The document discusses strategies for percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs). It describes:
1. The antegrade approach is the most commonly used, with success rates of 60-80%. Tapered guidewires are first-choice to probe microchannels.
2. A four-wire strategy is recommended, starting with a polymer-coated wire and progressing to stiffer wires if needed.
3. Advanced techniques like parallel wiring or antegrade dissection and reentry may be used if initial wiring fails.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
The document discusses strategies for percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs). It describes:
1. The antegrade approach is the most commonly used, with success rates of 60-80%. Tapered guidewires are first-choice to probe microchannels.
2. A four-wire strategy is recommended, starting with a polymer-coated wire and progressing to stiffer wires if needed.
3. Advanced techniques like parallel wiring or antegrade dissection and reentry may be used if initial wiring fails.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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10 Benefits an EPCR Software should Bring to EMS Organizations Traumasoft LLC
The benefits of an ePCR solution should extend to the whole EMS organization, not just certain groups of people or certain departments. It should provide more than just a form for entering and a database for storing information. It should also include a workflow of how information is communicated, used and stored across the entire organization.
Mercurius is named after the roman god mercurius, the god of trade and science. The planet mercurius is named after the same god. Mercurius is sometimes called hydrargyrum, means ‘watery silver’. Its shine and colour are very similar to silver, but mercury is a fluid at room temperatures. The name quick silver is a translation of hydrargyrum, where the word quick describes its tendency to scatter away in all directions.
The droplets have a tendency to conglomerate to one big mass, but on being shaken they fall apart into countless little droplets again. It is used to ignite explosives, like mercury fulminate, the explosive character is one of its general themes.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
The document discusses various AI tools from OpenAI like GPT-3 and DALL-E 2, as well as ChatGPT. It explores how search engines are using AI and things to consider around AI-generated content. Potential SEO uses of ChatGPT are also presented, such as generating content at scale, conducting topic research, and automating basic coding tasks. The document encourages further reading on using ChatGPT for SEO purposes.
More than Just Lines on a Map: Best Practices for U.S Bike Routes
This session highlights best practices and lessons learned for U.S. Bike Route System designation, as well as how and why these routes should be integrated into bicycle planning at the local and regional level.
Presenters:
Presenter: Kevin Luecke Toole Design Group
Co-Presenter: Virginia Sullivan Adventure Cycling Association
Ride the Storm: Navigating Through Unstable Periods / Katerina Rudko (Belka G...DevGAMM Conference
Has your project been caught in a storm of deadlines, clashing requirements, and the need to change course halfway through? If yes, then check out how the administration team navigated through all of this, relocating 160 people from 3 countries and opening 2 offices during the most turbulent time in the last 20 years. Belka Games’ Chief Administrative Officer, Katerina Rudko, will share universal approaches and life hacks that can help your project survive unstable periods when there seem to be too many tasks and a lack of time and people.
This presentation was designed to provide strategic recommendations for a brand in decline. The deck also incorporates a situational assessment, including a brand identity, positioning, architecture, and portfolio strategy for the Brand.
Presentation originally created for NYU Stern's Brand Strategy course. Design by Erica Santiago & Chris Alexander.
1. CHOICE AND USE OF APPROPRIATE
GUIDEWIRE IN PCI
SAJY KURUTTUKULAM
2. CONTENTS
COMPONENTS OF A GUIDE WIRE
WORKHORSE WIRE
WIRES FOR DIFFERENT OCCASIONS
TRACKABILITY
KNOW YOUR WIRE
CLASSIFICATION
PROPERTIES OF AN IDEAL WIRE
3. COMPONENTS OF A WIRE
core,
distal tip and
outer covering.
4. CORE
The inner part of the guide wire is referred to as
the core.
Extends throughout the shaft of the wire
It is the stiffest part of the wire that gives the
stability and steerability to the guide wire.
6. CORE MATERIALS
Stainless steel
Provides excellent support, pushability, torque,
good shapability.
BUT
Less flexible in comparison to newer core
materials and more susceptible to kinking.
13. The selection of a guidewire
essential component
INFLUENCED BY
vessel anatomy
the lesion morphology
the devices to be used
operator's experience and preference.
14. LEFT MAIN PCI
The choice of a guidewire is not of critical importance.
Wire selection usually includes spring tip guidewire
designed for frontline lesions, for example, ChoICE™
Floppy (Boston Scientific), Hi-Torque Balance
Middleweight (Abbott Vascular)
15. LEFT MAIN PCI
The choice of a guidewire is not of critical importance.
