With the passage of time, PROTACs technology has entered an unprecedented stage of development in recent years. According to the different requirements of customers, BOC Sciences can design, synthesize, optimize PROTAC molecules, establish analytical methods and carry out the biological evaluation. Please visit https://protac.bocsci.com for more information.
With the passage of time, PROTACs technology has entered an unprecedented stage of development in recent years. Scientists gradually see the absolute advantages of this technology, which can not only transform non-drug target (undruggable) into feasible drug target (druggable) but also resolve the problem of drug resistance of existing targets. In recent years, we have made great efforts to develop the (PROTAC) platform of protein degradation technology to provide research tools for small molecules targeting so-called non-proprietary drugs, in order to better help customers and help customers in the process of new drug research and development. According to the different requirements of customers, BOC Sciences can design, synthesize, optimize PROTAC molecules, establish analytical methods and carry out the biological evaluation.
With the passage of time, PROTACs technology has entered an unprecedented stage of development in recent years. According to the different requirements of customers, BOC Sciences can design, synthesize, optimize PROTAC molecules, establish analytical methods and carry out the biological evaluation. Please visit https://protac.bocsci.com for more information.
With the passage of time, PROTACs technology has entered an unprecedented stage of development in recent years. Scientists gradually see the absolute advantages of this technology, which can not only transform non-drug target (undruggable) into feasible drug target (druggable) but also resolve the problem of drug resistance of existing targets. In recent years, we have made great efforts to develop the (PROTAC) platform of protein degradation technology to provide research tools for small molecules targeting so-called non-proprietary drugs, in order to better help customers and help customers in the process of new drug research and development. According to the different requirements of customers, BOC Sciences can design, synthesize, optimize PROTAC molecules, establish analytical methods and carry out the biological evaluation.
Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we analyzed plasma samples from animals treated with either the indirect FXa inhibitor FONDAPARINUX or the dipeptidylpeptidase IV inhibitor AB192. Signals correlating with the treatment were subsequently identified and assessed with respect to protease-dependent consensus cleavage motifs and occurrence of downstream targets. It could be shown that regulated peptides were either substrates, products or downstream targets of the inhibited protease. The results from the present study demonstrate that the in vivo analysis of peptides by peptidomics has the potential to broaden the knowledge of inhibitor related effects in vivo and that this method may pave the way to develop predictive biomarkers.
As a most notable member in the stilbenoid family, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has a wide range of biological activities which may have the impact on human health, including antioxidant, anti-inflammatory, cardioprotective, antiviral, anticancer, and antiaging properties as demonstrated in in vitro and animal studies.
The concentration of this amino acid is higher in tomato compared with many vegetables such as carrots, onions or pepper. In addition, glutamate provides the characteristic ‘‘umami taste’’ to foods with high free glutamate content such as cheese, tomato and mushrooms, which are major ingredients in cooking.
Novozymes Veltis® – Engineerd albumins for optimized drug dosingNiklas Andersson
Novozymes Veltis® is a clinically-proven half-life extension technology based on engineered albumins that allows drug developers to optimize dose size and frequency to achieve improved patient compliance.
Imalek (Imatinib Mesylate Tablets) is used to treat certain types of cancer (such as acute lymphoblastic leukemia, chronic myeloid leukemia, gastrointestinal stromal tumors, and myelodysplastic/myeloproliferative diseases) and blood problems.
Slide present, the recently used hepatoprotective agent (oriental and synthetic agent), along with the recently ongoing researches ( including references).
Canvax™ offers a wide range of high quality Human Recombinant Proteins for several research applications like ELISA, Western Blot, Antibody Production or Protein array.
Metabolic investigation of segmental overgrowth: new insights in pathogenic m...BiologInc
[Biolog Webinar] Dr. Luigi Boccuto's presentation of his investigation of the pathogenic mechanisms of segmental overgrowth caused by mosaic mutations in the genes of the PI3K-AKT pathway. He will describe how Biolog Phenotype MicroArray™ Technology is used to identify new treatment targets and test compounds with potential therapeutic effects.
Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we analyzed plasma samples from animals treated with either the indirect FXa inhibitor FONDAPARINUX or the dipeptidylpeptidase IV inhibitor AB192. Signals correlating with the treatment were subsequently identified and assessed with respect to protease-dependent consensus cleavage motifs and occurrence of downstream targets. It could be shown that regulated peptides were either substrates, products or downstream targets of the inhibited protease. The results from the present study demonstrate that the in vivo analysis of peptides by peptidomics has the potential to broaden the knowledge of inhibitor related effects in vivo and that this method may pave the way to develop predictive biomarkers.
As a most notable member in the stilbenoid family, resveratrol (3,5,4′-trihydroxy-trans-stilbene) has a wide range of biological activities which may have the impact on human health, including antioxidant, anti-inflammatory, cardioprotective, antiviral, anticancer, and antiaging properties as demonstrated in in vitro and animal studies.
The concentration of this amino acid is higher in tomato compared with many vegetables such as carrots, onions or pepper. In addition, glutamate provides the characteristic ‘‘umami taste’’ to foods with high free glutamate content such as cheese, tomato and mushrooms, which are major ingredients in cooking.
Novozymes Veltis® – Engineerd albumins for optimized drug dosingNiklas Andersson
Novozymes Veltis® is a clinically-proven half-life extension technology based on engineered albumins that allows drug developers to optimize dose size and frequency to achieve improved patient compliance.
Imalek (Imatinib Mesylate Tablets) is used to treat certain types of cancer (such as acute lymphoblastic leukemia, chronic myeloid leukemia, gastrointestinal stromal tumors, and myelodysplastic/myeloproliferative diseases) and blood problems.
Slide present, the recently used hepatoprotective agent (oriental and synthetic agent), along with the recently ongoing researches ( including references).
Canvax™ offers a wide range of high quality Human Recombinant Proteins for several research applications like ELISA, Western Blot, Antibody Production or Protein array.
Metabolic investigation of segmental overgrowth: new insights in pathogenic m...BiologInc
[Biolog Webinar] Dr. Luigi Boccuto's presentation of his investigation of the pathogenic mechanisms of segmental overgrowth caused by mosaic mutations in the genes of the PI3K-AKT pathway. He will describe how Biolog Phenotype MicroArray™ Technology is used to identify new treatment targets and test compounds with potential therapeutic effects.
The goal of neuroprotection is to shield neurons against damage, whether that damage is caused by environmental factors, pathogens, or neurodegenerative illnesses. Inhibiting protein-based deposit buildup, oxidative stress, and neuroinflammation, as well as rectifying abnormalities of neurotransmitters like dopamine and acetylcholine, are some of the ways in which medicinal herbs have neuroprotective effects [1-3]. This review will focus on the ways in which medicinal herbs may protect neurons.
This slides were prepared for My Post Graduation activities and seminar most of them are from sources such as slide share, Pub Med, Standard Pharmacology Textbooks ....
Feel free to comment/correct/suggest Thank you
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
Have you ever wanted a Ruby client API to communicate with your web service? Smithy is a protocol-agnostic language for defining services and SDKs. Smithy Ruby is an implementation of Smithy that generates a Ruby SDK using a Smithy model. In this talk, we will explore Smithy and Smithy Ruby to learn how to generate custom feature-rich SDKs that can communicate with any web service, such as a Rails JSON API.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
2. Our presentation contains information on each
item, including structures or diagrams.
To learn more, follow the link in the Product Name
to visit our website.
