Muhammad Shamsul Azim Khan, Ph.D., is an experienced researcher in synthetic organic chemistry with over 10 years in R&D, specializing in multi-step synthesis of various compounds and the development of separation methods. He holds a Ph.D. in macromolecular chemistry from Masaryk University and has extensive industrial and academic experience, including postdoctoral positions and numerous publications. His research interests include active pharmaceutical ingredients and supramolecular chemistry, combined with skills in various advanced analytical techniques.

1. CURRICULUM VITAE
1
PERSONAL INFORMATION
Name: Muhammad Shamsul Azim Khan, Ph.D.
Date of birth: 30-12-1975
Nationality: Bangladesh
Current mail address: Podjavorinské 1598/6, Chodov, 149 00 Praha, Czech Republic
[with permanent residency (s trvalým pobytem) in the Czech Republic]
European driving license: Group “B” - active
Email: azim2005@gmail.com
Mobile: + 420-776 837 244 (Czech Republic).
Skype ID: azimchem
Linkedin profile: https://cz.linkedin.com/in/msakhan1975
KEY SKILLS AND ABILITIES / RESEARCH INTERESTS
• experienced in synthetic organic chemistry (10 years, research and development sector)
• custom / multi-step synthesis (from mg to multi-gram scale) of new/old compounds including
macrocyclic receptors (cucurbit[n]urils, cyclodextrin dimer, calix[n]phyrin, porphyrin and
porphyrinoids), heterocycles, biologically active compounds, functionalized carbohydrates etc.
• development of separation and purification method using various chromatographic instruments
(HPLC-MS: preparative/analytical etc.) and characterization of the synthesized compounds using
various spectroscopies (FT-NMR, UV-vis, FT-IR, etc.)
• experienced in qualitative and quantitative measurement of supramolecular binding interactions
between synthetic receptor and other chemical entity such as drug
• independent, dedicated, resourceful, strong analytical ability, innovative
• excellent communication and presentation skills
• research interest includes design and synthesis of active pharmaceutical ingredient (API), fine
chemicals, new drug discovery, medicinal and analytical chemistry etc.
• experienced R & D chemist in the paint and surface coating industry
ACADEMIC QUALIFICATION
1. 09/2006 - 09/2012
Ph.D. degree completed (Field: Macromolecular Chemistry)
Department of Chemistry, Masaryk University in Brno, Czech Republic
2. 2001 - 1999
M.Sc. in Organic Chemistry (Thesis - Organic synthesis)
Department of Chemistry, Jahangirnagar University, Savar - 1342, Dhaka, Bangladesh
Result: 1st class 2nd position (Obtained marks - 71.86 %)
3. 1999 - 1993
B.Sc. (Honors) in Chemistry
Department of Chemistry, Jahangirnagar University, Savar-1342, Dhaka, Bangladesh
Result: 1st class 1st position (Obtained marks - 69.25 %)
4. 1993 - 1991
Higher Secondary Certificate (H.S.C) Exam’1993
Dhaka College, Dhaka, Bangladesh
Result: 1st division (Obtained marks - 69.9 %)
5. 1991 - 1989
Secondary School Certificate (S.S.C) Exam’1991
A.K. Higher Secondary School, Dhaka-1236, Bangladesh
Result: 1st division with star marks (Obtained marks - 77 %)
RESEARCH FELLOWSHIP / ACADEMIC / INDUSTRIAL JOB EXPERIENCE
1. 05/2013 - 06/2015 (2-year, 2-month)
Postdoctoral research fellow (co-financed by EU grant)
University of Chemical Technology Prague, Technická 5, Prague 6, Czech Republic

2. CURRICULUM VITAE
2
Project title: Synthesis, purification and characterization of
i) calix[n]phyrin (n=4, 6) conjugates with Tröger’s base (TB) for sensing cations or anions, and
ii) TB-Tris(mannose) cluster
Accomplishments: Multi-step synthesis of Calix[n]phyrin-Tröger’s base (TB) (n= 4, 6) conjugates
was performed with the aim to construct a possible molecular tweezer for sensing cation or anion
(Scheme 1).
Multistep synthesis of a selectively functionalized D (+)-mannose derivative with the aim to construct
a TB-mannose cluster conjugate which is supposed to be water soluble and would interact with
various biological entities like protein, amino acid etc.
2. 01/2015 – 05/2015 (4-month)
Visiting postdoctoral fellow (porphyrin chemistry research group of Prof. L. Latos-Grażyński)
Department of Chemistry, University of Wroclaw, Wroclaw, Poland
Project title: Synthesis, purification and characterization of a carbachlorin molecule (structurally
related to a Chlorin molecule, 20 π electron system) and it’s complexation with transition metal.
Accomplishments: Final carbachlorin was synthesized with optimization and characterized.
3. 08/2011 – 12/2012 (1-year, 5-month)
Research assistant
Institute of Organic Chemistry and Biochemistry (IOCB), Academy of Science of the Czech Republic
(AS CR), Flemingovo nám. 2, 166 10 Praha 6, Czech Republic
Project title: Synthesis, purification and characterization of αβ-cyclodextrin (CD) heteroduplex and
it’s complexation with guest molecules.
β- CD
α- CD α- CD
β- CD
α- CD
β- CD

