This document summarizes Fred Moyer's talk on comprehensive container-based service monitoring with Kubernetes and Istio. The talk covered Istio architecture and deployment, using the Istio sample bookinfo application, and monitoring the application with Istio metrics and Grafana dashboards. It also discussed Istio Mixer metrics adapters, math and statistics concepts like histograms and quantiles, and monitoring concepts like service level objectives, indicators, and agreements. The talk provided exercises for attendees to deploy sample applications and create custom metrics adapters.