The document discusses how HTML5 and cloud computing enable new types of mobile and global web applications. It describes how HTML5 allows for richer front-end experiences across devices, while the cloud provides elastic, globally distributed backends. The synergies between HTML5, responsive design, and cloud services are explored, including examples of using location data, social integration, and responsive layouts in a mobile and global application architecture combining HTML5, Azure cloud services, and a responsive template-based front-end.