Conducting multi centre clinical trials presents both challenges and opportunities that significantly impact the advancement of medical research and patient care. This article explores the complex landscape of multi centre trials, highlighting the various hurdles faced by researchers and the potential benefits that can be harnessed. Challenges encompass diverse regulatory environments, logistical intricacies, and communication disparities across different sites. Harmonizing protocols, ensuring consistent data collection, and addressing ethical considerations emerge as critical obstacles. Despite these challenges, multi centre trials offer a range of opportunities, including enhanced diversity in patient populations, increased statistical power, and the potential for generalized findings. Collaborative efforts fostered through multi centre trials contribute to a broader understanding of interventions and therapies, ultimately shaping evidence based medical practices. By addressing challenges and capitalizing on opportunities, the medical research community can maximize the impact of multi centre clinical trials on patient outcomes and healthcare advancements. Deepika Thammineni | Manisha Shinde "Challenges and Opportunities in Conducting Multi-Centre Clinical Trials" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59799.pdf Paper Url:https://www.ijtsrd.com/other-scientific-research-area/other/59799/challenges-and-opportunities-in-conducting-multicentre-clinical-trials/deepika-thammineni
Clinical trials form the backbone of medical progress, yet enrolling participants presents a range of obstacles. Discover the key challenges researchers face, from eligibility criteria to trust issues, and learn how innovative strategies are revolutionizing the way we approach clinical trial enrollment. This blog delves into the heart of these challenges and proposes solutions to ensure that medical research continues to thrive for the benefit of all.
Clinical Enrollment challenges in clinical trialsprocth2
This document discusses the challenges of clinical trial enrollment and potential strategies to overcome them. It identifies 7 key challenges: lack of awareness/information, stringent eligibility criteria, geographic barriers, complex informed consent processes, mistrust in the medical system, patient burden, and communication barriers. The conclusion emphasizes that addressing all of these issues through comprehensive, patient-centered approaches can enhance recruitment and produce more robust trial results.
A Protocol For Retrospective Translational Science Case Studies Of Health Int...Allison Koehn
This document presents a protocol for conducting retrospective case studies of successful health interventions to better understand the translational research process. The protocol outlines guidelines for selecting cases, key elements to analyze, and methods/data sources. The goal is to systematically study the chain of events from basic discovery to implementation and impacts. By applying this common approach, researchers can generate comparable case studies and insights to inform the "science of translational science" through cross-case analysis. Understanding factors that enable or hinder translation may help speed the process and maximize research impacts.
Exploring the Use of Real-World Evidence in Health Technology Assessment (HTA)ClinosolIndia
Real-world evidence (RWE) refers to data obtained from real-world settings, such as electronic health records, claims databases, wearable devices, and patient registries. Health Technology Assessment (HTA) is a systematic evaluation of the clinical, economic, and social impacts of healthcare technologies. The use of real-world evidence in HTA is gaining traction as a valuable complement to traditional randomized controlled trials (RCTs) and can provide additional insights into the effectiveness, safety, and value of healthcare interventions. Here are some key points exploring the use of real-world evidence in HTA
Real world Evidence and Precision medicine bridging the gapClinosolIndia
Real-world evidence and precision medicine represent complementary forces reshaping the healthcare landscape. The synergy between these realms offers a pathway to more personalized, effective, and patient-centered care. As technology, data analytics, and collaborative initiatives advance, the integration of real-world evidence into precision medicine practices holds the promise of revolutionizing how healthcare is delivered, ensuring that treatments are not only scientifically sound but also tailored to the unique characteristics and experiences of individual patients.
Patient-Centric Clinical Trials: Empowering Participants and Enhancing Outcomes'ClinosolIndia
Patient-centric clinical trials prioritize the needs and perspectives of participants, aiming to empower them and enhance overall trial outcomes. By involving patients in the design, conduct, and evaluation of clinical trials, patient-centric approaches aim to improve recruitment and retention rates, increase patient engagement and satisfaction, and generate more meaningful and applicable results. Here are some key aspects of patient-centric clinical trials
Data Standards and Interoperability in Clinical Research and Data ManagementClinosolIndia
Data standards and interoperability play a crucial role in clinical research and data management. They ensure that data collected from various sources can be effectively shared, integrated, and analyzed across different systems and organizations. Here's an overview of data standards and interoperability in the context of clinical research and data management
Clinical trials form the backbone of medical progress, yet enrolling participants presents a range of obstacles. Discover the key challenges researchers face, from eligibility criteria to trust issues, and learn how innovative strategies are revolutionizing the way we approach clinical trial enrollment. This blog delves into the heart of these challenges and proposes solutions to ensure that medical research continues to thrive for the benefit of all.
Clinical Enrollment challenges in clinical trialsprocth2
This document discusses the challenges of clinical trial enrollment and potential strategies to overcome them. It identifies 7 key challenges: lack of awareness/information, stringent eligibility criteria, geographic barriers, complex informed consent processes, mistrust in the medical system, patient burden, and communication barriers. The conclusion emphasizes that addressing all of these issues through comprehensive, patient-centered approaches can enhance recruitment and produce more robust trial results.
A Protocol For Retrospective Translational Science Case Studies Of Health Int...Allison Koehn
This document presents a protocol for conducting retrospective case studies of successful health interventions to better understand the translational research process. The protocol outlines guidelines for selecting cases, key elements to analyze, and methods/data sources. The goal is to systematically study the chain of events from basic discovery to implementation and impacts. By applying this common approach, researchers can generate comparable case studies and insights to inform the "science of translational science" through cross-case analysis. Understanding factors that enable or hinder translation may help speed the process and maximize research impacts.
Exploring the Use of Real-World Evidence in Health Technology Assessment (HTA)ClinosolIndia
Real-world evidence (RWE) refers to data obtained from real-world settings, such as electronic health records, claims databases, wearable devices, and patient registries. Health Technology Assessment (HTA) is a systematic evaluation of the clinical, economic, and social impacts of healthcare technologies. The use of real-world evidence in HTA is gaining traction as a valuable complement to traditional randomized controlled trials (RCTs) and can provide additional insights into the effectiveness, safety, and value of healthcare interventions. Here are some key points exploring the use of real-world evidence in HTA
Real world Evidence and Precision medicine bridging the gapClinosolIndia
Real-world evidence and precision medicine represent complementary forces reshaping the healthcare landscape. The synergy between these realms offers a pathway to more personalized, effective, and patient-centered care. As technology, data analytics, and collaborative initiatives advance, the integration of real-world evidence into precision medicine practices holds the promise of revolutionizing how healthcare is delivered, ensuring that treatments are not only scientifically sound but also tailored to the unique characteristics and experiences of individual patients.
Patient-Centric Clinical Trials: Empowering Participants and Enhancing Outcomes'ClinosolIndia
Patient-centric clinical trials prioritize the needs and perspectives of participants, aiming to empower them and enhance overall trial outcomes. By involving patients in the design, conduct, and evaluation of clinical trials, patient-centric approaches aim to improve recruitment and retention rates, increase patient engagement and satisfaction, and generate more meaningful and applicable results. Here are some key aspects of patient-centric clinical trials
Data Standards and Interoperability in Clinical Research and Data ManagementClinosolIndia
Data standards and interoperability play a crucial role in clinical research and data management. They ensure that data collected from various sources can be effectively shared, integrated, and analyzed across different systems and organizations. Here's an overview of data standards and interoperability in the context of clinical research and data management
Listening to the Patient - Leveraging Direct-to-Patient Data Collection to Sh...John Reites
This document discusses how engaging patients directly through online surveys can provide valuable input to clinical trial design and improve the likelihood of study success.
In two case studies, patients provided feedback that (1) resulted in adjusting patient reported outcome survey cutoff scores, expanding the eligible patient pool ten-fold, and (2) encouraged investigators to approach patients about postmortem research by indicating they were comfortable discussing such issues. Direct engagement of over 250 patient assessments has supported development of study protocols, feasibility calculations, and recruitment plans. Involving patients early in the design process through digital technologies can help address recruitment challenges and optimize trials.
Scope and significance of evidence based research in nursing practice27 5-20Mallika Vhora
1) Evidence-based research in nursing is important to ensure quality patient care based on the best available research evidence. It has led to improved outcomes for patients, providers, and healthcare systems.
2) Future directions of evidence-based nursing research include conducting higher quality studies using various methodologies, synthesizing findings, translating research into practice, and examining outcomes. There will also be a focus on cultural competence and patient input.
3) Nurse researchers are likely to study health promotion, disease prevention, social determinants of health, evidence-based practice implementation, and vulnerable populations. Collaboration between nurses and researchers will expand to address fundamental healthcare issues.
Novel Approaches to Clinical Trial Design and Implementationijtsrd
This document discusses novel approaches to clinical trial design and implementation, including adaptive designs, Bayesian techniques, and master protocol designs (basket and umbrella designs).
Adaptive designs allow modifications to trials after initiation without compromising validity. Bayesian techniques incorporate prior data to improve precision. Master protocol designs evaluate multiple drugs/diseases within one trial structure (basket evaluates one drug in multiple diseases; umbrella evaluates multiple drugs in one disease).
The document outlines advantages like accelerated development and reduced costs, and disadvantages like complexity. Overall, novel approaches can make trials more efficient while maintaining scientific integrity.
College Writing II Synthesis Essay Assignment Summer Semester 2017.docxclarebernice
College Writing II Synthesis Essay Assignment Summer Semester 2017
Directions:
For this assignment you will be writing a synthesis essay. A synthesis is a combination of two or more summaries and sources. In a synthesis essay you will have three paragraphs, an introduction, a synthesis and a conclusion.
In the introduction you will give background information about your topic. You will also include a thesis statement at the end of the introduction paragraph. The thesis statement should describe the goal of your synthesis. (informative or argumentative)
The second paragraph is the synthesis. You will combine two summaries of two different articles on the same topic. You will follow all summary guidelines for these two paragraphs. The synthesis will most likely either argue or inform the reader about the topic.
The conclusion paragraph should summarize the points of your essay and restate the general ideas.
For this essay you will read two research articles on a similar topic to the previous critical review essay as you can use this research in your inquiry paper. You will summarize both articles in two paragraphs and combine the paragraphs for your synthesis. In the synthesis you must include the main ideas of the articles and the author, title, and general idea in the first sentences.
This essay will be three pages long and the first draft and peer review are due June 15. You must turn them in hardcopy in class so you can do a peer review.
Running head: THESIS DRAFT 1
THESIS DRAFT 3Thesis Draft
Katelyn B. Rhodes
D40375299
DeVry University
Point-of-Care Testing (PoCT) has dramatically taken over the field of clinical laboratory testing since it’s introduction approximately 45 years ago. The technologies utilized in PoCT have been refined to deliver accurate and expedient test results and will become even more sensitive and accurate in order to dominate the field of clinical laboratory testing. Furthermore, there will be a dramatic increase in the volume of clinical testing performed outside of the laboratory. New and emerging PoCT technologies utilize sophisticated molecular techniques such as polymerase chain reaction to aid in the treatment of major health problems worldwide, such as sexually transmitted infections (John & Price, 2014).
