Chronic kidney disease (CKD) is the deterioration of renal function over time. The main causes are diabetes and high blood pressure, which can damage the kidneys. Early stages may be asymptomatic, but later stages can cause fatigue, edema, and other issues as kidney function declines. Diagnosis involves testing kidney function and imaging tests. While CKD has no cure, treatment focuses on controlling blood pressure and diabetes, following a kidney-friendly diet, and dialysis or transplant for end-stage renal disease.