This document discusses best practices for running Cassandra on Amazon EC2. It recommends instance sizes like m1.xlarge for most use cases. It emphasizes configuring data and commit logs on ephemeral drives for better performance than EBS volumes. It also stresses the importance of distributing nodes across availability zones and regions for high availability. Overall, the document provides guidance on optimizing Cassandra deployments on EC2 through choices of hardware, data storage, networking and operational practices.