Historic Timeline
In the early-to-mid 1990’s, bench top analyzers entered the clinical laboratory scene. These analyzers were much smaller than the conventional analyzers being used, and utilized touch-screen PCs for ease of use. For this reason, they were able to be used closer to the patient’s bedside or outside of the laboratory environment. However, at this point in time, laboratory testing results were stored within the device and would have to then be sent to the main central laboratory for analysis.
Technology in the mid-to-late 1990’s permitted analyzers to be much smaller so that they may be easily carried to the patient’s location. Computers also became more ...
NASSCOM CoE IoT spearheaded a high-level industry roundtable to discuss firsthand the challenges & opportunities in India’s clinical trial industry and how technology can accelerate development
Personalized eProtocol Design A Data Driven Approach with AIijtsrd
This review explores the transformative potential of Artificial Intelligence AI in reshaping clinical trial methodologies, focusing on cardiovascular and oncological applications. Drawing insights from oncology, the article by C K, KW J, WW T 2019 delves into how AI could redefine clinical trials in cardiovascular medicine. Shifting the paradigm towards personalized medicine, the study highlights lessons learned and prospects for AI integration in cardiovascular research. The article by H, P S, A B, J H 2019 examines the role of AI in clinical trial design, emphasizing trends in pharmacological sciences. The review underscores the evolving landscape of AI applications, emphasizing its impact on optimizing trial design processes. Delso et al. 2021 present a comprehensive guide on designing AI driven clinical trials in Nuclear Medicine. The article addresses key considerations for implementing AI in this specialized field, offering insights into future directions and challenges. Dr. A. V. Padmaja | Anusha Vemulapally | Jampula Srikanth "Personalized eProtocol Design: A Data-Driven Approach with AI" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63456.pdf Paper Url: https://www.ijtsrd.com/pharmacy/other/63456/personalized-eprotocol-design-a-datadriven-approach-with-ai/dr-a-v-padmaja
Navigating the Ethical Landscape: Unraveling Ethical Issues in Clinical TrialsThe Lifesciences Magazine
Here are Unraveling Ethical Issues in Clinical Trials: 1. Informed Consent 2. Vulnerable Populations 3. Placebo Use 4. Randomization 5. Data Transparency
Lessons from the UK: Data access, patient trust & real-world impact with heal...Varsha Khodiyar
HDR UK is facilitating health data access in the UK for researchers through The Innovation Gateway. This allows researchers to discover and access de-identified health data from various custodians. HDR UK has emphasized transparency and patient/public involvement. During the COVID-19 pandemic, HDR UK coordinated data-driven research efforts and accelerated data access to support priority studies. This included enabling a clinical trial to more rapidly recruit participants using daily COVID test results. HDR UK is also laying the foundations for an international health data alliance to support open COVID-19 research globally.
Clinical trials are necessary for medical research. Producing new medicines to the market depends on the strength of research organizations and drug companies to test and verify their work vigorously through their Clinical Trials, but finding people willing to participate is notoriously tricky.
This document summarizes a presentation about the Patient Centered Outcomes Research Institute (PCORI) and its methods. It discusses how PCORI funds research to help patients make informed healthcare decisions by producing high-quality evidence. Key points include that PCORI research must be patient-centered, compare at least two alternatives, and use outcomes that matter to patients. It also outlines PCORI's research portfolio, methodology standards, and application review process.
Virtual clinical trials revolutionize traditional research methods by employing digital technologies for remote participant engagement, data collection, and monitoring. By utilizing wearable devices, telemedicine platforms, and mobile apps, these trials streamline processes, enabling participants to contribute real-time data from anywhere, increasing diversity and convenience.
https://www.rootsanalysis.com/reports/virtual-clinical-trial-service-provides-market.html
The Changing Landscape of Clinical Research Regulations: Updates and Implicat...ClinosolIndia
The landscape of clinical research regulations is constantly evolving to adapt to the changing needs of the research community, advancements in scientific understanding, and the protection of research participants. Here are some key updates and implications that have shaped the current state of clinical research regulations
Chapter 7. The Evidence for Evidence-Based Practice Implem.docxspoonerneddy
Chapter 7. The Evidence for Evidence-Based Practice
Implementation
Marita G. Titler
Background
Overview of Evidence-Based Practice
Evidence-based health care practices are available for a number of conditions such as asthma,
heart failure, and diabetes. However, these practices are not always implemented in care
delivery, and variation in practices abound.1–4 Traditionally, patient safety research has focused
on data analyses to identify patient safety issues and to demonstrate that a new practice will lead
to improved quality and patient safety.5 Much less research attention has been paid to how to
implement practices. Yet, only by putting into practice what is learned from research will care be
made safer.5 Implementing evidence-based safety practices are difficult and need strategies that
address the complexity of systems of care, individual practitioners, senior leadership, and—
ultimately—changing health care cultures to be evidence-based safety practice environments.5
Nursing has a rich history of using research in practice, pioneered by Florence Nightingale.6–
9 Although during the early and mid-1900s, few nurses contributed to this foundation initiated
by Nightingale,10 the nursing profession has more recently provided major leadership for
improving care through application of research findings in practice.11
Evidence-based practice (EBP) is the conscientious and judicious use of current best
evidence in conjunction with clinical expertise and patient values to guide health care
decisions.12–15 Best evidence includes empirical evidence from randomized controlled trials;
evidence from other scientific methods such as descriptive and qualitative research; as well as
use of information from case reports, scientific principles, and expert opinion. When enough
research evidence is available, the practice should be guided by research evidence in conjunction
with clinical expertise and patient values. In some cases, however, a sufficient research base may
not be available, and health care decisionmaking is derived principally from nonresearch
evidence sources such as expert opinion and scientific principles.16 As more research is done in a
specific area, the research evidence must be incorporated into the EBP.15
Models of Evidence-Based Practice
Multiple models of EBP are available and have been used in a variety of clinical settings.16–36
Although review of these models is beyond the scope of this chapter, common elements of these
models are selecting a practice topic (e.g., discharge instructions for individuals with heart
failure), critique and syntheses of evidence, implementation, evaluation of the impact on patient
care and provider performance, and consideration of the context/setting in which the practice is
implemented.15, 17 The learning that occurs during the process of translating research into
practice is valuable information to capture and feed back into the process, so that.
Chapter 7. The Evidence for Evidence-Based Practice Implem.docxmccormicknadine86
Chapter 7. The Evidence for Evidence-Based Practice
Implementation
Marita G. Titler
Background
Overview of Evidence-Based Practice
Evidence-based health care practices are available for a number of conditions such as asthma,
heart failure, and diabetes. However, these practices are not always implemented in care
delivery, and variation in practices abound.1–4 Traditionally, patient safety research has focused
on data analyses to identify patient safety issues and to demonstrate that a new practice will lead
to improved quality and patient safety.5 Much less research attention has been paid to how to
implement practices. Yet, only by putting into practice what is learned from research will care be
made safer.5 Implementing evidence-based safety practices are difficult and need strategies that
address the complexity of systems of care, individual practitioners, senior leadership, and—
ultimately—changing health care cultures to be evidence-based safety practice environments.5
Nursing has a rich history of using research in practice, pioneered by Florence Nightingale.6–
9 Although during the early and mid-1900s, few nurses contributed to this foundation initiated
by Nightingale,10 the nursing profession has more recently provided major leadership for
improving care through application of research findings in practice.11
Evidence-based practice (EBP) is the conscientious and judicious use of current best
evidence in conjunction with clinical expertise and patient values to guide health care
decisions.12–15 Best evidence includes empirical evidence from randomized controlled trials;
evidence from other scientific methods such as descriptive and qualitative research; as well as
use of information from case reports, scientific principles, and expert opinion. When enough
research evidence is available, the practice should be guided by research evidence in conjunction
with clinical expertise and patient values. In some cases, however, a sufficient research base may
not be available, and health care decisionmaking is derived principally from nonresearch
evidence sources such as expert opinion and scientific principles.16 As more research is done in a
specific area, the research evidence must be incorporated into the EBP.15
Models of Evidence-Based Practice
Multiple models of EBP are available and have been used in a variety of clinical settings.16–36
Although review of these models is beyond the scope of this chapter, common elements of these
models are selecting a practice topic (e.g., discharge instructions for individuals with heart
failure), critique and syntheses of evidence, implementation, evaluation of the impact on patient
care and provider performance, and consideration of the context/setting in which the practice is
implemented.15, 17 The learning that occurs during the process of translating research into
practice is valuable information to capture and feed back into the process, so that ...
This document presents a systematic review of 254 publications that used data-driven methods to determine "de facto" patient care pathways from electronic health records and administrative data. The majority (217) derived pathways from administrative or clinical data. Most (173) applied additional analytical techniques, and many (131) combined pathways with other data for insights. The review found that these methods can provide useful empirical information for healthcare planning, management, and practice, though the topic is still emerging. Limitations include the broad scope limiting discussion of methodological issues.
This document discusses clinical pathways and their relationship to clinical guidelines and personalized medicine. It provides definitions of clinical pathways and guidelines, and outlines some key components that clinical pathways should include, such as being detailed, evidence-based, and transparent in their development. The document notes concerns that some pathways developed by payers may overly emphasize cost control and limit treatment options, which could conflict with personalized medicine. It argues pathways should be led by providers and allow flexibility for clinical judgment rather than a "cookie cutter" approach.
Physicians' use of clinical practice guidelines (CPGs) remains insufficient despite dissemination efforts. This study examined factors affecting CPG use among resident physicians in Japan. A survey of 535 residents at 61 hospitals found that a physician's habitual CPG use, CPG-related education, and the combination of an individual's digital preference and a hospital's superior IT infrastructure were associated with more frequent CPG use. Specifically, physicians who received CPG education worked at hospitals with better IT systems and access to databases. Their CPG use was also more likely to involve electronic resources. The study aims to identify effective strategies for promoting CPG implementation by clarifying how individual and organizational factors interact.
Physicians' use of clinical practice guidelines (CPGs) remains insufficient despite dissemination efforts. This study examined factors affecting CPG use among resident physicians in Japan. A survey of 535 residents at 61 hospitals found that a physician's habitual CPG use, CPG-related education, and the combination of an individual's digital preference and a hospital's superior IT infrastructure were associated with more frequent CPG use. Specifically, physicians who received CPG education worked at hospitals with better IT systems and access to databases. Their CPG use was also more likely to involve electronic resources. Having a habit of using CPGs for patient care strongly predicted their frequent use. Improving physicians' behaviors, education, and the interface of individual
Challenges in Implementing Innovations in Midwifery Practice An Overviewijtsrd
Midwifery Nursing and women’s health emphasize the caring of women who are in need of care in their reproductive life as well nurturing in the journey from the womb to the beautiful world. As a midwife, she would be a great specialist to care the women from menarche to menopause. On other aspect, this branch of nursing provides optimum and comprehensive care in prenatal, natal and postpartum for the mothers and to get their newborns healthy and charming. Innovations, research findings are many, in this era. Unfortunately, in the health care system in a challenging facet to implement these innovative practices in midwifery. We the midwives to think innovatively to implement the findings and research evidences as a style of quality care to the woman and child. Mrs. Jasmi Manu "Challenges in Implementing Innovations in Midwifery Practice: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35698.pdf Paper Url: https://www.ijtsrd.com/medicine/nursing/35698/challenges-in-implementing-innovations-in-midwifery-practice-an-overview/mrs-jasmi-manu
Current Trends in Clinical Trial Design and Execution ClinosolIndia
Adaptive Trial Designs: Adaptive trials allow for modifications to key aspects of a trial while it is ongoing, such as sample size, treatment arms, or endpoints. This flexibility can help optimize resources, reduce costs, and improve the efficiency of clinical trials.
