Neulasta Onpro kit eliminates need for additional clinic visit after chemotherapy. Given the racially diverse population in our institution, we investigated acceptance of Onpro kit among patients on chemotherapy.Single-institution, retrospective review conducted in patients with GI tumors who received Onpro kit within 1 hour of completion of systemic chemotherapy from Jan 2014 through Jan 2018...
Use of complementary and alternative medicine by cancer patients at the Unive...home
CAM use is common among cancer patients in Nigeria. Most users do not obtain the
expected benefits, and adverse events are not uncommon. Every clinician in the field of oncology
should ask his/her patients about the use of CAM; this knowledge will enable them to better
counsel the patients
Objective: To evaluate the utility of a targeted lecture in improving FP awareness amongst clinicians.
Design: This is a dual institution, prospective survey-based study assessing if an educational lecture can increase the likelihood of FP consideration, discussion, and referral.
Use of complementary and alternative medicine by cancer patients at the Unive...home
CAM use is common among cancer patients in Nigeria. Most users do not obtain the
expected benefits, and adverse events are not uncommon. Every clinician in the field of oncology
should ask his/her patients about the use of CAM; this knowledge will enable them to better
counsel the patients
Objective: To evaluate the utility of a targeted lecture in improving FP awareness amongst clinicians.
Design: This is a dual institution, prospective survey-based study assessing if an educational lecture can increase the likelihood of FP consideration, discussion, and referral.
Establishment of a Rehabilitation Clinic for Colorectal Cancer. Will it End P...daranisaha
Colorectal cancer (CRC) is the third most common diagnosis and the second most lethal malignancy in both men and women.
To establish a rehabilitation clinic in the oncology department in hospitals and address its positive effect on colorectal cancer patients’ need.
How general internists can participate in the continuum of care for patients with cancer. (Talk given at Internal Medicine Grand Rounds, St. Elizabeth Hospital, General Santos City, 10 Feb 2021.)
Cancer Clinical Trials_ USA Scenario and Study Designs.pdfProRelix Research
Clinical trials in oncology are vital for the advancement of cancer treatments and
care. The US is at the forefront of these clinical trials, with many different study
designs being used to assess the efficacy and safety of new treatments. This article
will explore the current state of oncology clinical trial services in the US, as well as
discuss different types of study designs that are commonly used. It will provide
insight into how these trials are conducted, what data is collected, and how this
information can be used to improve patient care.
The United States Food and Drug Administration (FDA) has released
several guidance documents over the years through the Oncology Center
of Excellence to support the development of oncologic treatments and
diagnoses. Furthermore, information on the clinical trials for the treatment
of different types of cancer or specific interventions can be found on the
National Cancer Institute (NCI) website and Clinical Trials. Currently,
ClinicalTrials.gov, a website maintained by the National Library of
Medicine (NLM) and the National Institutes of Health (NIH) contains
listings of publicly and privately sponsored trials and includes information
on 91,937 studies related to cancer indicating the high volume of
research being conducted in this field.According to the World Health Organization (WHO), cancer is the leading
cause of death worldwide, with a death rate of one in six in 2020 (1).
Aside from the high mortality rate and morbidity associated with cancer, it
also negatively impacts the quality of life and poses a significant financial
burden on patients and payers making it imperative to develop effective
treatments for the disease. According to Global Cancer Observatory
(GLOBACAN), the United States accounted for 13.3% of all estimated
new cases of cancer in 2020 (2). In 2020, the single leading type of
cancer in the United States was breast cancer (11.1%) followed by lung
cancer (10%), prostrate (9,2%), colorectum (6.8%), and melanoma of the
skin (4.2%). Despite the significant prevalence of cancer and numerous
clinical trials conducted for oncology treatments, data have shown an
almost 95% attrition rate for anticancer drugs from Phase I trials until
marketing authorization. Various factors such as inaccurate preclinical
models, lack of suitable biomarkers in clinical trials, and a disconnect
between industry, academia, and regulators are responsible for the high
attrition rate (3). Therefore, it is vital to develop suitable study designs
and protocols for candidate molecules such that they obtain regulatory
approval and can be marketed. In addition to these challenges, the
development of anti-cancer agents comes at a monumental cost of an
estimated $2.8 billion. Several factors such as the choice of relevant
endpoints, the choice of appropriate biomarkers that are guided by tumor
biology, and careful patient selection are expected to improve the overall
fate of oncologic agents in the clinical trial phase
10 STRATEGIC POINTS 2
Ten Strategic Points
Grand Canyon University
DNP-815- O502: Scientific Underpinnings
10 Strategic Points Table
(Use this table to complete the 10 Strategic Points document for your project.)
