An undergraduate lecture on Congenital Anomalies, Inflammatory & Neoplastic Disorders of Esophagus for medical students delivered by Dr Muhammad Omair Riaz
Congenital anomalies of esophagus-Tracheoesophageal fistula, Esophageal atresia, esophageal stenosis, esophageal duplication cyst, esophageal webs or rings,, diverticulum of esophagus and congenital short esophagus
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
Congenital anomalies of esophagus-Tracheoesophageal fistula, Esophageal atresia, esophageal stenosis, esophageal duplication cyst, esophageal webs or rings,, diverticulum of esophagus and congenital short esophagus
Different esophageal disorders are discussed in this lecture. The learning objectives are to understand:
The anatomy and physiology of the oesophagus and their relationship to disease.
The clinical features, investigations, and treatment of benign and malignant disease with particular reference to the common adult disorders.
Topics include: Surgical anatomy, Physiology, Symptoms, Investigations, Congenital lesions: TOF and Atresia, Benign tumours, Cancer of oesophagus, Foreign bodies,Oesophageal perforation, Gastro-oesophageal reflux diease, Hiatal hernia,
Oesophageal motility disorders: achalasia and diffuse spasm, Oesophgeal diverticula.
and Others.
CHRONIC DYSPEPSIA
Seminar Prepared by :-
Ali Abdulazeem
Shilan Adnan Abdulrahman
Alaa Shamil
Guldan Hameed
Internal Medicine
College of Medicine - University of Kirkuk
Swallowing of any foregion body like coins, pins,seeds,buttton batteries and platic pieces is common in children.In older persons pieces of bone (fish or chicken) or part of loose denture is common. It becomes an emergency situation and needs urgent treatment.In this ppp I have discussed this problem in a brief and clear way
Swallowing of any foregion body like coins, pins,seeds,buttton batteries and platic pieces is common in children.In older persons pieces of bone (fish or chicken) or part of loose denture is common. It becomes an emergency situation and needs urgent treatment.In this ppp I have discussed this problem in a brief and clear way
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.ppthendra472440
suatu materi tentang kelainan anatomi sistem pencernan yg berhubungan dengan obstertri dan ginekologi. termasuk lambung, usus halus, usus besar, rektum dan anus. Dapat berguna untuk penapisan sebelum bayi lahir. Diharapkan dengan materi ini dapat meningkatkan pengetahuan mahasiswa dalam ilmu yang berkaitan dengan Gastrointestinal terpadu. digunakan pada masyarakat umum dan sekitarnya.
A quick review of the various benign pathologic conditions of Gallbladder,intended primarily for the Undergraduate students; Based on Bailey & Love's Short Practise of Surgery latest edition.
Esophagus /certified fixed orthodontic courses by Indian dental academy Indian dental academy
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An undergraduate lecture on immunologic tolerance, it's various types and how a breakdown of tolerance contributes to the pathogenesis of autoimmune diseases. Additionally a small quiz at the end to gauge the students' learning.
An undergraduate lecture on role of MHC in antigen presentation including an overview of antigen presentation pathways as well as MHC Class I and II proteins
Basic immunology, antigens and antibodiesOmair Riaz
An introductory presentation for undergraduate medical students on antigens and antibodies, immunoglobulins, primary and secondary antibody responses, active and passive immunity
An undergraduate lecture on pathophysiology of Chronic Obstructive Pulmonary Disease for Medical Students by Dr Muhammad Omair Riaz (Consultant Immunologist)
A lecture on Chemical Mediators of inflammation as a part of undergraduate pathology curriculum. The lecture is primarily based on Robbin's textbook of pathology
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
7. Esophagus – Congenital Anomalies
Effects
Either form of fistula can lead to aspiration,
suffocation, pneumonia, and severe fluid and
electrolyte imbalances.
Developmental abnormalities of the esophagus are
associated with congenital heart defects,
genitourinary malformations, and neurologic disease.
9. Lacerations
Longitudinal mucosal tears near the
gastroesophageal junction are termed Mallory-
Weiss tears
Most often associated with severe retching or
vomiting secondary to acute alcohol intoxication.
10. Lacerations
Mechanism
Normally, a reflex relaxation of the gastroesophageal
musculature precedes the antiperistaltic contractile
wave associated with vomiting. It is speculated that
this relaxation fails during prolonged vomiting, with
the result that refluxing gastric contents overwhelm
the gastric inlet and cause the esophageal wall to
stretch and tear.
These tears usually cross the gastroesophageal
junction and may also be located in the proximal
gastric mucosa.
11.
12. Chemical and Infectious Esophagitis
Stratified squamous mucosa of the esophagus may
be damaged by a variety of irritants including
alcohol, corrosive acids or alkalis, excessively hot
fluids, and heavy smoking.
Symptoms range from self-limited pain, particularly
on swallowing, that is, odynophagia, to hemorrhage,
stricture, or perforation in severe cases
13. Chemical and Infectious Esophagitis
Esophageal infections in otherwise healthy
individuals are uncommon
Most often due to herpes simplex virus.
Infections in patients who are debilitated or
immunosuppressed, as a result of disease or
therapy, is more common and can be caused by
herpes simplex virus, cytomegalovirus (CMV), or
fungal organisms. Among fungi, candidiasis is most
common, although mucormycosis and aspergillosis
are also seen.