Real-world Evidence (RWE): There is an increasing interest in incorporating real-world data and evidence into clinical trial design. RWE involves the use of data collected outside of traditional clinical trials, such as electronic health records, patient registries, and claims databases, to generate insights on treatment effectiveness, safety, and patient outcomes.
Patient-Centric Trials: There is a growing emphasis on patient-centricity in clinical trial design. This includes involving patients in trial planning, considering patient preferences, and incorporating patient-reported outcomes as endpoints. Patient-centric trials aim to improve patient recruitment, retention, and overall trial experience.
Virtual and Decentralized Trials: The COVID-19 pandemic has accelerated the adoption of virtual and decentralized trial approaches. These trials leverage digital technologies, remote monitoring, telemedicine, and home-based visits to reduce the need for frequent site visits and increase patient accessibility, particularly for those who may face geographical or mobility barriers.
Precision Medicine and Biomarker-Based Trials: Advances in genomics and molecular biology have led to an increased focus on precision medicine and biomarker-based trials. These trials aim to identify patient subgroups that are more likely to respond to specific treatments based on their genetic or biomarker profiles, allowing for more targeted and personalized approaches to therapy.
Data Analytics and Artificial Intelligence (AI): The use of data analytics and AI in clinical trial design and execution is gaining momentum. These technologies can help identify patterns, predict outcomes, optimize trial protocols, and streamline data collection and analysis processes, leading to more efficient and informed decision-making.
Collaborative and Platform Trials: Collaborative and platform trials involve partnerships between multiple stakeholders, including academia, industry, patient advocacy groups, and regulatory agencies. These trials aim to streamline trial operations, facilitate data sharing, and enable a more efficient evaluation of multiple interventions or treatment combinations simultaneously.
Risk-Based Monitoring: Traditional on-site monitoring of all trial sites can be resource-intensive. Risk-based monitoring focuses resources on higher-risk areas and uses a combination of centralized monitoring, statistical algorithms, and targeted on-site visits to ensure data quality and patient safety while optimizing resource utilization.
Regulatory Innovations: Regulatory agencies are increasingly exploring innovative approaches to support more efficient and accelerated clinical trials.
‘Six Sigma Technique’ A Journey Through its Implementationijtsrd
The manufacturing industries all over the world are facing tough challenges for growth, development and sustainability in today’s competitive environment. They have to achieve apex position by adapting with the global competitive environment by delivering goods and services at low cost, prime quality and better price to increase wealth and consumer satisfaction. Cost Management ensures profit, growth and sustainability of the business with implementation of Continuous Improvement Technique like Six Sigma. This leads to optimize Business performance. The method drives for customer satisfaction, low variation, reduction in waste and cycle time resulting into a competitive advantage over other industries which did not implement it. The main objective of this paper ‘Six Sigma Technique A Journey Through Its Implementation’ is to conceptualize the effectiveness of Six Sigma Technique through the journey of its implementation. Aditi Sunilkumar Ghosalkar "‘Six Sigma Technique’: A Journey Through its Implementation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64546.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64546/‘six-sigma-technique’-a-journey-through-its-implementation/aditi-sunilkumar-ghosalkar
Edge Computing in Space Enhancing Data Processing and Communication for Space...ijtsrd
Edge computing, a paradigm that involves processing data closer to its source, has gained significant attention for its potential to revolutionize data processing and communication in space missions. With the increasing complexity and data volume generated by modern space missions, traditional centralized computing approaches face challenges related to latency, bandwidth, and security. Edge computing in space, involving on board processing and analysis of data, offers promising solutions to these challenges. This paper explores the concept of edge computing in space, its benefits, applications, and future prospects in enhancing space missions. Manish Verma "Edge Computing in Space: Enhancing Data Processing and Communication for Space Missions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64541.pdf Paper Url: https://www.ijtsrd.com/computer-science/artificial-intelligence/64541/edge-computing-in-space-enhancing-data-processing-and-communication-for-space-missions/manish-verma
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Listening to the Patient - Leveraging Direct-to-Patient Data Collection to Sh...John Reites
This document discusses how engaging patients directly through online surveys can provide valuable input to clinical trial design and improve the likelihood of study success.
In two case studies, patients provided feedback that (1) resulted in adjusting patient reported outcome survey cutoff scores, expanding the eligible patient pool ten-fold, and (2) encouraged investigators to approach patients about postmortem research by indicating they were comfortable discussing such issues. Direct engagement of over 250 patient assessments has supported development of study protocols, feasibility calculations, and recruitment plans. Involving patients early in the design process through digital technologies can help address recruitment challenges and optimize trials.
Scope and significance of evidence based research in nursing practice27 5-20Mallika Vhora
1) Evidence-based research in nursing is important to ensure quality patient care based on the best available research evidence. It has led to improved outcomes for patients, providers, and healthcare systems.
2) Future directions of evidence-based nursing research include conducting higher quality studies using various methodologies, synthesizing findings, translating research into practice, and examining outcomes. There will also be a focus on cultural competence and patient input.
3) Nurse researchers are likely to study health promotion, disease prevention, social determinants of health, evidence-based practice implementation, and vulnerable populations. Collaboration between nurses and researchers will expand to address fundamental healthcare issues.
Novel Approaches to Clinical Trial Design and Implementationijtsrd
This document discusses novel approaches to clinical trial design and implementation, including adaptive designs, Bayesian techniques, and master protocol designs (basket and umbrella designs).
Adaptive designs allow modifications to trials after initiation without compromising validity. Bayesian techniques incorporate prior data to improve precision. Master protocol designs evaluate multiple drugs/diseases within one trial structure (basket evaluates one drug in multiple diseases; umbrella evaluates multiple drugs in one disease).
The document outlines advantages like accelerated development and reduced costs, and disadvantages like complexity. Overall, novel approaches can make trials more efficient while maintaining scientific integrity.
College Writing II Synthesis Essay Assignment Summer Semester 2017.docxclarebernice
College Writing II Synthesis Essay Assignment Summer Semester 2017
Directions:
For this assignment you will be writing a synthesis essay. A synthesis is a combination of two or more summaries and sources. In a synthesis essay you will have three paragraphs, an introduction, a synthesis and a conclusion.
In the introduction you will give background information about your topic. You will also include a thesis statement at the end of the introduction paragraph. The thesis statement should describe the goal of your synthesis. (informative or argumentative)
The second paragraph is the synthesis. You will combine two summaries of two different articles on the same topic. You will follow all summary guidelines for these two paragraphs. The synthesis will most likely either argue or inform the reader about the topic.
The conclusion paragraph should summarize the points of your essay and restate the general ideas.
For this essay you will read two research articles on a similar topic to the previous critical review essay as you can use this research in your inquiry paper. You will summarize both articles in two paragraphs and combine the paragraphs for your synthesis. In the synthesis you must include the main ideas of the articles and the author, title, and general idea in the first sentences.
This essay will be three pages long and the first draft and peer review are due June 15. You must turn them in hardcopy in class so you can do a peer review.
Running head: THESIS DRAFT 1
THESIS DRAFT 3Thesis Draft
Katelyn B. Rhodes
D40375299
DeVry University
Point-of-Care Testing (PoCT) has dramatically taken over the field of clinical laboratory testing since it’s introduction approximately 45 years ago. The technologies utilized in PoCT have been refined to deliver accurate and expedient test results and will become even more sensitive and accurate in order to dominate the field of clinical laboratory testing. Furthermore, there will be a dramatic increase in the volume of clinical testing performed outside of the laboratory. New and emerging PoCT technologies utilize sophisticated molecular techniques such as polymerase chain reaction to aid in the treatment of major health problems worldwide, such as sexually transmitted infections (John & Price, 2014).
Historic Timeline
In the early-to-mid 1990’s, bench top analyzers entered the clinical laboratory scene. These analyzers were much smaller than the conventional analyzers being used, and utilized touch-screen PCs for ease of use. For this reason, they were able to be used closer to the patient’s bedside or outside of the laboratory environment. However, at this point in time, laboratory testing results were stored within the device and would have to then be sent to the main central laboratory for analysis.
Technology in the mid-to-late 1990’s permitted analyzers to be much smaller so that they may be easily carried to the patient’s location. Computers also became more ...
NASSCOM CoE IoT spearheaded a high-level industry roundtable to discuss firsthand the challenges & opportunities in India’s clinical trial industry and how technology can accelerate development
Personalized eProtocol Design A Data Driven Approach with AIijtsrd
This review explores the transformative potential of Artificial Intelligence AI in reshaping clinical trial methodologies, focusing on cardiovascular and oncological applications. Drawing insights from oncology, the article by C K, KW J, WW T 2019 delves into how AI could redefine clinical trials in cardiovascular medicine. Shifting the paradigm towards personalized medicine, the study highlights lessons learned and prospects for AI integration in cardiovascular research. The article by H, P S, A B, J H 2019 examines the role of AI in clinical trial design, emphasizing trends in pharmacological sciences. The review underscores the evolving landscape of AI applications, emphasizing its impact on optimizing trial design processes. Delso et al. 2021 present a comprehensive guide on designing AI driven clinical trials in Nuclear Medicine. The article addresses key considerations for implementing AI in this specialized field, offering insights into future directions and challenges. Dr. A. V. Padmaja | Anusha Vemulapally | Jampula Srikanth "Personalized eProtocol Design: A Data-Driven Approach with AI" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63456.pdf Paper Url: https://www.ijtsrd.com/pharmacy/other/63456/personalized-eprotocol-design-a-datadriven-approach-with-ai/dr-a-v-padmaja
Navigating the Ethical Landscape: Unraveling Ethical Issues in Clinical TrialsThe Lifesciences Magazine
Here are Unraveling Ethical Issues in Clinical Trials: 1. Informed Consent 2. Vulnerable Populations 3. Placebo Use 4. Randomization 5. Data Transparency
Lessons from the UK: Data access, patient trust & real-world impact with heal...Varsha Khodiyar
HDR UK is facilitating health data access in the UK for researchers through The Innovation Gateway. This allows researchers to discover and access de-identified health data from various custodians. HDR UK has emphasized transparency and patient/public involvement. During the COVID-19 pandemic, HDR UK coordinated data-driven research efforts and accelerated data access to support priority studies. This included enabling a clinical trial to more rapidly recruit participants using daily COVID test results. HDR UK is also laying the foundations for an international health data alliance to support open COVID-19 research globally.
Clinical trials are necessary for medical research. Producing new medicines to the market depends on the strength of research organizations and drug companies to test and verify their work vigorously through their Clinical Trials, but finding people willing to participate is notoriously tricky.
This document summarizes a presentation about the Patient Centered Outcomes Research Institute (PCORI) and its methods. It discusses how PCORI funds research to help patients make informed healthcare decisions by producing high-quality evidence. Key points include that PCORI research must be patient-centered, compare at least two alternatives, and use outcomes that matter to patients. It also outlines PCORI's research portfolio, methodology standards, and application review process.