10 Strategic Points
Comments/Feedback
Broad Topic Area
Impact of Medication Administration Errors on 3-4-Year-old Leukemia Patients
Literature Review
A. Verghese, A., Charlton, B., Kassirer, J. P., Ramsey, M., & Ioannidis, J. P. (2015). Inadequacies of physical examination as a cause of medical errors and adverse events: a collection of vignettes. The American journal of medicine, 128(12), 1322-1324.
The article looks at the “Inadequacies of physical examination as a cause of medical errors and adverse events: a collection of vignettes” from the American journal of medicine. It takes into consideration the fact that, the oversights in the corporeal assessment are a medical fault which aren’t studied via chart evaluation. Furthermore, the article states that these oversights in the corporeal assessments may be the primary contributors to the neglected or late diagnosis besides unnecessary exposure to contrast as well as radiation on the Leukemia patients. Either the authors indicate that the incorrect treatments resulting from these delays leads to unfavorable results like fainting on the Leukemia patient, lack of appetite on the side of the patient, worsening the Leukemia conditions which eventually can lead to early death of the patient.
B. Hockings, J. K., Owolabi, D. K., Broyles, J. E., & Wheelis, S. C. (2017). Impact of medication administration error on over 3 years Leukemia patients and the stimulating factors in acute leukemia and stem cell transplant patients. Supportive Care in Cancer, 25(6), 1853-1858.
The authors of this article explored the “Impact of medication administration error on over 3 years Leukemia patients and the stimulating factors in acute leukemia and stem cell transplant patients.” This article is from supportive care in cancer and it was retrieved from Google Scholar. The article authors acknowledge the fact that, the medication administration errors lead to severe impacts on the health conditions of the patient more especially the ones who are 3 – 4 years of Leukemia. According to the authors, the impacts associated with the medication administration errors may lead to worsening of the health condition of the patient, the rate of Leukemia advancement into higher stages may also increase with treatment or managing of this deadly disease being more complicated. The authors argue that using erroneous medicines, the Leukemia advancement increases without the knowledge of the patient which makes even the survival chances of the patient to reduce due to stress upon realizing that there was an error in his or her medication.
C. Douer, D. (2016). Efficacy and safety of vincristine sulfate liposome injection in the treatment of adult acute lymphocytic leukemia. The oncologist, 21(7), 840-847.
...
Multidisciplinary Approach to Prostate Cancer and Changes in Treatment Decisi...CrimsonpublishersCancer
In order to demonstrate the impact of multi-disciplinary care in the community oncology setting, we evaluated treatment decisions following the initiation of a dedicated genitourinary multi-disciplinary clinic (GUMDC).
ISSN 2347-2251
It appears that you're describing the scope of a scientific journal. This journal covers a wide range of topics related to both Pharmaceutical Sciences and Biological Sciences of the scopus database journal.
Indo-American Journal of Pharma and Bio Sciences is an international, online, English-language journal that publishes articles on pharmaceutical and biological sciences of the ugc carelist journals.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journals to publish paper.
Scientific development is an ever-evolving journey, driven by the exchange of data and ideas among researchers across the globe.One such remarkable publication dedicated to facilitating this exchange within the fields of Pharmacy and Bio Sciences is the Indo-American Journal of Pharma and Bio Sciences of the published research.
The Indo-American Journal of Pharma and Bio Sciences plays a crucial role in the scientific community by providing a platform for the exchange and dissemination of research findings in the fields of Pharmacy and Bio Sciences is the sscope and journal of the journal research paper.
