Abstract
This presentation includes a brief review of research into boredom, normal brain resting state and corresponding default mode[s].
The possible equivalence to the brain activity of those with FASD in relation to “being bored” is explored, with reference to brain anatomy and function.
Actual FASD clinical cases are presented to illustrate what individuals with FASD mean by “boredom”: describing the role of perseveration as a relief process.
Finally, the manner in which these processes are misinterpreted is explored, with implications for Psychiatry and the Justice System.
Abstract
This presentation includes a brief review of research into boredom, normal brain resting state and corresponding default mode[s].
The possible equivalence to the brain activity of those with FASD in relation to “being bored” is explored, with reference to brain anatomy and function.
Actual FASD clinical cases are presented to illustrate what individuals with FASD mean by “boredom”: describing the role of perseveration as a relief process.
Finally, the manner in which these processes are misinterpreted is explored, with implications for Psychiatry and the Justice System.
Negative symptoms are regarded as deficits in the brain circuitry concerning reward (nucleus accumbens), motivation and pleasure.
It includes the symptoms of alogia, avolition, asociality,blunted affect,anhedonia and abulia etc.
It is classified into two types, Enduring Primary Negative Symptoms and Transitory Secondary Negative Symptoms.
To gather more details about Schizophrenia and Treatment of Negative Symptoms in Schizophrenia refer doctor's article --> https://www.icliniq.com/articles/emotional-and-mental-health/moving-beyond-the-positive-recognition-and-treatment-of-negative-symptoms-in-schizophrenia#classification-of-negative-symptom
Management of Psychiatric Emergencies at Primary Care: Suicide and AggressionTuti Mohd Daud
These slides are not meant to be comprehensive in covering the two major topics in psychiatric emergencies. Readers are encouraged to refer to the references provided for further reading.
The Classification of Mental Disorders, EldergillAnselm Eldergill
Analyses how mental disorders are classified and the problems and limitations of classification. From Mental Health Review Tribunals — Law and Practice (Sweet & Maxwell, London, 1997).
Classics in the History of Psychology Aninternet resource .docxbartholomeocoombs
Classics in the History of Psychology
An
internet resource developed by
Christopher D.
Green
York University, Toronto, Ontario
ISSN 1492-3713
(Return to index)
The Myth of Mental Illness
By
Thomas S. Szasz (1960)
First published in American Psychologist, 15,
113-118.
Posted
January 2002
My aim in this essay is to raise the question "Is there such a thing as mental
illness?" and to argue that there is not. Since the notion of mental
illness is extremely widely used nowadays, inquiry into the ways in which this
term is employed would seem to be especially indicated. Mental illness, of course, is not literally a
"thing" -- or physical object -- and hence it can "exist"
only in the same sort of way in which other theoretical concepts exist. Yet,
familiar theories are in the habit of posing, sooner or later -- at least to
those who come to believe in them -- as "objective truths" (or
"facts"). During certain
historical periods, explanatory conceptions such as deities, witches, and
microorganisms appeared not only as theories but as self-evident causes of
a vast number of events. I submit that
today mental illness is widely regarded in a somewhat similar fashion, that is,
as the cause of innumerable diverse happenings.
As an antidote to the complacent use of the notion of mental illness --
whether as a self-evident phenomenon, theory, or cause--let us ask this
question: What is meant when it is asserted that someone is mentally ill?
In what follows I shall describe briefly the main uses to
which the concept of mental illness has been put. I shall argue that this notion has outlived
whatever usefulness it might have had and that it now functions merely as a
convenient myth.
MENTAL ILLNESS AS A SIGN OF BRAIN DISEASE
The notion of mental illness derives it
main sup- port from such phenomena as syphilis of the brain or delirious
conditions-intoxications, for instance -- in which persons are known to
manifest various peculiarities or disorders of thinking and behavior. Correctly
speaking, however, these are diseases of the brain, not of the mind. According to one school of thought, all
so-called mental illness is of this type.
The assumption is made that some neurological defect, perhaps a very
subtle one, will ultimately be found for all the disorders of thinking and
behavior. Many contemporary psychiatrists, physicians, and other
scientists hold this view. This position
implies that people cannot have troubles -- expressed in what are now
called "mental illnesses" -- because of differences in personal
needs, opinions, social aspirations, values, and so on. All problems in living are attributed
to physicochemical processes which in due time will be discovered by medical research.
"Mental illnesses" are thus regarded as basically no different than all other diseases (that is,
of the body). The only difference, in
this view, between mental and bodily diseases is that the former, affecting the
brain, manifest themselves by means of me.
MENTAL HEALTH MUST BE BROADLY DEFINED IN TERMS THAT ARE CULTURALLY SENSITIVE AND INCLUSIVE.
THE CRITERIA FOR MENTAL HEALTH MUST BE EMPIRICALLY AND LONGITUDINALLY VALIDATED.
VALIDATION MEANS PAYING SPECIAL ATTENTION TO CROSS-CULTURAL STUDIES.
This ppt presentation discusses about the various models of mental illness. I found it useful to download as it gives a fair idea about various models which are generally not found in books.
Negative symptoms are regarded as deficits in the brain circuitry concerning reward (nucleus accumbens), motivation and pleasure.
It includes the symptoms of alogia, avolition, asociality,blunted affect,anhedonia and abulia etc.
It is classified into two types, Enduring Primary Negative Symptoms and Transitory Secondary Negative Symptoms.
To gather more details about Schizophrenia and Treatment of Negative Symptoms in Schizophrenia refer doctor's article --> https://www.icliniq.com/articles/emotional-and-mental-health/moving-beyond-the-positive-recognition-and-treatment-of-negative-symptoms-in-schizophrenia#classification-of-negative-symptom
Management of Psychiatric Emergencies at Primary Care: Suicide and AggressionTuti Mohd Daud
These slides are not meant to be comprehensive in covering the two major topics in psychiatric emergencies. Readers are encouraged to refer to the references provided for further reading.
The Classification of Mental Disorders, EldergillAnselm Eldergill
Analyses how mental disorders are classified and the problems and limitations of classification. From Mental Health Review Tribunals — Law and Practice (Sweet & Maxwell, London, 1997).
Classics in the History of Psychology Aninternet resource .docxbartholomeocoombs
Classics in the History of Psychology
An
internet resource developed by
Christopher D.
Green
York University, Toronto, Ontario
ISSN 1492-3713
(Return to index)
The Myth of Mental Illness
By
Thomas S. Szasz (1960)
First published in American Psychologist, 15,
113-118.
Posted
January 2002
My aim in this essay is to raise the question "Is there such a thing as mental
illness?" and to argue that there is not. Since the notion of mental
illness is extremely widely used nowadays, inquiry into the ways in which this
term is employed would seem to be especially indicated. Mental illness, of course, is not literally a
"thing" -- or physical object -- and hence it can "exist"
only in the same sort of way in which other theoretical concepts exist. Yet,
familiar theories are in the habit of posing, sooner or later -- at least to
those who come to believe in them -- as "objective truths" (or
"facts"). During certain
historical periods, explanatory conceptions such as deities, witches, and
microorganisms appeared not only as theories but as self-evident causes of
a vast number of events. I submit that
today mental illness is widely regarded in a somewhat similar fashion, that is,
as the cause of innumerable diverse happenings.
As an antidote to the complacent use of the notion of mental illness --
whether as a self-evident phenomenon, theory, or cause--let us ask this
question: What is meant when it is asserted that someone is mentally ill?
In what follows I shall describe briefly the main uses to
which the concept of mental illness has been put. I shall argue that this notion has outlived
whatever usefulness it might have had and that it now functions merely as a
convenient myth.
MENTAL ILLNESS AS A SIGN OF BRAIN DISEASE
The notion of mental illness derives it
main sup- port from such phenomena as syphilis of the brain or delirious
conditions-intoxications, for instance -- in which persons are known to
manifest various peculiarities or disorders of thinking and behavior. Correctly
speaking, however, these are diseases of the brain, not of the mind. According to one school of thought, all
so-called mental illness is of this type.