3. CURRICULUM VITAE
3
Accomplishments: αβ-CD heteroduplex was synthesized by oxidative coupling between α-CD dithiol
(6-step synthesis) and β-CD dithiol (6-step synthesis). Selective synthesis of the aforementioned
heteroduplex was also performed in the presence of custom made template. Method of its separation
and purification was developed using chromatography - gradient elution: LC-MS (waters), reverse
phase-preparative/analytical, flash etc.). In water, the duplex showed high binding affinities
(determined by VP-ITC technique) with several probe guests.
4. 09/2006 - 02/2011 (4-year, 5-month)
Ph.D. research student [Doctoral stipend + Dean award (54- month) + Rector award (12-month)]
Department of Chemistry, Masaryk University in Brno, Czech Republic
Dissertation title: Modified cucurbit[n]urils: synthesis and supramolecular interactions.
Accomplishments: My Ph.D. dissertation comprised of four projects: two major independent and two
collaborative projects.
Major projects: Two new water soluble functionalized cucurbit[n]urils (A and B, CB[n], n = 6) were
synthesized, purified and characterized and their supramolecular interactions with organic guests were
studied. Binding modes of the macrocycle B (hexamethylcucurbit[6]uril, MeCB[6]) with viologen
guests (MeV2+
and MeV+
) in solution and solid state were determined. Macrocycle B exhibited strong
binding affinity toward MeV2+
guest (K = 105
M-1
) in pure water. 1
H NMR and UV-vis titration
experiments showed remarkable weakening of the B-MeV2+
complex in the presence of NaCl.
Synthesis of macrocycle A was the first example of substituted CB[6] with one substituent at the
methylene bridge position. New method of synthesis, isolation and purification was developed. The
results introduced a milestone concept in the chemistry of CB[n] compound and further extend its area
of application.
Collaborative projects: In one project, new method of deprotection of a propylene glycoluril dimer
(C) was introduced. In the second project, a CB[6] based supramolecular shuttle (rotaxane) was
constructed based on the complexation studies between CB[6] and a bispyridinium ethylene guest.
5. 11/2005 - 02/2006 (4-month)
Research student
University of Chemical Technology Prague, Technická 5, Prague 6, Czech Republic
Project summary: Synthesis, purification and characterization of binaphthalene based receptors for
binding anions.
6. 10/2004 - 07/2005 (10-month)
Research student [UNESCO - IUPAC Postgraduate course in polymer science (with research)]
Institute of Macromolecular Chemistry, AS CR, Heyrovského nám. 2, Praha 6, Czech Republic
A B

4. CURRICULUM VITAE
4
Accomplishments: A series of bisphosphonic acid compounds (I-III, strong chelating agents) having
functional groups: NH2, OH, Br, H2C=C- were synthesized and characterized for surface modification
of magnetic oxide nanoparticles such as magnetite (Fe3O4), and Co-ferrite.
7. 08/2002 - 03/2004
Assistant Chemist (production, quality control, research and development)
Pailac paint and chemical company (Pvt.) Ltd., Dhaka, Bangladesh
8. 05/2002 - 07/2002
Lecturer in Chemistry, College of development alternative (CODA), Dhaka, Bangladesh
9. 1999 – 2001
M.Sc. thesis student
Thesis title: Synthesis of Schiff bases, thiadiazoline derivatives and some heterocyclic compounds as
probes for pharmacological studies especially as Anti-cancer agents.
Accomplishments: A series of aldehyde-Δ2
-1, 3, 4-thiadiazolines (Scheme 1) were synthesized from
oxidative cyclization of the aldehyde thiosemicarbazones in acetic anhydride in hot condition. In
addition, some of the aldehyde thiosemicarbazone underwent cyclization with p-substituted
phenacylbromide to give the phenylthiazolyl hydrazone (Scheme 3). Some of the synthesized
compounds were shown to have cytotoxic and antibacterial activity.
EXPERIENCE IN INSTRUMENTATION
1. Varian/Bruker 300/400/500 MHz FT-NMR (manual/autosampler), 2. UV-vis and FT-IR
spectroscopy, 3. RP preparative chromatography (Biotage - Horizon fraction collector) and flash
chromatography, 4. RP preparative/ analytical LC-MS with fraction collector (Waters), HPLC, Gel
permeation chromatography, Ion exchange chromatography, 5. Theoretical knowledge on MALDI-
TOF MS, 6. VP - ITC (microcal), 7. Autoclave, 8. Potentiometric titrator (Metrohm), 9. Rotary
evaporator, 10. High vacuum - Argon setup for moisture free and inert reaction, 11. Dry solvent setup
under inert atmosphere

