- DALY (disability-adjusted life year) is a measure that quantifies overall disease burden, expressed as years lost due to ill-health, disability or early death. It is calculated as the sum of years of life lost due to premature mortality (YLL) and years lost due to disability (YLD) for a particular disease or health condition. DALY was developed by the World Health Organization and World Bank to help set priorities for health research and interventions. India's leading causes of DALY are ischemic heart disease, chronic obstructive pulmonary disease, and diarrheal diseases.