Cortellis for Clinical Trial Intelligence (CTI) provides clinical trial data and analytics to help pharmaceutical companies make better strategic decisions. It contains global clinical trial protocols and outcomes for drugs, devices, and biomarkers. CTI integrates this data with other scientific and commercial information in Thomson Reuters platforms. It delivers an intuitive web portal for searching, filtering, and exporting clinical trial information. Additional analytics and visualization tools help users gain insights. Life sciences professional services consultants also assist with custom analytics and benchmarking.

1. MESSAGING PLATFORM
CORTELLIS FOR CLINICAL TRIAL INTELLIGENCE
MICHAEL PASSANANTE
DIRECTOR, PRODUCT MARKETING

2. CTI BACKGROUND

3. CLINICAL TRIAL CHALLENGES IN PHARMA
• Competitive Assessment
– What are the competitive opportunities and associated barriers for a
given drug based on clinical trial data?
– Which trials will I compete against for recruitment?
– Who are my competitors and which indications are they pursuing or not
pursuing?
– When are their products likely to launch?
– Why are competitors pursuing specific sub-populations for their
investigational drugs?
• Trial Design, Patient Recruitment, and Operations
– What is the patient demand by country and patient segment?
– What trial design will increase likelihood of approval while speeding trial
execution?
– Which adverse events can I expect and how can I manage them?

4. CLINICAL TRIAL CHALLENGES IN PHARMA
• Marketing and Business Development
– Will the safety profile of my drug create a competitive advantage over
similar drugs?
– Which messages, based on clinical trial data, will bolster my market
position against my competition?
– Where can I find licensing/collaboration opportunities?
• Secure Information Integration and Delivery
– How can companies integrate information and share it across the
enterprise so it is available to the right person at the right time?

5. HOW CTI ADDRESSES THESE
CHALLENGES
• Broader Data Landscape
– CTI is closely linked with other scientific and commercial information from Thomson
Reuters allowing for a richer investigation of the drugs, sponsors, science, and
regulatory concerns surrounding clinical trials than competitive products offer
• Ease of Use
– CTI is delivered in the Cortellis web portal which offers an intuitive searching
experience, flexible exporting, and dozens of filtering options
• Information Integration
– With Cortellis for Information Integration you can host your proprietary clinical trial
information alongside data from CTI in the Cortellis web portal, creating a central
data repository for all of your clinical data
• Analytics
– CTI delivers a broad array of analytics that turn large amounts of data into user
friendly charts and visualizations so insights can be quickly found and shared
• Services
– The Life Sciences Professional Services team has deep experience in clinical
consulting and benchmarking to assist you with answering complex clinical
questions involving clinical trial design, site selection, and disease landscaping

6. MESSAGING PLATFORM

7. • The following four messages serve as the organizing principles
for the Messaging Platform
• Guidelines on how to tailor these messages for each audience
segment appear in the Audience Messaging Guide
CTI Messaging Platform
Key Messages
7

8. SUPPORTING THEMES PROOF POINTS
KEY MESSAGE
UNMATCHED EXPERIENCE: You can collaborate with Cortellis for Clinical Trial Intelligence
through an intuitive interface– wherever you are and however you need– to make faster, more
informed decisions with confidence.
• Intuitive interface organizes our data intelligently
• Dynamic filters (over 30)
• Relevancy rankings
• Convert results (for those with Cortellis for CI
access)
• Hompage portlets highlighting major activity
• Robust export (export 5,000 records at once vs.
20 or 40 by Trialtrove)
• Tight drug pipeline integration
• iPad compatible web portal
Ease of use
We use our intuitive search interface to deliver the
knowledge you need quickly and easily.
Precision
With a breadth of content at your fingertips, you’ll
be able to locate the specific information you need
to move your research forward—or uncover new
opportunities.
Productivity
Take the most direct path from hypothesis to
development. Use our information to pinpoint those
projects with the most potential so you know you’re
taking the best steps forward.
8

