This document describes a Ph.D. thesis that studied the seismic response of an instrumented multi-story reinforced concrete building in India. Acceleration time histories recorded in the building during the 2001 Bhuj earthquake are analyzed to determine modal parameters, floor accelerations and velocities, storey drifts, and other response quantities. Ambient vibration tests are conducted to identify the building's modal properties. Soil properties at the site are determined through in-situ and laboratory tests. Finite element models of the building with different levels of complexity are developed and analyzed under earthquake ground motions, both with and without considering soil-structure interaction effects. The observed and computed responses are then compared.