Wire selection usually includes spring tip guidewire
designed for frontline lesions, for example, ChoICE™
Floppy (Boston Scientific), Hi-Torque Balance
Middleweight (Abbott Vascular)
FOR LEFT MAIN OR RCA OSTIAL PCI AN
EXTRASUPPORT WIRE IS PREFERED
16. BIFURCATION PCI
In the presence of difficulties accessing the side
branch some hydrophilic wires such as the ChoICE™
PT Floppy (Boston Scientific), PT Graphix™ (Boston
Scientific) or Asahi Fielder (Abbott Vascular) may
become useful.
These wires have higher risk to perforate the distal
vessel if allowed to migrate into small side branched or
too distally. Therefore it is important to monitor the
distal position of the wire tip. These wires also
should not to be jailed because of the risk of wire
rupture during pullback.
17. DISSECTIONS
ChOICE Floppy
Asahi Soft .
The parallel wire technique can be recommended if a
dissection plane is entered with the first wire
Ochiai M, Ashida K, Araki H, Ogata N, Okabayashi
H, Obara C. The latest wire technique for chronic total
occlusion. Ital Heart J 2005;6:489-93..
18. CALCIFIED LESIONS
ChoICE Floppy (Boston Scientific).
If it fails to cross the lesion, the next step is to choose
floppy hydrophilic wire such as the ChoICE PT
Floppy (Boston Scientific) or Asahi Fielder (Abbott
Vascular)
34. PENETRATION FORCE
. The “penetration force” of a wire depends on both the
tip load and the cross-sectional area of the wire tip.
For wires of similar tip dimension, those with greater
tip load are stiffer and have greater penetration force
and pushability than ones with smaller tip load
For wires having similar tip load, those with a tapered
end have greater penetration force than ones with an
untapered end.
43. Lesion specific CTO approaches
DRILLING
(controlled)
“Workhorse technique”
Most CTOs with discrete
entry point after initial attempt
with soft (intermediate wires)
Stiff , hydrophobic
non-tapered wires
45. Lesion specific CTO approaches
Penetration
• Blunt entry point
• Heavily calcific or resistant lesions
•
Alternative to “drilling” as the
“work horse technique” after initial soft wire failure
Super stiff
tapered wires
46. Lesion specific CTO approaches
Penetration
Asahi Conquest (regular) and Pro
Cross It 400
Persuader 9 gm
Super stiff
tapered wires
59. purpose of the coating
To reduce frictions by facilitating the movement of the
wire within the coronary anatomy and across the
lesion, helping the wire negotiate tortuous anatomy,
— To improve deliverability by facilitating the
movement of interventional equipment over the wire.
60. types of coatings
Hydrophilic coatings attract water and are applied over
the entire working length of the wire, including tip
coils. When dry, the coating is a thin, non-slippery
solid. Upon contact with liquids, such as saline or
blood, the coating becomes a slippery gel-like surface
that acts to reduce friction with the vessel walls and
increase trackability. Hydrophilic coating provides a
lubricious, low friction feel inside the vessel and more
trackability.
61. Hydrophobic coatings are silicone based coatings
which repel water and are applied on the working
length of the wire, with the exception of the distal tip.
They require no activation by liquids to create a "waxlike" surface and to achieve the desired effect
— to reduce friction and increase trackability of the
wire. Silicone coating has higher friction, more stable
feel inside the vessel.
83. CTO Wires (Stiffer)
Non-coated /
Hydrophobic
TIP
Non-tapered Tapered
Miracle 3,4.5,6
Cross It 100 - 400
Hydrophilic
TIP
Non-tapered
Pilot 50,100,150
Tapered
Conquest Pro
84. Tapered
wires
Pros:
Minimizes tip resistance and
Select small vascular micro-channels within the CTO.
Cons
These needle like tips can also easily dissect and
perforate the vessel wall.
93. Lesion specific CTO approaches
DRILLING
(controlled)
“Workhorse technique”
Most CTOs with discrete
entry point after initial attempt
with soft (intermediate wires)
Stiff , hydrophobic
non-tapered wires
95. Lesion specific CTO approaches
Penetration
• Blunt entry point
• Heavily calcific or resistant lesions
•
Alternative to “drilling” as the
“work horse technique” after initial soft wire failure
Super stiff
tapered wires
96. Lesion specific CTO approaches
Penetration
Asahi Conquest (regular) and Pro
Cross It 400
Persuader 9 gm
Super stiff
tapered wires
97.
98.
99.
100.
101.
102.
103.
104. purpose of the coating
To reduce frictions by facilitating the movement of the
wire within the coronary anatomy and across the
lesion, helping the wire negotiate tortuous anatomy,
— To improve deliverability by facilitating the
movement of interventional equipment over the wire.
