This document summarizes several topics discussed at a science communication event:
1) It discusses the importance of scientists acting as poets, chefs, and cheerleaders to create conversation about their research among the public.
2) It lists areas of biomedical research, science communication research, and frontiers in computing that were discussed.
3) It provides brief updates on collaborations studying genetic variants related to heart conditions and Horizon 2020 projects on responsible research and innovation.
Making an Impact: How Digitised Resources Change LivesSimon Tanner
This paper will draw upon the research done by the author from a wide number of sources and will provide a compelling account of the advantages of digitised content.
The paper will cover using case studies and exemplars from across the sectors information on:
Where the value and impact can be found in digitised resources,
What modes of value and impact are achievable, and
Who are the beneficiaries gaining from the impact and value?
Special attention is worth paying to the proposal of 5 modes of value for digitised resources. The basic value modes suggested here may act as a guide for future digitisation impact assessment. If these value models to society as a whole are satisfied then many other benefits identified in this paper will also accrue.
This document therefore provides strong information to support:
Fundraising and revenue development plans,
Audience development,
Designing evaluation and impact assessment,
Project planning, and
Planning activities to augment digitised resources.
The aim is to provide key information and strong exemplars for the following primary stakeholders:
Memory institutions and cultural heritage organisations such as libraries, museums and archives.
Holders and custodians of special collections.
Managers, project managers and fundraisers who are seeking to justify further investment in digitised resources.
Academics looking to establish digital projects and digital scholarship collaborations with collection owners.
Making an Impact: How Digitised Resources Change LivesSimon Tanner
This paper will draw upon the research done by the author from a wide number of sources and will provide a compelling account of the advantages of digitised content.
The paper will cover using case studies and exemplars from across the sectors information on:
Where the value and impact can be found in digitised resources,
What modes of value and impact are achievable, and
Who are the beneficiaries gaining from the impact and value?
Special attention is worth paying to the proposal of 5 modes of value for digitised resources. The basic value modes suggested here may act as a guide for future digitisation impact assessment. If these value models to society as a whole are satisfied then many other benefits identified in this paper will also accrue.
This document therefore provides strong information to support:
Fundraising and revenue development plans,
Audience development,
Designing evaluation and impact assessment,
Project planning, and
Planning activities to augment digitised resources.
The aim is to provide key information and strong exemplars for the following primary stakeholders:
Memory institutions and cultural heritage organisations such as libraries, museums and archives.
Holders and custodians of special collections.
Managers, project managers and fundraisers who are seeking to justify further investment in digitised resources.
Academics looking to establish digital projects and digital scholarship collaborations with collection owners.
"GrinUGR - Co-Laboratory on Digital Cultures in Social Sciences and Humanities. A view on Digital Humanities and Social Sciences".
This presentation was given at the New Trends Seminars organised by the eHumanities Group in Amsterdam (March 13th, 2014).
Science as an Open Enterprise – Geoffrey BoultonOpenAIRE
Science as an Open Enterprise – Geoffrey Boulton, University of Edinburgh.
University of Minho Open Access Seminar & OpenAIRE Interoperability Workshop (7 Feb. 2013) - Session: Open Science, Open Data and Repositorie.
Digital Humanities_ Bridging Technology and Humanities for a Digital Age.pdfJasmineLowlarnce
There has been a significant shift in how universities and research institutions operate in this digital age. As a result of the humanities' openness to the possibilities offered by technological advances, a new multidisciplinary area has emerged: digital humanities. With dissertation homework help, learning about the goal of this interdisciplinary field is to deepen our understanding of humanities topics like history, literature, language, and art through the use of computational techniques, data analysis, as well as digital tools. The field of Digital Humanities serves as a pivotal link between the evergreen insights of the arts and the ever-evolving capabilities of technological advances, opening up novel avenues for scholarly inquiry and practical application.
“All together now...” Mobilising the (digital) humanities in the Information AgeDaniel Paul O'Donnell
A student-focussed discussion of the impact of the information revolution on the research humanities with some examples from my own work, including SSHRC and GRAND-DH-funded material. Present at the University of Basel October 13, 2014.
Greenlight For Girls 20 November BrusselsMRancourt
Registration is now open for our greenlight for girls event - a new social initiative encourage young women to consider a future in math, science, engineering and technology.
"GrinUGR - Co-Laboratory on Digital Cultures in Social Sciences and Humanities. A view on Digital Humanities and Social Sciences".
This presentation was given at the New Trends Seminars organised by the eHumanities Group in Amsterdam (March 13th, 2014).
Science as an Open Enterprise – Geoffrey BoultonOpenAIRE
Science as an Open Enterprise – Geoffrey Boulton, University of Edinburgh.
University of Minho Open Access Seminar & OpenAIRE Interoperability Workshop (7 Feb. 2013) - Session: Open Science, Open Data and Repositorie.
Digital Humanities_ Bridging Technology and Humanities for a Digital Age.pdfJasmineLowlarnce
There has been a significant shift in how universities and research institutions operate in this digital age. As a result of the humanities' openness to the possibilities offered by technological advances, a new multidisciplinary area has emerged: digital humanities. With dissertation homework help, learning about the goal of this interdisciplinary field is to deepen our understanding of humanities topics like history, literature, language, and art through the use of computational techniques, data analysis, as well as digital tools. The field of Digital Humanities serves as a pivotal link between the evergreen insights of the arts and the ever-evolving capabilities of technological advances, opening up novel avenues for scholarly inquiry and practical application.
“All together now...” Mobilising the (digital) humanities in the Information AgeDaniel Paul O'Donnell
A student-focussed discussion of the impact of the information revolution on the research humanities with some examples from my own work, including SSHRC and GRAND-DH-funded material. Present at the University of Basel October 13, 2014.
Greenlight For Girls 20 November BrusselsMRancourt
Registration is now open for our greenlight for girls event - a new social initiative encourage young women to consider a future in math, science, engineering and technology.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. Poets, chefs and cheerleaders
• On Chef Scientist, Poet Scientists, and Cheer Scientists
• Wagensberg: Trascendence of a museum cannot be assessed by the
number of its visitors, but by the conversation it creates
• Trascendence of research can (also) be assessed by the conversation it
creates among people, society
3. Looking forward
• Biomedical research
• Science communication research
• Frontiers in computing
Miquel Duran, IQCC UdG, Science Slam, 13/5/2019
4. Interpreting Non-Coding Variants to
Predict the Risk of Brugada Syndrome
Collaboration with Sara Pagans, Dept. Medicina +
Centre de Genètica Cardiovascular + IdibGI.
5. Horizon 2020: Responsible
Research and Innovation
Science with and for society
• Digital Science
Communication
• Magic and Science
• Low-Cost Communication of
Research
6. #clowcore
• Our research is usually difficult to communicate to the public
• Our research lies on complex concepts that society does not
quite understand (let's suppose we do understand them, of
course)
• Explaining in a plain way buckyball, helium hydride,
aromaticity, entropy, chemical bond, bond critical point,
electron density, entangles pairs, quantum mechanics, ...
Communication to Bienal
de Química in Donostia on
May'19: 52 games with the
Periodic Table
7. Frontiers in Computing
The world is pushing technology, methodology, and
frontiers of science
Artificial Intelligence in (Quantum) Chemistry
Quantum Computing in (Quantum) Chemistry
IBM Q suite of Quantum
Computing Simulator...
and computer too.
Students welcome!