The assumption is made that some neurological defect, perhaps a very
subtle one, will ultimately be found for all the disorders of thinking and
behavior. Many contemporary psychiatrists, physicians, and other
scientists hold this view. This position
implies that people cannot have troubles -- expressed in what are now
called "mental illnesses" -- because of differences in personal
needs, opinions, social aspirations, values, and so on. All problems in living are attributed
to physicochemical processes which in due time will be discovered by medical research.
"Mental illnesses" are thus regarded as basically no different than all other diseases (that is,
of the body). The only difference, in
this view, between mental and bodily diseases is that the former, affecting the
brain, manifest themselves by means of me.
MENTAL HEALTH MUST BE BROADLY DEFINED IN TERMS THAT ARE CULTURALLY SENSITIVE AND INCLUSIVE.
THE CRITERIA FOR MENTAL HEALTH MUST BE EMPIRICALLY AND LONGITUDINALLY VALIDATED.
VALIDATION MEANS PAYING SPECIAL ATTENTION TO CROSS-CULTURAL STUDIES.
This ppt presentation discusses about the various models of mental illness. I found it useful to download as it gives a fair idea about various models which are generally not found in books.
Asian Journal of Psychiatry 3 (2010) 96–98Special article.docxfestockton
Asian Journal of Psychiatry 3 (2010) 96–98
Special article
Depression vs. ‘‘understandable sadness’’: is the difference clear, and is it
relevant to treatment decisions?
Mario Maj
Department of Psychiatry, University of Naples, Naples, Italy
Contents lists available at ScienceDirect
Asian Journal of Psychiatry
j o u r n a l h o m e p a g e : w w w . e l s e v i e r . c o m / l o c a t e / a j p
A R T I C L E I N F O
Article history:
Received 2 July 2010
Accepted 8 July 2010
One of the items of the ‘‘neo-Kraepelinian credo’’, articulated in
the 1970s, was ‘‘there is a boundary between the normal and the
sick’’. In other terms, it was maintained that there is a clear,
qualitative distinction between persons who have a mental
disorder and persons who have not (Blashfield, 1984). A corollary
to this item was the statement that ‘‘depression, when carefully
defined as a clinical entity, is qualitatively different from the mild
episodes of sadness that everyone experiences at some point in his
or her life’’ (Blashfield, 1984). Apparently in line with this
statement was the observation that tricyclic antidepressants were
active only in people who were clinically depressed; when
administered to other people, they did not act as stimulant and
did not alter their mood.
Today, the picture appears much less clear, and this is certainly
in part a consequence of the evolution of psychiatric treatments.
Guidelines for treatment of major depression often contain
contradictory statements in this respect: on the one hand, the
assertion that it is important to clearly differentiate clinical
depression from normal adaptive responses to stress; on the other,
the warning that antidepressant medications are effective even in
the presence of significant life stress, and should not be withheld
solely because the condition is understandable. These statements
beget two questions: (a) Are we really able to distinguish between
a ‘‘dysfunctional’’ and an ‘‘adaptive’’ response to an adverse life
event? (b) Is this distinction clinically relevant, since treatment
decisions are expected not to be influenced by whether the
condition is understandable or not, but only by its clinical picture,
severity, duration and by the degree of impairment of social
functioning? These are questions with significant political, ethical,
scientific and clinical implications, which have become particu-
larly visible and pressing in the past few decades, in parallel to the
escalation of the prevalence rates of depression in community
E-mail address: [email protected]
1876-2018/$ – see front matter � 2010 Elsevier B.V. All rights reserved.
doi:10.1016/j.ajp.2010.07.004
studies, of the estimated social costs of depression, of the number
of patients in treatment for depression, and of the prescriptions of
antidepressant medications.
The National Comorbidity Survey, published in 1994, reported
that the 1-year prevalence of major depression in the US adult
community was about 10%, and the l ...
Essay on The History of Psychology
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A University College London presentation by Professor Anselm Eldergill on civil applications and orders under the Mental Health Act 1983. Excludes community treatment orders which are dealt with as a separate presentation.
Mental Health Tribunal Powers: Final Report on Part V of Mental Health Act 1983Anselm Eldergill
This is the final report of the Tribunal, Hospital Managers and Safeguards Working Group on the Reform of Part V of the Mental Health Act 1983 (which deals with a Mental Health Tribunal's powers). I chaired the Working Group, which formed part of the Independent Review of the Mental Health Act Tribunal chaired by Sir Simon Wesseley. Some of our recommendations were accepted and found their way into the final report of the Independent Review; others did not. Perhaps the main disappointments were that two fairly straightforward recommendations were not incorporated in the report: that the tribunal's discretionary power of discharge should be restored to what was intended by Parliament, and that tribunals dealing with a restricted case should be obliged to discharge the restrictions if they are no longer necessary to protect the public from serious harm.
The application of sympathy and intuitive understanding is a prerequisite for the objective observation of mental phenomena in others. Consequently, empathy and compassion are instruments of justice and the notion that objective decision-making is undermined or contaminated by them is impossible to support. Because proceedings involve a person’s personal welfare, an objective ‘rational’ decision is one based on the subjective (personal) feelings of the relevant people, including those which the judge believes are irrational or illogical. If the judge is uninterested in the person’s problems and the underlying causes, such a narrow field of view necessarily leads to a narrow understanding of the overall situation.
Professor Anselm Eldergill, Judge of the Court of Protection, LondonAnselm Eldergill
Resume, January 2018. Interested in new opportunities in 2018, whether judicial, international human rights, academic or return to practice. UK or abroad.
Mental Health and Mental Disorder: The Legal Significance of Medical ConceptsAnselm Eldergill
Analyses key medical terms and concepts for the benefit of legal representatives who represent individuals who appeal against their detention under mental health laws: concepts such as normal, abnormal, disorder, illness, disease, personality, etc
An article which analyses the function and conduct of legally-chaired inquiries. The author is a judge and former Coroner who chaired many homicide and suicide inquiries commissioned by the Department of Health.
Summary of the organisation of the NHS from 1948 to 2003. Reproduced because recent reorganisations of NHS services often seem to be made in ignorance of the past and/or to replicate previous mistakes.
A defence of liberal mental health laws. An old presentation from 2003, when more authoritarian legislation was proposed, sub-titled: 'In defence of Liberalism'.
One of the most developed cities of India, the city of Chennai is the capital of Tamilnadu and many people from different parts of India come here to earn their bread and butter. Being a metropolitan, the city is filled with towering building and beaches but the sad part as with almost every Indian city
ICH Guidelines for Pharmacovigilance.pdfNEHA GUPTA
The "ICH Guidelines for Pharmacovigilance" PDF provides a comprehensive overview of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines related to pharmacovigilance. These guidelines aim to ensure that drugs are safe and effective for patients by monitoring and assessing adverse effects, ensuring proper reporting systems, and improving risk management practices. The document is essential for professionals in the pharmaceutical industry, regulatory authorities, and healthcare providers, offering detailed procedures and standards for pharmacovigilance activities to enhance drug safety and protect public health.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
Explore our infographic on 'Essential Metrics for Palliative Care Management' which highlights key performance indicators crucial for enhancing the quality and efficiency of palliative care services.
This visual guide breaks down important metrics across four categories: Patient-Centered Metrics, Care Efficiency Metrics, Quality of Life Metrics, and Staff Metrics. Each section is designed to help healthcare professionals monitor and improve care delivery for patients facing serious illnesses. Understand how to implement these metrics in your palliative care practices for better outcomes and higher satisfaction levels.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...
Claissifying and Diagnosing Mental Disorder
1. 1
19. Classifying and diagnosing mental disorder
INTRODUCTION
It was noted in the previous chapter that assessment is the process of collecting in -
formation relevant to the diagnosis, management, and treatment of a patient's clini-
cal condition. The recording of a patient's symptoms, and the conduct of any special
investigations, is initially undertaken to identify the type of disorder from which he
suffers. A diagnosis is a short-hand way of describing what is wrong with a patient
and it involves assigning the patient's case to a particular known class, such as
schizophrenia, by reference to an accepted classification of mental disorders. Con-
clusions can then be reached about the causes, probable course, and treatment of the
condition in question. Before considering the diagnostic process the way in which
mental disorders are classified must therefore first be dealt with.
