Welcome to Group 11 …
Presenting….
COENZYME
DNA Hackers, BMB DU
By …
DNA Hackers, BMB DU
• Fatema Zohra Sadia
• Rasel Khan Manik
• Nazmus Shakib
• Delowar Hossen
Enzyme and Cofactor
Apoenzyme Cofactor Holoenzyme
DNA Hackers, BMB DU
Enzyme and Cofactor
Cofactor
Coenzyme Prosthetic Group
DNA Hackers, BMB DU
What is coenzyme ?
DNA Hackers, BMB DU
• Loosely bound organic cofactors
• Aid the proper functioning of the enzyme
How coenzymes work ?
DNA Hackers, BMB DU
How coenzymes work ?
DNA Hackers, BMB DU
Special features of coenzyme !
• Thermostable
• Not enzyme specific
• Loosely bound and reversible
DNA Hackers, BMB DU
DNA Hackers, BMB DU
Coenzyme Classification
Coenzyme
Metabolic Coenzyme Vitamin Derived
DNA Hackers, BMB DU
Coenzyme :- Biotin
Source: Vitamin H
Function :-Transfer CO2
Get introduced with few important coenzymes…
Get introduced with few important coenzymes…
Adenosine Triphosphate (ATP)
DNA Hackers, BMB DU
Coenzyme :- ATP
Source :- Metabolic Intermediate
Function :- Transfer Phosphate group
Get introduced with few important coenzymes…
Coenzyme :- NAD+
Source :- Niacin
Function :- Electron Acceptor
DNA Hackers, BMB DU
DNA Hackers, BMB DU
Coenzyme :- Pyridoxal-phosphate
Source :- Pyridoxine (vitamin B6)
Function :- Amino groups transfer
Get introduced with few important coenzymes…
DNA Hackers, BMB DU
Coenzyme :- Coenzyme A
Source :- Pantothenate (B5)
Function :- Transfer Acyl group
Get introduced with few important coenzymes…
Coenzyme Deficiency…
Biotin
1.Dry skin
2.Hair fall
3.Digestive tract issues
4.Dermatitis
DNA Hackers, BMB DU
Coenzyme Deficiency…
NADPH
1. Cell toxification
2. RedReduced A.A. Glu Dehydrogenase
3. Steroid Biosynthesis drops
DNA Hackers, BMB DU
Coenzyme Deficiency…
Coenzyme Deficiency
FAD Cheilosis
TPP Beri Beri
Coenzyme A MCAD Deficiency
Tetrahydrofolate Megaloblastic Anemia
DNA Hackers, BMB DU
Besides…
Thank You
DNA Hackers, BMB DU

Coenzyme (Intro)