4. 11685 Bavachin
• Flavonoid that activates the estrogen receptors
ERα and ERβ (EC50s = 320 and 680 nM,
respectively)
• Stimulates osteoblast proliferation and
differentiation and prevents bone loss following
ovariectomy in rats
• Less potently inhibits acyl-coenzyme A:cholesterol
acyltransferase (IC50 = 86 µM)
Phytoestrogen
5. 11844 α-Glycyrrhetinic Acid
• One of two epimers produced by removal of glucose from the
triterpenoid saponin glycyrrhizic acid (Item No. 11847), the
other being β-glycyrrhetinic acid (Item No. 11845)
• Inhibits intercellular communication through gap junctions
• Blocks gap junctions involving connexin-43 (also known as gap
junction α-1 protein) and connexin-26 (gap junction β-2 protein)
Gap junction blocker
6. 19286 Esculetin
• A natural plant phenolic that shares features of
coumarins and catechols
• Inhibits 5-LO and 12-LO (ID50s = 4 and 2.5 µM,
respectively)
• Binds iron and also inhibits other iron-containing
enzymes, including the lysine-specific
demethylase KDM5B
• Promotes TRAIL-induced apoptosis in cancer cells
• Used as an antioxidant to reduce ROS and
modulate oxidant-sensitive enzymes
• Anti-fungal activities
Lipoxygenase inhibitor
7. 19588 D-Fructose-6-phosphate (sodium salt)
• A sugar intermediate of the glycolytic pathway formed by the
isomerization of glucose-6-phosphate
• Further phosphorylated to fructose-1,6-bisphosphate, which is
one of the rate-limiting steps in glycolysis
• Because cancer cells adopt glycolysis as a major source of
metabolic energy production, this pathway has become a new
target for cancer chemotherapy
• Used to help identify, differentiate, and characterize the enzymes
in glycolysis
Glycolytic pathway intermediate
8. 19716 NCT-502
• Inhibits PHGDH, inhibiting serine synthesis from 3-
phosphoglycerate in cells (IC50 = 3.7 µM)
• Reversibly blocks the production of glucose-derived
serine in cells
19718 NCT-503
• Inhibits PHGDH, inhibiting serine synthesis from 3-
phosphoglycerate in cells (IC50 = 2.5 µM)
• Reduces the production of glucose-derived serine in cells
• Suppresses the growth of PHGDH-dependent MDA-MB-
468 cancer cells both in vitro and in mice bearing
orthotopic xenograft tumors
3-phosphoglycerate dehydrogenase inhibitors
9. 19847 Diosgenin
• A natural steroid sapogenin with antioxidant and anti-
inflammatory activities
• Protective against metabolic and cardiovascular diseases
and can have immunomodulatory and estrogenic effects
19849 Deoxyschizandrin
• A lignan with liver-protective, antitumor, and antioxidant
activities
• Adiponectin receptor 2 agonist (IC50 = 3.5 µM)
• Protective role in a rat model of myocardial ischemia-
reperfusion injury
• Down-regulates the increased production of nitric oxide,
TNF-α and IL-6 induced by LPSboth in BV-2 cells and
primary microglia cells
Natural antioxidants
10. 19865 Procyanidin B2
• Flavanol with potent antioxidant activity
• A dimer of epicatechin (Item No. 11807) that scavenges hydroxyl
radical and superoxide anion more potently than epicatechin and
procyanidin B4
19867 Rhapontin
• A stilbenoid glycoside first isolated from rhubarb rhizomes
• Converted by glucosidases to rhapontigenin (Item No. 13293), a
resveratrol analog with antioxidant and anti-cancer activity
19868 Rutin (hydrate)
• A flavonol glycoside with iron chelating and antioxidant properties
• Anti-inflammatory, anti-cancer, and anti-fibrosis effects and displays
hepato- and neuroprotective actions
Natural antioxidants
11. 19861 Paeoniflorin
• Monoterpene glycoside that modulates NMDA and TRPV1
receptors
• Inhibits testosterone synthesis and stimulates aromatase
activity
• Reduces inflammatory signaling by inhibiting p38 MAP
kinase
• Blocks pancreatic cancer cell apoptosis by suppressing
MMP-9 and ERK signaling
• Analgesic and anti-inflammatory actions
19862 Paeonol
• Phenolic compound with anti-oxidative actions
• Analgesic, anti-inflammatory, and hepatoprotective effects
Analgesics
12. 19870 Chrysophanol
• An anthraquinone with antibacterial, antiviral, anti-inflammatory, and anticancer activities
• Inhibits hepatitis B viral DNA production and HBsAg secretion in HepG2 2.2.15 cells.
