1. Curriculum Vitae (CV)
PERSONAL DATA
1-1 Personal details
• Family Name : ABUDUNIA
• First Name : Abdulmalik
• Gender : Male
• Date of birth : 1/1/1978
• City of Birth : Hajjah-Yemen
• Country of Birth : Yemen
• Nationality : Yemen
• Marital status : Married
• No. of children : 3
• No. of Passport : 03810286
• Expiry date of Passport : 09/02/2016
1-2 Current address
• Street : G5 . Amal1 , Yaagob Almansour,No462.
• Postal Zip Code :10000
• City : Rabat
• Country : Morocco
• Telephone mobile: 00212632751300
• E-mail : abdul-malik2009@live.fr
1-3 Permanent Personal Address
• Street : Abu Dhabi . Safia . Ans Supermarket
• Postal Zip Code : 01244540
• City : Sana'a
• Country : Yemen
• Telephone mobile : 00967777863211, 00967777414188
2- ACADEMIC EDUCATION
2-1- Second Degree.
• Omar Ibn- AL-Ghtab School .
• Hajjah - Yemen.
2- 2- Bachelor Degree in Pharmacy .
• University : Sana’a -Yemen
• Faculty of Medicine and pharmacy
2-3- Master Degree in Pharmaceutical biotechnology
• University : Mohammed V - Agdal,
• University Department : Faculty of Science
• City : Rabat
• State : Master degree of biotechnology in the field of health .

2. • Country : Morocco
• Degree obtained : Good
• In Discipline : Very good
• Title of Master thesis
• ( Evaluation of ability of Calendula arvensis as antimicrobial drugs) .
2-4 - Diploma of High Superior Study of Clinical Pharmacy (equivalence of
master degree)
• City : Rabat
• State : Equivalent Master
• Country : Morocco .
• Subject of the degree: only courses
• Duration to obtain degree : 2 years
• Starting date : 2009/2010
• Graduate date : 2011/2012
• Total Grade : VERY GOOD
• University: Mohammed V – Suissi
• Faculty of Medicine and pharmacy
• - Courses and Awards
• Attestation success in French language .
• City : Rabat
• State : Equivalent Diploma
• Country : Morocco .
• Subject of the degree: courses
• Duration to obtain degree : 1 years
• Starting date : 2008/2009
• Graduate date : 2009/2010
• Total Grade : VERY GOOD
• University: Mohammed V – Suissi
• Faculty of Education Science
• Attestation success in English language
• Seeds Institute ,Sana'a Capital .Yemen .
• Attestation best Research Scientific paper : « Drug combination and application on
helicobacter pylori ». Sana’a University, Faculty of Medicine and pharmacy Yemen
• Participate in workshop for Arabic students in Beirut- Lebanon.
• Attestation success in use « Windows - power point . Excel . Word »
• Miage School – Rabat . Morocco .
• Attestation of work in «pharmacy » Dr. Abdul kader Almawtakil hospital
• Sana’a .Yemen .
• Attestation of work in « Raghdan pharmacy »
• Sana’a .Yemen .
• Attestation of work as supervisor on group of « Al-majd pharmacy »
• Sana’a .Yemen .

3. • Attestation of work as medical repretensive on group of « Sanofi-Aventis » part-time
-6 years ago in Yemen
• Sana’a .Yemen .
3- ACADEMIC BACKGROUND AND SKILLS
3-1- Experience in Nanomedicine
• Participation in Workshop « Computational genomic » in CNRST - 2 week in Rabat-
Morocco .
• Participation in Workshop « Analysis of cytometry in flux » - Hassan 2 University-
Mohammedia- Morocco .
• Participation in Workshop « Genetic medical » - Institute National of Gene -16- 18
Rabat-Morocco .
• Participation in Workshop « Synthesis of biomedical and protein engineering » -Shoeb
ALdockali University – Al-Jadidah .
• Participation in Workshop « 7th County Scientific congress of Trans Mediterranean
heterocyclic chemistry (TRAMECH-7)» - November 27-30,2013-Rabat-Morocco.
