The document discusses several key issues affecting children globally including child poverty, material deprivation, and lack of opportunities that hinder children's development. It outlines vulnerabilities children face at different stages of life from in utero to adolescence. These include exposure to infections and malnutrition before birth, stunting during early childhood, lack of education access during school-age years, and few opportunities for youth. The life cycle approach is presented as a tool to assess multidimensional poverty across ages.