Dr. Somasekhara Bondalapati has over 9 years of experience in organic chemistry research and development. He holds a Ph.D. in Heterocyclic Chemistry and has expertise in chemical synthesis, compound purification, and spectral analysis. He has contributed over 20 publications to international journals and has an h-index of 8. His background includes experience developing synthetic routes, conducting multi-step reactions, and collaborating with research teams.

1. Key Skills
Organic Chemistry and Physical
Organic Chemistry
Macro and Micro Scale Synthesis
from 20 g to 10 mg
Analysis 1
H-NMR, MASS & IR
Spectral Data of Organic Molecules
Moisture & Light Sensitive
Reactions
Drying of Organic Solvents
Applied Research / Application of
Organic Materials
Impurity Synthesis
Method Development & Validation
Targeting assignments in Research & Development in Organic Chemistry
Profile Summary
Qualified Ph.D in Heterocyclic Chemistry, offering 9 years rich experience
in conducting high quality scientific research assignments such as Chemical
Synthesis of Proteins and Stereoselective Synthesis of Tetrahydro-pyrans,
Thiopyrans & Quinolones
Strong skills and a proven track record in synthetic organic chemistry,
compound purification, and structural characterization
Skilled in planning and organizing day-to-day research activities and
resolving procedural problems as appropriate to the timely completion of
research objectives
Profound literature search skills, ability to design & improve synthetic
routes to support studies and deliver large scale compounds
Highly motivated, creative, and able to maintain excellent documentation
of their work
Able to collaborate proficiently and communicate effectively with
colleagues and management teams
Possess excellent oral and written communication skills in English, and a
strong work ethic
Contributed 20 articles, published in international journals, with Average
Impact Factor of 5 per journal and Scopus h-Index of 8
Timeline
Dr. SOMASEKHAR BONDALAPATI
ACCOMPLISHED RESEARCH &
DEVELOPMENT PROFESSIONAL
somasekhar.bondalapati@gmail.com
+918790885109
Bachelors in
Science
Masters in
Science
(Organic
Chemistry)
Doctorate of
Philosophy
(Heterocyclic
Chemistry)
2001 - 2004 2004 - 2006 2007- 2012
Postdoctoral
Fellow -
Department
of Chemistry
2012-2016

2. Education
Research Assignments
Doctorate of Philosophy (Heterocyclic Chemistry) from Department of
Chemistry, Indian Institute of Technology, Guwahati, Assam, India in
2012
Masters in Science (Organic Chemistry) from T.J.P.S College, Acharya
Nagarjuna University, Guntur, Andhra Pradesh, India with 62.09% marks
in year 2006
Bachelors in Science (Mathematics, Physics & Chemistry) from J.K.C
College, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
with 63.35% marks in year 2004
Sep’12 – Sep’-16
Jul’2007 – Aug’2012
Technion, Israel as Postdoctoral Fellow - Department of Chemistry
Project: Total Chemical Synthesis of Proteins with Aid of Unnatural Aminoacids
Advisor: Prof. Ashraf Brik
Scope: The project involves total chemical synthesis of proteins of length
150aa to 250aa. It involves working on Fmoc-SPPS and various Peptidic
Manipulations such as, Native Chemical Ligation, Peptide Thioester Synthesis
and Desulfurization Reactions. The project also involves synthesis of Unnatural
Aminoacid, Mercaptolysine through a 14 Step Synthesis thereby enabling the
Peptide Fragment Ligation on Ε-amine of Lysine.
Responsibilities:
Setting-up the reactions, monitoring & analyzing progress, working-up &
isolating products and interpreting spectral data
Maintaining lab operations, including instruments, glass wares &
apparatus and ensuring overall cleanliness of labs
Ensuring safety aspects in the lab and maintaining awareness of
hazardous nature of chemicals; incorporating safety practices in daily
work
Performing technical transfer of molecules from lab to pilot plant and pilot
plant to commercial scale
Planning research strategies and execution of projects; performing root
cause analysis and scale-up from lab to manufacturing
Documenting all the development in experiments and researches
Studying journals & research materials of research being carried out in
other companies and keeping up to date with the developments
Analyzing research results; troubleshooting processes
Writing papers and getting them published in pharmaceutical journals
Collaborating with different researchers, academics, scientists and
research institutes
Department of Chemistry, Indian Institute of Technology, Guwahati,
Assam, India
Thesis: Stereoselective Synthesis of Tetrahydro-pyrans, Thiopyrans,
Quinolones
Advisor: Prof. Anil K. Saikia
Scope: The project involved development of novel strategies for synthesis of
Saturated 6-Membered Heterocycles. It involves development of Lewis Acid
Mediated Oxonium-Ene, Thionium-Ene, Aza-Ene and Prins Cyclization reactions
to obtain Teterhydro -Pyrans, -Thiopyrans, -Quinoines & Fluorinated
Tetrahydropyrans respectively. In order to achieve the required starting
materials for these afore mentioned reactions, various organic reactions were
performed such as Grignard Reaction, Mistunobu Reaction, Sharpless
Epoxidation, Aldol Condensation, Michael Addition Reaction, Baylis Hillman
Reaction, Carbonyl-ene Reaction, and some Air & Moisture Sensitive C-C
Coupling Reactions
Highlight: Guided & mentored 4 M.Sc. project students and 2 newly joined
Ph.D. students for conducting reactions