THE CLASSIFICATION OF MENTAL DISORDERS
Classification is the grouping of things according to a logical scheme for organising
and classifying them and assigning them their proper places. More particularly,
phenomena are assigned to designated classes on the basis of perceived common
characteristics. Both legal and medical classifications of mental disorders exist.
Medical classifications indicate which conditions are regarded as being mental or
behavioural disorders and therefore suitable for medical treatment. Particular diag-
noses are considered to be associated with particular prognoses and outcomes. The
precise diagnosis may profoundly affect the clinician's opinion about whether
in-patient treatment is necessary for the patient's health or safety or to protect others
and, more specifically, the extent to which treatment is likely to alleviate or prevent
a deterioration of the patient's condition. Sartorius, until recently the Director of the
World Health Organisation's Division of Mental Health, ascribes part of the wide-
ranging interest of lawyers in medical classifications to the fact that "the absence of
physical signs and laboratory abnormalities in many psychiatric disturbances makes
psychiatric disorders much more dependent on the consensus of what in a given
society is normal, what is abnormal, what is asocial and what is part of a disease."
LEGAL CLASSIFICATIONS
N. Sartorius, in Sources and Traditions of Classification in Psychiatry (ed. N. Sartorius, et al., World
Health Organisation/Hogrefe & Huber, 1990),p.1.
2. 2
Section 1 of the Mental Health Act 1983 distinguishes between four legal clas ses of
mental disorder (mental illness, psychopathic disorder, mental impairment, severe
mental impairment) three of which are defined. Various sections of the Act provide
for reclassifying the legal form of mental disorder from which a detained patient is
recorded as suffering. Legally defining "mental disorder", and sub-dividing mental
disorders into different statutory classes, serves the purpose of defining as far as
practicable the group of citizens to whom the various compulsory powers conferred
by the Act apply and the circumstances in which resort may be made to them. The
legal classification of mental disorders set out in section 1 of the Mental Health Act
1983 has already been considered (051). Here, it may simply be noted that the
classifications set out in mental health legislation have tended to adopt the
classification of mentally abnormal states set out at the time in the World Health
Organisation's International Classification of Diseases, that classification having
been in official usage in the United Kingdom for half a century.
MEDICAL CLASSIFICATIONS
Sartorius has emphasised that classification is a way of seeing the world, a reifica-
tion of an ideological position and of an accepted standard of theory and know-
ledge: "Classifying means creating, defining or confirming boundaries of concepts.
Through these, in turn, we define ourselves, our future and our past, the territory of
our discipline, its importance and its exclusiveness. No other intellectual act is of
such importance." These views are shared by Kendell, the foremost authority on the
classification of mental disorders, who has variously described the process of
classification as one of the most fundamental activities of any branch of learning and
necessary if any useful communication is to take place. The whole process of
language is based on classification and on assumed associations and relationships
between certain objects or phenomena: every common noun, such as a tree, denotes
the existence of a category or class of objects. Furthermore, not to attempt to
delineate mental disorders is still to classify them, because rejecting the notion of
distinct categories of disorder is in essence a statement that there exists only mental
health and mental disorder and no distinct sub-types of each. Classification also has
important practical benefits. In the first place, until categories can be identified, "one
is unable to begin to count, and until counting is possible one cannot know how big
the problems are or deploy the resources intelligently in an endeavour to control the
problems." The identification of specific syndromes is also an essential first-stage in
identifying their aetiology and pathology and "rational treatment can only be based
upon a satisfactory system of classification of diagnoses." A distinction between
different kinds of mental disorder "is therefore inevitable. The only open issues are
whether this classification is going to be public or private, stable or unstable, reliable
K. Menninger, The vital balance: the life process in mental healthand illness (VikingPress, 1963).
See e.g. R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E.
Kendell & A.K. Zealley, Churchill Livingstone, 1993), p.277. Psychiatrists are sometimes said to be
either "lumpers" or "splitters." The former believe that schizophrenia is a single "disease," with variations
in presentation being accounted for by different individual responses to the "disease." The latter consider
that there are a number of distinguishable sub-types of schizophrenia, such as hebephrenic schizophrenia,
andso forth.
International Classification of Impairments, Disabilities, and Handicaps: A manual of classification
relating to the consequences of disease (WorldHealthOrganisation, 1976), p.35.
A. Sims andD. Owens, Psychiatry (Baillière Tindall, 6thed., 1993), p.34.
3. 3
or unreliable, valid or invalid." Attempting to avoid classification altogether would
be "crippling clinically and scientifically."
ASSOCIATED TERMS
Nomenclature, nosology, ontology, and diagnosis are related and, to some extent,
overlapping terms that refer to various aspects of the conceptualis ation of disease.
The first three of these terms have not yet been dealt with although they are routine-
ly referred to in medical literature. They are therefore briefly mentioned here.
Nomenclature
Nomenclature (literally, "class name") denotes the agreed or approved list of cat-
egories or titles of disorders within a classification which are used to communicate
the results of the diagnostic process,schizophrenia being one example.
Nosology
Nosology is the study of the classification, grouping and ordering of diseases and
their relationship to one another. It includes the formulation of principles for differ-
entiating one disease from another. Ideally, nosology would provide a differenti-
ation of discrete diseases and for each describe a specific cause and specific
treatments; a typical clinical picture, natural history and outcome; and objective tests
for confirming the diagnosis. The nosology of mental disorders has, however,
remained problematic ever since the endeavour was first attempted and the area
remains split into rival schools.
Ontology
One definition of classification is that it is "a means of giving order to a group of
disconnected facts." Underlying the question of nosology is that of ontology, which
is the study of whether things actually exist in the real world or are merely products
of our own ways of studying and classifying the world. For example, although we
still classify stars by constellations, we now know that their apparent unity is an
illusion caused by the perspective of the observer. The different stars within each
constellation most often lie not together in space but many light years apart. Akin to
this, Allport's view of psychiatric classifications was that "all typologies place
boundaries where boundaries do not belong. They are artificial categories ... each
theorist slices nature in any way he chooses and finds only his own cuttings worthy
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.277.
J.K. Wing, "Differential diagnosis of schizophrenia" in Schizophrenia — An overview and practical
handbook (ed. D.J. Kavanagh, Chapman& Hall, 1992), p.19.
In very general terms, the contemporary biomedical approach reflects the Platonic tradition that the
different categories of mental disorder constitute a number of discrete disease entities ("the categorical
view"). The Hippocratic or Aristotelian tradition holds instead that mental health and mental disorder
form a continuum: differences in presentation relate to the chronicity and severity of mental phenomena,
beingstages andvariants of anindivisible unitarypsychosis.
A Dictionary of Epidemiology (ed. J.M. Last, International Epidemiological Association/Oxford
UniversityPress, 3rded., 1995), p.29.
4. 4
of admiration." It is possible therefore that differentiating between different classes
of mental disorder is similar to the division of painters or musicians into different
schools, a matter of convenience rather than science. While it may be convenient to
classify certain music as jazz or certain art as post-impressionist, these distinctions
are essentially artificial and no real, or objectively measurable, unity between the
works so classified can be discerned. At any rate, the classification of certain paint-
ings as abstract may, as with mental disorder, be based on a conception that their
essential distinguishing feature is a lack of any order. If so, the objects may be
placed in the class "disordered" but attempting to then order that class may be
contradictory and offend reality. The issue has important practical implications. For
example, Schneider was concerned that clinical facts are often ignored in order to
prevent the classificatory systembreaking down. Consequently, he preferred what he
called "unsystematic typologies," within which the different names represented
descriptions rather than diagnoses ofmental states.