9. SUPPORTING THEMES PROOF POINTS
KEY MESSAGE
FLEXIBLE ACCESS: We understand your need for the latest knowledge and are
committed to creating innovative technologies that allow you to take control of the best
information out there. Bring our content beyond the search engine to interact with it and
discover new ways of analyzing the information that drives your research decisions.
• Our technology enables content manipulation
(API (programmatic access), RSS)
• Content is flexible upon delivery and accessible
across all formats (i.e. corporate intranets)
• Cortellis for Information Integration (CII), which
allows you to integrate your own clinical trial
competitive intelligence on the Cortellis platform,
alongside our content.
Mobility
Access information without boundaries—when it’s
required, wherever you are, on a variety of
platforms—and keep up-to-date on time-sensitive
data.
Freedom to create
We give you the freedom to collaborate with our
content—on your own interface, in the ways that
best suit your needs—so you can create new
knowledge to inform your work.
Clarity
Our standardized taxonomies deliver the
information you need in language you can
understand and incorporate.
9

10. SUPPORTING THEMES PROOF POINTS
KEY MESSAGE
TRUSTED CONTENT: At every step of the way, we keep you focused on what’s most
important: Making decisions that move your projects forward. We provide the right
information, when it’s most needed, to inform those critical choices—making possible the
scientific breakthroughs that drive business results and medical success stories.
• We deliver the right information early in the
research process
• Cortellis CTI coverage extends into medical
device and biomarker-related trials
• Cortellis CTI is tightly integrated with Cortellis CI,
the premier pipeline offering in the marketplace
• Rely on our expertly abstracted and peer-
reviewed content that is assembled by a global
team of over 100 scientific editors
• Outstanding Credentials
o CMR experience – 15+ years
o Supporting clinical development in the
optimization of global clinical performance
metrics, analysis, and trending through its
business
o Producing the largest clinical literature database
(DDF) since 1964
o Curating clinical trials for Integrity since 2001
o Curating clinical trials for TRPharma since 2007
Innovation
Arming you with the focused information you need,
we give you the clarity to uncover the unexpected
insights that inspire new ideas and increase your
bottom line.
Confidence
Our information gives you the enhanced
perspective that enables you to make better, more
informed decisions—and the certainty that they’re
the right ones.
Reliability
We have the information that is meaningful to your
work. You can always depend on our experts to
source and select vital information you can trust.
10

11. SUPPORTING THEMES PROOF POINTS
KEY MESSAGE
SUPERIOR ANALYTICS: We deliver easy to use, visual dashboards and other analytic
tools that reduce the time spent compiling and analyzing clinical trial information to speed
time to approval and enhance competitive positioning.
• Basic visualizations show the distribution of
indication, intervention, sponsor, phase,
recruitment status, country design, and active
control
• Spotfire visualizations deliver insight into trial
timelines and disease segmentation
• Visualizations can be pulled and shared in
PowerPoint easily so findings can be shared with
senior management and updated easily
• Our team of experts in Professional Services can
customize analytics and reporting to meet your
unique business challenges
Consistent
Our analytics provide information in a uniform way
so insights can be gleaned and shared across your
enterprise
Focused
We help you focus on what is important in order to
answer your questions faster
Tailored
Powerful standard visualizations are more powerful
when enhanced by the expert advice of our clinical
professionals
11

12. CTI Description - Short
• Thomson Reuters Cortellis™ for Clinical Trials Intelligence provides
you with the information needed to evaluate market opportunities,
identify potential barriers, and make better informed decisions
regarding clinical trial development and operations.

13. CTI Description - Long
• Thomson Reuters Cortellis™ for Clinical Trials Intelligence provides you with
the information needed to evaluate market opportunities, identify potential
barriers, and make better informed decisions regarding clinical trial design and
operations.
• Cortellis™ for Clinical Trials Intelligence includes global clinical trial protocols
and outcomes for drugs, medical devices and biomarkers expertly uncovered
and unified from a variety of data sources. It integrates with other key
intelligence areas from Thomson Reuters including drug pipeline, deals, and
patents to provide unique insights that support a wide variety of strategic
decision making.
• The Cortellis web portal will enhance your interrogation of clinical trial
information with robust searching, alerting, and exporting capabilities. Additional
delivery options include dynamic real-time visualizations, access to data via
APIs, and integration with your existing knowledge platforms and workflow
solutions.
• Life Sciences Professional Services supports clinical development in the
optimization of global clinical performance metrics, analysis, and trending
through its business. Expertise includes over 15 years experience operating
CMR International.