Adherence to Antiretroviral Therapy among HIVPositive Patients in Central Hos...Efe Clement Abel
Abstract: Adherence is the quantified level to which an individual follows a prescribed treatment and a low level of adherence to antiretroviral therapy(ART) adversely affects a patient’s treatment outcome and results in a rebound of plasma viraemia, development of resistant strains of HIV, more rapid immune deterioration, development of AIDS and death. This study is aimed at assessing the level of adherence to ART among HIV-positive patients assessing care in Central Hospital, Warri, Delta State, Nigeria. A descriptive cross-sectional study. Data were obtained using a semi-structured, interviewer-administered questionnaire and analysed using SPSS version 23. A total of 303 persons were recruited for the study. The mean age of respondents was 36.2±10.8years. Less than half of the subjects (45.5%) were adherent to their ART. Among the non-adherent subjects, the common reasons reported for missing doses of ART were forgetfulness (50.9%), too busy with other things (43.6%) and away from home (35.8%). This study showed that adherence to ART among the study population was poor. Forgetfulness, too busy with other things and being away from home were the most common reason for non-adherence. It is, therefore, recommended that; regular health education should be organised for HIV patients on ART on the importance of being adherent to their ART, regular assessment of adherence to ART should be carried out and a method of reminding patients who are non-adherent to ART on the need to take their ART as at when due should be considered as part of the routine services provided by ART centres.
The prevalence, patterns of usage and people's attitude towards complementary...home
The prevalence of CAM in Chatsworth is similar to findings in other parts of the
world. Although CAM was used to treat many different ailments, this practice could not be
attributed to any particular demographic profile. The majority of CAM users were satisfied with
the effects of CAM. Findings support a need for greater integration of allopathic medicine and
CAM, as well as improved communication between patients and caregivers regarding CAM usage.
Pancreatic Adenocarcinoma with Isolated Venous Involvement: Is Neoadjuvant Tr...EditorSara
Neoadjuvant Treatment (NAT) is indicated in locally advanced tumors and improves the results of subsequent surgery. In borderline tumors, the place of this preoperative treatment is more controversial, probably because borderline tumors are a heterogeneous group. We focused on the tumors with venous involvement without any arterial involvement and studied the results of neoadjuvant treatment in this particular group.
APL:Retinoic Acid and Retinoid Pharmacology, a Breakthrough TodayEditorSara
Acute promyelocytic leukemia(APL),a specific characteristic of t(15;17) chromosomal translocation,molecular gene analyses are conclusive in vivo evidence that oncogenic pml/RARa fusion plays a crucial role in APL leukemogenesis [1-3]. Since the introduction of initial 13-cis retinoic acid(13-cis RA)[4],and currently all-trans RA(ATRA) [5] and tamibarotene [6],RA plus chemotherapy or RA plus As2O3 regimen is currently the standard of care [7]...
Hairy Cell Leukemia (HCL) is a rare subtype of B-cell chronic lymphoid leukemia which was first described by Bertha Bouroncle in 1958 [1]. The annual incidence of HCL is approximately 0.3 cases per 100,000 and the disease comprises 2-3% of all leukaemia?s in the Western world [2,3]...
STAT-6 In Hodgkin Lymphoma Pathobiology and Treatment-Review of the LiteratureEditorSara
Classical Hodgkin Lymphoma (cHL), consists of rare neoplastic Hodgkin and Reed-Sternberg cells (HRS) residing in a prominent inflammatory background. HRS show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS with various other types of cells in the microenvironment, but also through genetic lesions...
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Similar to Racial Differences in Accepting Pegfilgrastim Onpro Kit (On-Body Injector) Use Among Cancer Patients
Establishment of a Rehabilitation Clinic for Colorectal Cancer. Will it End P...daranisaha
Colorectal cancer (CRC) is the third most common diagnosis and the second most lethal malignancy in both men and women.
To establish a rehabilitation clinic in the oncology department in hospitals and address its positive effect on colorectal cancer patients’ need.
How general internists can participate in the continuum of care for patients with cancer. (Talk given at Internal Medicine Grand Rounds, St. Elizabeth Hospital, General Santos City, 10 Feb 2021.)
Cancer Clinical Trials_ USA Scenario and Study Designs.pdfProRelix Research
Clinical trials in oncology are vital for the advancement of cancer treatments and
care. The US is at the forefront of these clinical trials, with many different study
designs being used to assess the efficacy and safety of new treatments. This article
will explore the current state of oncology clinical trial services in the US, as well as
discuss different types of study designs that are commonly used. It will provide
insight into how these trials are conducted, what data is collected, and how this
information can be used to improve patient care.
The United States Food and Drug Administration (FDA) has released
several guidance documents over the years through the Oncology Center
of Excellence to support the development of oncologic treatments and
diagnoses. Furthermore, information on the clinical trials for the treatment
of different types of cancer or specific interventions can be found on the
National Cancer Institute (NCI) website and Clinical Trials. Currently,
ClinicalTrials.gov, a website maintained by the National Library of
Medicine (NLM) and the National Institutes of Health (NIH) contains
listings of publicly and privately sponsored trials and includes information
on 91,937 studies related to cancer indicating the high volume of
research being conducted in this field.According to the World Health Organization (WHO), cancer is the leading
cause of death worldwide, with a death rate of one in six in 2020 (1).