5. CURRICULUM VITAE
5
COMPUTER LITERACY AND EXPERIENCE ON RESEARCH DATA BASE
MS-Office applications (word, excel, power point), adobe photoshop and illustrator, chemical
structure drawing softwares (Isis draw, ChemBioOffice), data analysis softwares (Origin, PSI-plot),
scanning, computer hardware and trouble shooting, e-mail and internet browsing.
SciFinder Scholar, Reaxys, Reference Manager Software, End note, Chemical abstracts on CD, Web
of Science.
LIST OF PUBLICATIONS (Total citation= 48, according to Google Scholar since 2009)
8. L. Gilberg, M S A. Khan, M. Enderesova, V. Sindelar.
Cucurbiturils substituted on methylene bridge.
Organic Letters, 16 (9), 2446-2449, 2014 (IF 6.142, 2012)
7. V. Kolman, M S A. Khan, M. Babinsky, R. Marek, V. Sindelar.
Supramolecular shuttle based on inclusion complex between cucurbit[6]uril and bispyridinium
ethylene.
Organic Letters, 13 (23), 6148-6151, 2011. (IF 5.862, 2011)
6. M. Stancl, M S A. Khan, V. Sindelar.
1,6-Dibenzylglycoluril for Synthesis of deprotected glycoluril dimer.
Tetrahedron, 67, 8937-8941, 2011. (IF 3.025, 2011)
5. M S A. Khan, D. Heger, M. Necas, V. Sindelar.
Remarkable salt effect on stability of supramolecular complex between modified cucurbit[6]uril and
methylviologen in aqueous media.
Journal of Physical Chemistry B, 113 (32), 11054-11057, 2009. (IF 4.19, 2009)
4. M S A. Khan, V. Sindelar.
Synthesis of modified cucurbit[n]urils.
Chemické listy, 102, 1245-1246, 2008. (IF 0.62, 2010)
3. M S A. Khan, M. Benes.
Functionalized bisphosphonic acids for surface modification of magnetic iron oxide and other metal
oxides.
In book of proceedings, p.27-32. EUROGREENPOL- First European Summer School on Green
Chemistry of Polymers, Iasi, Romania, 21-27 August 2005.
2. M S A. Khan, M. Rabiul Islam, S. Malik, H. Duddeck.
Synthesis of some aldehyde schiff bases of 4-amino-1,2,4-triazine-3-thione and p-substituted
phenylthiazolyl derivatives and their cytotoxic activities.
Journal of the Bangladesh Chemical Society, 17(1), 52-58, 2004.
1. M. Rabiul Islam, M S A. Khan, D. Devnath, M. Mizanur Rahman Khan.
Synthesis of some aldehyde- Δ2-1, 3, 4 -thiadiazoline heterocycles.
Journal of the Bangladesh Chemical Society, 16(2), 124-132, 2003.
CONFERENCE PARTICIPATION (INCLUDING BOOK OF ABSTRACT)
7. 49th Advances in Organic, Bio-organic and Pharmaceutical Chemistry, Liblice2014, 7-9.
November 2014, Lazne Belohrad, Czech Republic
Contribution: Poster (P27)
In book of abstract: Tröger’s Base (TB) Conjugates with Calix[n]phyrins, p. 73.
6. XII International Congress of Young Chemists, ‘YoungChem2014’
8 - 12. October’ 2014, Szczecin, Poland
Contribution: Poster (P37)
In book of abstract: Tröger’s Base (TB) Conjugates with Calix[n]phyrins, p. 109.
5. Modified cucurbit[6]uril and its supramolecular interactions with methylviologen. In Chemické
listy, Book of Abstracts – Progress in organic, bio-organic and pharmaceutical chemistry –
“LIBLICE 2009“. 103, p.961, ISSN 0009-2770, 2009
4. 44. conference on progress in organic, bio-organic and pharmaceutical chemistry, Liblice, 27-29.
November 2009, Czech Republic
Contribution: Oral presentation

6. CURRICULUM VITAE
6
3. 10th international conference on calixarenes (ICC) Seoul. (13-16 July 2009) - Department of
Chemistry, Korea University, Seoul, Korea
Contribution: Poster
2. 1st international conference on cucurbiturils (ICCB), Pohang, Korea (July 10-11, 2009) -
Department of Chemistry, Pohang University of Science and Technology
Contribution: Poster
1. 4th meeting on chemistry and life, Brno. (Sept 9-11, 2008) - Faculty of Chemistry, Brno University
of Technology
Contribution: Poster
LANGUAGE SKILLS
English: excellent (2nd language)
Czech : very good (secured velmi dobře, 80%, )
Bengali: mother tongue
Hindi : passive
I hereby declare that all the information stated above is correct.
Signature: