The document describes the 5 stages of chronic kidney disease based on glomerular filtration rate (GFR). Stage 1 involves kidney damage and normal GFR. Stage 2 includes kidney damage and mildly decreased GFR. Stage 3 is characterized by moderately decreased GFR. Stage 4 shows a severely decreased GFR. Stage 5 is kidney failure requiring dialysis or kidney transplant as the GFR is less than 15.

1. CKD 6 th October 2008

2. 5 Stages of Chronic Kidney Disease Less than 15 Kidney failure (dialysis or kidney transplant needed) 5 15 to 29 Severe decrease in GFR 4 30 to 59 Moderate decrease in GFR 3 60 to 89 Kidney damage and mild decrease in GFR 2 More than 90 Kidney damage (protein in the urine) and normal GFR 1 More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age, ethnic group) At increased risk Glomerular Filtration Rate (GFR) Description Stage

3. 5 Stages of Chronic Kidney Disease Less than 15 Kidney failure (dialysis or kidney transplant needed) 5 15 to 29 Severe decrease in GFR 4 30 to 59 Moderate decrease in GFR 3 60 to 89 Kidney damage and mild decrease in GFR 2 More than 90 Kidney damage (protein in the urine) and normal GFR 1 More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age, ethnic group) At increased risk Glomerular Filtration Rate (GFR) Description Stage

4. 5 Stages of Chronic Kidney Disease Simvastatin 40mg OK } Less than 15 Kidney failure (dialysis or kidney transplant needed) 5 15 to 29 Severe decrease in GFR 4 30 to 59 Moderate decrease in GFR 3 60 to 89 Kidney damage and mild decrease in GFR 2 More than 90 Kidney damage (protein in the urine) and normal GFR 1 More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age, ethnic group) At increased risk Glomerular Filtration Rate (GFR) Description Stage

5. 5 Stages of Chronic Kidney Disease Simvastatin 40mg OK } } Simvastatin above 10mg with caution Less than 15 Kidney failure (dialysis or kidney transplant needed) 5 15 to 29 Severe decrease in GFR 4 30 to 59 Moderate decrease in GFR 3 60 to 89 Kidney damage and mild decrease in GFR 2 More than 90 Kidney damage (protein in the urine) and normal GFR 1 More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age, ethnic group) At increased risk Glomerular Filtration Rate (GFR) Description Stage

6. 5 Stages of Chronic Kidney Disease Simvastatin 40mg OK } } Atorvastatin, no dose adjustment required Less than 15 Kidney failure (dialysis or kidney transplant needed) 5 15 to 29 Severe decrease in GFR 4 30 to 59 Moderate decrease in GFR 3 60 to 89 Kidney damage and mild decrease in GFR 2 More than 90 Kidney damage (protein in the urine) and normal GFR 1 More than 90 Risk factors for kidney disease (e.g., diabetes, high blood pressure, family history, older age, ethnic group) At increased risk Glomerular Filtration Rate (GFR) Description Stage

7. original patent expires: 20th July 2010 supplementary protection certificate: 6th November 2011