Coslashelly
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However, there’s hope. Now, this strong moisturizer does more on your dermis than even manufacturer identify anti-agers
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Myths about acne
- Blackheads are caused by a buildup of oil, skin debris, and proteins in pores when skin cell turnover is slowed, not dirt. Pores cannot open and close but steam and exfoliation can help clear pores. Stronger acne products are not necessarily better as they may cause more irritation with no additional benefit. While the sun may initially reduce acne inflammation, long-term sun exposure damages collagen and increases acne risks like scarring. The right makeup, like mineral or non-comedogenic foundations, can improve acne whereas toothpaste is not meant for skin and can cause irritation.
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Hazardous Effects of Cosmetics on Health
Many common cosmetic and personal care products contain hazardous chemicals. Approximately 1000 of the 7000 ingredients allowed by the FDA in skin care products are known to be harmful and another 900 are known carcinogens. Common offenders include sodium lauryl/laureth sulfate (SLS/SLES) used in 90% of shampoos which can cause skin irritation; mineral oil, a petroleum byproduct used in many baby products that clogs pores and hinders skin function; synthetic fragrances containing up to 200 chemicals linked to health issues like asthma and migraines; antibacterials like triclosan that may be toxic or carcinogenic; and chemicals like butyl acetate and butylated hydroxytoluene
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Acne is caused by infected hair follicles on the face, back, and chest. During puberty, changes in hormone levels cause follicles to produce excess oil that can become trapped with dead skin cells, leading to blackheads or infected pimples. People with acne often feel self-conscious and depressed due to the skin condition. Many treatments aim to clear blackheads and allow oil to flow freely from follicles again in order to heal spots, including pills, creams, and procedures from dermatologists. However, acne can be difficult to treat and sometimes only improves over time.
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Many common cosmetic and personal care products contain hazardous chemicals. Approximately 1000 of the 7000 ingredients allowed by the FDA in skin care products are known to be harmful and another 900 are known carcinogens. Common offenders include sodium lauryl/laureth sulfate (SLS/SLES) used in 90% of shampoos which can cause skin irritation; mineral oil, a petroleum byproduct used in many baby products that clogs pores and hinders skin function; synthetic fragrances containing up to 200 chemicals linked to health issues like asthma and migraines; antibacterials like triclosan that may be toxic or carcinogenic; and chemicals like butyl acetate and butylated hydroxytoluene
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This document discusses skin functions, problems, and solutions. It covers topics like epidermis and dermis structure, oil production, comedones, acne pathogenesis and treatment, UV damage, skin aging manifestations, wrinkles, pigmentation, dry skin, and technological solutions. The key points are that skin has barrier, sweat, blood vessel, and nerve functions; acne is caused by increased sebum and bacteria; UV damage impacts DNA and causes free radicals; skin aging results in collagen/elastin loss and wrinkles; and lifestyle habits and new technologies can help maintain healthy skin.
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预订购，请游览 http://homepreneur.vemma.com
或联系 --> FB 【https://www.facebook.com/vemmabizinfo】
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Wechat 【cathfan】
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Virender Singh Jaryal is seeking a challenging career opportunity in finance with a competitive environment. He has 11 years of experience in accounts and finance. He is pursuing an MBA in finance and holds qualifications including an M.Comm and B.Comm. His skills include financial planning and analysis, budgeting and forecasting, accounting and internal controls. Currently he works as a senior officer of accounts for Afcons Infrastructure Ltd where he has worked since 2010.
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The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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