Aside from the high mortality rate and morbidity associated with cancer, it
also negatively impacts the quality of life and poses a significant financial
burden on patients and payers making it imperative to develop effective
treatments for the disease. According to Global Cancer Observatory
(GLOBACAN), the United States accounted for 13.3% of all estimated
new cases of cancer in 2020 (2). In 2020, the single leading type of
cancer in the United States was breast cancer (11.1%) followed by lung
cancer (10%), prostrate (9,2%), colorectum (6.8%), and melanoma of the
skin (4.2%). Despite the significant prevalence of cancer and numerous
clinical trials conducted for oncology treatments, data have shown an
almost 95% attrition rate for anticancer drugs from Phase I trials until
marketing authorization. Various factors such as inaccurate preclinical
models, lack of suitable biomarkers in clinical trials, and a disconnect
between industry, academia, and regulators are responsible for the high
attrition rate (3). Therefore, it is vital to develop suitable study designs
and protocols for candidate molecules such that they obtain regulatory
approval and can be marketed. In addition to these challenges, the
development of anti-cancer agents comes at a monumental cost of an
estimated $2.8 billion. Several factors such as the choice of relevant
endpoints, the choice of appropriate biomarkers that are guided by tumor
biology, and careful patient selection are expected to improve the overall
fate of oncologic agents in the clinical trial phase
10 STRATEGIC POINTS 2
Ten Strategic Points
Grand Canyon University
DNP-815- O502: Scientific Underpinnings
10 Strategic Points Table
(Use this table to complete the 10 Strategic Points document for your project.)
10 Strategic Points
Comments/Feedback
Broad Topic Area
Impact of Medication Administration Errors on 3-4-Year-old Leukemia Patients
Literature Review
A. Verghese, A., Charlton, B., Kassirer, J. P., Ramsey, M., & Ioannidis, J. P. (2015). Inadequacies of physical examination as a cause of medical errors and adverse events: a collection of vignettes. The American journal of medicine, 128(12), 1322-1324.
The article looks at the “Inadequacies of physical examination as a cause of medical errors and adverse events: a collection of vignettes” from the American journal of medicine. It takes into consideration the fact that, the oversights in the corporeal assessment are a medical fault which aren’t studied via chart evaluation. Furthermore, the article states that these oversights in the corporeal assessments may be the primary contributors to the neglected or late diagnosis besides unnecessary exposure to contrast as well as radiation on the Leukemia patients. Either the authors indicate that the incorrect treatments resulting from these delays leads to unfavorable results like fainting on the Leukemia patient, lack of appetite on the side of the patient, worsening the Leukemia conditions which eventually can lead to early death of the patient.
B. Hockings, J. K., Owolabi, D. K., Broyles, J. E., & Wheelis, S. C. (2017). Impact of medication administration error on over 3 years Leukemia patients and the stimulating factors in acute leukemia and stem cell transplant patients. Supportive Care in Cancer, 25(6), 1853-1858.
The authors of this article explored the “Impact of medication administration error on over 3 years Leukemia patients and the stimulating factors in acute leukemia and stem cell transplant patients.” This article is from supportive care in cancer and it was retrieved from Google Scholar. The article authors acknowledge the fact that, the medication administration errors lead to severe impacts on the health conditions of the patient more especially the ones who are 3 – 4 years of Leukemia. According to the authors, the impacts associated with the medication administration errors may lead to worsening of the health condition of the patient, the rate of Leukemia advancement into higher stages may also increase with treatment or managing of this deadly disease being more complicated. The authors argue that using erroneous medicines, the Leukemia advancement increases without the knowledge of the patient which makes even the survival chances of the patient to reduce due to stress upon realizing that there was an error in his or her medication.
C. Douer, D. (2016). Efficacy and safety of vincristine sulfate liposome injection in the treatment of adult acute lymphocytic leukemia. The oncologist, 21(7), 840-847.
...
Multidisciplinary Approach to Prostate Cancer and Changes in Treatment Decisi...CrimsonpublishersCancer
In order to demonstrate the impact of multi-disciplinary care in the community oncology setting, we evaluated treatment decisions following the initiation of a dedicated genitourinary multi-disciplinary clinic (GUMDC).
