CoffeeScript is a language that compiles to JavaScript. It simplifies JavaScript syntax by removing semicolons and curly braces, using indentation to define code blocks instead. CoffeeScript provides syntactic sugar that generates cleaner JavaScript code. Variables are private by default and functions return the last statement. CoffeeScript uses operators like 'is' and 'isnt' instead of '==' and '!=' and loops through arrays and objects differently than JavaScript.