Short presentation about Churg-Strauss syndrome, its definition, pathophysiology, diagnosis, and treatment; as well as some clinical cases

3. Erythematous,
purpuric papules
with overlying
erosions and
crusts on the
elbow
Erythematous,
purpuric
papules on the
lateral aspect of
the left foot
Erythematous, purpuric papules on the
dorsum of the left hand

5. Multiple changes of the small vessels with foci of fibrin deposition.
Leukocytoclasis. Malformed granuloma with interspersed eosinophils
(Hematoxylin & eosin, X20 and X400)

10. External photograph demonstrating
periorbital erythema, mild
periorbital edema, and left sided
ptosis
External photograph demonstrating
axial proptosis of the left eye

13. Hematoxylin and eosin stain at 50X
magnification of orbital tissue reveals
multinucleated giant cells arranged into
granulomas (arrows) with necrotic centers
(caseating granuloma).
A granuloma (100X) with a highly eosinophilic (bright pink)
necrotic center (caseation).

25. Renal biopsy from a patient with CSS shows
circumferential, transmural necrotizing
arteritis surrounded by numerous eosinophils
and by lymphocytes. Eosinophils invade the
media (arrows)
Periodic acid-Schiff stain
of a glomerulus in CSS
reveals segmental
necrosis (white arrow),
a cellular crescent in
Bowman space, and
rupture of Bowman
capsule (black arrow)
with periglomerular
inflammation.