• Participation in Workshop « 5th Scientific Days CEDOC- SVS»-Mohammed V-Suissi-
Faculty of medicine and pharmacy- Rabat - Morocco.
• Lecture in pharmaceutical biotechnology 1-11-Alrazi University - Sana’a – Yemen.
• Lecture in Clinical pharmacy - Alnaser University - Sana’a – Yemen.
• Experience practice in « bacteriology Medical» -Institute National of Gene for 2
Months , Rabat Morocco.
• Experience practice in « Culture cells » - Biopharma - Society for 1 Months , Rabat
Morocco .
3-2- International Publications :
• Our research work has been accepted for publication in journal of chemical and
pharmaceutical research
Available online www.jocpr.com
Journal of Chemical and PharmaceuticalResearch, 2014, 6(8):156-161
ResearchArticle ISSN : 0975-7384 CODEN(USA) : JCPRC5
Evaluation of antibacterialactivity of extracts from Calendulaaventis flowers
Abdul-Malik Abudunia*1,2,4, M’Hammed Ansar2, Jamal Taoufik2, Youssef Ramli3,
ElMokhtar Essassi3, Azeddine Ibrahimi1 and Khadija Khedid4
1Biotechnology Laboratory (Med-Biotech), Faculty of Medicine and Pharmacy, Mohammed V University-
Souissi,Rabat, Morocco
2Department of Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University-
Rabat, Morocco
3Department of Heterocyclic Organic Chemistry Laboratory, Faculty of Sciences, Mohammed V University-
Agdal,Rabat, Morocco
4Department of Bacteriology, National Institute of Health (INH), Avenue, Ibn Batouta -Agdal, Rabat, Morocco
_____________________________________________________________________________________
ABSTRACT
Calendula arvensis(C.A.) is one of the herbs used in traditional medicine in Morocco , Due to its essential oil it is
recognized by its smell and warmth characteristic .This work aims to evaluate the antibacterial activity ofC.A.
flower extracts , Hexanolic and methanolic extracts were obtained by the method of soxhlet , while aqueous extract
was obtained by maceration in cold water. Antibacterial activity screening was conducted by the well diffusion
method according to the clinical and laboratory standard institute guidelines using 6 Gram positive and 7 Gram

4. negative bacteria (sensitive and multidrug-resistant) .The results indicated that ,the methanolic extracts of C.A.
flowers generally showed high inhibitory activity against Gram-positive and Gram negative bacteria except
Acinetobacterbaumanii , Proteusmirabilis and Listeria monocytogenes,The C.A. flowers hexanolic extract
inhibited all bacteria of Gram-positive and Gram negative bacteria except,Staphylococcus aureus
MRSA,Streptococcusagalactiae and Acinetobacter baumanii ,There were no inhibitory effects of the aqueous
extracts against all tested bacterial strainsexcept Rhodococcuss equi and Morganella morganii,MICs valuesof
methanolic extractswere between 12.5-25μg/ml . while MICs of values of hexanolic extracts were between 6.25-12.5
μg/ml . In conclusion the obtained resultsshow an antibacterial potency oforganic extracts of C.A. flowers. C.A.
flowers Hexanolic extractswere bactericidal for most bacteria while methanolic extracts were bacteriostatic .
Key words: Calendula arvensis, antibacterial activity, MICs, MBCs, medicinal plant.
• Our research work which we wait for publication in other journal
• Antioxidant and Cytotoxic activities of Extracts from Calendula Arvensis Flowers on
Acute myeloid leukemia cells
Abdul-Malik Abudunia1*,2, Ilias Marmouzi2, Nadia El Madani2, M’Hammed Ansar3,Jamal Taoufik3, Youssef
RAMLI3 ,My El Abbes Faouzi 2, El Mokhtar Essassi3, Abdelkarim Salama1 and Azeddine Ibrahimi1*
1
Department of Biotechnology Laboratory (Med-Biotech) , Faculty of Medicine and pharmacy, Mohammed V University-
Souissi , Rabat , Morocco.