105. types of coatings
Hydrophilic coatings attract water and are applied over
the entire working length of the wire, including tip
coils. When dry, the coating is a thin, non-slippery
solid. Upon contact with liquids, such as saline or
blood, the coating becomes a slippery gel-like surface
that acts to reduce friction with the vessel walls and
increase trackability. Hydrophilic coating provides a
lubricious, low friction feel inside the vessel and more
trackability.
106. Hydrophobic coatings are silicone based coatings
which repel water and are applied on the working
length of the wire, with the exception of the distal tip.
They require no activation by liquids to create a "waxlike" surface and to achieve the desired effect
— to reduce friction and increase trackability of the
wire. Silicone coating has higher friction, more stable
feel inside the vessel.
107. ASAHI Soft
Tip load: 1.0 g
Radiopaque length: 3 cm
Outside diameter: 0.014"
Coating: Hydrophobic
Tip style: Core to tip
Polymer cover: none
108. PROPERTIES OF AN IDEAL
GUIDEWIRE
Several properties are desirable in an ideal
guidewire, but no single guidewire may possess all of
them. Guidewires must be chosen based on the
requirement of an individual case.
120. HI-TORQUE BALANCE
Tip load: 0.6 g
Radiopaque length: 3 or 40
cm
Outside diameter: 0.014"
Tip Outside diameter:
0.014"
Coating: Hydrophilic or phobic
Tip style: Shaping Ribbon
Polymer cover: none
Core Material:
ELASTINITE Nitinol
121.
122. Components of a
guidewire. There are
three main components
of guidewire structure:
core, distal tip and outer
covering. The design of
the guidewire tip: (A)
core-to-tip, (B) shaping
ribbon.
127. Coating
The coating is the outer covering on the core that
keeps the overall diameter consistent and
influences the wire performance.
Almost all wires have a proximal PTFE coating.
“True coating”
Distal tip – 30 cm
To reduce friction
To increase maneuverability
128.
129. Wire types – based on coating
– Hydrophilic coating
(ChoICE Floppy - Boston Scientific;
PT Graphix- Boston Scientific;
Asahi Fielder - Abbott Vascular)
– Hydrophobic coating
Asahi Soft - AbbottVascular
- Non-coated
130. Hydrophilic wires
Eg. Hydrotrack (Medtronic), M coat
(Terumo)
Hydrocoat (Pilot)
PROS
Offer good manoeuvrability in tortuous vessels.
CONS
More likely to penetrate beneath plaque and dissect
Hydrophilic wires also tend to select small branches or
vasavasorum and perforate more frequently.
131. Non-Coated / Hydrophobic wires
Pros
More controllable (and therefore less likely to dissect)
Provide better tactile feel
Cons
Poor trackability
Wire tip becomes stiffer, torque response
increases, but less tip resistance is transmitted to
the operator, making it easier to enter a false
channel.
132. purpose of the coating
To reduce frictions by facilitating the movement of the
wire within the coronary anatomy and across the
lesion, helping the wire negotiate tortuous anatomy,
— To improve deliverability by facilitating the
movement of interventional equipment over the wire.
133. types of coatings
Hydrophilic coatings attract water and are applied over
the entire working length of the wire, including tip
coils. When dry, the coating is a thin, non-slippery
solid. Upon contact with liquids, such as saline or
blood, the coating becomes a slippery gel-like surface
that acts to reduce friction with the vessel walls and
increase trackability. Hydrophilic coating provides a
lubricious, low friction feel inside the vessel and more
trackability.
134. Hydrophobic coatings are silicone based coatings
which repel water and are applied on the working
length of the wire, with the exception of the distal tip.
They require no activation by liquids to create a "waxlike" surface and to achieve the desired effect
— to reduce friction and increase trackability of the
wire. Silicone coating has higher friction, more stable
feel inside the vessel.
135. ASAHI Soft
Tip load: 1.0 g
Radiopaque length: 3 cm
Outside diameter: 0.014"
Coating: Hydrophobic
Tip style: Core to tip
Polymer cover: none
136. Workhorse Guidewires
ATW/ATW Marker
• Stabilizer
• BMW / BMW Universal
• Zinger
• Cougar XT
• Asahi Light / Medium
• Asahi Standard
• Asahi Prowater Flex
• Choice Floppy
• Luge
• IQ
• Forte Floppy
• Runthrough NS
• Galeo
137. PROPERTIES OF AN IDEAL
GUIDEWIRE
Several properties are desirable in an ideal
guidewire, but no single guidewire may possess all of
them. Guidewires must be chosen based on the
requirement of an individual case.
141. 1977
Blunt, closed-end,
Inner balloon catheter with a
short guide-wire attached to its tip
• Non-manoeuvrable catheter.