ISSN 2347-2251
It appears that you're describing the scope of a scientific journal. This journal covers a wide range of topics related to both Pharmaceutical Sciences and Biological Sciences of the scopus database journal.
Indo-American Journal of Pharma and Bio Sciences is an international, online, English-language journal that publishes articles on pharmaceutical and biological sciences of the ugc carelist journals.
ISSN 2347-2251
Manuscripts should be carefully checked for grammatical and punctuation errors. All papers undergo peer review. Please note that all articles published in this journal represent the opinions of the authors and do not necessarily reflect the official policy of the Journal of Indo-American Journal of Pharma and Bio Sciences of the journals to publish paper.
Scientific development is an ever-evolving journey, driven by the exchange of data and ideas among researchers across the globe.One such remarkable publication dedicated to facilitating this exchange within the fields of Pharmacy and Bio Sciences is the Indo-American Journal of Pharma and Bio Sciences of the published research.
The Indo-American Journal of Pharma and Bio Sciences plays a crucial role in the scientific community by providing a platform for the exchange and dissemination of research findings in the fields of Pharmacy and Bio Sciences is the sscope and journal of the journal research paper.
Adherence to Antiretroviral Therapy among HIVPositive Patients in Central Hos...Efe Clement Abel
Abstract: Adherence is the quantified level to which an individual follows a prescribed treatment and a low level of adherence to antiretroviral therapy(ART) adversely affects a patient’s treatment outcome and results in a rebound of plasma viraemia, development of resistant strains of HIV, more rapid immune deterioration, development of AIDS and death. This study is aimed at assessing the level of adherence to ART among HIV-positive patients assessing care in Central Hospital, Warri, Delta State, Nigeria. A descriptive cross-sectional study. Data were obtained using a semi-structured, interviewer-administered questionnaire and analysed using SPSS version 23. A total of 303 persons were recruited for the study. The mean age of respondents was 36.2±10.8years. Less than half of the subjects (45.5%) were adherent to their ART. Among the non-adherent subjects, the common reasons reported for missing doses of ART were forgetfulness (50.9%), too busy with other things (43.6%) and away from home (35.8%). This study showed that adherence to ART among the study population was poor. Forgetfulness, too busy with other things and being away from home were the most common reason for non-adherence. It is, therefore, recommended that; regular health education should be organised for HIV patients on ART on the importance of being adherent to their ART, regular assessment of adherence to ART should be carried out and a method of reminding patients who are non-adherent to ART on the need to take their ART as at when due should be considered as part of the routine services provided by ART centres.
The prevalence, patterns of usage and people's attitude towards complementary...home
The prevalence of CAM in Chatsworth is similar to findings in other parts of the
world. Although CAM was used to treat many different ailments, this practice could not be
attributed to any particular demographic profile. The majority of CAM users were satisfied with
the effects of CAM. Findings support a need for greater integration of allopathic medicine and
CAM, as well as improved communication between patients and caregivers regarding CAM usage.
Pancreatic Adenocarcinoma with Isolated Venous Involvement: Is Neoadjuvant Tr...EditorSara
Neoadjuvant Treatment (NAT) is indicated in locally advanced tumors and improves the results of subsequent surgery. In borderline tumors, the place of this preoperative treatment is more controversial, probably because borderline tumors are a heterogeneous group. We focused on the tumors with venous involvement without any arterial involvement and studied the results of neoadjuvant treatment in this particular group.
APL:Retinoic Acid and Retinoid Pharmacology, a Breakthrough TodayEditorSara
Acute promyelocytic leukemia(APL),a specific characteristic of t(15;17) chromosomal translocation,molecular gene analyses are conclusive in vivo evidence that oncogenic pml/RARa fusion plays a crucial role in APL leukemogenesis [1-3]. Since the introduction of initial 13-cis retinoic acid(13-cis RA)[4],and currently all-trans RA(ATRA) [5] and tamibarotene [6],RA plus chemotherapy or RA plus As2O3 regimen is currently the standard of care [7]...
Hairy Cell Leukemia (HCL) is a rare subtype of B-cell chronic lymphoid leukemia which was first described by Bertha Bouroncle in 1958 [1]. The annual incidence of HCL is approximately 0.3 cases per 100,000 and the disease comprises 2-3% of all leukaemia?s in the Western world [2,3]...
