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Crystalloids
TYPES OF
CRYSTALLOID
S
โ€ข When the concentration of the
particles is similar to that of
plasma, it doesn't move into
cells and remains within the
extracellular compartment thus
increasing intravascular volume
โ€ข Eg: 0.9% NaCl, Ringerโ€™s lactate,
D5W
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 2
2. Hypotonic
solutions
โ€ข Compared with intracellular fluid ,
hypotonic solutions have a lower
concentration of solutes
โ€ข These solutions will hydrate cells,
although their use may deplete fluid
within the circulatory system
โ€ข Eg: 0.45% sodium chloride , 0.33%
sodium chloride, 0.2% sodium
chloride, and 2.5% dextrose in water
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 3
3. Hypertonic
solutions
โ€ข Solution that have a higher
tonicity or solute concentration
โ€ข The osmotic pressure gradient
draws water out of the
intracellular space, increasing
extracellular fluid volume, so
they are used as volume
expanders
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 4
7. FLUID
CHART
โ€ข provide major EC electrolytes
โ€ข corrects both water and
electrolyte deficit
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 5
Contra
indications
โ€ข Avoid in pre eclamptic patients,
CHF, renal disease and
cirrhosis Dehydration with
severe hypokalemia โ€“ deficit of
IC potassium
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 6
Indications
WAT E R A N D S A LT D E P L E T I O N โ€“
D I A R R H O E A , V O M I T I N G ,
E X C E S S I V E D I U R E S I S
H Y P O V O L E M I C S H O C K
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 7
WHEN TO BE GIVEN?
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 8
DISADVANTAGE
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 9
RINGERโ€™S
LACTATE
โ€ข Osmolarity = 273 mOs/L The
most physiologically adaptable
fluid because its electrolyte
content is most closely related
to the composition of the
body's blood serum and
plasma
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 0
Indications
D 5 W
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 1
DISAVANTAGE
S
โ€ข D5W is not good for patients with renal failure
or cardiac problems since it could cause fluid
overload
โ€ข patients at risk for intracranial pressure
should not receive D5W since it could
increase cerebral edema D5W shouldn't be
used in isolation to treat fluid volume deficit
because it dilutes plasma electrolyte
concentrations Never mix dextrose with
blood as it causes blood to hemolyze
โ€ข Not used for resuscitation, because the
solution won't remain in the intravascular
space
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 2
DNS
โ€ข Composition : Na Cl โ€“ 154
mEq, glucose 50
gm Pharmacological basis
: Supply major EC
electrolytes, energy and fluid to
correct dehydration
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 3
Effects of large volume
crystalloids infusion
โ€ข Delayed healing of anastomosis
Large volume ,rapid infusion
crystalloids causes
hypercoagulability due to reduction
in AT 3 Ruttmann TG, James MF
โ€ข Effects on coagulation due to
intravenous crystalloid or colloid in
patients undergoing vascular
surgery
โ€ข Br J Anesth 2002 ; 89 : 999 - 1003
2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 4

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Crystalloids iv fluids management anaesthesia

  • 2. TYPES OF CRYSTALLOID S โ€ข When the concentration of the particles is similar to that of plasma, it doesn't move into cells and remains within the extracellular compartment thus increasing intravascular volume โ€ข Eg: 0.9% NaCl, Ringerโ€™s lactate, D5W 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 2
  • 3. 2. Hypotonic solutions โ€ข Compared with intracellular fluid , hypotonic solutions have a lower concentration of solutes โ€ข These solutions will hydrate cells, although their use may deplete fluid within the circulatory system โ€ข Eg: 0.45% sodium chloride , 0.33% sodium chloride, 0.2% sodium chloride, and 2.5% dextrose in water 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 3
  • 4. 3. Hypertonic solutions โ€ข Solution that have a higher tonicity or solute concentration โ€ข The osmotic pressure gradient draws water out of the intracellular space, increasing extracellular fluid volume, so they are used as volume expanders 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 4
  • 5. 7. FLUID CHART โ€ข provide major EC electrolytes โ€ข corrects both water and electrolyte deficit 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 5
  • 6. Contra indications โ€ข Avoid in pre eclamptic patients, CHF, renal disease and cirrhosis Dehydration with severe hypokalemia โ€“ deficit of IC potassium 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 6
  • 7. Indications WAT E R A N D S A LT D E P L E T I O N โ€“ D I A R R H O E A , V O M I T I N G , E X C E S S I V E D I U R E S I S H Y P O V O L E M I C S H O C K 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 7
  • 8. WHEN TO BE GIVEN? 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 8
  • 9. DISADVANTAGE 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 9
  • 10. RINGERโ€™S LACTATE โ€ข Osmolarity = 273 mOs/L The most physiologically adaptable fluid because its electrolyte content is most closely related to the composition of the body's blood serum and plasma 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 0
  • 11. Indications D 5 W 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 1
  • 12. DISAVANTAGE S โ€ข D5W is not good for patients with renal failure or cardiac problems since it could cause fluid overload โ€ข patients at risk for intracranial pressure should not receive D5W since it could increase cerebral edema D5W shouldn't be used in isolation to treat fluid volume deficit because it dilutes plasma electrolyte concentrations Never mix dextrose with blood as it causes blood to hemolyze โ€ข Not used for resuscitation, because the solution won't remain in the intravascular space 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 2
  • 13. DNS โ€ข Composition : Na Cl โ€“ 154 mEq, glucose 50 gm Pharmacological basis : Supply major EC electrolytes, energy and fluid to correct dehydration 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 3
  • 14. Effects of large volume crystalloids infusion โ€ข Delayed healing of anastomosis Large volume ,rapid infusion crystalloids causes hypercoagulability due to reduction in AT 3 Ruttmann TG, James MF โ€ข Effects on coagulation due to intravenous crystalloid or colloid in patients undergoing vascular surgery โ€ข Br J Anesth 2002 ; 89 : 999 - 1003 2 / 1 1 / 2 0 2 4 S A M P L E F O O T E R T E X T 1 4