Any overdose is primarily a respiratory emergency as poisons do not change their chemical structure but instead threaten breathing. The body needs a constant supply of air with adults needing 1.5 liters every 5 seconds, so rescue breathing is crucial for any non-breathing patient to prevent organ and brain damage from oxygen deprivation. Naloxone is a secondary treatment since it does not always work, and responders should always prioritize respiratory assistance even when administering large doses of Naloxone.