• Reduces the level of nitric oxide and PGE2 production by diminishing the expression of
inducible nitric oxide synthase and COX-2 in BV2 microglia
• Induces necrosis through the production of ROS in J5 human liver cancer cells
19873 Isobavachalcone
• Chalcone with antibacterial, antifungal, anticancer, anti-reverse transcriptase, antitubercular,
and antioxidant activities
• Inhibits the growth of MGC803 gastric cancer cells by regulating the protein expression of
caspase-3, Bcl-2, and Bax and by inhibiting Akt and ERK signaling pathways
• Inhibits oligomerization and fibrillization of Aβ42 in an SH-SY5Y cell model of Aβ42 aggregation
Antibacterial/ Antiviral
13. 19872 Ginkgolide C
• Flavone with a selective platelet activating factor
receptor antagonist (IC50 = 37.6 μM)
• Increases lipolysis and inhibits adipogenesis in
adipocytes via the activated AMPK pathway
PAF receptor antagonist
14. 20184 Oligomycin D
• Inhibits the mitochondrial F1FO-ATPase
• Used to uncouple oxidative phosphorylation from
electron transport
• Inhibits K-Ras plasma membrane localization in MDCK
cells (IC50 = 3.49 nM) and is cytotoxic to SW620 colon
cancer cells (IC50 = 36 µM)
20185 Oligomycin E
• Exhibits relatively weak antifungal activity compared to
other oligomycins, yet is active against Gram-positive
bacteria
• Demonstrates strong antitumor activity against HeLa
cells (IC50 = 14 ng/ml)
Antibiotics
15. 20188 Teicoplanin A2-3
• Major component of the teicoplanin complex that is
broadly effective against Gram-positive bacteria
20189 Teicoplanin A2-4
• Component of the teicoplanin complex that is broadly
effective against Gram-positive bacteria
20192 Teicoplanin A2-5
• The most non-polar metabolite in the family of
teicoplanins
20193 Teicoplanin A3-1
• Degradation product of teicoplanins A2-1 to 5
Antibiotics
17. 20061 MDMB-FUBINACA metabolite M1
• An expected metabolite of MDMB-FUBINACA and ADB-FUBINACA
17761 AB-FUBINACA metabolite 3
• An expected metabolite of AB-FUBINACA
19730 5-fluoro BEPIRAPIM (hydrochloride)
• A synthetic cannabinoid whose physiological and toxicological
properties are not known
Forensic Science
18. 19567 ortho-Fluorobutyryl fentanyl (hydrochloride)
• An opioid whose physiological and toxicological properties are not known
19735 para-Fluorofentanyl (hydrochloride) (CRM)
• Activates the human μ opioid receptor with greater potency than fentanyl
(EC50s = 4.2 and 28.8 nM for para-fluorofentanyl and fentanyl, respectively)
19736 β-Hydroxythiofentanyl (hydrochloride) (CRM)
• An opioid regulated as a Schedule I controlled substance in the United States
19883 Benzyl fentanyl (hydrochloride)
• An opioid that is reported to have low opioid activity in a mouse analgesia hot
plate assay
Forensic Science
19. 19737 MT-45 (hydrochloride) (CRM)
• A piperazine that displays potent analgesic activity
comparable to morphine despite being structurally
unrelated to most other opioids
19794 Tiletamine (hydrochloride)
• A non-competitive NMDA receptor antagonist used in
veterinary medicine for its anesthetic and sedative
properties, which are comparable to ketamine
19745 2,6-DMA (hydrochloride)
• An amphetamine that acts as a serotonin 5-HT2 receptor
agonist (apparent pA2 = 5.09)
Forensic Science
20. 19275 4’-methoxy-α-Ethylaminovalerophenone (hydrochloride)
• A cathinone whose physiological and toxicological properties are not known
20132 Benzocaine
• A topical anesthetic commonly found as an adulterant in cocaine
20200 5α-dihydro-11-keto Testosterone
• A metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has
been shown to act as a full androgen receptor agonist with equal potency as that of
dihydrotestosterone
Forensic Science
21. 19222 AH 7921-d3 (CRM)
• An internal standard for the quantification of AH7921 by GC- or LC-MS
19507 MT-45-d11 (hydrochloride) (CRM)
• An internal standard for the quantification of MT-45 by GC- or LC-MS
19928 Fentanyl-d5 (hydrochloride) (CRM)
• An internal standard for the quantification of fentanyl by GC- or LC-MS
19947 β-Hydroxythiofentanyl-d5 (hydrochloride) (CRM)
• An internal standard for the quantification of β-hydroxythiofentanyl
(hydrochloride) by GC- or LC-MS
Forensic Science