Virtual clinical trials revolutionize traditional research methods by employing digital technologies for remote participant engagement, data collection, and monitoring. By utilizing wearable devices, telemedicine platforms, and mobile apps, these trials streamline processes, enabling participants to contribute real-time data from anywhere, increasing diversity and convenience.
https://www.rootsanalysis.com/reports/virtual-clinical-trial-service-provides-market.html
The Changing Landscape of Clinical Research Regulations: Updates and Implicat...ClinosolIndia
The landscape of clinical research regulations is constantly evolving to adapt to the changing needs of the research community, advancements in scientific understanding, and the protection of research participants. Here are some key updates and implications that have shaped the current state of clinical research regulations
Chapter 7. The Evidence for Evidence-Based Practice Implem.docxspoonerneddy
Chapter 7. The Evidence for Evidence-Based Practice
Implementation
Marita G. Titler
Background
Overview of Evidence-Based Practice
Evidence-based health care practices are available for a number of conditions such as asthma,
heart failure, and diabetes. However, these practices are not always implemented in care
delivery, and variation in practices abound.1–4 Traditionally, patient safety research has focused
on data analyses to identify patient safety issues and to demonstrate that a new practice will lead
to improved quality and patient safety.5 Much less research attention has been paid to how to
implement practices. Yet, only by putting into practice what is learned from research will care be
made safer.5 Implementing evidence-based safety practices are difficult and need strategies that
address the complexity of systems of care, individual practitioners, senior leadership, and—
ultimately—changing health care cultures to be evidence-based safety practice environments.5
Nursing has a rich history of using research in practice, pioneered by Florence Nightingale.6–
9 Although during the early and mid-1900s, few nurses contributed to this foundation initiated
by Nightingale,10 the nursing profession has more recently provided major leadership for
improving care through application of research findings in practice.11
Evidence-based practice (EBP) is the conscientious and judicious use of current best
evidence in conjunction with clinical expertise and patient values to guide health care
decisions.12–15 Best evidence includes empirical evidence from randomized controlled trials;
evidence from other scientific methods such as descriptive and qualitative research; as well as
use of information from case reports, scientific principles, and expert opinion. When enough
research evidence is available, the practice should be guided by research evidence in conjunction
with clinical expertise and patient values. In some cases, however, a sufficient research base may
not be available, and health care decisionmaking is derived principally from nonresearch
evidence sources such as expert opinion and scientific principles.16 As more research is done in a
specific area, the research evidence must be incorporated into the EBP.15
Models of Evidence-Based Practice
Multiple models of EBP are available and have been used in a variety of clinical settings.16–36
Although review of these models is beyond the scope of this chapter, common elements of these
models are selecting a practice topic (e.g., discharge instructions for individuals with heart
failure), critique and syntheses of evidence, implementation, evaluation of the impact on patient
care and provider performance, and consideration of the context/setting in which the practice is
implemented.15, 17 The learning that occurs during the process of translating research into
practice is valuable information to capture and feed back into the process, so that.
Chapter 7. The Evidence for Evidence-Based Practice Implem.docxmccormicknadine86
Chapter 7. The Evidence for Evidence-Based Practice
Implementation
Marita G. Titler
Background
Overview of Evidence-Based Practice
Evidence-based health care practices are available for a number of conditions such as asthma,
heart failure, and diabetes. However, these practices are not always implemented in care
delivery, and variation in practices abound.1–4 Traditionally, patient safety research has focused
on data analyses to identify patient safety issues and to demonstrate that a new practice will lead
to improved quality and patient safety.5 Much less research attention has been paid to how to
implement practices. Yet, only by putting into practice what is learned from research will care be
made safer.5 Implementing evidence-based safety practices are difficult and need strategies that
address the complexity of systems of care, individual practitioners, senior leadership, and—
ultimately—changing health care cultures to be evidence-based safety practice environments.5
Nursing has a rich history of using research in practice, pioneered by Florence Nightingale.6–
9 Although during the early and mid-1900s, few nurses contributed to this foundation initiated
by Nightingale,10 the nursing profession has more recently provided major leadership for
improving care through application of research findings in practice.11
Evidence-based practice (EBP) is the conscientious and judicious use of current best
evidence in conjunction with clinical expertise and patient values to guide health care
decisions.12–15 Best evidence includes empirical evidence from randomized controlled trials;
evidence from other scientific methods such as descriptive and qualitative research; as well as
use of information from case reports, scientific principles, and expert opinion. When enough
research evidence is available, the practice should be guided by research evidence in conjunction
with clinical expertise and patient values. In some cases, however, a sufficient research base may
not be available, and health care decisionmaking is derived principally from nonresearch
evidence sources such as expert opinion and scientific principles.16 As more research is done in a
specific area, the research evidence must be incorporated into the EBP.15
Models of Evidence-Based Practice
Multiple models of EBP are available and have been used in a variety of clinical settings.16–36
Although review of these models is beyond the scope of this chapter, common elements of these
models are selecting a practice topic (e.g., discharge instructions for individuals with heart
failure), critique and syntheses of evidence, implementation, evaluation of the impact on patient
care and provider performance, and consideration of the context/setting in which the practice is
implemented.15, 17 The learning that occurs during the process of translating research into
practice is valuable information to capture and feed back into the process, so that ...
This document presents a systematic review of 254 publications that used data-driven methods to determine "de facto" patient care pathways from electronic health records and administrative data. The majority (217) derived pathways from administrative or clinical data. Most (173) applied additional analytical techniques, and many (131) combined pathways with other data for insights. The review found that these methods can provide useful empirical information for healthcare planning, management, and practice, though the topic is still emerging. Limitations include the broad scope limiting discussion of methodological issues.
This document discusses clinical pathways and their relationship to clinical guidelines and personalized medicine. It provides definitions of clinical pathways and guidelines, and outlines some key components that clinical pathways should include, such as being detailed, evidence-based, and transparent in their development. The document notes concerns that some pathways developed by payers may overly emphasize cost control and limit treatment options, which could conflict with personalized medicine. It argues pathways should be led by providers and allow flexibility for clinical judgment rather than a "cookie cutter" approach.
Physicians' use of clinical practice guidelines (CPGs) remains insufficient despite dissemination efforts. This study examined factors affecting CPG use among resident physicians in Japan. A survey of 535 residents at 61 hospitals found that a physician's habitual CPG use, CPG-related education, and the combination of an individual's digital preference and a hospital's superior IT infrastructure were associated with more frequent CPG use. Specifically, physicians who received CPG education worked at hospitals with better IT systems and access to databases. Their CPG use was also more likely to involve electronic resources. The study aims to identify effective strategies for promoting CPG implementation by clarifying how individual and organizational factors interact.
Physicians' use of clinical practice guidelines (CPGs) remains insufficient despite dissemination efforts. This study examined factors affecting CPG use among resident physicians in Japan. A survey of 535 residents at 61 hospitals found that a physician's habitual CPG use, CPG-related education, and the combination of an individual's digital preference and a hospital's superior IT infrastructure were associated with more frequent CPG use. Specifically, physicians who received CPG education worked at hospitals with better IT systems and access to databases. Their CPG use was also more likely to involve electronic resources. Having a habit of using CPGs for patient care strongly predicted their frequent use. Improving physicians' behaviors, education, and the interface of individual
Challenges in Implementing Innovations in Midwifery Practice An Overviewijtsrd
Midwifery Nursing and women’s health emphasize the caring of women who are in need of care in their reproductive life as well nurturing in the journey from the womb to the beautiful world. As a midwife, she would be a great specialist to care the women from menarche to menopause. On other aspect, this branch of nursing provides optimum and comprehensive care in prenatal, natal and postpartum for the mothers and to get their newborns healthy and charming. Innovations, research findings are many, in this era. Unfortunately, in the health care system in a challenging facet to implement these innovative practices in midwifery. We the midwives to think innovatively to implement the findings and research evidences as a style of quality care to the woman and child. Mrs. Jasmi Manu "Challenges in Implementing Innovations in Midwifery Practice: An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd35698.pdf Paper Url: https://www.ijtsrd.com/medicine/nursing/35698/challenges-in-implementing-innovations-in-midwifery-practice-an-overview/mrs-jasmi-manu
Current Trends in Clinical Trial Design and Execution ClinosolIndia
Adaptive Trial Designs: Adaptive trials allow for modifications to key aspects of a trial while it is ongoing, such as sample size, treatment arms, or endpoints. This flexibility can help optimize resources, reduce costs, and improve the efficiency of clinical trials.
Real-world Evidence (RWE): There is an increasing interest in incorporating real-world data and evidence into clinical trial design. RWE involves the use of data collected outside of traditional clinical trials, such as electronic health records, patient registries, and claims databases, to generate insights on treatment effectiveness, safety, and patient outcomes.
Patient-Centric Trials: There is a growing emphasis on patient-centricity in clinical trial design. This includes involving patients in trial planning, considering patient preferences, and incorporating patient-reported outcomes as endpoints. Patient-centric trials aim to improve patient recruitment, retention, and overall trial experience.
Virtual and Decentralized Trials: The COVID-19 pandemic has accelerated the adoption of virtual and decentralized trial approaches. These trials leverage digital technologies, remote monitoring, telemedicine, and home-based visits to reduce the need for frequent site visits and increase patient accessibility, particularly for those who may face geographical or mobility barriers.
Precision Medicine and Biomarker-Based Trials: Advances in genomics and molecular biology have led to an increased focus on precision medicine and biomarker-based trials. These trials aim to identify patient subgroups that are more likely to respond to specific treatments based on their genetic or biomarker profiles, allowing for more targeted and personalized approaches to therapy.
Data Analytics and Artificial Intelligence (AI): The use of data analytics and AI in clinical trial design and execution is gaining momentum. These technologies can help identify patterns, predict outcomes, optimize trial protocols, and streamline data collection and analysis processes, leading to more efficient and informed decision-making.
Collaborative and Platform Trials: Collaborative and platform trials involve partnerships between multiple stakeholders, including academia, industry, patient advocacy groups, and regulatory agencies. These trials aim to streamline trial operations, facilitate data sharing, and enable a more efficient evaluation of multiple interventions or treatment combinations simultaneously.
Risk-Based Monitoring: Traditional on-site monitoring of all trial sites can be resource-intensive. Risk-based monitoring focuses resources on higher-risk areas and uses a combination of centralized monitoring, statistical algorithms, and targeted on-site visits to ensure data quality and patient safety while optimizing resource utilization.
Regulatory Innovations: Regulatory agencies are increasingly exploring innovative approaches to support more efficient and accelerated clinical trials.