STAT-6 In Hodgkin Lymphoma Pathobiology and Treatment-Review of the LiteratureEditorSara
Classical Hodgkin Lymphoma (cHL), consists of rare neoplastic Hodgkin and Reed-Sternberg cells (HRS) residing in a prominent inflammatory background. HRS show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS with various other types of cells in the microenvironment, but also through genetic lesions...
Lipocalin 2 as a Potential Diagnostic and/or Prognostic Biomarker in Prostate...EditorSara
Lipocalin 2 (LCN2) is a 25 kDa secreted protein, initially purified from neutrophil granules, and mainly expressed in immune cells, hepatocytes, renal cells, prostate, cells of the respiratory tract and cardiomyocytes. LCN2 belongs to the family of lipocalins known for their ability to traffic small hydrophobic molecules such as lipids and retinoids...
As an Obstetrics & Gynaecology, member of National Breast Cancer Foundation and a woman I find it very important to raise awareness about the importance of early detection of Breast Cancer. Make a difference! Spread the word about mammograms and encourage communities, organisations, your friends and family memebrs to get involved! Your help matters...
Peripheral T-Cell Lymphomas: Progress in TreatmentEditorSara
Peripheral T-Cell Lymphomas (PTCL) arises from mature T-cells and they represent an extremely heterogeneous group. They are sub-classified into three major groups based on clinical presentation and localization, namely the nodal, extra nodal and leukemic PTCL. This review focuses on nodal PTCL which are the most frequently encountered entities...
Circulatingtumordna (Ctdna) in Prostate Cancer: Current Insights and New Pers...EditorSara
Prostate Cancer (PC) is the common tumor in men, which represents one of leading cause of cancer death throughout the world. Most patients were diagnosed too late for curative treatment. So, it is necessary to develop a minimal invasive method to identify novel biomarkers. Currently, plasma DNA has attracted increasing attention as a potential tumor marker..
The Role of Immunity in Chemotherapy-Resistant Patient with Pembrolizumab: A ...EditorSara
Approaches are limited for treating advanced Non-Small-Cell Lung Cancer (NSCLC) with multidrug resistance but without ALK and EGFR mutations. Pembrolizumab (KEYTRUDA) brings on unprecedented clinical benefit in various cancer types..
Deadenylase Expression in Small Cell Lung Cancer Related To Clinical Characte...EditorSara
Lung cancer is the second common malignancy and the most aggressive cancer worldwide with late diagnosis and poor prognosis. The search for biomarkers that promote early diagnosis and improve therapeutic strategies focuses to the understanding of the mechanisms underlying cancer development and progression. The deregulation of gene expression is one of the cancer hallmarks reflected to the stability..
Stereotactic Radiation Therapy of Lung Cancers and Subsequent Parenchymal Alt...EditorSara
Stereotactic body radiation therapy (SBRT) is one of the standard radical treatments in stage I nonsmall cell lung cancer (NSCLC) and an option for lung metastases. The pulmonary parenchymal CT alterations at 3, 6 and 12 months are the object of a prospective analysis in patients submitted to SBRT, to define factors affecting the different radiological alterations...
Higher Rates of Helicobacter Pylori Infection and Gastric Intestinal Metaplas...EditorSara
The rate of Helicobacter pylori (H. pylori) infection is higher in minority patients in the United States [1]. Gastric intestinal metaplasia (IM) is associated with H. pylori infection and carries an increased risk for gastric cancer over time, in particular for patients from regions of high gastric cancer incidence [2]. We aimed to compare the rates of Helicobacter pylori infection and gastric intestinal metaplasia...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...EditorSara
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies...
Myelomastocytic leukemia is a very rare variant of myeloid leukemia, behaves clinically very aggressive and belongs to the group of so-called metachromatic leukemias. Metachromatic leu- kemias comprise leukemias with at least 10 to 20% tumor cells exhibiting metachromatic gran- ules: mast cell leukemia...
Analysis of Treatment Option for Synchronous Liver Metastases and Colon Recta...EditorSara
Colorectal or bowel cancer is one of the major cause of cancer worldwide. Research has shown that 15 to 20 % colorectal cancer patients are also diagnosed with synchronous liver metastases (LM) at presentation and about one third eventually develop liver lesions (Leporrier, Maurel, Chiche, Bara, Segol, and Launoy, 2006; Manfredi, Lepage, Hatem, Coatmeur, Faivre, and Bou-vier, 2006)...