14. AUDIENCE MESSAGING GUIDE

15. 1
2
3
4
Clinical Development
Business Development & Licensing
Marketing
Scientists
5 Clinical Operations
Our target audiences
15

16. Clinical
Development
Clinical Development professionals are often MDs or PhDs. Their essential role is to plan trial
strategies, ensure regulatory submissions reflect the correct interpretation of trial information,
and manage timelines and budgets. They want to understand the competitive trial landscape so
that their products can be positioned in the marketplace around relevant indications/patients,
plan for potential adverse events and safety concerns, and estimate trial timelines.
üExplore indications that
competitors are pursuing
üView the development status of
competitors’ drugs in a disease
or MoA
üPresent their drug in its
competitive context to their
senior leaders
üPredict when clinical trials for
competitive drugs will end
üDetermine whether definable
sub-populations might respond
better to their drug than the
general disease population
üInvestigate why competitors are
pursuing specific sub-
populations
üDetermine which adverse
events to expect and how to
manage them
üUnderstand the competitive
advantage of a drug based on
it’s safety profile compared to
similar drugs
UNMATCHED EXPERIENCE
Highlight ease of use and filtering capabilities
Ability to find or analyze trials by the drug intervention’s drug class, mechanism of action or
technology
Discover trials in which the intervention is being tested for the first time in a given indication.
Locate ‘proof of concept’ trials - the first small patient trials with efficacy endpoints or efficacy
biomarkers.
MESSAGING GUIDELINES
TRUSTED CONTENT
Highlight our track record offering pipeline and other scientific information. Cortellis CTI is tightly
integrated with Cortellis CI and other datasets available on the Cortellis platform.
15 Years of delivering clinical solutions through our Professional Services team/CMR
CTI coverage extends into medical device and biomarker-related trials
SUPERIOR ANALYTICS
Basic visualizations show the distribution of indication, intervention, sponsor, phase, recruitment
status, country design, and active control
Spotfire visualizations deliver insight into trial timelines and disease segmentation
Visualizations can be pulled and shared in PowerPoint easily so findings can be shared with
senior management and updated easily
WHAT THEY WANT TO DO
16

17. Business
Development
Business development and licensing people are driven by the bottom line. They need specific,
timely information to make fast decisions that often have huge financial implications. As
constant travelers, they need our content to be accessible at any given place and time. They
want see the relationship between deal terms and early clinical research criteria to determine
how deals should be constructed. They are also on the lookout for promising drugs going
through clinical trials.
ü Find potential partners who
have conducted past trials
targeting my patient
population, who also have a
history of making the kind of
deals I’m interested in
üLook at recent deals that
were made despite trial
results not being ideal (e.g.
endpoints not met) to spot
hidden potential
üAnalyze deals at the sub-
phase (e.g. 2b) and sub-TA
level (
üe.g. HER2+
ü Access the latest
information anytime,
anywhere and on any delivery
model
UNMATCHED EXPERIENCE
Highlight ease of use and filtering capabilities to discover the details of deals
Mention iPad compatibility
MESSAGING GUIDELINES
TRUSTED CONTENT
Highlight our track record offering pipeline and other scientific information. Cortellis CTI is tightly
integrated with Cortellis CI, the premier pipeline offering in the marketplace
15 Years of delivering clinical solutions through our Professional Services team/CMR
CTI coverage extends into medical device and biomarker-related trials
WHAT THEY WANT TO DO
17
SUPERIOR ANALYTICS
Basic visualizations show the distribution of indication, intervention, sponsor, phase, recruitment
status, country design, and active control
Spotfire visualizations deliver insight into trial timelines and disease segmentation
Visualizations can be pulled and shared in PowerPoint easily so findings can be shared with
senior management and updated easily

