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Dr Md Shamshir Alam, PhD
Associate Professor
MM College of Pharmacy
Mullana-Ambala, India
Chronic obstruction pulmonary disease
● Chronic obstruction pulmonary disease (COPD) involves chronic bronchitis and
emphysema in which a pair of two commonly co-existing diseases of the lung
are present in which the airways become narrowed. This result in limitation of
the flow of air to and from the lungs causing shortness in breath.
● In COPD, less air flows in and out of the airways because of one or more of
the following reasons:
1.The airways and air sacs lose the property of elasticity.
2.The walls between many of the air sacs are destroyed.
3.The walls of the airways become thick and inflamed.
4.The airway make more mucus than usual, which tend to clog them.
BRONCHITIS
• Bronchitis is a condition in which the bronchial tube become inflamed.
• Types of bronchitis
– Acute bronchitis
–Chronic bronchitis
EMPHYSEMA
• Emphysema is defined as enlargement of the air space distal to the terminal
bronchioles with the destruction of their wall of the alveoli.
• Types emphysema
– Centrilobular Emphysema
– Panlobular Emphysema
Types
● Smoking
● Older age
● Occupational exposure
● Air pollution
● Sudden airways contraction due to
inhalation of irritant.
● Genetics Alpha-1-Antitrypsin deficiency
Causes of COPD
● Cigratte smoking
● Occupational dust and chemical
● Environmental tobacco smoke
● Indoor and outdoor air pollution
● Nutrition
● Infection
● Aging population
Risk factors of COPD
● Chronic cough
● Wheezing
● Sputum production
● Chest tightness
● Weight loss
● Resipratory infection
● Respiratory insufficiency
Clinical characteristics of COPD
ACUTE
● Sore throat
● Fatigue (Tiredness)
● Fever
● Runny nose
● Vomiting & Diarrhea
● Persistent cough
● Cough may produce clear mucus
● Shrotness in breath
● Coughing produce large amount of mucus.
Signs and symptoms of COPD
CHRONIC:
● Coughing
● Wheezing and Chest discomfort
● Coughing Produce large amount of mucus.
HISTORY COLLECTION
● Medical history
● Smoking history
● Exposed to dust, fumes, vapour, and air pollution
MUCUS
● To see whether the patient have a bacterial infection
OTHER
● Chest X-Ray
● Lung function test
● Complete Blood Count (CBC)
Diagnostic evaluation of COPD
BRONCHODILATOR
Β2 Agonist
● Short acting:- Salkutamol, Texbutaline
● Long acting:- Salmetrol, Formoterol
Anti-cholenergic Agent
● Ipratropium, Tiotropium
GLUCOCORTICOIDS COMBINATION THERAPY
● β2 Agonist + Corticosteroid
Management of COPD
OTHER
● Antioxidant agents
● Mucolytic agents
● Phosphodiesterase-4-inhibitors
● Antibiotics
● Oxygen therapy
● Vaccination
Thank you

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COPD ppt

  • 1. Dr Md Shamshir Alam, PhD Associate Professor MM College of Pharmacy Mullana-Ambala, India
  • 2. Chronic obstruction pulmonary disease ● Chronic obstruction pulmonary disease (COPD) involves chronic bronchitis and emphysema in which a pair of two commonly co-existing diseases of the lung are present in which the airways become narrowed. This result in limitation of the flow of air to and from the lungs causing shortness in breath. ● In COPD, less air flows in and out of the airways because of one or more of the following reasons: 1.The airways and air sacs lose the property of elasticity. 2.The walls between many of the air sacs are destroyed. 3.The walls of the airways become thick and inflamed. 4.The airway make more mucus than usual, which tend to clog them.
  • 3. BRONCHITIS • Bronchitis is a condition in which the bronchial tube become inflamed. • Types of bronchitis – Acute bronchitis –Chronic bronchitis EMPHYSEMA • Emphysema is defined as enlargement of the air space distal to the terminal bronchioles with the destruction of their wall of the alveoli. • Types emphysema – Centrilobular Emphysema – Panlobular Emphysema Types
  • 4. ● Smoking ● Older age ● Occupational exposure ● Air pollution ● Sudden airways contraction due to inhalation of irritant. ● Genetics Alpha-1-Antitrypsin deficiency Causes of COPD
  • 5. ● Cigratte smoking ● Occupational dust and chemical ● Environmental tobacco smoke ● Indoor and outdoor air pollution ● Nutrition ● Infection ● Aging population Risk factors of COPD
  • 6. ● Chronic cough ● Wheezing ● Sputum production ● Chest tightness ● Weight loss ● Resipratory infection ● Respiratory insufficiency Clinical characteristics of COPD
  • 7. ACUTE ● Sore throat ● Fatigue (Tiredness) ● Fever ● Runny nose ● Vomiting & Diarrhea ● Persistent cough ● Cough may produce clear mucus ● Shrotness in breath ● Coughing produce large amount of mucus. Signs and symptoms of COPD
  • 8. CHRONIC: ● Coughing ● Wheezing and Chest discomfort ● Coughing Produce large amount of mucus.
  • 9.
  • 10. HISTORY COLLECTION ● Medical history ● Smoking history ● Exposed to dust, fumes, vapour, and air pollution MUCUS ● To see whether the patient have a bacterial infection OTHER ● Chest X-Ray ● Lung function test ● Complete Blood Count (CBC) Diagnostic evaluation of COPD
  • 11. BRONCHODILATOR Β2 Agonist ● Short acting:- Salkutamol, Texbutaline ● Long acting:- Salmetrol, Formoterol Anti-cholenergic Agent ● Ipratropium, Tiotropium GLUCOCORTICOIDS COMBINATION THERAPY ● β2 Agonist + Corticosteroid Management of COPD
  • 12. OTHER ● Antioxidant agents ● Mucolytic agents ● Phosphodiesterase-4-inhibitors ● Antibiotics ● Oxygen therapy ● Vaccination