Drug overdoses cause acute respiratory failure as poisons do not change their chemical structure, but instead prevent the diaphragm from controlling breathing and providing the 1.5 liters of air needed every 5 seconds. Naloxone is a secondary treatment as it does not always work, so any respiratory patient needs continuous assistance through rescue breathing or other means to prevent cells, tissues, and organs like the brain from dying without oxygen. High doses of Naloxone may be needed along with ongoing respiratory support.

1. Poisons (drugs) did not magically change their chemical structure and
start causing death by cardiac arrest. Drug OD is acute respiratory
failure. Our diaphragm still controls our breathing, adult needs 1.5
liters of air every 5 seconds. Naloxone is second line defense because
it does not always work and every second you withhold the air from
any respiratory patient every cell, tissue and organ is dying lack of
oxygen, especially the brain. Note massive doses Naloxone used, and
continuous respiratory assist. Rescue breathing lay responder same.
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