Similar to Challenges and Opportunities in Conducting Multi Centre Clinical Trials (20)
‘Six Sigma Technique’ A Journey Through its Implementationijtsrd
The manufacturing industries all over the world are facing tough challenges for growth, development and sustainability in today’s competitive environment. They have to achieve apex position by adapting with the global competitive environment by delivering goods and services at low cost, prime quality and better price to increase wealth and consumer satisfaction. Cost Management ensures profit, growth and sustainability of the business with implementation of Continuous Improvement Technique like Six Sigma. This leads to optimize Business performance. The method drives for customer satisfaction, low variation, reduction in waste and cycle time resulting into a competitive advantage over other industries which did not implement it. The main objective of this paper ‘Six Sigma Technique A Journey Through Its Implementation’ is to conceptualize the effectiveness of Six Sigma Technique through the journey of its implementation. Aditi Sunilkumar Ghosalkar "‘Six Sigma Technique’: A Journey Through its Implementation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64546.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64546/‘six-sigma-technique’-a-journey-through-its-implementation/aditi-sunilkumar-ghosalkar
Edge Computing in Space Enhancing Data Processing and Communication for Space...ijtsrd
Edge computing, a paradigm that involves processing data closer to its source, has gained significant attention for its potential to revolutionize data processing and communication in space missions. With the increasing complexity and data volume generated by modern space missions, traditional centralized computing approaches face challenges related to latency, bandwidth, and security. Edge computing in space, involving on board processing and analysis of data, offers promising solutions to these challenges. This paper explores the concept of edge computing in space, its benefits, applications, and future prospects in enhancing space missions. Manish Verma "Edge Computing in Space: Enhancing Data Processing and Communication for Space Missions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64541.pdf Paper Url: https://www.ijtsrd.com/computer-science/artificial-intelligence/64541/edge-computing-in-space-enhancing-data-processing-and-communication-for-space-missions/manish-verma
Dynamics of Communal Politics in 21st Century India Challenges and Prospectsijtsrd
Communal politics in India has evolved through centuries, weaving a complex tapestry shaped by historical legacies, colonial influences, and contemporary socio political transformations. This research comprehensively examines the dynamics of communal politics in 21st century India, emphasizing its historical roots, socio political dynamics, economic implications, challenges, and prospects for mitigation. The historical perspective unravels the intricate interplay of religious identities and power dynamics from ancient civilizations to the impact of colonial rule, providing insights into the evolution of communalism. The socio political dynamics section delves into the contemporary manifestations, exploring the roles of identity politics, socio economic disparities, and globalization. The economic implications section highlights how communal politics intersects with economic issues, perpetuating disparities and influencing resource allocation. Challenges posed by communal politics are scrutinized, revealing multifaceted issues ranging from social fragmentation to threats against democratic values. The prospects for mitigation present a multifaceted approach, incorporating policy interventions, community engagement, and educational initiatives. The paper conducts a comparative analysis with international examples, identifying common patterns such as identity politics and economic disparities. It also examines unique challenges, emphasizing Indias diverse religious landscape, historical legacy, and secular framework. Lessons for effective strategies are drawn from international experiences, offering insights into inclusive policies, interfaith dialogue, media regulation, and global cooperation. By scrutinizing historical epochs, contemporary dynamics, economic implications, and international comparisons, this research provides a comprehensive understanding of communal politics in India. The proposed strategies for mitigation underscore the importance of a holistic approach to foster social harmony, inclusivity, and democratic values. Rose Hossain "Dynamics of Communal Politics in 21st Century India: Challenges and Prospects" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64528.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/history/64528/dynamics-of-communal-politics-in-21st-century-india-challenges-and-prospects/rose-hossain
Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in...ijtsrd
Background and Objective Telehealth has become a well known tool for the delivery of health care in Saudi Arabia, and the perspective and knowledge of healthcare providers are influential in the implementation, adoption and advancement of the method. This systematic review was conducted to examine the current literature base regarding telehealth and the related healthcare professional perspective and knowledge in the Kingdom of Saudi Arabia. Materials and Methods This systematic review was conducted by searching 7 databases including, MEDLINE, CINHAL, Web of Science, Scopus, PubMed, PsycINFO, and ProQuest Central. Studies on healthcare practitioners telehealth knowledge and perspectives published in English in Saudi Arabia from 2000 to 2023 were included. Boland directed this comprehensive review. The researchers examined each connected study using the AXIS tool, which evaluates cross sectional systematic reviews. Narrative synthesis was used to summarise and convey the data. Results Out of 1840 search results, 10 studies were included. Positive outlook and limited knowledge among providers were seen across trials. Healthcare professionals like telehealth for its ability to improve quality, access, and delivery, save time and money, and be successful. Age, gender, occupation, and work experience also affect health workers knowledge. In Saudi Arabia, healthcare professionals face inadequate expert assistance, patient privacy, internet connection concerns, lack of training courses, lack of telehealth understanding, and high costs while performing telemedicine. Conclusions Healthcare practitioners telehealth perceptions and knowledge were examined in this systematic study. Its collection of concerned experts different personal attitudes and expertise would help enhance telehealths implementation in Saudi Arabia, develop its healthcare delivery alternative, and eliminate frequent problems. Badriah Mousa I Mulayhi | Dr. Jomin George | Judy Jenkins "Assess Perspective and Knowledge of Healthcare Providers Towards Elehealth in Saudi Arabia: A Systematic Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64535.pdf Paper Url: https://www.ijtsrd.com/medicine/other/64535/assess-perspective-and-knowledge-of-healthcare-providers-towards-elehealth-in-saudi-arabia-a-systematic-review/badriah-mousa-i-mulayhi
The Impact of Digital Media on the Decentralization of Power and the Erosion ...ijtsrd
The impact of digital media on the distribution of power and the weakening of traditional gatekeepers has gained considerable attention in recent years. The adoption of digital technologies and the internet has resulted in declining influence and power for traditional gatekeepers such as publishing houses and news organizations. Simultaneously, digital media has facilitated the emergence of new voices and players in the media industry. Digital medias impact on power decentralization and gatekeeper erosion is visible in several ways. One significant aspect is the democratization of information, which enables anyone with an internet connection to publish and share content globally, leading to citizen journalism and bypassing traditional gatekeepers. Another aspect is the disruption of conventional media industry business models, as traditional organizations struggle to adjust to the decrease in advertising revenue and the rise of digital platforms. Alternative business models, such as subscription models and crowdfunding, have become more prevalent, leading to the emergence of new players. Overall, the impact of digital media on the distribution of power and the weakening of traditional gatekeepers has brought about significant changes in the media landscape and the way information is shared. Further research is required to fully comprehend the implications of these changes and their impact on society. Dr. Kusum Lata "The Impact of Digital Media on the Decentralization of Power and the Erosion of Traditional Gatekeepers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64544.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64544/the-impact-of-digital-media-on-the-decentralization-of-power-and-the-erosion-of-traditional-gatekeepers/dr-kusum-lata
Online Voices, Offline Impact Ambedkars Ideals and Socio Political Inclusion ...ijtsrd
This research investigates the nexus between online discussions on Dr. B.R. Ambedkars ideals and their impact on social inclusion among college students in Gurugram, Haryana. Surveying 240 students from 12 government colleges, findings indicate that 65 actively engage in online discussions, with 80 demonstrating moderate to high awareness of Ambedkars ideals. Statistically significant correlations reveal that higher online engagement correlates with increased awareness p 0.05 and perceived social inclusion. Variations across colleges and a notable effect of college type on perceived social inclusion highlight the influence of contextual factors. Furthermore, the intersectional analysis underscores nuanced differences based on gender, caste, and socio economic status. Dr. Kusum Lata "Online Voices, Offline Impact: Ambedkar's Ideals and Socio-Political Inclusion - A Study of Gurugram District" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64543.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/political-science/64543/online-voices-offline-impact-ambedkars-ideals-and-sociopolitical-inclusion--a-study-of-gurugram-district/dr-kusum-lata
Problems and Challenges of Agro Entreprenurship A Studyijtsrd
Noting calls for contextualizing Agro entrepreneurs problems and challenges of the agro entrepreneurs and for greater attention to the Role of entrepreneurs in agro entrepreneurship research, we conduct a systematic literature review of extent research in agriculture entrepreneurship to overcome the study objectives of complications of agro entrepreneurs through various factors, Development of agriculture products is a key factor for the overall economic growth of agro entrepreneurs Agro Entrepreneurs produces firsthand large scale employment, utilizes the labor and natural resources, This research outlines the problems of Weather and Soil Erosions, Market price fluctuation, stimulates labor cost problems, reduces concentration of Price volatility, Dependency on Intermediaries, induces Limited Bargaining Power, and Storage and Transportation Costs. This paper mainly devoted to highlight Problems and challenges faced for the sustainable of Agro Entrepreneurs in India. Vinay Prasad B "Problems and Challenges of Agro Entreprenurship - A Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64540.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64540/problems-and-challenges-of-agro-entreprenurship--a-study/vinay-prasad-b
Comparative Analysis of Total Corporate Disclosure of Selected IT Companies o...ijtsrd
Disclosure is a process through which a business enterprise communicates with external parties. A corporate disclosure is communication of financial and non financial information of the activities of a business enterprise to the interested entities. Corporate disclosure is done through publishing annual reports. So corporate disclosure through annual reports plays a vital role in the life of all the companies and provides valuable information to investors. The basic objectives of corporate disclosure is to give a true and fair view of companies to the parties related either directly or indirectly like owner, government, creditors, shareholders etc. in the companies act, provisions have been made about mandatory and voluntary disclosure. The IT sector in India is rapidly growing, the trend to invest in the IT sector is rising and employment opportunities in IT sectors are also increasing. Therefore the IT sector is expected to have fair, full and adequate disclosure of all information. Unfair and incomplete disclosure may adversely affect the entire economy. A research study on disclosure practices of IT companies could play an important role in this regard. Hence, the present research study has been done to study and review comparative analysis of total corporate disclosure of selected IT companies of India and to put forward overall findings and suggestions with a view to increase disclosure score of these companies. The researcher hopes that the present research study will be helpful to all selected Companies for improving level of corporate disclosure through annual reports as well as the government, creditors, investors, all business organizations and upcoming researcher for comparative analyses of level of corporate disclosure with special reference to selected IT companies. Dr. Vaibhavi D. Thaker "Comparative Analysis of Total Corporate Disclosure of Selected IT Companies of India" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64539.pdf Paper Url: https://www.ijtsrd.com/other-scientific-research-area/other/64539/comparative-analysis-of-total-corporate-disclosure-of-selected-it-companies-of-india/dr-vaibhavi-d-thaker
The Impact of Educational Background and Professional Training on Human Right...ijtsrd
This study investigated the impact of educational background and professional training on human rights awareness among secondary school teachers in the Marathwada region of Maharashtra, India. The key findings reveal that higher levels of education, particularly a master’s degree, and fields of study related to education, humanities, or social sciences are associated with greater human rights awareness among teachers. Additionally, both pre service teacher training and in service professional development programs focused on human rights education significantly enhance teacher’s knowledge, skills, and competencies in promoting human rights principles in their classrooms. Baig Ameer Bee Mirza Abdul Aziz | Dr. Syed Azaz Ali Amjad Ali "The Impact of Educational Background and Professional Training on Human Rights Awareness among Secondary School Teachers" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64529.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64529/the-impact-of-educational-background-and-professional-training-on-human-rights-awareness-among-secondary-school-teachers/baig-ameer-bee-mirza-abdul-aziz
