The document outlines commonly used instruments in experimental pharmacology, focusing on their applications and requirements for recording muscle contractions. It discusses various instruments like the kymograph machine, hot plate analgesiometer, and electro-convulsiometer, along with examples of drugs evaluated using these tools. The session aims to equip learners with the ability to identify and understand the use of these instruments in pharmacological studies.

1. Commonly Used Instruments in
Experimental Pharmacology
Pharma Learning Forever
Prof. Shaikh Abusufiyan
Assistant Professor,
AIKTC-School of Pharmacy,
New Panvel-410206

2. At the end of this e-learning session you are able to…
q Identify commonly used instruments
and their application in experimental
pharmacology.
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3. Basic Instrument For recording contraction of muscles

4. q KEYMOGRAPH MACHINE:
Ø Requirements:
• Rotating Drum
• Organ bath with thermostat
• Aeration Tube
• Recording lever
• PSS Reservoir

5. Digital kymograph machine with
rotating drum:

6. Organ bath with thermostat

7. Aeration Tube/ Oxygen Tube

8. Recording lever

9. PSS Reservoir

10. Q&A
Q.1 Give requirement for basic setup needed for recording
contraction of muscles by using keymograph machine?
Q.2 What is use of organ bath?
Q.3 What is role of recording lever?
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11. Instruments for evaluation of Invivo
Experiments

12. Hot Plate Analgesiometer:
• Application: For studying analgesic
activity of drugs.
• Example of drug Evaluated: Morphine,
Aspirin etc

13. Electro-convulsiometer:
• Application: For studying anti-
convulsant activity by using MES
induced convulsion.
• Example of Drug Evaluated: Phenytoin.

14. ACTOPHOTOMETER
• Application: For studying both CNS
Stimulant and CNS depressant drugs
• Example of Drug Evaluated:
• CNS Stimulant: Caffeine
• CNS Depressant: Diazepam

15. ROTA ROD APPERATUS
• Application: For studying muscle
relaxant activity of drugs
• Example of Drug Evaluated:
• Diazepam

16. COOK’S POLE CLIMBING
APPARATUS
• Application: For studying cognitive
function specially in case of anti-
psychotic drugs
• Example of Drug Evaluated:
• Chlorpromazine

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