An Adrenal Mass in a Patient with Lynch SyndromeEditorSara
Adrenocortical cancer (ACC) is a rare malignancy (estimated annual incidence 0.7 to 2.0 cases per million individuals worldwide) with a poor prognosis. In contrast, Lynch Syndrome (LS) is a much more commonly encountered hereditary syndrome that predisposes individuals to colon cancer and multiple other malignancies.
Linitis plastica is a diffuse form of gastric cancer and accounts for about 10% of all cases of gastric malignancy and its exact general population distribution is unknown. There are no characteristic or specific symptoms, the symptoms are similar to those of other forms of stomach cancer and can manifest as a feeling of fullness after eating, nausea and vomiting, epigastric pain, weight loss, and progressive dysphagia [1]. Plastic linitisis characterized by malignant glandular proliferation of cricoid cells in the fibrous stroma, which ultimately leads to thickening and rigidity of the stomach wall.
On February 21, 2020, at Codogno Hospital (in the Lodi?s Province, Lombardy, Italy), Italy?s Coronavirus ?patient one? was discovered. In the following week the cases within the Province of Lodi increased exponentially and it was interpreted as a disease cluster originating from the hospital.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Racial Differences in Accepting Pegfilgrastim Onpro Kit (On-Body Injector) Use Among Cancer Patients
1. Racial Differences in Accepting Pegfilgrastim Onpro Kit (On-
Body Injector) Use Among Cancer Patients
Saif MW1*
, Hackenyos DW2
, Smith MH2
, Healey P2
, Relias V2
and Wasif K3
1
Northwell Health Cancer Institute, Lake Success, NY, USA
2
Tufts Medical Center, Boston, MA, Tufts University School of Medicine, Boston, MA, USA
3
Simmons University, Boston, MA, USA
Volume 1 Issue 6- 2019
Received Date: 12 Feb 2019
Accepted Date: 22 Feb 2019
Published Date: 25 Feb 2019
1. Abstract
1.1. Background: Neulasta Onpro kit eliminates need for additional clinic visit after chemother-
apy. Given the racially diverse population in our institution, we investigated acceptance of Onpro
kit among patients on chemotherapy.
1.2. Research Design and Methods: Single-institution, retrospective review conducted in patients
with GI tumors who received Onpro kit within 1 hour of completion of systemic chemotherapy
from Jan 2014 through Jan 2018. Clinic/nursing notes and pharmacy records were reviewed to
identify patients who refused Onpro kit and to discern reasons for refusal, including racial reason.
1.3. Results: Total 238 orders for kit were voided amongst 68 patients (Caucasian 41; African
American 7; Spanish 3; Asian 17). Overall, 15/68 patients refused kit (22%) of these 87% were
Asian. The reasons for refusal included dislike of bulky attachment to skin, request to place kit on
stomach instead of arm, trepidation over unwitnessed administration of drug, fear of reaction, dis-
posal at home, fear of pain, lack of confirmation of proper dose administration, and need for MRI.
1.4. Conclusions: While Onpro kit is an attractive alternative, 22% of patients with voided orders,
mainly of Asian race, declined its application. We believe the current study represents the first look
at important racial differences in accepting Onpro kit. Consideration of patients’ cultural heritage,
race, ethnicity and education may facilitate communication between physicians and patients to
achieve optimal cancer care.
Clinics of Oncology
Citation:Saif MW, Hackenyos DW, Smith MH, Healey P, Relias V and Wasif K, Racial Differences in
Accepting Pegfilgrastim Onpro Kit (On-Body Injector) Use Among Cancer Patients. Clinics of Oncology.
2019; 1(6): 1-4.
