Primary malignant schwannoma is a rare neoplasm of nerve sheath origin. It is a cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classifi ed as sarcoma. The estimated incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) in general population is 0.001% and in patients with Neurofi bromatosis 1 (NF-1) is 2-5%. It is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft-tissue sarcoma. They are highly aggressive and occur in the second or third decade. This neoplasm usually affects the extremities. There is strong association between MPNSTs and neurofi bromatosis (NF-1) and previous irradiation. We present the case of a 61-year-old woman manifesting with recurrent sciatalgy near for the fourth and fi fth lumbar vertebral bodies. She underwent resection of a mass at the L4-5 level that was subsequently recognized as a malignant peripheral nerve sheath tumor.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Primary malignant schwannoma is a rare neoplasm of nerve sheath origin. It is a cancer of the connective tissue surrounding nerves. Given its origin and behavior it is classifi ed as sarcoma. The estimated incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) in general population is 0.001% and in patients with Neurofi bromatosis 1 (NF-1) is 2-5%. It is an uncommon spindle cell sarcoma accounting for approximately 5% of all soft-tissue sarcoma. They are highly aggressive and occur in the second or third decade. This neoplasm usually affects the extremities. There is strong association between MPNSTs and neurofi bromatosis (NF-1) and previous irradiation. We present the case of a 61-year-old woman manifesting with recurrent sciatalgy near for the fourth and fi fth lumbar vertebral bodies. She underwent resection of a mass at the L4-5 level that was subsequently recognized as a malignant peripheral nerve sheath tumor.
Leiomyoma is a benign tumor that originates from smooth
muscle cell. The most common sites are the uterus, gastrointestinal tract & skin. Leiomyoma is a relatively uncommon smooth muscle tumor rarely found in the head and neck. Enzinger and Weiss (1995), analyzed a total of 7748 leiomyomas, 95% of the tumors occurred in the female genitalia (uterus), 3% in the skin, 0.9% in the gastrointestinal tract and the remainder at various sites including skull base.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Journal of Pathology & Microbiology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Pathology & Microbiology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of Pathology & Microbiology. Journal of Pathology & Microbiology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of pathology & microbiology.
Journal of Pathology & Microbiology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
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is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
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is exceptional. Here, we report a case of papillary thyroid carcinoma revealed by frontal skull metastasis.
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https://crimsonpublishers.com/ero/fulltext/ERO.000510.php
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Although papillary thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull
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An Unusual Case of Secondary in Sphenoid Sinus from Carcinoma Prostate by George MV in Experiments in Rhinology & Otolaryngology
https://crimsonpublishers.com/ero/fulltext/ERO.000518.php
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An Unusual Presentation of Squamous Cell Carcinoma of Bilateral Temporal Bones by Titas Kar in Experiments in Rhinology & Otolaryngology
Squamous cell carcinoma of temporal bone is a rare entity, comprising of a very small percentage of all head neck tumours, mostly occurring in aged population. Bilateral presentation of tumours in both temporal bones is extremely rare and only a few cases have been reported. We report a case of bilateral squamous cell carcinoma of both temporal bones in a young adult male patient who presented very late.
https://crimsonpublishers.com/ero/fulltext/ERO.000510.php
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Neoadjuvant Treatment (NAT) is indicated in locally advanced tumors and improves the results of subsequent surgery. In borderline tumors, the place of this preoperative treatment is more controversial, probably because borderline tumors are a heterogeneous group. We focused on the tumors with venous involvement without any arterial involvement and studied the results of neoadjuvant treatment in this particular group.
