Combinatorial chemistry allows chemists to synthesize large numbers of similar compounds in a short period of time. The compounds generated are analogues of existing biologically active compounds. The goal is to find new medicines that are more effective or have fewer side effects than existing drugs. The process involves attaching different alcohols or acyl chlorides to polymer beads via linkers, generating multiple variations in parallel that can then be efficiently tested for biological activity. This approach dramatically accelerates drug discovery by enabling many compounds to be screened at once.

1. Combinatorial chemistry
Name – Rahul Pandey
42720210011
Green Chemistry 20CYH-211B

2. What is Combinatorial Chemistry
• Synthesising a large number of similar
compounds in a short period of time.
• Compounds that are generated are analogues of
compounds that are already biologically active
• Chemists want to find a new medicine that is
more effective than an existing one, or causes
fewer side effects

3. 1. Take some beads made from a polymer
2. React the beads with a group called a linker
3. Mix the bead in with an alcohol that you want
to use in a chemical reaction. The linker will
bind to it and hold it on the bead.

4. 4. Have 6 reaction vessels each containing a
different acyl chloride. Put a 1/6 of your beads
into a mesh bag and put into a container.

5. 5. Esterification occurs forming 6 different
esters.
6. The beads are removed from the vessel by
lifting up the mesh bag. They are washed to
remove any unreacted acyl chloride

6. 7. A reaction is used to break the linker
group down.
8. The polymer beads are reused
9. You have made 6 different esters which can
now be tested for biological activity

7. Large numbers of similar compounds have
been synthesised in a very short period
of time. Imagine how much longer it would
take if you did the reaction with one alcohol
and acyl chloride, and then did it again with a
different acyl chloride, and then again,
and again…. 36 times!