The NSW CLEAR case-control study collects lifestyle and demographic information as well as biospecimens from people with cancer and controls in New South Wales, Australia. It has recruited over 9,400 participants since 2006, with the majority recruited through targeted identification of cancer patients. The most common cancer types are breast, prostate, colorectal, melanoma, and lung cancer. CLEAR is a valuable resource for cancer researchers, with the potential to advance understanding of cancer causes and outcomes.