This document provides guidance on developing effective patient education handouts. It emphasizes the importance of understanding your audience and their health literacy level in order to communicate key health messages clearly. Guidelines are provided on establishing a clear purpose, addressing specific behaviors, using plain language at a 5th grade reading level, incorporating culturally sensitive content, and employing a logical genre with purposeful images to maximize patient learning. References are included to help assess readability, search for appropriate images, and apply principles of multimedia learning.