3. Publications
"Expanding the Chemical Toolbox for the Synthesis of Large and Unique
Proteins"; Bondalapati. S., Jbara. M., Brik. A.; Nat. Chem. 2016, 8,
407-418.
“Nonenzymatic Polyubiquitination of Expressed Proteins”; Hemantha H.P.,
Bavikar S.N., Herman-Bachinsky. Y., Haj-Yahya. N., Bondalapati. S.,
Ciechanover. A., Brik. A. J. Am. Chem. Soc. 2014, 136, 2665-2673.
“Chemical Synthesis of Phosphorylated Ubiquitin and Diubiquitin Exposes
Positional Sensitivities of E1-E2 Enzymes and Deubiquitinases”;
Bondalapati. S., Mansour. W., Nakasone M.A., Maity S.K., Glickman
M.H., Brik A.; Chem. Eur. J. 2015, 21, 7360-7364.
"Rapid and Site-Selective Modification of Polysaccharides for Biomaterial
Applications in Regenerative Medicine"; Bondalapati. S., Ruvinov. E.,
Kryukov. O., Cohen. S., Brik, A.; Macromol. Rapid Commun. 2014, 35,
1754-1762.
“Dehydroalanine-Based Diubiquitin Activity Probes"; Haj-Yahya. N,
Hemantha. H.P., Meledin. R, Bondalapati. S., Seenaiah. M., Brik. A.;
Org. Lett. 2014, 16, 540-543
“A Novel Synthesis of Oxabicyclo-[3.3.1]-Nonanone via (3, 5) - Oxonium-
Ene Reaction”; Saha. P, Reddy UC, Bondalapati. S., Saikia A.K.; Org.
Lett. 2010, 12, 1824-1826.
“Diastereoselective Synthesis of Substituted Tetrahydrothiopyrans via
Thionium-Ene Cyclizationreaction”; Bondalapati. S., Gogoi. P, Indukuri.
K. Saikia A. K. J. Org. Chem. 2012, 77, 2608-2612.
“A Stereoselective One-Pot, Three-Component Synthesis of 4-
Aryltetrahydropyrans via Prins-Friedel-Crafts Reaction”; Reddy U.C.,
Bondalapati. S., Saikia A.K. J. Org. Chem. 2009, 74, 2605-2608.
"Lewis Acid Mediated Intramolecular C–C Bond Formation of Alkyne-
Epoxide Leading to Six-Membered Nitrogen and Oxygen Heterocycles";
Ghosh. P., Saha. P., Bondalapati. S., Indukuri. K, Saikia A.K. J. Org.
Chem. 2014, 79, 4119-4124.
“An Efficient Synthesis of 2, 3-Dihydropyran and 4-Methylene
Tetrahydropyran via Oxonium-Ene Cyclization Reaction”; Bondalapati.
S., Reddy U.C., Saha. P., Saikia A.K.; Org. Biomol. Chem. 2011, 9,
3428-3438.
“Diastereoselective Synthesis of Substituted Tetrahydoquinolines via Aza-
ene Cyclizationreaction”; Bondalapati. S., Indukuri. K., Kotipalli. T,
Saikia AK; Eur. J. Org. Chem. 2013, 1625-1629.
“Stereoselective Synthesis of 2, 6-disubstituted-4-aryltetrahydropyrans
using Sakurai-Hosomi-Prins-Friedel-Crafts Reaction”; Reddy. U.C.,
Bondalapati. S., Saikia A. K.; Eur. J. Org. Chem. 2009, 1625-1629.
“Stereoselective, One-Pot, Three-Component Synthesis of 4-
Aryltetrahydropyrans from Epoxides via Prins-Cyclization Reaction”;
Indukuri. K, Bondalapati. S., Kotipalli. T., Gogoi. P., Saikia A.K.;
Synlett, 2011, 233-238.
“Synthesis of 2, 3-dihydro-4-pyranones from Epoxides via Intermolecular
[4+2] Cycloaddition Reaction”; Indukuri. K., Bondalapati. S., Saikia
A.K.; RSC Adv. 2012, 2, 9398-9402.
“Application of a Novel 1,3-diol with a Benzyl Backbone as Chiral Ligand
for Asymmetric Oxidation of Sulfides to Sulfoxides”; Gogoi. P., Kotipalli.
T., Indukuri. K., Bondalapati. S., Saha. P., Saikia A.K.; Tetrahedron
Lett. 2012, 53, 2726-2729.
"Scandium (III) Triflate Catalyzed Synthesis of Primary Homoallylic
Alcohols via Carbonyl-Enereaction"; Sultana. S., Bondalapati. S.,
Indukuri. K, Gogoi. P., Saha. P., Saikia A.K.; Tetrahedron Lett. 2013,
54, 1576-1578.
“Unveiling the Mode of Action of Antibacterial Labdane Diterpenes from
Alpinia Nigra (Gaertn.) B. L. Burtt Seeds"; Ghosh. S., Indukuri. K.,
Bondalapati. S., Saikia A.K.; Rangan, L. Eur. J. Med. Chem. 2013, 66,
101-105.