• Impossible to perform
independent movements of the
wire and balloon.
142. 1982
John B Simpson et al reported the
first experience with a new over-thewire balloon system.
Could be passed beyond the coronary
stenosis, providing a platform for the
subsequent delivery of the balloon catheter.
144. Wire tip
Wire tip – important component.
Decides the wire characteristics
CTO Wires
145. Radio-opaque tip
Visibility of the wire tip is provided by
radiopaque platinum coils that are usually
placed at the distal tip 2 to 3 cm in length, but
maybe much longer.
Galeo Wires – 3 cm distal radio-opaque tip.
BMW wire – 3 cm distal radio-opaque tip
146. Standard wire structure
0.014 inch diameter
Tapered tip to 0.009/0.010 in some
PTFE coating – whole length.
Tip – coated/non-coated
Tip has a radioopaque platinum coil.
151. How to select guide wires for
CTO?
Start with a Soft wire
Floppy wires
Hydrophilic floppy wire
Then go to harder (stiffer) wires
Tapered tip wires
Tapered and hydrophilic tip
Always exchange the stiff wire for a soft
wire once crossed
152.
153.
154.
155. Side branch at CTO
1. Hydrophilic wires
may not succeed.
2.Careful penetration
to enter the plaque.
156. KINETIX Guidewire.
Replaces conventional spring coil design,
to provide more efficient energy transfer
from physician hand to guide wire tip, for
turn-for-turn torque response.
157.
158.
159. Guide wires for PCI
Guidewire selection depends on the
patient, vessel and lesion characteristics.
Guide wire selection is crucial for a safe and
successful procedure.
164. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING
165. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING(tapered, untapered),
CORE MATERIAL
166. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING(tapered, untapered),
CORE MATERIAL(stainless steel, Nitinol, high-tensile
stainless steel),
DEVICE SUPPORT
167. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING(tapered, untapered),
CORE MATERIAL(stainless steel, Nitinol, high-tensile
stainless steel),
DEVICE SUPPORT
168. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING(tapered, untapered),
CORE MATERIAL(stainless steel, Nitinol, high-tensile
stainless steel),
DEVICE SUPPORT(light, moderate support, extra
support),
TARGET LESION
169. CATEGORISATION
TIP FLEXIBILITY(floppy/soft, intermediate, stiff),
TIP COATING(hydrophilic hydrophobic, No coating)
TIP STYLE(one-piece core-to-tip, two-piece core with
shaping ribbon),
TIP TAPERING(tapered, untapered),
CORE MATERIAL(stainless steel, Nitinol, high-tensile
stainless steel),
DEVICE SUPPORT(light, moderate support, extra
support),
TARGET LESION(workhorse/frontline wires, CTO
wires, wires for tortuous lesions,
173. Components of a
guidewire. There are
three main
components of
guidewire structure:
core, distal tip and
outer covering. The
design of the guidewire
tip: (A) core-to-tip, (B)
shaping ribbon.
174. Components of a guide wire
Core
Outer covering
Distal tip
175. The effect of different guide
wires on the trackability of
coronary stent
delivery systems
176. The effect of different guide
wires on the trackability of
coronary stent
friction properties and flexibility of the stent
delivery systems
system
constitution of the vessel
properties of the guide wire
177.
178. HI-TORQUE BALANCE
Tip load: 0.6 g
Radiopaque length: 3 or 40
cm
Outside diameter: 0.014"
Tip Outside diameter:
0.014"
Coating: Hydrophilic or phobic
Tip style: Shaping Ribbon
Polymer cover: none
Core Material: ELASTINITE
Nitinol
187. CTO Wires (Stiffer)
Non-coated /
Hydrophobic
TIP
Non-tapered Tapered
Miracle 3,4.5,6
Cross It 100 - 400
Hydrophilic
TIP
Non-tapered
Pilot 50,100,150
Tapered
Conquest Pro
188. Tapered wires
Pros:
Minimizes tip resistance and
Select small vascular micro-channels within the CTO.
Cons
These needle like tips can also easily dissect and perforate
the vessel wall.
196. Lesion specific CTO approaches
DRILLING
(controlled)
“Workhorse technique”
Most CTOs with discrete
entry point after initial attempt
with soft (intermediate wires)
Stiff , hydrophobic
non-tapered wires
198. Lesion specific CTO approaches
Penetration
• Blunt entry point
• Heavily calcific or resistant lesions
•
Alternative to “drilling” as the
“work horse technique” after initial soft wire failure
Super stiff
tapered wires
199. Lesion specific CTO approaches
Penetration
Asahi Conquest (regular) and Pro
Cross It 400
Persuader 9 gm
Super stiff
tapered wires