United Prime Publications: http://unitedprimepub.com
*Corresponding Author (s): M. Wasif Saif, MD, MBBS, Deputy Physician-in-Chief and
Director of Medical Oncology, Northwell Health Cancer Institute, 1111 Marcus Avenue,
Lake Success, NY 11042, USA, Fax: 516-321-2271, Tel: 516-321-2238, E-mail: wsaif@
northwell.edu
Research Article
2. Keywords
Chemotherapy; Pegfilgras-
tim; Neutropenia; Leukope-
nia,; Fever; Side effects
3. Introduction
Neutropenia is a serious adverse complication of myelosuppres-
sive chemotherapy that predisposes patients to life-threatening
infection, hospitalization and delays in treatment. This is associ-
ated with significant mortality as well as increased health-care as-
sociated costs [1]. Chemotherapy induced neutropenia has been
mitigated by advent of granulocyte stimulating factors. The first
of this class of drug to be widely used was filgrastim, a recom-
binant version of endogenous growth factor that stimulates the
proliferation and differentiation of neutrophils. Due to its small
size, filgrastim is rapidly cleared by the kidneys and requires dai-
ly dosing. Pegfilgrastim, a filgrastim molecule linked to a large
polyethylene glycol molecule, is a popular alternative as the large
PEGylated moiety slows renal clearance and requires dosing only
once during a chemotherapy cycle [2]. Per the dosing adminis-
tration instructions, pegfilgrastim should not be given 14 days
before or 24 hours after administration of cytotoxic chemothera-
py. This is largely based on a theoretical risk of paradoxically in-
creasing hematologic toxicity as GCSF is thought to increase the
population of chemotherapy-susceptible granulocyte precursors
[3]. This dosing regimen is cumbersome; often requiring patients
to make additional office visits. In light of this, the dosing of peg-
filgrastim has been made moot through the introduction of the
OnPro® Delivery Kit [4]. This is a device that can be adhered to
the skin on the day of chemotherapy administration and auto-
injects the recipient on the following day, thus eliminating the
need for a return office visit. While this is an attractive alterna-
tive, some patients may hesitate or decline its use either due to
3. United Prime Publications: http://unitedprimepub.com 3
5.3. Toxicities
There were no episodes of grade 3 or 4 neutropenia or febrile neu-
tropenia among all these patients and related adverse events were
mainly bone pain as expected.
6. Discussion
In 2017, we presented the first study in GI malignancies to report
the current study represents the first study to look at important
ethnic differences in accepting the Onpro kit. This study detected
ethnic differences and supports the importance of cultural factors
in determining therapies chosen, underlying the need to facilitate
communication between physicians and patients and to provide
educational material to the patients to achieve optimal cancer
care.
There has been a constant effort to overcome the challenge of de-
laying administrating pegfilgrastim on the same day of chemo-
therapy but many studies show conflicting results [13-16]. Per the
dosing administration instructions, pegfilgrastim should not be
given 14 days before or 24 hours after administration of cytotoxic
chemotherapy. This is largely based on a theoretical risk of para-
doxically increasing hematologic toxicity as GCSF is thought to
increase the population of chemotherapy-susceptible granulocyte
precursors [3]. This dosing regimen is cumbersome; often requir-
ing patients to make additional office visits. This was a main im-
petus to develop anew formulation, such as the OnPro® Delivery
Kit [4].This is a device that can be adhered to the skin on the day
of chemotherapy administration and auto-injects the recipient on
the following day, thus eliminating the need for a return office
visit. While this is an attractive alternative, our study showed that
over 20% of the patient who would qualify for this device decline
its application for many reasons including the fear of unknown,
not liking a bulky attachment to their skin or having trepidation
over an un-witnessed administration of pegfilgrastim both for
fear of reaction and/or lack of confirmation of proper dose ad-
ministration.
In the current era of medicine, shared doctor–patient decision-
making plays a crucial role in improving the patient-level factors,
such as preferences for treatment, and subsequently can improve
health care quality. As described earlier in the paper, ethnic as
well as racial disparities towards acceptance of therapy is an
under-explored field in both malignant and non-malignant dis-
eases. Our study again supports the fact that in addition to other
factors, reluctance to accept proven treatments by minorities can
contribute to health disparities. Once identified, we must under-
take interventions to address racial/ethnic differences in patient
decision-making.
Our study has limitations.Most notably, the small sample size
and being a single institution retrospective analysis, it may limit
the extrapolation of results to a more diverse patient population.
However, it addresses an important clinical issue that warrants
urgent attention to dissolve the racial disparity in acceptance of
a FDA-approved treatment. Consideration of patients’ cultural
heritage may facilitate communication between physicians and
patients to achieve optimal cancer care. It would be interesting
to look at experience or market share of manufacturer in Asian
countries. Moreover, translated patient brochures and videos
could be very helpful.
7. Conclusions
We believe the current study represents the first study to look
at important racial differences in accepting Neulasta Onpro® kit.
This study detected racial differences and supports importance
of cultural factors in determining therapies chosen, underlying
the need to facilitate communication between physicians and
patients and to provide educational material to the patients to
achieve optimal cancer care.
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Volume 1 Issue 6 -2019 Research Article