A Study on the Effective Teaching Learning Process in English Curriculum at t...ijtsrd
“One Language sets you in a corridor for life. Two languages open every door along the way” Frank Smith English as a foreign language or as a second language has been ruling in India since the period of Lord Macaulay. But the question is how much we teach or learn English properly in our culture. Is there any scope to use English as a language rather than a subject How much we learn or teach English without any interference of mother language specially in the classroom teaching learning scenario in West Bengal By considering all these issues the researcher has attempted in this article to focus on the effective teaching learning process comparing to other traditional strategies in the field of English curriculum at the secondary level to investigate whether they fulfill the present teaching learning requirements or not by examining the validity of the present curriculum of English. The purpose of this study is to focus on the effectiveness of the systematic, scientific, sequential and logical transaction of the course between the teachers and the learners in the perspective of the 5Es programme that is engage, explore, explain, extend and evaluate. Sanchali Mondal | Santinath Sarkar "A Study on the Effective Teaching Learning Process in English Curriculum at the Secondary Level of West Bengal" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd62412.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/62412/a-study-on-the-effective-teaching-learning-process-in-english-curriculum-at-the-secondary-level-of-west-bengal/sanchali-mondal
The Role of Mentoring and Its Influence on the Effectiveness of the Teaching ...ijtsrd
This paper reports on a study which was conducted to investigate the role of mentoring and its influence on the effectiveness of the teaching of Physics in secondary schools in the South West Region of Cameroon. The study adopted the convergent parallel mixed methods design, focusing on respondents in secondary schools in the South West Region of Cameroon. Both quantitative and qualitative data were collected, analysed separately, and the results were compared to see if the findings confirm or disconfirm each other. The quantitative analysis found that majority of the respondents 72 of Physics teachers affirmed that they had more experienced colleagues as mentors to help build their confidence, improve their teaching, and help them improve their effectiveness and efficiency in guiding learners’ achievements. Only 28 of the respondents disagreed with these statements. With majority respondents 72 agreeing with the statements, it implies that in most secondary schools, experienced Physics teachers act as mentors to build teachers’ confidence in teaching and improving students’ learning. The interview qualitative data analysis summarized how secondary school Principals use meetings with mentors and mentees to promote mentorship in the school milieu. This has helped strengthen teachers’ classroom practices in secondary schools in the South West Region of Cameroon. With the results confirming each other, the study recommends that mentoring should focus on helping teachers employ social interactions and instructional practices feedback and clarity in teaching that have direct measurable impact on students’ learning achievements. Andrew Ngeim Sumba | Frederick Ebot Ashu | Peter Agborbechem Tambi "The Role of Mentoring and Its Influence on the Effectiveness of the Teaching of Physics in Secondary Schools in the South West Region of Cameroon" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64524.pdf Paper Url: https://www.ijtsrd.com/management/management-development/64524/the-role-of-mentoring-and-its-influence-on-the-effectiveness-of-the-teaching-of-physics-in-secondary-schools-in-the-south-west-region-of-cameroon/andrew-ngeim-sumba
Design Simulation and Hardware Construction of an Arduino Microcontroller Bas...ijtsrd
This study primarily focuses on the design of a high side buck converter using an Arduino microcontroller. The converter is specifically intended for use in DC DC applications, particularly in standalone solar PV systems where the PV output voltage exceeds the load or battery voltage. To evaluate the performance of the converter, simulation experiments are conducted using Proteus Software. These simulations provide insights into the input and output voltages, currents, powers, and efficiency under different state of charge SoC conditions of a 12V,70Ah rechargeable lead acid battery. Additionally, the hardware design of the converter is implemented, and practical data is collected through operation, monitoring, and recording. By comparing the simulation results with the practical results, the efficiency and performance of the designed converter are assessed. The findings indicate that while the buck converter is suitable for practical use in standalone PV systems, its efficiency is compromised due to a lower output current. Chan Myae Aung | Dr. Ei Mon "Design Simulation and Hardware Construction of an Arduino-Microcontroller Based DC-DC High-Side Buck Converter for Standalone PV System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64518.pdf Paper Url: https://www.ijtsrd.com/engineering/mechanical-engineering/64518/design-simulation-and-hardware-construction-of-an-arduinomicrocontroller-based-dcdc-highside-buck-converter-for-standalone-pv-system/chan-myae-aung
Sustainable Energy by Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadikuijtsrd
Energy becomes sustainable if it meets the needs of the present without compromising the ability of future generations to meet their own needs. Some of the definitions of sustainable energy include the considerations of environmental aspects such as greenhouse gas emissions, social, and economic aspects such as energy poverty. Generally far more sustainable than fossil fuel are renewable energy sources such as wind, hydroelectric power, solar, and geothermal energy sources. Worthy of note is that some renewable energy projects, like the clearing of forests to produce biofuels, can cause severe environmental damage. The sustainability of nuclear power which is a low carbon source is highly debated because of concerns about radioactive waste, nuclear proliferation, and accidents. The switching from coal to natural gas has environmental benefits, including a lower climate impact, but could lead to delay in switching to more sustainable options. “Carbon capture and storage” can be built into power plants to remove the carbon dioxide CO2 emissions, but this technology is expensive and has rarely been implemented. Leading non renewable energy sources around the world is fossil fuels, coal, petroleum, and natural gas. Nuclear energy is usually considered another non renewable energy source, although nuclear energy itself is a renewable energy source, but the material used in nuclear power plants is not. The paper addresses the issue of sustainable energy, its attendant benefits to the future generation, and humanity in general. Paul A. Adekunte | Matthew N. O. Sadiku | Janet O. Sadiku "Sustainable Energy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64534.pdf Paper Url: https://www.ijtsrd.com/engineering/electrical-engineering/64534/sustainable-energy/paul-a-adekunte
Concepts for Sudan Survey Act Implementations Executive Regulations and Stand...ijtsrd
This paper aims to outline the executive regulations, survey standards, and specifications required for the implementation of the Sudan Survey Act, and for regulating and organizing all surveying work activities in Sudan. The act has been discussed for more than 5 years. The Land Survey Act was initiated by the Sudan Survey Authority and all official legislations were headed by the Sudan Ministry of Justice till it was issued in 2022. The paper presents conceptual guidelines to be used for the Survey Act implementation and to regulate the survey work practice, standardizing the field surveys, processing, quality control, procedures, and the processes related to survey work carried out by the stakeholders and relevant authorities in Sudan. The conceptual guidelines are meant to improve the quality and harmonization of geospatial data and to aid decision making processes as well as geospatial information systems. The established comprehensive executive regulations will govern and regulate the implementation of the Sudan Survey Geomatics Act in all surveying and mapping practices undertaken by the Sudan Survey Authority SSA and state local survey departments for public or private sector organizations. The targeted standards and specifications include the reference frame, projection, coordinate systems, and the guidelines and specifications that must be followed in the field of survey work, processes, and mapping products. In the last few decades, there has been a growing awareness of the importance of geomatics activities and measurements on the Earths surface in space and time, together with observing and mapping the changes. In such cases, data must be captured promptly, standardized, and obtained with more accuracy and specified in much detail. The paper will also highlight the current situation in Sudan, the degree to which survey standards are used, the problems encountered, and the errors that arise from not using the standards and survey specifications. Kamal A. A. Sami "Concepts for Sudan Survey Act Implementations - Executive Regulations and Standards" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63484.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63484/concepts-for-sudan-survey-act-implementations--executive-regulations-and-standards/kamal-a-a-sami
Towards the Implementation of the Sudan Interpolated Geoid Model Khartoum Sta...ijtsrd
The discussions between ellipsoid and geoid have invoked many researchers during the recent decades, especially during the GNSS technology era, which had witnessed a great deal of development but still geoid undulation requires more investigations. To figure out a solution for Sudans local geoid, this research has tried to intake the possibility of determining the geoid model by following two approaches, gravimetric and geometrical geoid model determination, by making use of GNSS leveling benchmarks at Khartoum state. The Benchmarks are well distributed in the study area, in which, the horizontal coordinates and the height above the ellipsoid have been observed by GNSS while orthometric heights were carried out using precise leveling. The Global Geopotential Model GGM represented in EGM2008 has been exploited to figure out the geoid undulation at the benchmarks in the study area. This is followed by a fitting process, that has been done to suit the geoid undulation data which has been computed using GNSS leveling data and geoid undulation inspired by the EGM2008. Two geoid surfaces were created after the fitting process to ensure that they are identical and both of them could be counted for getting the same geoid undulation with an acceptable accuracy. In this respect, statistical operation played an important role in ensuring the consistency and integrity of the model by applying cross validation techniques splitting the data into training and testing datasets for building the geoid model and testing its eligibility. The geometrical solution for geoid undulation computation has been utilized by applying straightforward equations that facilitate the calculation of the geoid undulation directly through applying statistical techniques for the GNSS leveling data of the study area to get the common equation parameters values that could be utilized to calculate geoid undulation of any position in the study area within the claimed accuracy. Both systems were checked and proved eligible to be used within the study area with acceptable accuracy which may contribute to solving the geoid undulation problem in the Khartoum area, and be further generalized to determine the geoid model over the entire country, and this could be considered in the future, for regional and continental geoid model. Ahmed M. A. Mohammed. | Kamal A. A. Sami "Towards the Implementation of the Sudan Interpolated Geoid Model (Khartoum State Case Study)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63483.pdf Paper Url: https://www.ijtsrd.com/engineering/civil-engineering/63483/towards-the-implementation-of-the-sudan-interpolated-geoid-model-khartoum-state-case-study/ahmed-m-a-mohammed
Activating Geospatial Information for Sudans Sustainable Investment Mapijtsrd
Sudan is witnessing an acceleration in the processes of development and transformation in the performance of government institutions to raise the productivity and investment efficiency of the government sector. The development plans and investment opportunities have focused on achieving national goals in various sectors. This paper aims to illuminate the path to the future and provide geospatial data and information to develop the investment climate and environment for all sized businesses, and to bridge the development gap between the Sudan states. The Sudan Survey Authority SSA is the main advisor to the Sudan Government in conducting surveying, mappings, designing, and developing systems related to geospatial data and information. In recent years, SSA made a strategic partnership with the Ministry of Investment to activate Geospatial Information for Sudans Sustainable Investment and in particular, for the preparation and implementation of the Sudan investment map, based on the directives and objectives of the Ministry of Investment MI in Sudan. This paper comes within the framework of activating the efforts of the Ministry of Investment to develop technical investment services by applying techniques adopted by the Ministry and its strategic partners for advancing investment processes in the country. Kamal A. A. Sami "Activating Geospatial Information for Sudan's Sustainable Investment Map" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63482.pdf Paper Url: https://www.ijtsrd.com/engineering/information-technology/63482/activating-geospatial-information-for-sudans-sustainable-investment-map/kamal-a-a-sami
Educational Unity Embracing Diversity for a Stronger Societyijtsrd