THE STRUCTURE OF A CLASSIFICATION
Ideally, a classification (or "taxonomy") should be characterised by naturalness (the
classes correspond to the nature of the thing being classified); exhaustiveness and
mutual exclusivity (every member of the group will fit into one and only one class in
the system); usefulness (the classification is practical); simplicity (the sub-classes are
not excessive); and constructability (the set of classes can be constructed by a
demonstrably systematic procedure). There may be tiers , sub-classes or sub-
divisions. Classes may be dimensional (height 5' 2"–5'4"; IQ 100–120, etc.) or cate-
gorical (short, fat, etc.). Traditionally, psychiatry has always used a categorical
classification or "typology." That is, "it has divided its subject-matter, psychiatric
illness, into a number of separate and mutually exclusive categories like schizo-
phrenia, mania and Alzheimer's disease." The way in which the classification tree is
constructed will inevitably affect the results produced so that a person may meet the
criteria for a diagnosis of schizophrenia set out in one classification but not another.
The use of hierarchies
Almost every psychiatric symptom of significance is capable of appearing in the
presence of nearly every other symptom. Because this is so, Kendell has variously
commented upon the problems which then arise in applying to psychiatry one of the
fundamental principles of medicine: to try to account for a patient's symptoms by a
single diagnosis. The approach usually adopted is to arrange symptoms in an arbit-
rary hierarchy, with the least common at the top and the most widespread at the
bottom, since this represents almost the only way of making a single diagnosis.
A point made by Eliot in the nineteenth century: "Your pier-glass or extensive surface of polished steel
made to be rubbed by a housemaid, will be minutely and multitudinously scratched in all directions; but
place now against it a lighted candle as a centre of illumination, and lo ! the scratches will seemto arrange
themselves in a fine series of concentric circles round that little sun. It is demonstrable that the scratches
are going everywhere impartially, and it is only your candle which provides the flattering illusion of a
concentric arrangement, its light falling with an exclusive optical selection. These things are a parable.
The scratches are events, and the candle is the egoism of any person now absent ..." George Eliot,
Middlemarch (Penguin English Library,1965), p.297. First publishedin 1871–72.
A Dictionary of Epidemiology (ed. J.M. Last, International Epidemiological Association/Oxford
UniversityPress, 3rded., 1995), p.29.
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.292.
5. 5
Thus, if there is clear evidence of brain disease that establishes the diagnosis and,
likewise, in the absence of such evidence, clear features of schizophrenia often
establish that diagnosis even if affective symptoms are also present. While the ap-
proach allows for some sort of ordered classification, the danger is that the
classification provides order rather than reflects reality, so that the classification is
dictating to the latter rather than accounting for it.
The classificatory criteria
As a matter of logic, the different methods of classifying mental disorders focus on
the different stages ofthe disease process:
The classification and diagnosis of physical diseases are mostly based on their
aetiology or pathology, that is diseases are classified according to their known causes
or biological abnormalities. Most authors take the view that a classification based on
aetiology and pathology is most desirable since it is most useful in practice.
However, because most psychiatric disorders (including schizophrenia and mood
disorders) have no known unifying aetiology or pathology, they must be classified
by their outcome, response to treatment, or according to patterns of symptoms
observed to frequently occur together(the "syndrome" approach).
Classification by aetiology and pathology
An aetiological classification describes the cause of the disorder and, if it is unique
to the specific condition, provides a clear prognosis and treatment plan or focus for
research into treatment. Consequently, a classification of infections based on the
identity of infecting organisms is more useful than one based on purely clinical phe-
nomena, such as the presence of fever. It is, however, impossible to describe dis-
ease purely in terms of an external cause such as an infectious agent because the
same agent can produce very different diseases. Many mental disorders are also
aetiologically very diverse, that is they have a "multi-factorial aetiology" rather than
any simple single cause. For example, "depressive disorder can be regarded as a final
common pathway which may have multiple causes, even in a single case." Thus, the
same cause may produce very different diseases and the same disease may have
many different causes. Consequently, Bradley notes that even if our knowledge of
aetiology was complete the classification of disease in terms of cause could never be
satisfactory. Abnormalities of structure and function — the pathology which is the
basis of symptoms and signs — must be taken into account when diseases are
classified. Again, though, pathology cannot provide a satisfactory taxonomy alone
because the nature of the infecting organism is often crucially important in the
management of the patient. Moreover, in some cases, such as Alzheimer's disease,
the precise pathology is not clear until after the patient's death, following post-
mortem examination of the brain. In any case, because the aetiology and pathology
of the vast majority of severely disabling psychiatric disorders remains unknown —
both pre and post mortem — classification by such means is presently impossible.
Classification by outcome or treatment response
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), pp.278–279.
J.M. PfefferandG. Waldron, Psychiatric Differential Diagnoses (Churchill Livingstone,1987).
Aetiology Pathology Manifestation Outcome
6. 6
Classification by outcome alone is of limited practical value. Such a classification
affords no prediction of the outcome since it is the outcome which retrospectively
defines the diagnosis, whereas most doctors wish to know the diagnosis and
prognosis before commencing treatment. Furthermore, many disorders have a wide
range of outcomes. A classification based on response to a particular treatment is
similarly unsatisfactory. There are few, if any, specific treatments in psychiatry and
the different therapies are not mutually exclusive. Response to ECT does not
establish that the individual had a depressive disorder, nor does failure to respond to
antipsychotics mean that he is not psychotic or does not have schizophrenia.
Classification by symptoms (syndromes)
Although acknowledged not to be particularly satisfactory, the symptomological ap-
proach to classification is by default generally used in psychiatry. For a symptom to
be used diagnostically, its occurrence must be typical of that condition and it must
occur relatively frequently. Clusters of symptoms may be observed to occur in con -
junction and to develop or remit according to a broadly identifiable pattern, persist-
ing for a characteristic length of time. These clusters of symptoms therefore occur
together as identifiable constellations or syndromes — "syndrome" being a Greek
word meaning "running together." The syndrome can be named and classified, e.g.
schizophrenia. Such a classificatory scheme does not depend upon knowing the
cause of the disorder or the abnormal pathology responsible for the patient's symp -
toms. It is based merely on the identification of a pattern of symptoms sufficiently
distinctive to justify an inference that they are the product of some discrete medical
condition. A doctor who then examines a patient and observes the characteristic
symptom pattern may diagnose that the particular condition and prescribe a certain
treatment. Research into the syndrome may later confirm that it is a "disease" with
characteristic features in terms of its causes, the people whom it affects, its course
and likely outcome. Thus, a person with a certain grouping of symptoms and blood
test results has leukaemia, which can be shown to have a certain natural course and
to respond better to some treatments than others. Blood tests and other routine
examinations may confirm various distinguishable sub-types, the validity of which
can be demonstrated by their relatively high predictive power in terms of response to
treatment, outcome and test-retest reliability. The problem with many psychiatric
disorders is that their existence as distinct illnesses cannot be demonstrated in this
way, there being few tests of any diagnostic utility which can distinguish between
different types of mental disorder. For example, there is no known organic or
physiological abnormality which accounts for hebephrenic schizophrenia and is only
found in patients with the disorder. Consequently, the psychiatrist must rely "upon
the consensus among his colleagues that a particular constellation of symptoms or
phenomena tend to occur together and can be recognised as a syndrome." Whether or
not certain recognised syndromes do in reality represent distinct disease processes
depends upon the correctness of the observations and inferences made about the way
in which symptoms and signs coalesce, as well as the validity of this kind of disease
reasoning itself. As matters presently stand, conditions such as schizophrenia are
ultimately concepts the validity of which has yet to be demonstrated. Nevertheless,
most established diseases were originally defined by their syndromes and "as
knowledge about their etiology slowly accumulated they came, one by one, to be
A. Sims, Symptoms in the Mind (Baillière Tindall, 1988),p.6.
C. Thompson, TheInstruments of Psychiatric Research (John Wiley& Sons, 1989), p.3.
7. 7
defined at some more fundamental level. The clinical syndrome 'phthisis' became
pulmonary tuberculosis, defined by the presence of tubercle bacilli in sputum or
post-mortem lung ... and Down's syndrome became trisomy 21, defined by the
presence of that additional chromosome, as soon as it was apparent that the
syndrome was invariably associated with that chromosomal abnormality."
PROBLEMS CLASSIFYING SYNDROMES
The difficulties involved in constructing any classification of mental disorders by
syndrome are formidable and should not be underestimated —
The approach depends upon pinpointing characteristic and recurring
patterns of symptoms and signs. However, while the correct identification
of a rump of features distinctive of an illness requires accurate observation,
recording and deduction, decisions about even the presence or absence of
particular symptoms have been shown to be relatively unreliable.
