This document discusses challenge driven innovation and its implications for policy approaches. It proposes a 3-step conceptual approach to challenge driven innovation: 1) feasibility assessment, 2) experimentation, and 3) roll-out. While innovation policies still focus on science and market-driven approaches, demand-driven and challenge-driven innovation is emerging. Real systemic challenge-driven innovation policies are still lacking. The document examines experiences with challenge-driven innovation in healthcare, education, and entrepreneurship ecosystems. It concludes that challenge-driven innovation has potential for growth and societal issues but remains untapped due to institutional barriers.