14.
15.
16. Reflux Esophagitis
The stratified squamous epithelium of the esophagus
is resistant to abrasion from foods but is sensitive to
acid.
Submucosal glands, which are most abundant in the
proximal and distal esophagus, contribute to
mucosal protection by secreting mucin and
bicarbonate.
The tone of the lower esophageal sphincter prevents
reflux of acidic gastric contents, which are under
positive pressure and would otherwise enter the
esophagus.
Reflux of gastric contents into the lower
esophagus is the most frequent cause of
17.
18. Esophageal Varices
Venous blood from the GI tract passes through the
liver, via the portal vein, before returning to the heart.
This circulatory pattern is responsible for the first-
pass effect in which drugs and other materials
absorbed in the intestines are processed by the liver
before entering the systemic circulation.
Diseases that impede this flow cause portal
hypertension and can lead to the development of
esophageal varices
19. Pathogenesis
Portal hypertension results in the development
of collateral channels at sites where the portal
and caval systems communicate.
These collateral veins allow some drainage to occur,
but at the same time they lead to development of
congested subepithelial and submucosal venous
plexi within the distal esophagus and proximal
stomach.
These vessels, termed varices, develop in the vast
majority of cirrhotic patients, most commonly in
association with alcoholic liver disease
20. Morphology
Varices are tortuous dilated veins lying primarily within
the submucosa of the distal esophagus and proximal
stomach. Venous channels directly beneath the
esophageal epithelium may also become massively
dilated.
Varices may not be grossly obvious in surgical or
postmortem specimens, because they collapse in the
absence of blood flow and are obscured by the overlying
mucosa.
Variceal rupture results in hemorrhage into the lumen or
the esophageal wall, in which case the overlying mucosa
appears ulcerated and necrotic. If rupture has occurred in
the past, venous thrombosis, inflammation, and evidence
of prior therapy may also be present.
21. Clinical Features
Gastroesophageal varices are present in nearly half
of the patients with cirrhosis, and 25-40% of patients
with cirrhosis develop variceal bleeding.
Approximately 12% of previously asymptomatic
varices bleed each year.
Variceal hemorrhage is an emergency.
22.
23. Barret Esophagus
A complication of chronic GERD that is
characterized by intestinal metaplasia within the
esophageal squamous mucosa.
The incidence of Barrett esophagus is rising, and it is
estimated to occur in as many as 10% of individuals
with symptomatic GERD.
Barrett esophagus is most common in white males
and typically presents between 40 and 60 years of
age.
The greatest concern in Barrett esophagus is that it
confers an increased risk of esophageal
adenocarcinoma.
24. Morphology
Diagnosis of Barrett esophagus requires endoscopic
evidence of metaplastic columnar mucosa above the
gastroesophageal junction.
Microscopically, intestinal-type metaplasia is seen as
replacement of the squamous esophageal epithelium
with goblet cells.
These are diagnostic of Barrett esophagus
28. Esophagus - Neoplastic disorders
The vast majority of esophageal cancers fall into one
of two types
Adenocarcinoma
Squamous cell carcinoma.
29. Esophagus - Adenocarcinoma
Most esophageal adenocarcinomas arise from
Barrett esophagus.
Increased rates of esophageal adenocarcinoma may
be partly due to the increased incidence of obesity-
related gastroesophageal reflux and Barrett
esophagus.
Additional risk factors include tobacco use and
exposure to radiation.
Conversely, risk is reduced by diets rich in fresh
fruits and vegetables. Some serotypes of
Helicobacter pylori are associated with decreased
risk of esophageal
30. Esophagus – Adenocarcinoma
Morphology
Esophageal adenocarcinoma usually occurs in the
distal third of the esophagus and may invade the
adjacent gastric cardia.
Initially appearing as flat or raised patches in
otherwise intact mucosa, large masses of 5 cm or
more in diameter may develop.
Alternatively, tumors may infiltrate diffusely or
ulcerate and invade deeply. Microscopically, Barrett
esophagus is frequently present adjacent to the
tumor. Tumors most commonly produce mucin and
form glands often with intestinal-type morphology;
31.
32. Esophagus – Squamous Cell Carcinoma
Esophageal squamous cell carcinoma occurs in adults
older than age 45 and affects males four times more
frequently than females.
Risk factors include alcohol and tobacco use, poverty,
caustic esophageal injury, achalasia, tylosis, Plummer-
Vinson syndrome, diets that are deficient in fruits or
vegetables, and frequent consumption of very hot
beverages.
Previous radiation to the mediastinum also predisposes
individuals to esophageal carcinoma
Esophageal squamous cell carcinoma is nearly eight-fold
more common in African Americans than Caucasians
33. Esophagus – Squamous Cell Carcinoma
Morphology
Polypoid, or exophytic tumors, protrude into and
obstruct the lumen.
Maybe either ulcerated or diffusely infiltrative lesions
that spread within the esophageal wall and cause
thickening, rigidity, and luminal narrowing.
They may invade surrounding structures including
the respiratory tree, causing pneumonia; the aorta,
causing catastrophic exsanguination; or the
mediastinum and pericardium.
Most squamous cell carcinomas are moderately to
welldifferentiated
34.
35. THANK YOU
You can have these slides from slideshare
www.slideshare/OmairRiaz