This practical limitation is compounded by the absence of any agreed
terminology with which to describe what is observed. Although a precise
language is necessary to record observed phenomena, psychiatry lacks this.
Once language cannot be agreed certainty is impossible. Every research
finding must be translated and, as with any form of literature, some distor-
tion and loss of meaning is inevitable. These limitations have led Professor
Kathleen Jones to conclude that description and observation must come
before the construction of scales and the formulation of hypotheses about
associations between symptoms: "it is not only computers which suffer
from the problem of 'garbage in, garbage out.'"
In theory, the construction of syndromes begins with pinpointing character-
istic and recurring patterns of symptoms and signs which are not specific to
a particular individual and so cannot be explained in terms of his peculiar
characteristics but only as the peculiar characteristics of a distinctive illness.
However, considerable practical problems arise from the fact that it is not
illnesses per se which are being classified but people suffering from illness.
This distinction is of fundamental importance. Variability "is the law of life.
As no faces are the same, so no two bodies are alike, and no two individuals
react alike and behave alike under the abnormal conditions which we know
as disease." In consequence, widely different symptoms and signs may
result from a common cause so that Huntington's chorea, although
transmitted by a known single gene, is associated with a wide variety of
psychiatric syndromes. The clinical picture is therefore "most often
profoundly coloured and sometimes decisively shaped by factors specific to
the individual and his environment. Hence the notorious difficulty in
identifying separate disease processes in psychiatry." Or, as Yellowlees put
See R.E. Kendell, "Schizophrenia: A Medical View of a Medical Concept" in What is Schizophrenia? (ed.
W.F. Flack et al., Springer-Verlag, 1990),p.64.
K. Jones, "Social science in relation to psychiatry" in Companion to psychiatric studies (ed. R.E. Kendell
& A.K. Zealley, Churchill Livingstone,1993), p.12.
Sir W. Osler, Medical education in Counsels andIdeals (Houghton Mifflin, 2nded., 1921).
R.E. Kendell, "Schizophrenia: A Medical View of a Medical Concept" in What is Schizophrenia? (ed.
W.F. Flack et al., Springer-Verlag, 1990),p.67.
W.A. Lishman, Organic Psychiatry, The Psychological Consequences of Cerebral Disorder (Blackwell
Scientific Publications, 2nd ed., 1987), p.3. There is no identifiable single set of symptoms which
8. 8
it: "As the symptoms of any form of mental disorder vary enormously in
different patients, the results ... are analogous to those obtained by arranging
books in a library, some according to the author, some according to the
subject, some according to the size, and so me according to the colour of the
binding."
Although marked individual differences can sometimes be explained as
atypical presentations, it is often difficult in practice to determine whether a
particular constellation of symptoms is an atypical variation of an estab-
lished syndrome, such as schizophrenia; a discrete sub-type of the disorder,
such as hebephrenic schizophrenia; or a mutation of two co-existing but
distinct forms of mental disorder, such as schizophrenia and depression
("schizoaffective disorder").
Certain mental phenomena are found both in people considered to be
mentally healthy and those believed to be mentally disordered. For
example, a feeling which a person has that he has previously visited a place
unknown to him may be a symptom of te mporal lobe epilepsy or a
manifestation of general anxiety or fatigue. The same symptom observed in
two people may therefore be symptomatic of illness in one person but not
another and, when considered in isolation, not merely of little diagnostic
value but confusing.
Even when not found in the normal population and so indicative of a patho-
logical process, any given symptom may be symptomatic of several
different disorders and, when viewed in isolation, incapable of sustaining a
single di- agnosis. For example, Schneider's first-rank symptoms of
schizophrenia are encountered in temporal lobe epilepsy, brain diseases, and
in amphetamine intoxication. The significance of a symptomtherefore often
depends upon the precise context so that it is known by the co mpany it
keeps. Unfortunately, most symptoms are promiscuous and few, if any, are
specific to a particular disorder. Symptoms may be commonly present and
valuable diagnostically but not universally present or definitive. Some
diseases have very few symptoms; others share the same symptoms; and a
symptom may sometimes be primary and other times secondary, e.g.
depression resulting from hypothyroidism.
It has been noted that some of this variation may be explained as the differ-
ent effects of the same disease in different bodies. Having regard to this,
Kendell has pointed out that each patient has some attributes which he
shares with all patients, certain attributes which he shares with some but not
all patients, and yet other attributes unique to that individual. Because this is
constitutes normal health and therefore no single syndrome of normal health. The many different
syndromes of normal mental health each constitute a norm from which deviation caused by a single
pathological process may be observed. Consequently, for each pathological process the number of
different types of abnormality precisely equals the number of types of normal health ("no syndrome
syndrome").
H. Yellowlees, To Define True Madness (PelicanBooks,Rev. ed., 1955),p.7.
As to this, Crow has noted that schizophrenia and bipolar disorder share many characteristics and several
research workers are beginning to wonder whether at least some of their determinants may be common to
both. See e.g. T. Crow, "Psychosis as a continuum and the virogene concept" British Medical Bulletin 43,
754–768.
R.E. Kendell, "Schizophrenia: A Medical View of a Medical Concept" in What is Schizophrenia? (ed.
W.F. Flack et al., Springer-Verlag, 1990),p.66.
9. 9
so, the same disorder or disease is likely to affect all people identically in
certain respects, different classes of people distinguished by certain key
attributes in ways common only to members of the class, and each person
within a class in yet other ways peculiar to him. Accordingly, a particular
disease or disorder may produce in one person or class of persons
symptoms and signs identical to those manifested in another person or
group as a result of a quite separate illness, with the result that it is wrongly
inferred that the same disorder is responsible for these common symptoms.
A further complication in defining disease in terms of a specific set of
features is that disease patterns change over time for reasons that are poorly
understood. This partly reflects the fact that the characteristics of a country's
people changes over time — even if there has been no immigra- tion or
emigration — so that England, both culturally and medically, is a vastly
different country now than a hundred years ago. It is, however, impossible
to know whether the people have changed but the disease itself has
remained unchanged or whether variations in presentation also reflect an
evolution of the disease, in which case even classifications by aetiology or
pathology require periodic revision.
More prosaically, advances in treatment also change the presentation of
disease. Few seriously disabling diseases are now allowed to run their
natural course and most textbooks describe features which are rarely seen
today. Although, as Kendell has noted, this does not necessarily change the
spectrum of disease, it influences the type of symptoms and signs
commonly observed,upon which syndromes are constructed and classified.
Some diseases are therefore both anachronistic and anachoristic. If a single
disorder is subject to sexual, racial, cultural or temporal fluctuations, the
underlying unity may go undetected and it erroneously be construed as a
number of separate disorders.
An imaginative way of addressing these problems is to attempt to identify
points of rarity in disease patterns, symptoms which even if not commonly
present are nevertheless, when present, evidence of a particular disease.
Unfortunately, such attempts have generally been unsuccessful.
Underlying all these observations is the basic question of the validity of
disease reasoning and the syndrome approach. Whether there are genuine
boundaries between the clinical syndromes in current classifications, and
between those syndromes and normality, is ultimately a conundrum.
Although, as Kendell has variously noted, the existence of interforms does
not of itself invalidate distinguishing between two different syndromes,
most mental disorders do nevertheless appear to lack discrete boundaries
and to shade into one another. The traditional research method of
comparing people with one diagnosis with control subjects who have
another diagnosis or no diagnosis "rests on the assumption that those with
Most transparently, people of different genders, races or cultures have some personal characteristics not
shared by persons falling outside their particular class. However, it is just as true that a man from one
culture may have some characteristics in common with a woman from another culture which he does not
also share with other men fromhis cultural background.
G.W. Bradley, Disease, Diagnosis andDecisions (JohnWiley& Sons, 1993), p.20.
10. 10
the target diagnosis have something in common which is absent in the case
of the controls. If this assumption is invalid, the traditional research
paradigm cannot hope to yield meaningful findings."