2
Department of Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team Mohamed V University -Souissi,
Faculty of Medicine and Pharmacy,. BP 6203, Rabat Instituts, Rabat, Morocco.
3Department of Medicinal Chemistry laboratory, Faculty of Medicine and pharmacy, Mohammed V University- Rabat,
Morocco.
ABSTRACT
Numerous studies have been focused on natural anticarcinogenic agents.Many antioxidants have been identified as
anticarcinogens. Antimutagens have also been proposed as cancer chemopreventive agents. The use of natural products as
anticancer has a long history that began with traditional medicine. The present study is aimed to investigate the phytochemical
content, the antioxidants properties and the effects of extracts of Calendula arvensis (C.A.) flowers on the growth of cancer cells
of myeloid cell .The different solvent extracts (Methanol, Hexanol and Water) were assessed for phenolic and flavonoid
content.Their cytotoxicity using MTT [3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium] bioassay.These cells were
cultured in MEC (Minimum Essential Communications) medium and incubated with the serial dilutions of extract (2–0.00093
mg/ml) in CO2 incubator at 37°C for 48 h,The results indicated that , Methanolic and aqueous extract exhibited maximum
antimyeloid cancer activity having IC50 (the concentration of an individual compound leading to 50% inhibition) value 31
µg/ml against myeloid cell line. Significant percentage of inhibition (90%) in the Methanol and aqueous extract of C.A. flowers
at 48 h of exposure and concentration 50 mg/ml (p < 0.034 ) against acute myeloid leukemia cells, indicates the presence of some
structural moiety responsible for this observed antiproliferative effect. In vivo study and structural elucidation of its bioactive
principle are in progress. Our findings highlight the potential of this plant for its possible clinical use to counteract malignancy
development as antimyeloid cell cancer bioagent .
Key words: Calendula arvensis, Phenolic content, flavonoid content ,Antioxidant activity ,Cytotoxic, antimyeloid leukemia
cell bioagent.
• Screening of Extracts from Calendula Arvensis flowers for treatment of diarrhea and
urinary tract infection .
Abdul-Malik ABUDUNIA*1,2,4 , M’Hammed ANSAR2 , Jamal TAOUFIK2, Youssef RAMLI3, El Mokhtar ESSASSI3 ,
Azeddine IBRAHIMI1 and Khadija KHEDID4.
1
Biotechnology Laboratory (Med-Biotech) , Faculty of Medicine and pharmacy,
Mohammed V University-Souissi, Rabat , Morocco.
2
Department of Medicinal Chemistry laboratory, Faculty of Medicine and pharmacy, Mohammed V University - Rabat,
Morocco.
3
Department of Heterocyclic Organic Chemistry Laboratory, Faculty of Sciences, Mohammed V University -Agdal , Rabat,
Morocco.
4
Department of Bacteriology, National Institute of Health (INH), P.O. Box 769, 27, Avenue Ibn Batouta -Agdal , Rabat,
Morocco.

5. ABSTRACT
This work aims to Screening of extracts from Calendula Arvensis flowers for treatment of diarrhea and urinary tract infection,
Hexanolic and methanolic extracts were obtained by the method of Soxhlet , while aqueous extract was obtained by
maceration in cold water. Antibacterial activity screening was conducted by the well diffusion method according to the clinical
and laboratory standard institute guidelines using 3 bacteria strain namely Salmonella blockley , Salmonella aequatoria and
Salmonella braenderup , 4 bacteria strains sensitive and multidrug-resistant namely E.coli enteropathogenes, E.coli 1 , E. coli 2
and E. coli MDR,The results indicated that , all extracts of C.A. flowers generally showed high inhibitory activity against
Salmonella aequatoria ,The C.A. flowers methanolic extract inhibited E. coli 1 , E.coli 2 and Salmonella braenderup ,The C.A.
flowers hexanolic extract inhibited E. coli 1 , E. coli 2, There were no inhibitory effects of extracts against Salmonella
blockley, E.coli enteropathogenes and E.coli MDR, MICs values of methanolic extracts were 12.5μg/ml . While MICs of values
of hexanolic extracts were between 6.25-12.5 μg/ml . The C.A. flowers Hexanolic extracts were bactericidal for most bacteria
while methanolic extracts were bacteriostatic .In conclusion , the obtained results show an antibacterial potency of organic
extracts of C.A. flowers .