In a rapidly changing global landscape, the importance of education as a unifying force cannot be overstated. This paper explores the crucial role of educational unity in fostering a stronger and more inclusive society through the embrace of diversity. By examining the benefits of diverse learning environments, the paper aims to highlight the positive impact on societal strength. The discussion encompasses various dimensions, from curriculum design to classroom dynamics, and emphasizes the need for educational institutions to become catalysts for unity in diversity. It highlights the need for a paradigm shift in educational policies, curricula, and pedagogical approaches to ensure that they are reflective of the diverse fabric of society. This paper also addresses the challenges associated with implementing inclusive educational practices and offers practical strategies for overcoming barriers. It advocates for collaborative efforts between educational institutions, policymakers, and communities to create a supportive ecosystem that promotes diversity and unity. Mr. Amit Adhikari | Madhumita Teli | Gopal Adhikari "Educational Unity: Embracing Diversity for a Stronger Society" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64525.pdf Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/education/64525/educational-unity-embracing-diversity-for-a-stronger-society/mr-amit-adhikari
Integration of Indian Indigenous Knowledge System in Management Prospects and...ijtsrd
The diversity of indigenous knowledge systems in India is vast and can vary significantly between different communities and regions. Preserving and respecting these knowledge systems is crucial for maintaining cultural heritage, promoting sustainable practices, and fostering cross cultural understanding. In this paper, an overview of the prospects and challenges associated with incorporating Indian indigenous knowledge into management is explored. It is found that IIKS helps in management in many areas like sustainable development, tourism, food security, natural resource management, cultural preservation and innovation, etc. However, IIKS integration with management faces some challenges in the form of a lack of documentation, cultural sensitivity, language barriers legal framework, etc. Savita Lathwal "Integration of Indian Indigenous Knowledge System in Management: Prospects and Challenges" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63500.pdf Paper Url: https://www.ijtsrd.com/management/accounting-and-finance/63500/integration-of-indian-indigenous-knowledge-system-in-management-prospects-and-challenges/savita-lathwal
DeepMask Transforming Face Mask Identification for Better Pandemic Control in...ijtsrd
The COVID 19 pandemic has highlighted the crucial need of preventive measures, with widespread use of face masks being a key method for slowing the viruss spread. This research investigates face mask identification using deep learning as a technological solution to be reducing the risk of coronavirus transmission. The proposed method uses state of the art convolutional neural networks CNNs and transfer learning to automatically recognize persons who are not wearing masks in a variety of circumstances. We discuss how this strategy improves public health and safety by providing an efficient manner of enforcing mask wearing standards. The report also discusses the obstacles, ethical concerns, and prospective applications of face mask detection systems in the ongoing fight against the pandemic. Dilip Kumar Sharma | Aaditya Yadav "DeepMask: Transforming Face Mask Identification for Better Pandemic Control in the COVID-19 Era" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd64522.pdf Paper Url: https://www.ijtsrd.com/engineering/electronics-and-communication-engineering/64522/deepmask-transforming-face-mask-identification-for-better-pandemic-control-in-the-covid19-era/dilip-kumar-sharma
Streamlining Data Collection eCRF Design and Machine Learningijtsrd
Efficient and accurate data collection is paramount in clinical trials, and the design of Electronic Case Report Forms eCRFs plays a pivotal role in streamlining this process. This paper explores the integration of machine learning techniques in the design and implementation of eCRFs to enhance data collection efficiency. We delve into the synergies between eCRF design principles and machine learning algorithms, aiming to optimize data quality, reduce errors, and expedite the overall data collection process. The application of machine learning in eCRF design brings forth innovative approaches to data validation, anomaly detection, and real time adaptability. This paper discusses the benefits, challenges, and future prospects of leveraging machine learning in eCRF design for streamlined and advanced data collection in clinical trials. Dhanalakshmi D | Vijaya Lakshmi Kannareddy "Streamlining Data Collection: eCRF Design and Machine Learning" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-8 | Issue-1 , February 2024, URL: https://www.ijtsrd.com/papers/ijtsrd63515.pdf Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/63515/streamlining-data-collection-ecrf-design-and-machine-learning/dhanalakshmi-d
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.
Temple of Asclepius in Thrace. Excavation resultsKrassimira Luka
The temple and the sanctuary around were dedicated to Asklepios Zmidrenus. This name has been known since 1875 when an inscription dedicated to him was discovered in Rome. The inscription is dated in 227 AD and was left by soldiers originating from the city of Philippopolis (modern Plovdiv).
This document provides an overview of wound healing, its functions, stages, mechanisms, factors affecting it, and complications.
A wound is a break in the integrity of the skin or tissues, which may be associated with disruption of the structure and function.
Healing is the body’s response to injury in an attempt to restore normal structure and functions.
Healing can occur in two ways: Regeneration and Repair
There are 4 phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This document also describes the mechanism of wound healing. Factors that affect healing include infection, uncontrolled diabetes, poor nutrition, age, anemia, the presence of foreign bodies, etc.
Complications of wound healing like infection, hyperpigmentation of scar, contractures, and keloid formation.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
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meticulous planning to ensure that participants'
information remains secure and compliant with local
regulations.[2]
Logistical and operational challenges also loom large
in the realm of multi-centre clinical trials.
Coordinating activities, procedures, and data
collection among various sites demands robust
communication channels and standardized protocols.
Ensuring uniformity in the administration of
interventions and the collection of data is paramount
to maintaining the integrity of trial outcomes. This
often requires comprehensive training of site
personnel and continuous monitoring to identify and
address any deviations from the study protocol.
Additionally, the geographical dispersion of trial sites
can lead to delays in data sharing, hindering real-time
insights and decision-making.[2]
Quality control and monitoring present further
hurdles in multi-centre trials. Ensuring consistent data
collection and management practices across different
locations is essential to generate reliable and
comparable results. However, variations in data
collection methods, data entry errors, and
discrepancies in assessing endpoints can compromise
data quality. Implementing robust monitoring systems
that include on-site visits and remote monitoring is
crucial to detect and rectify issues promptly.
Moreover, differences in healthcare practices and
local customs can introduce confounding variables,
impacting the consistency of treatment administration
and patient assessment.[1,2]
Cultural and socioeconomic factors also exert a
significant influence on the success of multi-centre
clinical trials. Healthcare practices, patient
preferences, and perceptions of medical research can
vary widely across different regions and
communities. Language barriers, cultural norms, and
beliefs about research participation can affect the
willingness of individuals to enroll in trials.
Moreover, socioeconomic disparities can create
inequalities in trial participation, potentially limiting
the diversity of the study population and raising
concerns about the generalizability of results.
Despite these challenges, strategies and solutions
have emerged to mitigate the complexities associated
with multi-centre clinical trials. Regulatory
harmonization initiatives, such as the guidelines set
forth by the International Conference on
Harmonisation (ICH), aim to align regulatory
requirements across countries. Centralized protocol
management, electronic data capture systems, and
real-time monitoring technologies have streamlined
trial operations and enhanced data quality. Training
programs that emphasize protocol adherence and
cross-cultural sensitivity have been pivotal in
ensuring consistent and ethical conduct across diverse
settings.[3]
Benefits of Multi-Centre Clinical Trials
Multi-centre clinical trials offer a multitude of
benefits that make them a vital and impactful
approach in the realm of medical research. These
trials, conducted across multiple medical institutions
and involving diverse patient populations, provide
unique advantages that contribute to the advancement
of scientific knowledge and the improvement of
patient care. Some of the key benefits of multi-centre
clinical trials include:
1. Enhanced Generalizability:
Multi-centre trials encompass a broader spectrum of
participants from different geographic locations,
socioeconomic backgrounds, and healthcare settings.
This diversity enhances the generalizability of the
trial results, allowing researchers to draw conclusions
that are more applicable to real-world patient
populations. The findings from multi-centre trials are
better poised to reflect the variability present in actual
clinical practice.
2. Diverse Patient Populations:
By involving multiple sites, multi-centre trials have
the opportunity to enroll participants with a wide
range of demographic characteristics, disease
severities, and genetic profiles. This diversity ensures
that the trial results are not biased towards a specific
group and can be extrapolated to a broader patient
population.
3. Access to Specialized Expertise:
Different medical institutions often have unique areas
of expertise, specialized facilities, and experienced
clinicians. Multi-centre trials allow researchers to tap
into these resources, enhancing the quality of the trial
and the depth of understanding of the interventions
being studied. This can be especially valuable for
complex interventions or rare diseases.
4. Accelerated Recruitment and Enrollment:
Participant recruitment is a critical and often time-
consuming aspect of clinical trials. With multiple
sites enrolling participants simultaneously, multi-
centre trials can achieve quicker recruitment, leading
to faster trial completion and potentially earlier
availability of results. This is particularly
advantageous in time-sensitive research areas.
5. Comprehensive Data Collection:
Multi-centre trials facilitate the collection of a wide
range of data points, which can lead to more robust
and comprehensive insights. The diversity of data
collected across different sites can enrich the
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understanding of treatment effects, adverse events,
and patient responses.
6. Reduced Bias and Heterogeneity:
In single-centre trials, the findings might be
influenced by site-specific factors or patient
characteristics. Multi-centre trials mitigate this risk by
distributing participants across various locations,
reducing the impact of any single site's idiosyncrasies
on the overall results.
7. Validation of Results:
Replicating study findings across multiple sites adds
an extra layer of validation to the research outcomes.
Consistent results across diverse settings lend greater
credibility to the conclusions drawn from the trial.
8. Collaboration and Networking:
Multi-centre trials foster collaboration among
researchers, clinicians, and institutions. This
collaboration can lead to the exchange of ideas, best
practices, and innovative approaches, enriching the
overall research environment and potentially yielding
insights that wouldn't have been possible in a single-
centre setting.
9. Evaluation of Health Disparities:
Multi-centre trials can shed light on healthcare
disparities and variations in treatment effects across
different regions or populations. This insight is
valuable for tailoring interventions and healthcare
policies to address specific needs and inequities.
10. Regulatory Acceptance:
Regulators and health agencies often recognize the
importance of multi-centre trials in generating robust
evidence for medical interventions. Results from
well-designed and well-executed multi-centre trials
can carry greater weight in the regulatory decision-
making process.[4,5]
Challenges in Multi-Centre Clinical Trials
Conducting multi-centre clinical trials, while offering
a wealth of advantages, is not without its share of
challenges. These trials involve collaboration among
multiple sites, often located in different regions or
even countries, and this geographical dispersion
introduces a range of complexities that require careful
consideration and strategic planning.
Administrative and Regulatory Hurdles: One of the
foremost challenges in multi-centre clinical trials lies
in navigating the maze of administrative and
regulatory requirements. Regulatory agencies and
ethics committees may have varying interpretations of
guidelines and standards, leading to delays in
approvals. Each site might need to adhere to different
reporting and documentation procedures, adding to
the administrative burden. Harmonizing these
processes across sites is crucial to ensure a smooth
trial initiation and execution.
Logistical and Operational Complexities:
Coordinating activities across multiple sites demands
impeccable logistical planning and communication.
Standardizing procedures, training site personnel, and
ensuring consistent data collection methods are
essential for maintaining the integrity of the trial.
Differences in healthcare practices, patient
management protocols, and data recording systems
across sites can introduce variability, requiring
vigilant oversight to guarantee data accuracy and
comparability.
Quality Control and Monitoring: Monitoring the
trial's progress and ensuring adherence to the study
protocol is more intricate in multi-centre trials.
Quality control mechanisms must be established to
identify and rectify inconsistencies or deviations
promptly. Centralized monitoring systems and regular
site visits can help mitigate these challenges, but they
come with their own resource and coordination
demands.
Cultural and Socioeconomic Factors: Cultural
diversity across sites can have profound implications
for trial conduct and participant engagement.
Language barriers, varying healthcare beliefs, and
patient attitudes towards research participation can
impact the recruitment process and even affect patient
compliance. Tailoring trial materials and
communication strategies to address cultural nuances
becomes imperative to ensure equal representation
and ethical treatment of participants.
Data Management and Communication: Data
management becomes complex when dealing with
multiple sites using diverse data collection systems.
Ensuring data integrity and security while facilitating
efficient data sharing among sites is a logistical
challenge. The risk of data discrepancies or loss
necessitates robust strategies for data collection,
storage, and transmission.
Socioeconomic Disparities and Access to Care:
Multi-centre trials often involve sites situated in
disparate socioeconomic environments. This can lead
to disparities in healthcare infrastructure, resources,
and patient populations. Ensuring equitable access to
interventions and consistent care standards across
sites is essential to maintain the ethical conduct of the
trial.
Budgetary Constraints: Multi-centre trials can be
financially demanding due to the need for multiple
site setups, personnel training, and monitoring.
Allocating resources effectively across sites while
adhering to budgetary constraints requires careful
planning and negotiation with various stakeholders.
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Communication and Collaboration: Effective
communication and collaboration among sites are
pivotal for the success of multi-centre trials. Ensuring
that all sites are aligned with the study objectives,
protocols, and procedures is a continuous effort.
Communication breakdowns can lead to
misinterpretations, delays, or even compromised trial
integrity.[6]
Strategies and Solutions
Conducting multi-center clinical trials involves
addressing various challenges while capitalizing on
the opportunities they offer. Communication and
coordination among different sites are essential for
success. Establishing a dedicated project management
team can facilitate regular communication and ensure
all sites remain informed about the trial's progress.
Virtual meetings and project management software
can be valuable tools for maintaining real-time
communication and tracking milestones. To ensure
consistency in data collection and procedures, a
Manual of Procedures (MOP) can be developed. This
comprehensive document outlines standardized
protocols, assessments, and data collection methods.
Regular training workshops can familiarize site
personnel with the MOP, ensuring consistent
implementation across all participating sites.
Navigating regulatory compliance can be complex
due to varying institutional requirements and approval
processes. Appointing a regulatory expert who liaises
with each site's Institutional Review Board (IRB) or
Ethics Committee can streamline approvals and
ensure adherence to local regulations. A centralized
repository for regulatory documentation helps
monitor compliance and simplifies audits. Recruiting
and retaining participants at multiple sites requires
tailored strategies. Customized recruitment
campaigns that resonate with each site's patient
population can enhance enrollment. To boost
retention, offering incentives like travel
reimbursements or study-related resources can
demonstrate commitment to participant well-being.
Maintaining data quality and monitoring across
diverse sites is crucial. Introducing an independent
Data and Safety Monitoring Board (DSMB) can
provide impartial oversight. Regular site audits,
conducted by independent monitors, can identify and
address issues promptly, ensuring data accuracy and
protocol adherence. Managing logistics and supplies
uniformly is essential for fair and reliable results.
Centralizing procurement and distribution reduces
discrepancies among sites. Implementing a digital
inventory system allows sites to track supply levels
and request additional materials as needed.
Multi-center trials often involve sites with different
languages and cultural norms. Bilingual or
multilingual study coordinators can bridge language
gaps and ensure effective communication. Translating
study materials and consent forms into languages
commonly spoken by participants enhances their
understanding and engagement. Leveraging the
opportunities of multi-center trials involves
recognizing the benefits of diverse patient populations
and expertise. Collaborating with patient advocacy
groups and local healthcare providers can increase
enrollment from underrepresented populations.
Regular virtual meetings or online platforms for
information exchange enable investigators to share
insights and best practices, enriching the trial's
scientific value.
To expedite participant recruitment, central
recruitment dashboards can help monitor progress.
Recognizing site achievements with recruitment
incentives can motivate active participation. Ensuring
data accuracy is crucial; centralized data validation
processes and regular reconciliation between sites
help identify and rectify inconsistencies. For global
impact, collaboration with international research
networks expands the trial's reach. Adapting study
protocols to local healthcare systems and regulations
ensures seamless inclusion of diverse regions.
Establishing a publication committee allows
investigators from all sites to collectively analyze and
publish study results, fostering scientific
collaboration. By implementing these strategies and
solutions, multi-center clinical trials can overcome
challenges while capitalizing on the unique
opportunities they offer for advancement and
impactful medical discoveries.[7]
Case Studies and Examples
Case Study 1: Challenges in Patient Recruitment and
Retention
Challenge: A pharmaceutical company is conducting
a multi-center clinical trial for a rare genetic disorder.
One of the challenges they face is recruiting and
retaining a sufficient number of participants due to
the rarity of the condition.
Solution: The company collaborates with patient
advocacy groups to raise awareness about the trial.
They design patient-friendly recruitment materials
and offer travel reimbursement for participants,
making it easier for them to access the trial sites. The
trial's decentralized approach allows participants to
visit local clinics, reducing the burden of travel and
increasing retention rates.
Case Study 2: Standardization Across Diverse Sites
Challenge: An international research consortium is
conducting a multi-center trial to evaluate a new
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cancer treatment. They encounter difficulties in
maintaining standardized protocols and data
collection methods across various countries and
healthcare systems.
Solution: The consortium develops a comprehensive
Manual of Procedures (MOP) that is translated into
multiple languages. They conduct training workshops
at each site to ensure all personnel understand and
follow the standardized procedures. Regular virtual
meetings are held to discuss challenges and share best
practices, fostering a sense of collaboration among
diverse sites.
Case Study 3: Regulatory Variability
Challenge: A medical device company is conducting
a multi-center trial to assess the efficacy of a new
implant. They face regulatory challenges as each
country has different approval processes and
requirements.
Solution: The company establishes a regulatory task
force responsible for coordinating with each site's
regulatory authorities. They ensure that all necessary
documentation is submitted on time and facilitate
communication between sites to harmonize regulatory
approvals. This approach streamlines the approval
process and maintains adherence to local regulations.
Case Study 4: Data Quality and Monitoring
Challenge: A clinical research organization is
conducting a multi-center trial to test a new drug for a
chronic condition. They encounter issues with data
accuracy and quality control due to variations in data
collection practices among different sites.
Solution: The organization implements a centralized
electronic data capture (EDC) system that all sites
must use for data entry. Regular virtual meetings are
conducted to review data collection processes and
address any discrepancies. Independent monitors
periodically audit each site's data to ensure accuracy
and consistency.
Case Study 5: International Collaboration
Opportunity: An academic research consortium is
conducting a multi-center trial on a global scale to
study the effectiveness of a vaccine against a rapidly
spreading infectious disease.
Opportunity: By collaborating with research
institutions and healthcare organizations in different
countries, the consortium benefits from diverse
patient populations and epidemiological data. This
approach ensures that the vaccine's effectiveness is
tested across various genetic backgrounds and
regional variations in disease prevalence.
Case Study 6: Scientific Collaboration
Opportunity: A consortium of academic institutions is
conducting a multi-center trial to compare two
different surgical techniques for a specific medical
procedure.
Opportunity: Through regular virtual meetings and
collaborative platforms, investigators from different
sites share their experiences, insights, and preliminary
findings. This scientific collaboration allows for real-
time feedback and adjustments to the trial protocol,
ultimately leading to more informed decision-making
and robust study outcomes.
These case studies and examples highlight the various
challenges and opportunities inherent in conducting
multi-center clinical trials. They demonstrate how
innovative strategies and solutions can be applied to
overcome challenges and leverage the unique
advantages that multi-center trials offer for advancing
medical research and improving patient care.[2-6]
Future Directions and Trends
Decentralized Trials: With advancements in
technology, there's a growing trend towards
decentralized clinical trials. These trials leverage
remote monitoring, telemedicine, wearable devices,
and patient-reported outcomes to reduce the need for
participants to visit physical trial sites, thus improving
participant recruitment and retention.
Real-world Evidence Integration: The integration of
real-world data and evidence from electronic health
records, mobile health apps, and other sources is
gaining prominence. This approach can provide a
broader understanding of treatment outcomes and
patient experiences beyond the controlled trial
settings.
Adaptive Trial Designs: Adaptive trials allow for
modifications in trial design, such as dose
adjustments or patient population changes, based on
interim results. This approach enables more efficient
use of resources and quicker identification of
effective treatments.
Use of AI and Machine Learning: Artificial
intelligence (AI) and machine learning are being used
to analyze vast amounts of trial data, predict patient
outcomes, and identify potential safety concerns.
These technologies can also assist in patient
recruitment by identifying suitable candidates more
efficiently.
Personalized Medicine Trials: Advances in genomics
and biomarker discovery are enabling personalized
medicine trials. These trials focus on identifying
treatment responses based on individual genetic
makeup and other factors, leading to more targeted
and effective interventions.
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Virtual Reality and Simulation: Virtual reality (VR)
and simulation technologies are being explored for
training trial personnel, conducting virtual site audits,
and even simulating patient experiences to optimize
trial protocols.
Patient Engagement and Involvement: Including
patient input in trial design and decision-making is
becoming a priority. Patient engagement can improve
study design, recruitment strategies, and the relevance
of trial outcomes.
Global Collaborations: Collaborations between
research institutions, pharmaceutical companies, and
regulatory bodies are expected to become more
international. This trend can lead to more diverse
patient populations and enhanced generalizability of
trial results.
Data Sharing and Transparency: Greater emphasis is
being placed on data sharing and transparency in
clinical trials. Initiatives are being developed to share
trial data openly, promoting reproducibility and
advancing scientific knowledge.
Blockchain and Data Security: Blockchain
technology can enhance data security, ensuring the
integrity and confidentiality of trial data. It can also
facilitate transparent and traceable data sharing across
multiple sites.
Ethics and Participant-Centered Trials: Ethical
considerations and participant-centric approaches are
gaining attention. Ensuring participant privacy,
informed consent, and equitable access to trial
benefits are becoming integral to trial design.
Regulatory Innovation: Regulatory bodies are
exploring innovative ways to streamline trial
approvals while maintaining patient safety.
Harmonization of regulations across countries and
adaptive pathways for drug approvals are being
explored.
Patient-Reported Outcomes (PROs): Incorporating
patient-reported outcomes in trials can provide
insights into the impact of treatments on patients'
daily lives and quality of life, offering a more holistic
understanding of treatment effects.[8]
Conclusion
Conducting multi-center clinical trials presents a
dynamic landscape that encompasses both challenges
and opportunities. These trials play a pivotal role in
advancing medical knowledge, evaluating
interventions, and improving patient care. While
facing coordination hurdles, regulatory complexities,
and data standardization issues, multi-center trials
also offer the advantage of diverse patient
populations, enhanced expertise, and global impact.
To navigate these challenges and leverage these
opportunities, strategies such as effective
communication, standardized protocols, and
streamlined regulatory processes are crucial.
Embracing technological innovations like
decentralized trials, AI-driven data analysis, and
patient engagement tools can transform trial
methodologies and lead to more efficient and patient-
centric research.
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