Summary
The picture is therefore kaleidoscopic although it is unclear whether the primary
problem is the phenomenal complexity of what is being observed or the perspective
from which it is being observed. No single set of observations can ever be precisely
replicated. Each individual patient gives the kaleidoscope a turn before the observer
looks through the lens at the ever-changing patterns of crystals. Not surprisingly,
Osler wrote in 1921 that "the problems of disease are more complicated and more
difficult than any others with which the trained mind has to grapple." Some 70 years
later, Bradley reached a similar conclusion, writing that the difficulties "cannot
easily be overcome making it unlikely that there will ever be a durable classification
of disease. It may well be that the symptoms of mental distress are more dictated by
personality and environment than by any pathology, the effect of which is simply to
imbalance what was previously, if precariously, balanced in the particular individual.
Or the answer may be simply that it is logically impossible to classify disorder in an
ordered way, to rationally arrange what is deranged. The essential and defining
feature of mental disorder is the demolition of structure, disjunction rather than
conjunction. Until some underlying and unifying pathology is stumbled upon, the
syndrome approach, based as it is on the external manifestations of internal
processes, may therefore be contradictory. Having invented the term "mental
disorder" to express the idea of behaviour which appears to a rational observer to
lack coherence, it is arguably mere vanity to then rigorously scrutinise the idea in the
expectation of identifying organised sub-forms of disorder. Whether or not this is so,
there may be much to be said for Bentall's suggestion that research should
concentrate on particular symptoms before attempting to map their possible
constellations—
"There is a perfectly logical alternative to using diagnostic classifications as
independent variables in research into psychopathology: researchers could abandon the
attempt to classify psychotic illness (at least for the time being) and make the actual
phenomena they encounter in the clinic, that is to say particular types of complaints or
behaviours (usually described as 'symptoms') the focus of their efforts. For example,
investigators might study hallucinations, delusions, disordered discourse, flat affect, or
any other symptom."
CONTEMPORARY CLASSIFICATIONS
Given these considerable problems, it is not surprising that the validity and reliability
of both past and contemporary classifications of mental disorder has always been a
matter of dispute. In particular, Menninger reviewed and listed many classifications
spanning 2500 years and was dismissive of the usefulness and validity of the
R.P. Bentall, "The classification of schizophrenia" in Schizophrenia — An overview and practical
handbook (ed. D.J. Kavanagh, Chapman& Hall, 1992), p.24.
Sir W. Osler, Medical education in Counsels andIdeals (Houghton Mifflin, 2nded., 1921).
G.W. Bradley, Disease, Diagnosis andDecisions (JohnWiley& Sons, 1993), p.20..
R.P. Bentall, "The classificationof schizophrenia," supra,p.34.
11. 11
exercise. Although syndromes such as schizophrenia and depression are still widely
used, most attempts to create coherent links between clinical symptoms, causal
factors, and prognostic types have failed. Consequently, contemporary classifications
vary both with regard to the types of mental disorder considered to be distinct
entities and, when this can be agreed, their respective hallmarks. Providing two or
more competing classifications are being used appro- priately, Kendell has
emphasised that one must simply concede that the alternative definitions embrace
different populations and examine which of the competing definitions most
successfully meets some criterion like homogeneity of outcome or treatment
response. This is because, in the last resort, "all diagnostic concepts stand or fall by
the strength of the prognostic and therapeutic implications they embody. The ability
to predict the outcome of an illness, and to alter this course of events if need be, have
always been the main functions of medicine." Unfortunately, although a diagnosis
should provide therapeutic and prognostic indicators, these are often relatively weak
in psychiatry and "the existing evidence for the validity of most psychiatric disorders
is rather meagre, but by no means non-existent."
THE ICD–10 CLASSIFICATION
The classification of mental disorders in official usage in England and Wales is the
World Health Organisation's International Classification of Diseases and, more par-
ticularly, that part of it dealing with mental and behavioural disorders. The tenth
revision (ICD–10), published in 1992, took nine years to prepare and included field
trials using the draft text in 194 different countries, after which further revisions
were made. The ICD-10 Classification of Mental and Behavioural Disorders (the
"Blue Book") contains clinical descriptions and diagnostic guidelines for the
disorders listed within it. In the tenth revision, the previous distinction between the
psychoses and neuroses has been laid aside and all mood disorders are now in a
single grouping. Inevitably, the classification reflects "compromises between
scientists with the most influential theories and the practice of senior clinicians at
national and international level." The classification is not entirely coherent because
of the tendency for each class to expand in order to incorporate alternative and
sometimes incompatible concepts. Nevertheless, its international status and the need
to conduct research according to a common set of guidelines means that there is a
mutual obligation to use it.
Format of ICD–10
K. Menninger, The vital balance: the life process in mental healthand illness (VikingPress, 1963).
N. Sartorius, in Sources and Traditions of Classification in Psychiatry (ed. N. Sartorius, et al., World
Health Organisation/Hogrefe & Huber, 1990),p.2.
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.290.
J.M. PfefferandG. Waldron, Psychiatric Differential Diagnoses (Churchill Livingstone,1987), p.4.
R.E. Kendell, "Diagnosis andclassification," supra, p.291.
The sixth revision (ICD–6), published in 1948, was the first to include a classification of mental disorders
(Section V: "Mental, Psychoneurotic and Personality Disorders"), although it was primarily a
classification of psychoses and mental deficiency. The sixth revision and the subsequent (expanded)
revisions haveall been adoptedby the Government.
There is also a separate book containingdiagnostic criteria for research(The "GreenBook").
J.K. Wing, "Differential diagnosis of schizophrenia" in Schizophrenia — An overview and practical
handbook (ed. D.J. Kavanagh, Chapman& Hall, 1992), p.17.
R.E. Kendell, "Diagnosis andclassification," supra, p.287.
R.E. Kendell, "Diagnosis andclassification," supra, p.196.
12. 12
The classification is divided into major groups ("blocks") of mental disorders.
Within these blocks, each type and sub-type of mental disorder is separately listed
and coded. Thus, one block is concerned with schizophrenia and similar disorders
(Block F20–F29). Schizophrenia is given the code F20 and a further digit is used to
record its various sub-types, such as paranoid schizophrenia (F20.0) and catatonic
schizophrenia (F20.2).
THE ICD–10 CLASSIFICATION — LIST OF CATEGORIES
Code Block (major group) Examples of disorders in block
F00–F09 Organic mental disorders v Alzheimer's disease
v Pick's disease
v Creutzfeldt-Jakob disease
v Parkinson's disease
v dementia, delirium.
F10–F19 Mental and behavioural disorders
due to psychoactive substance use
v due to alcohol
v due to opioids, cocaine, etc.
F20–F29 Schizophrenia, schizotypal and
delusional disorders
v schizophrenia
v schizotypaldisorder
v persistent delusional disorders
v schizoaffective disorders.
F30–F39 Mood (affective) disorders v manic episode
v bipolar affective disorder
v depressive episode
F40–F48 Neurotic, stress-related and
somatoform disorders
v hypochondriacal disorder
v phobic and anxiety disorders
v obsessive-compulsive disorder
F50–F59 Behavioural syndromes associated
with physiological disturbances and
physical factors
v Eating disorders
v sleep disorders
v premature ejaculation
F60–F69 Disorders of adultpersonality and
behaviour
v personality disorders
v habit and impulse disorders
v transsexualism, fetishism
F70–F79 Mental retardation v mental retardation
F80–F89 Disorders of psychological
development
v childhood autism
v specific spelling disorder
F90–F98 Behavioural and emotional disorders
with onset usuallyoccurring in
childhood and adolescence
v hyperkineticdisorders
v conduct disorders
v tics
F99 Unspecified mental disorder v not applicable
0
Operational definitions (diagnostic guidelines)
It has previously been noted that almost every symptom in psychiatry is capable of
occurring in conjunction with almost any other symptom. Thus, for example,
symptoms such as elation, flight of ideas and grandiose ideas are quite common in
13. 13
both schizophrenia and mania. Operational definitions (also known as diagnostic
guidelines or criteria) are therefore used to specify which combinations of symp-
toms are adequate to substantiate a diagnosis. They define what a clinician means
when he uses the term "schizophrenia" or "mania" and represent an attempt to stan-
dardise clinical practice and understanding. The introduction to the blue book
contains the following notes on the diagnostic guidelines set out in the ICD–10
classification—
"When the requirements laid down in the diagnostic guidelines are clearly fulfilled, the
diagnosis can be regarded as 'confident'. When the requirements are only partially
fulfilled, it is nevertheless useful to record a diagnosis for most purposes. It is then for
the diagnostician and other users of the diagnostic statements to decide whether to
record the lesser degrees of confidence (such as 'provisional' if more information is yet
to come, or 'tentative' if more information is unlikely to become available) that are
implied in these circumstances. Statements about the duration of symptoms are also
intended as general guidelines rather than strict requirements; clinicians should use
their own judgement about the appropriateness of choosing diagnoses when the
duration of particular symptoms is slightly longer or shorter than that specified ...
These descriptions and guidelines ... are simply a set of symptoms and comments that
have been agreed, by a large number of advisors and consultants in many different
countries, to be a reasonable basis for defining the limits of categories in the
classification of mental disorders."
THE DSM–IV CLASSIFICATION
The other main international classification of psychiatric disorders is the Diagnostic
and Statistical Manual of Mental Disorders produced by the American Psychiatric
Association, the fourth revision of which (DSM–IV) was published in 1994. This
classification is occasionally referred to in the text.
Format of DSM–IV
The classification describes the manifestations of the various mental disorders
delineated within it and diagnostic criteria are provided for each of them.
Epidemiological data is given for each disorder and differential diagnoses where
appropriate. The most distinctive feature of the clas sification is that it is a
"multi-axial" systemcontaining five different axes—
w Axis 1 is used to record clinical conditions which may be the focus of
medical attention,such as schizophrenia and mood disorders.
w Axis 2 consists of mental retardation and personality disorders, e.g. paranoid
personality disorder.
w Axis 3 lists any physical disorder or general medical condition that is present
in addition to the mental disorder, e.g. an endocrine disorder.
Classification of Mental and Behavioural Disorders, Tenth Revision (ICD-10): Clinical Descriptions and
Diagnostic Guidelines (WorldHealthOrganisation, 1992), p.2.
DSM-I was published in 1952, DSM-II in 1968, DSM-III in 1980, and a revised edition of the latter
(DSM-III-R) in 1987.
14. 14
w Axis 4 is used to record psychological, social and environmental problems
which have significantly contributed to the development of the current
mental disorder or exacerbated it, e.g. "housing problems" and "problems
with access to health care services."
w Axis 5 comprises the global assessment of functioning scale (GAF Scale),
which is used to record the clinician's judgement of the patient's overall
functioning during a particular period of time. The patient is rated on a
0–100 scale, with 100 representing superior functioning and 10 "persistent
danger of severely hurting self or others" (222). Because the GAF scale
provides a standard scale for gauging the risks associated with a patient's
mental state,it is an extremely useful tool in practice.
Because it is not merely a diagnostic tool, the DSM–IV classification is in many
respects superior to the ICD–10 classification. It allows for a more comprehensive
recording of the main features of each case: underlying intellectual and personality
problems; physical disorders possibly contributing to the mental disorder; contrib-
utory social problems; and the effect of the mental disorder on the patient's
functioning.
OTHER CLASSIFICATIONS
It must be emphasised that the ICD–10 and DSM–IV classifications, and the
diagnostic guidelines which form part of them, are but two of many medical
classifications of mental disorder. For conditions such as schizophrenia, none of the
competing definitions can be said to be right or wrong since there is as yet no
external criterion of validity. It is impossible to decide which is the most valid
because this would involve determining which of several different ways of defining
the syndrome of schizophrenia most accurately picks out patients possessing an
underlying abnormality which has yet to be identified. Although a core of typical
patients meet all definitions, there are significant differences in the populations of
patients covered by each of them. Each operational definition generates different
values for the incidence of a disorder, its heritability, its responsiveness to
therapeutic agents, and its prognosis. The concordance between the different sets of
operational criteria for conditions such as schizophrenia is "not impressive; in other
words the different criteria tend to diagnose different people as schizophrenic."
Consequently, it is important to realise that a patient who meets the somewhat
inclusive criteria for a diagnosis of schizophrenia in the ICD–10 classification may
not satisfy the more tightly-drawn operational criteria of another classification.
These observations similarly apply to other kinds of mental disorder.
R.E. Kendell, "Schizophrenia: A Medical View of a Medical Concept" in What is Schizophrenia? (ed.
W.F. Flack et al., Springer-Verlag, 1990),p.63.
R.P. Bentall, "The classification of schizophrenia" in Schizophrenia — An overview and practical
handbook (ed. D.J. Kavanagh, Chapman & Hall, 1992), p.25.; I.F. Brockington, et al., "Definitions of
schizophrenia: Concordance andpredictionof outcome" Psychol. Med. (1978) 8,399–412.
15. 15
DIAGNOSIS
Diagnosis forms part of the assessment process and, in general usage, the term refers
to the process of identifying the specific mental disorder from which the patient
suffers. For example, the diagnosis may be that the patient suffers from
schizophrenia or, more specifically, from a form of schizophrenia known by the
label "hebephrenic schizophrenia." A diagnosis is therefore a "short-hand way of
describing what is wrong with the patient" and reaching a diagnosis involves re-
cognising a particular disorder from its signs and symptoms so that, having identi-
fied it, conclusions can be reached about its causes, probable course, and treatment.
The diagnostic process thus consists of categorising problems in order to solve or
ameliorate themusing appropriate techniques and skills. The aim of the process is to
reduce clinical uncertainty because the diagnosis indicates what the individual
patient holds in common with previous patients and so "suggests that a successful
treatment plan used for somebody else with the same diagnosis may well lead to
benefit." Nevertheless, the diagnostic methods used by different clinicians are not
always comparable so that a patient's diagnosis but not his condition may change
over time. This is because diagnoses are subject to therapeutic fashions and innova-
tions and depend upon the classification and operational criteria being used. While
diagnosing a condition has benefits in terms of communication and research, there is
"no very great value in attaching a label to a patient's complaint if exactly the same
course of treatment would have been carried out whatever the label," unless it has a
predictive value. The importance of making a diagnosis lies in the fact that it is a
recipe for action and a predictor of outcome, rational treatment and prognosis
requiring a firm working diagnosis. Inappropriate reassurance, unnecessary treat-
ment and compulsion, and the dissemination of gloom are penalties to be paid for
taking too lax an approach to the diagnostic process.
VALIDITY AND RELIABILITY OF THE DIAGNOSIS
The validity of a diagnosis depends on the validity of the classification and oper-
ational criteria upon which it is founded and the reliability of the diagnostic process
itself. It has already been noted that the validity of diagnoses such as schizophrenia
cannot be conclusively demonstrated. Such disorders are hypothetical constructs.
While different diagnoses may arise because examiners have different concepts and
use different operational definitions, "most psychiatric diagnoses can never be
confirmed or refuted, for there is no external criterion to appeal to." Providing a
classification is used appropriately, it must ultimately be conceded that it embraces a
different population of patients than do other competing operational criteria.
Reliability refers to the consistency with which subjects are discriminated from one
another; in this context, the extent to which different diagnosticians will agree on a
Some psychiatrists, however, use the term more broadly to refer to a comprehensive evaluation that is not
limitedto identification ofspecific disorders.
J.M. PfefferandG. Waldron, Psychiatric Differential Diagnoses (Churchill Livingstone,1987).
A. Sims andD. Owens, Psychiatry (Baillière Tindall, 6thed., 1993), p.8.
These operational criteria may be implicit rather than explicit, as where a doctor applies the diagnostic
methods imbued in him during his training or makes diagnostic decisions based on personal experience
but without ever analysingthe basis of thedistinctions on whichhis practice is based.
A. Sims, Symptoms in the Mind (Baillière Tindall, 1988).
G.W. Bradley, Disease, Diagnosis andDecisions (JohnWiley& Sons, 1993), p.50.
Ibid.
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.279.
16. 16
diagnosis for a given patient. Reliability is therefore a means to an end, rather than
an end in itself, and its importance lies in the fact that it establishes a ceiling for
validity. The lower it is the lower the validity necessarily becomes. However, the
converse is not also true. If the operational criteria applied do not constitute a valid
delineation of the disease or disorder in question, reliability can be high while
validity remains trivial — in which case, high reliability is of little value.
The reliability of diagnoses
Reliability is usually measured in one of two ways. Either a diagnostic interview is
watched by a passive observer who makes his own independent diagnosis at the end
(observer method) or a second diagnostician conducts an independent interview with
the patient a few hours or days later (reinterview method). The observer method
over-estimates reliability because all variation in the conduct of the interview is
eliminated. The reinterview method, which in essence is the method used by the
tribunal's medical member or a psychiatrist instructed on the patient's behalf, may
underestimate reliability because of the time lag and the fact that the patient has
practised or thought about his answers. Thus, in one study, there was less than a 50
per cent. chance of a psychiatrist who interviewed a patient some days after a
colleague agreeing that a symptom was present. A considerable amount of re - search
has been conducted into the reliability of patients' diagnoses and the findings have
generally not been encouraging. Necessarily, a correct diagnosis may not be made
when clinical findings are inaccurate. Most studies suggest that agreement about the
presence or absence of physical signs is not very good, much of the agree- ment
being due simply to chance. While a study by Beck showed that only 54 per cent. of
specialists agreed about diagnosis, Kendell notes that organic and psychotic
disorders generally have higher reliability than neuroses and personality disorders.
That being so, reliability studies based on in-patients tend to produce higher overall
reliability than those based on out-patients. In the latter case, the frequency of
neurotic symptoms and maladaptive personality traits in the general popu lation
means that quantitative as well as merely qualitative judgements are involved.
Factors affecting the reliability of the diagnosis
There are various reasons for the low reliability of the diagnostic process, some of
which reflect the imperfect operation of the assumption that symptoms elicited are
present and those not elicited are absent. Bradley and Kendell have summarised the
main research findings and the main areas of weakness relate to the collection,
interpretation and judging of information:
w Different diagnoses may simply reflect that fact that clinicians have different
concepts and use different operational criteria. Because few psychiatric
illnesses have pathognomonic symptoms, most conditions have to be defined
by the presence of some or most of a group of symptoms rather than by the
presence of one key symptom. This "invites ambiguity and lowers reliability
still further unless operational definitions are adopted."
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.290.
N. Kreitman, et al., "The reliability of psychiatric assessment: an analysis" Journal of Mental Science
(1961)107: 887–908.
R.E. Kendell, "Diagnosis andclassification," supra, p.290.
G.W. Bradley, Disease, Diagnosis andDecisions (JohnWiley& Sons, 1993).
R.E. Kendell, "Diagnosis andclassification," supra, p.279.
17. 17
w In other cases, the patient's condition may not conform to the tidy, stereo-
typed descriptions found in textbooks. When patients possess some but not
all of the characteristic features of two or three different diagnostic cat-
egories, disagreements and the use of hybrid terms will necessarily be quite
common. Although the use of operational definitions increases reliability and
makes clear the concepts underpinning the diagnosis, their use varies in
practice. The diagnostic criteria applied are often implicit rather than explicit
and the clinician may fail to scrutinise or specify the assumed relationship
between the symptoms and diagnosis.
w Although structured interviews are generally unsuitable for ordinary clinical
purposes, because they do not permit a rapid focusing on the patient's main
difficulties, the free-ranging, unstructured, interviews used by clinicians are
nevertheless less reliable — and, in consequence, they are no longer used for
research purposes. While many of the principles involved in conducting a
non-structured interview are "simple enough, even self-evident, ... this does
not stop them being flouted even by experienced clinicians who ought to
know better."
w Unstructured interviews being relatively subjective, behavioural differences
between interviewers account for much of the observed unreliability. A
patient may give different accounts to different interviewers, partly because
of the way questions are asked. Different interviewers pose different ques -
tions, show interest and probe in different places and establish different
kinds of relationships with patients. The doctor's perception of the likelihood
of a certain diagnosis in his practice (the "prior probability") may affect the
information sought so that other information of crucial importance is over-
looked. Such preconceptions, in terms of their e xpectations of finding
different symptoms, are reflected both in the wording of questions and the
interpretation of ambiguous replies. Fixing on a diagnosis at an early stage
may similarly lead to a premature closure of options. Conceptual differ-
ences, involving the different usage of words such as anxiety or delusion and
the extent to which a graded characteristic had to be evident to be recorded
as present, can also affect the symptoms recorded and hence the diagnosis
reached.
w The importance attached to information may be inappropriate in several cir-
cumstances with a failure to attach correct weights to cues. Cues discovered
early on in an interview have been found to be given more emphasis in
coming to a diagnosis than the same cues given later on in the examination.
w There is also a natural tendency to overemphasise positive findings when a
negative finding may contain just as much information. This reflects a
natural human preference for evidence that proves rather than disproves a
hypothesis. Similarly, normal findings tend to be ignored when judging the
effect of a test on the likelihood of disease. Although a negative test should
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.281.
Ibid., p.280.
Ibid., pp.278–279.
18. 18
have the effect of making the diagnosis less likely, the clinician often ignores
this evidence.
w Even if no inappropriate emphasis is placed on particular clinical findings, a
clinician's inexperience may nevertheless result in failure to consider the
correct diagnosis in the first place.
w Conversely, clinical experience may occasionally be disadvantageous. While
analytical methods are slower but potentially more accurate, particularly for
the complicated cases, the doctor who is experienced in the task in hand is
more likely to use intuitive methods with a resulting advantage in speed.
Nevertheless, "it is as well to remember that whilst experience can be the
mainstay of diagnostic skill, overreliance on it can lead to nothing more than
making the same mistake with increasing confidence."
DISADVANTAGES OF DIAGNOSIS
Kendell has summarised some of the main disadvantages involved in giving a patient
a diagnosis. In the first place, most psychiatric diagnoses have pejorative
connotations. A diagnosis of schizophrenia or psychopathic disorder may have a
particularly harmful effect on the patient's self-esteemand the attitude and behaviour
of others towards him. Secondly, attaching a name to a condition may create a
spurious impression of understanding. However, to say that a person has
schizophrenia "actually says little more than that he has some puzzling but familiar
symptoms which have often been encountered before in other patients." Thirdly, all
too often doctors reify the diagnostic concept and treat the "disease" instead of trying
to relieve their patient's symptoms, anxieties and disabilities.
DIAGNOSTIC FORMULATIONS
A diagnostic formulation is not the same thing as a diagnosis. For the reasons given,
a diagnosis may be an inadequate means of conveying what the clinician regards as
the essence of the patient's predicament — why he broke down, in that particular
way, at that particular time. A diagnostic formulation involves considering and then
specifying these important elements of the case in a short account. Formulation and
diagnosis are equally necessary, but for quite different purposes — " ... the idea that
a diagnosis can, or should, be replaced by a formulation is based on a fundamental
misunderstanding of the nature of both. A formulation which takes account of the
unique features of the patient and his environment, and the interaction between them,
is often essential for any real understanding of his predicament, and for planning
effective treatment, but it is unusable in any situation in which populations or groups
of patients need to be considered."
G.A. Gorry, et al., "The diagnostic importance of the normal finding" New England Journal of Medicine
(1978) 298: 486–489; G.W. Bradley, Disease, Diagnosis and Decisions (John Wiley & Sons, 1993), p.55.
Indeed, it is of fundamental importance in tribunal proceedings to establish and list all of the operational
criteria which are not present in the particular case. All too often, a long interview is summarised in two
lines statingthat features a and b were elicited duringexamination, while the fact that features ctom were
not elicitedis impliedbut goes unrecorded.
G.W. Bradley, Disease, Diagnosis andDecisions (supra), p.68.
R.E. Kendell, "Diagnosis and classification" in Companion to psychiatric studies (ed. R.E. Kendell &
A.K. Zealley, Churchill Livingstone,1993), p.278.
Ibid.
Ibid., p.277.