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neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
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disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
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from mild to severe. A diagnosis of AUD requires that at least two of
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effects (tolerance, withdrawal). This chapter presents an overview
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the Third Nerve, Mimicking Cavernous Sinus Meningioma
1. Clinics of Oncology
ISSN: 2640-1037
Case Presentation
Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital
Extension along the Third Nerve, Mimicking Cavernous Sinus
Meningioma
Muhammad S*
Department of Neurosurgery, University Hospital Helsinki, Topeliuksenkatu 5, Helsinki, P.O. Box 266 FI-00029 HUS, Finland
2. Keywords
Leiomyosarcoma; Metastasis;
Cavernous sinus; Orbital
1. Abstract
Background: Leiomyosarcoma (LMS) metastasis in the central nervous system is extremely
rare. Metastatic LMSs have been described in the orbit, meninges, and skull base, however there
are no reports of LMS metastasis into the cavernous sinuswith primary origin from lower extrem-
ity and long silent disease period of 7 years.
Case presentation: We present a case of a 75-year-old woman with complaints of diplopia
for three months. An MRI scan revealed a contrast-enhancing lesion in the cavernous sinus,
extending along the third nerve through the left superior orbital fissure. In 2011, the patient was
diagnosed with and treated for a leiomyosarcoma of the left lower limb. The lesion mimicked a
meningioma in the MRI scan; intraoperatively, it appeared as a schwannoma of the third nerve.
The tumor was biopsied and partially resected, and the third nerve was decompressed. Radio
surgical treatment was recommended for the remaining tumor. We use an instructional intraop-
erative video to demonstrate the radiological and intraoperative aspects of LMS metastasis.
Conclusion:LMS can metastasize to the cavernous sinus, leading to varying degrees of oph-
thalmoplegia. Radio logically, metastatic LMS mimics a meningioma; intraoperatively, it mimics
a schwannoma.
3. Introduction
The metastasis of primary lung, breast and skin cancers is most
commonly detected in the brain. Other peripheral tumors, in-
cluding those from the gastrointestinal and urogenital tract,
rarely metastasize in the brain. Similarly, leiomyosarcoma (LMS)
metastasis in the central nervous system is extremely rare[1-8].
Although metastatic LMSs have been described in the orbit, me-
ninges and skull base[1-14], they have not been reported from the
lower extremity in the cavernous sinus. There are several reports
of LMSs in the cavernous sinus, however they were not distant
metastases – the LMS originated from vascular smooth muscles
in the cavernous sinus[8,10,13,15,16]. Here, we report the first
case of cavernous sinus LMS metastasis extending through the
superior orbital fissure along the third nerve, appearing radio
logically as a cavernous sinus meningioma and intraoperatively
as a schwannoma of the third nerve.
4. Case Report
A 75-year-old woman presented with third nerve palsy, expe-
riencing diplopia for three months. Upon examination, the pa-
tient was alert and oriented. Visual field was intact, and pupil
size was normal and reactive to light. The patient’s hearing and
facial nerve function were normal. In 2011, the patient received
surgical treatment of the leiomyosarcoma on her left lower leg.
An MRI scan revealed a contrast-enhancing space-occupying le-
sion in the left wall of the cavernous sinus, extending through
the superior orbital fissure along the third nerve (Figure 1 A-E).
No other pathology in the supra or infra-tentorial regions was
observed.
*Corresponding Author (s): Sajjad Muhammad, Department of Neurosurgery, Univer-
sity Hospital Helsinki, Topeliuksenkatu 5, Helsinki, P.O. Box 266, FI-00029 HUS, Fin-
land, Tel: 35503757488; Fax +358 9 471 87560; E-mail:ext-sajjad.muhammad@hus.fi
clinicsofoncology.com
Citation: ZMuhammad S, Cavernous Sinus Metastasis of Leiomyosarcoma with Orbital Extension along the
Third Nerve, Mimicking Cavernous Sinus Meningioma. Clinics of Oncology. 2019; 1(7):1-3.
Volume 2 Issue 1- 2019
Received Date: 18 Apr 2019
Accepted Date: 18 May2019
Published Date: 25 May 2019
3. Volume2 Issue 1 -2019 Case Presentation
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