This document provides an overview of Crimean-Congo hemorrhagic fever (CCHF), caused by a Nairovirus transmitted primarily by Hyalomma ticks. CCHF occurs in humans and animals in Africa, the Balkans, the Middle East, and Asia. In humans, it causes sudden onset fever, headaches, and can progress to hemorrhaging. The case fatality rate is 30-50%, with risk highest after tick bites. Animals often show no symptoms but can transmit the virus to ticks. Prevention focuses on avoiding tick bites and contact with infected tissues or unpasteurized dairy. There is no vaccine and supportive care is the only treatment for humans.
Dr. Phil Gauger - Influenza ‘A’ Virus in Swine: Overview of Disease and Diagn...John Blue
Influenza ‘A’ Virus in Swine: Overview of Disease and Diagnosis - Dr. Phil Gauger, Iowa State University Veterinary Diagnostic Laboratory, from 2015 Summer Swine Health Seminar, August 22, 2015, Wrightsville Beach, North Carolina, USA.
More presentations at http://www.swinecast.com/2015-boehringer-ingelheim-carolina-swine-health-seminar
In this presentation you will find about the zoonotic potential of rabies virus, its impact in terms of DALYs.
Epidemiology and geographical distribution of rabies.
You will learn about the reservoir and source of rabies, transmission of rabies virus.
You will also learn about the virology of rabies virus inculding its family, genus, its structure, its different protein and the replication cycle of rabies virus.
It will also put light on the pathogenesis of rabies virus and different stages of rabies virus infection.
Then it will discuss about the laboratory diagnosis of rabies virus infection in humans as well as in animals including specimen collection, culturing, microscopy, animal inoculation and molecular diagnosis.
After that, you will get information about the prevention and control of rabies and different successful control strategies adopted by several countries of the world.
In the end it will discuss the status of rabies in Pakistan and specially WHO responses to rabies control in pakistan.
Dr. Phil Gauger - Influenza ‘A’ Virus in Swine: Overview of Disease and Diagn...John Blue
Influenza ‘A’ Virus in Swine: Overview of Disease and Diagnosis - Dr. Phil Gauger, Iowa State University Veterinary Diagnostic Laboratory, from 2015 Summer Swine Health Seminar, August 22, 2015, Wrightsville Beach, North Carolina, USA.
More presentations at http://www.swinecast.com/2015-boehringer-ingelheim-carolina-swine-health-seminar
In this presentation you will find about the zoonotic potential of rabies virus, its impact in terms of DALYs.
Epidemiology and geographical distribution of rabies.
You will learn about the reservoir and source of rabies, transmission of rabies virus.
You will also learn about the virology of rabies virus inculding its family, genus, its structure, its different protein and the replication cycle of rabies virus.
It will also put light on the pathogenesis of rabies virus and different stages of rabies virus infection.
Then it will discuss about the laboratory diagnosis of rabies virus infection in humans as well as in animals including specimen collection, culturing, microscopy, animal inoculation and molecular diagnosis.
After that, you will get information about the prevention and control of rabies and different successful control strategies adopted by several countries of the world.
In the end it will discuss the status of rabies in Pakistan and specially WHO responses to rabies control in pakistan.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Embracing GenAI - A Strategic ImperativePeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
4. The Organism
• Crimean-Congo hemorrhagic fever vi
rus (CCHFV)
– Genus Nairovirus
– CCHF serogroup
• Extensive genetic diversity
– Viruses from
different geographic regions
7. Morbidity and Mortality: Hu
mans
• Case fatality rate: 30-50%
• Mortality rate: 10-80%
– Highest after tick bites
– Higher in some geographic areas
• Geographic differences in viral virulence sug
gested but unproven
– Also affected by availability of supportiv
e treatment in hospitals
8. Morbidity and Mortality:
Animals
• Large herbivores
– Highest seroprevalence
• Seroprevalence rates
– 13-36%
– More than 50%
• Animals asymptomatic
10. Vectors
• Transmitted by ticks
– Hyalomma spp. are principal vectors
• Transovarial
• Transstadial
• Venereal
– Other ixodid ticks
– Biting midges?
– Soft ticks?
11. Transmission in Humans
• Tick bites
• Contact with infected, crushed ticks
• Contact with infected animal tissues
• Ingestion of unpasteurized milk
• Contact with infected people
– Blood, tissues
• Horizontal transmission?
• Aerosol?
12. Transmission in Animals
• Viremic mammals can transmit CCHF
V to ticks
– Hares
– Hedgehogs
• Birds resistant to infection
– May act as mechanical vectors, transpor
ting infected ticks
– Might spread virus between regions
16. Disease in Humans
• Hemorrhagic phase
– Petechial rash
– Ecchymoses and large bruises
– Hematemesis
– Melena
– Epistaxis
– Hematuria
– Hemoptysis
– Bleeding from other sites
17. Disease in Humans
• Convalescent phase
– 10-20 days after illness onset
– Generalized weakness
– Tachycardia
– Other nonspecific symptoms
• Recovery usually complete but slow
– May take up to one year
• Subclinical infections uncommon
18. Diagnosis in Humans
• Virus isolation and identification
– Blood, plasma, tissues
– Cell culture or animal inoculation
– BSL-4 required
• RT-PCR
– Blood
– Highly sensitive
– Used for local variants
19. Diagnosis in Humans
• Serology
– Tests detect IgM or IgG (paired titers)
– Indirect immunofluorescence
– ELISA
• Past serologic tests
– Complement fixation
– Hemagglutination
20. Treatment in Humans
• Supportive
• Ribavirin
– No randomized human clinical trials to s
upport this therapy
• Passive immunotherapy
– Hyperimmune serum
– Value of treatment controversial
22. Species Affected
• Many species of wild and domesticat
ed mammals
– Hosts for immature ticks
• Small mammals
– Hosts for mature ticks
• Large herbivores
• Other potential hosts
– Birds mostly seronegative
– Reptiles rarely affected
23. Disease in Animals
• CCHFV infections usually asymptoma
tic in animals
• Mild clinical signs possible in experim
entally infected animals
– Newborn rodents
– Sheep and cattle
24. Diagnosis
• Serology
– IgG ELISA
– Complement fixation
– Indirect fluorescent antibody
• Virus isolation and other techniques
– Can detect viremia
– Not used diagnostically
26. Prevention and Control
• Avoid tick bites
– Tick repellents
– Environmental modification
– Avoidance of tick habitat
– Examination of skin and clothing
for ticks
– Clothing to prevent tick attachment
• Acaricides (animals)
27. Prevention and Control
• Avoid contact with infected blood
or tissues
– Wear protective clothing and gloves
• Food safety
– Do not consume unpasteurized milk
– Virus usually inactivated in meat by post
-slaughter acidification
– Virus also killed by cooking
28. Prevention and Control
• Strict universal precautions
– Use when caring for human patients
• Barrier nursing
• Isolation
• Use of gloves, face-shields and goggles
• Prophylactic treatment
– Ribavirin
• Stringent biosafety
precautions