4. Tools Used
Academic
Achievements
“Titanium Tetrafluoride: An Efficient Lewis Acid and Fluorinating Agent for
Stereoselective Synthesis of 4-Fluorotetrahydropyrans”; Bondalapati. S.,
Reddy. U.C., Kundu. D.S. and Saikia A. K. J. Fluor. Chem. 2010, 131,
320-324.
“Axial-Selectivity in Prins Cyclization Reaction: Synthesis of 4-
Iodotetrahydropyrans”; Bondalapati. S., Saikia A.K., Indukuri. K., Gogoi.
P.; Chem. Lett. 2011, 1176-1178.
"Chemical Synthesis of Ubiquitin Chains"; Hemantha. H.P., Bondalapati.
S., Singh. S, Brik A.; Curr. Protoc. Chem. Biol. 7, 229-248.
Chem Draw Pro-14
SciFinder and Reaxys Literature Search
ACD NMR Calculator, NMR Processer
Ranked All India 269 in Graduate Aptitude Test for Engineering (GATE) in
year 2007
Qualified for:
o PBC Fellowship from Israel in 2013
o CSIR-Senior Research Fellowship (CSIR-SRF) in 2010
o Joint CSIR-JRF, by the Council of Scientific and Industrial Research
(CSIR) and University Grants Commission (UGC) India in 2007
Won 1st
Prize in Eli-Lilly and Company Asia Outstanding Thesis Award
(Cash Prize of $ 1500) in 2012
Date of Birth: 19th
June 1984
Languages Known: English, Hindi, Telugu
Address: C/o Jaganmohanrao Bondalapati, Medikonduru, Guntur - 522438,
Andhra Pradesh, India
Personal Details
Schematic Representation of Ph.D Thesis Work

5. Other Notable Contributions in Ph.D

6. Schematic Representation of Work Done in Post-Doctoral Studies
Synthesis of δ-mercaptolysine
Synthesis of Diubiquitin Chains by Using SPPS and Native Chemical Ligation
i) Synthesis of desired peptide fragments(1-5) from SPPS

7. ii) Ligation of peptide fragments to obtain diubquitin chains via Native chemical
ligation(NCL)
In addition to the above demonstrated four different diubiquitin derivatives (each one of 150
AA length), I have also synthesized four analogues of SUMO-diUb’s, each of length 250 AA, to
study their selective binding with RAP80 protein.