18. Marketing
Marketers are primarily tasked with developing marketing and product positioning strategies for
their portfolio. They leverage clinical trial information to position their products based on their
safety and efficacy profiles versus competitors. Increasingly, this positioning is specific to
indications and patient sub-populations. Additionally, marketers must network with KOLs to
develop marketplace champions and uncover information about competitive products.
üTo competitively position their
product using the protocols
and/or outcomes of competitor's
clinical trials.
üTo know when competitive
clinical trials will start and/or end
to predict competitor's launch
timelines.
üTo know who the investigators
are on competitor's clinical trials,
so the marketer can reach out to
them for information on the
competitor's product.
üTo know who the best KOLs are
for marketing their products.
üTo position based on patient-
level segmentation
UNMATCHED EXPERIENCE
Highlight ease of use and filtering capabilities
Ability to find or analyze trials by the drug intervention’s drug class, mechanism of action or
technology
Discover trials in which the intervention is being tested for the first time in a given indication.
Locate ‘proof of concept’ trials - the first small patient trials with efficacy endpoints or efficacy
biomarkers.
MESSAGING GUIDELINES
TRUSTED CONTENT
Highlight our track record offering pipeline and other scientific information. Cortellis CTI is tightly
integrated with Cortellis CI, the premier pipeline offering in the marketplace
15 Years of delivering clinical solutions through our Professional Services team/CMR
CTI coverage extends into medical device and biomarker-related trials
WHAT THEY WANT TO DO
18
SUPERIOR ANALYTICS
Basic visualizations show the distribution of indication, intervention, sponsor, phase, recruitment
status, country design, and active control
Spotfire visualizations deliver insight into trial timelines and disease segmentation
Visualizations can be pulled and shared in PowerPoint easily so findings can be shared with
senior management and updated easily

19. Scientists
There are many different types of scientists and their concerns could include: 'biology' of
biomarkers and molecular profiles as predictive, diagnostic/disease-marking, and efficacy-
indicating agents, statistical design of clinical trials, mechanisms of action and their relation to
disease pathways and outcomes/adverse events, using outcomes across trials to gauge
efficacy/safety which is reflective of more diverse populations, determining what types of
patients are ideal treatment candidates for the developmental compound, picking the right dose
and regimen for the trial, and how to monitor patient safety during trials.
ü Gauge competitive innovation
by discovering when
interventions are going into
disease areas for the first time
ü Understanding how different
patient segments are being
addressed by various
compounds
ü Evaluate protocols, outcomes,
endpoints, treatment arms,
adverse events control products
and combination therapies
üWhich biomarkers are being
used for which purposes, and
which translate from preclinical,
for specific patient segments?
üWhat kind of statistical designs
are needed for regulatory
approval?
UNMATCHED EXPERIENCE
Highlight ease of use and filtering capabilities
Powerful indexes for disease therapy areas, actions & drug classes, when interventions go into a
therapy area for the first time, patient segment and eligibility criteria, endpoints, biomarkers,
combination therapies, trial designs, and adverse events
MESSAGING GUIDELINES
TRUSTED CONTENT
The depth and breadth of Thomson Reuters’ scientific information provides context and creates
connections to clinical data that no one else can
15 Years of delivering clinical solutions through our Professional Services team/CMR
CTI coverage extends into medical device and biomarker-related trials
WHAT THEY WANT TO DO
19
SUPERIOR ANALYTICS
Basic visualizations show the distribution of indication, intervention, sponsor, phase, recruitment
status, country design, and active control
Spotfire visualizations deliver insight into trial timelines and disease segmentation
Visualizations can be pulled and shared in PowerPoint easily so findings can be shared with
senior management and updated easily

20. Clinical
Operations
Clinical Operations professionals are responsible for running and monitoring clinical trials. They
are involved in site selection, patient and investigator recruitment, budgeting, and recording
information from the trials.
ü Interested in competitors
enrollment targets and timing
trends
üTo understand the regulatory
review timelines associated with
clinical trial authorization in
various countries
üUnderstand benchmarks, to
better inform when planned trials
can be completed
üNeed to find and profile
investigators with experience in
relevant TAs and patient
segments
üPredict when clinical trials for
competitive drugs will end
üTo understand where target
patient segments are
geographically located
üTo understand the
investigational review board
(IRB) timelines associated with
various sites
UNMATCHED EXPERIENCE
Highlight ease of use and filtering capabilities
MESSAGING GUIDELINES
TRUSTED CONTENT
Highlight our track record offering pipeline and regulatory information. Cortellis CTI is tightly
integrated with Cortellis CI, the premier pipeline offering in the marketplace
15 Years of delivering clinical solutions through our Professional Services team/CMR
CTI coverage extends into medical device and biomarker-related trials
SUPERIOR ANALYTICS
Basic visualizations show the distribution of indication, intervention, sponsor, phase, recruitment
status, country design, and active control
Spotfire visualizations deliver insight into trial timelines and disease segmentation
Visualizations can be pulled and shared in PowerPoint easily so findings can be shared with
senior management and updated easily
WHAT THEY WANT TO DO
20