter:@AskGinny  Blog:http://askginnyaboutdiabetes. blogspot.com or askginny@utah.gov 7