1. Comparison of Two Fluid-Management Strategies in Acute Lung Injury The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network* N Engl J Med, May, 2006;354:2564-75. Presented by 葉子洪 Supervisor 楊俊杰醫師 本檔僅供內部教學使用 檔案內所使用之照片之版權仍屬於原期刊 公開使用時 , 須獲得原期刊之同意授權

18. Protocol Conduct and Instructions 19% 21% Drotrecogin alfa use 32% 37% Systemic corticosteroids 29% 39% At least one blood transfusion 6% 4% Dobutamine use 6% 15% Fluid bolus 41% 10% Received furosemide 4.1 5.1 Protocol instructions per day 88% 91% The rate of compliance with instructions 43.8±2.5 41.3 ±1.6 The mean time from admission to the ICU to the first protocol instruction. (hours) Conservative Liberal

22. Fluid Balance − 1576 ± 519 ml 5287 ± 576 ml No shock at baseline, the cumulative seven-day fluid balance 2904 ± 1008 ml 10,138 ± 922 ml Shock at baseline, the cumulative seven-day fluid balance Conservative Liberal