Carpal tunnel syndrome is a compressive neuropathy of the median nerve as it passes through the carpal tunnel in the wrist. It commonly affects the general population, with risk factors including female sex, obesity, pregnancy, rheumatoid arthritis, and repetitive motions. Symptoms include numbness and tingling in the thumb, index, middle and half of ring fingers, especially awakening the patient at night. Diagnosis involves physical exam findings like thenar atrophy and positive Tinel's and Phalen's tests. Conservative treatment includes splinting, activity modification, and steroid injections, while surgery involves carpal tunnel release if conservative measures fail.