• Antifungal Activity of Essential Oils and Extracts from Moroccan Medicinal Plants
Against Human Pathogenic Candida spp.
Abdul-Malik ABUDUNIA*1,2,4 , M’Hammed ANSAR2 , Jamal TAOUFIK2, Youssef RAMLI2, El Mokhtar ESSASSI 3
, Azeddine IBRAHIMI1 and Khadija KHEDID4.
1
Department of Biotechnology Laboratory (Med-Biotech) , Faculty of Medicine and pharmacy, Mohammed V University-
Souissi, Rabat , Morocco.
2
Department of Medicinal Chemistry laboratory, Faculty of Medicine and pharmacy, Mohammed V University- Rabat, Morocco.
3
Department of Heterocyclic Organic Chemistry Laboratory, Faculty of Sciences, Mohammed V University -Agdal , Rabat,
Morocco.
4
Department of Bacteriology, Institute National of Health (INH), P.O. Box 769, 27, Avenue Ibn Batouta -Agdal , Rabat,
Morocco.
ABSTRACT
Essential oils and extracts obtained from many plants have recently gained a great popularity and scientific interest. The plants
has been reported to have antibacterial, antifungal, antiviral, antiparasitic and antidermatophytic properties. It is now considered
as a valuable source of natural products for development of medicines against various diseases and also for the development of
industrial products ,Oils of Syzygium aromaticum, Eucalyptus rossi ,Rosaminus officinalis , Thymus vulgaris and extracts of
hexanolic , methanolic and aqueous of Calendula arvensis flower’s were screened for their activity against 6 species of
Candida spp namely Candida tropicalis (2), Candida famata (2) and Candida glabrata (2),by
well diffusion method.The results showed that the maximum antimycotic activity was demonstrated by oils of Thymus vulgaris
,Rosaminus officinalis, Eucalyptus rossi and Syzygium aromaticum ,while the extracts of Calendula arvensis exhibited no
activity on these species except methanolic extracts showed activity on Candida tropicalis spp1 and Candida
famata spp1.These results support theplant oils which can be used to cure mycotic infections and plant oils may have role as
pharmaceutical and preservatives.
Keywords : Calendula arvensis , Essential oils , Antifungal activity , Candida spp .
3-2- Language Skills
• English language
• Very Good , Oral , Written , reading , second language in my country .
• French language
• Good , Oral , written , reading , My study Through 3 years ago in Morocco.
• Arabic language »
• Excellent , Oral , written , reading , Mother language.
4 - DOCTORAL PROJECT
• Title of doctoral thesis
• Valorisation of small molecules synthesis of pyridazin derivatives and Extracts from
Morocco Medicinal Plants as Antitumoral and Anti-inflammatory drugs.

6. • Another projects - Application choice
• Subject 1: Novel gel-associated drug-loaded nanocarriers for intratumoral delivery
• Subject 2 : Design of new multifunctional nanocarriers for proteins delivery
• Subject 3: Dental stem cell delivery through new injectable matrices for spinal cord
5 – REFERENCES
• First Reference :
• Name : Pro.Azeddine IBRAHIMI
• Title : professor of Biotechnology Medical
• Institution : Mohammed V- University Suissi
• Faculty of Medicine and Pharmacy ,
• Telephone : 00212660240131
• E-mail address : a.ibrahimi@um5s.net.ma
• Second Reference :
• Name : M’Hammed ANSAR
• Title : professor of Medicinal chemistry
• Institution : Mohammed V- University Suissi
• Faculty of Medicine and Pharmacy
• Telephone : 00212615181615
• E-mail address : ansarmhammed@gmail.com